What You Should Know About Subcutaneous and Transvenous ICD
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1 What You Should Know About Subcutaneous and Transvenous ICD N. A. Mark Estes III MD Professor of Medicine Tufts University School of Medicine Director, New England Cardiac Arrhythmia Center Tufts Medical Center Boston MA Friday October 27, 2017 HCM Summit Boston, MA
2 ICD in HCM Class I Class II Class III ICD should be placed IIA IIB ICD not recommended Prior cardiac arrest Sustained VT Family history SD-firstdegree relative LV wall thickness > 30 mm Recent unexplained syncope NSVT or BP ETT With other risk modifiers No prior cardiac arrest or sustained VT No risk factors
3
4 Subcutaneous ICD US Post Market Study 2013 Circulation US IDE Study US FDA Approval 2012 BS Acquires Cameron Health 2012 US IDE Study 2012 EFFORTLESS S-ICD Registry 2010 Bardy NEJM 2009 CE Mark Approval 2002 Concept
5 High risk genetic disorders HCM LQTS Brugada High risk for lead complications Young and active Previous device infections Diabetic and immunocomprised No venous access Occluded veins Congenital Heart Disease Transvensous leads undesirable Hemodialysis patients Younger Patients H/O Endocarditis or bacteremia S-ICD Candidates
6 Pre-implant evaluation
7 Proposed strategy to avoid inappropriate shocks in hypertrophic cardiomyopathy (HCM) patients.
8
9 Weinstock et al JAHA 2016
10 Maurizi et al Prevalence of subcutaneous implantable cardioverter- defibrillator candidacy based on template ECG screening in patients with hypertrophic cardiomyopathy Heart Rhythm 2016
11 Lambiase, EFFORTLESS S-ICD Registry, HRS 2012, Boston, MA CE Mark Approved. Caution: S-ICD is an investigational device limited to investigational use only under US federal law. Not for sale. The S-ICD System Operation S-ICD System is en1rely subcutaneous and can be placed using anatomical landmarks Three sensing vectors to iden1fy most robust cardiac signal Single-zone programming allows therapy to be delivered solely on measured heart rate Dual-zone programming ac1vates SVT discrimina1on algorithm to determine appropriateness of therapy
12 Rhythm Discrimination with a Subcutaneous Defibrillator Freedom from first inappropriate shock according to the number of zones programmed. Gold et al Heart Rhythm 2014.
13 Subcutaneous ICD 2008 Fidelis Lead Recall 2012 MADIT-RIT Moss AJ et al. NEJM Transvenous leads are the weak link in current ICDs Prolonged detection/high 2010 Riata rate Lead detection Recall is safe and improves outcomes Kleemann et al. Circulation May 2007
14 Lambiase, EFFORTLESS S-ICD Registry, HRS 2012, Boston, MA EFFORTLESS Registry Broad Range of ICD Indications Patients from a broad range of indications have received the S-ICD Ischemic (38%) Channelopathy (13%) Congential (3%) Non ischemic CM (10%) HCM (13%) ARVD (3%) Idiopathic VF (20%)
15 Lambiase, et al Evaluation of subcutaneous ICD early performance in hypertrophic cardiomyopathy from the pooled EFFORTLESS and IDE cohorts Heart Rhythm 2016
16 Lambiase, et al Evaluation of subcutaneous ICD early performance in hypertrophic cardiomyopathy from the pooled EFFORTLESS and IDE cohorts Heart Rhythm 2016
17 Lambiase, et al Evaluation of subcutaneous ICD early performance in hypertrophic cardiomyopathy from the pooled EFFORTLESS and IDE cohorts Heart Rhythm 2016
18 Lambiase, et al Evaluation of subcutaneous ICD early performance in hypertrophic cardiomyopathy from the pooled EFFORTLESS and IDE cohorts Heart Rhythm 2016
19 Lambiase, et al Evaluation of subcutaneous ICD early performance in hypertrophic cardiomyopathy from the pooled EFFORTLESS and IDE cohorts Heart Rhythm 2016
20 Lambiase, et al Evaluation of subcutaneous ICD early performance in hypertrophic cardiomyopathy from the pooled EFFORTLESS and IDE cohorts Heart Rhythm 2016
21 ICDs in HCM Pts. Total ICDs 305 Total SubQ ICDs 32 Total TV ICDs 273 Pts. w/ Shocks Received 7 Pts. w/ No Shocks Received 24 (+1 limited info) Pts. w/ Shocks Received 32 (+4 limited info) Pts. w/ No Shocks Received 174 (+63 limited info) Appropriate Shocks 1 Inappropriate Shocks 6 Appropriate Shocks 34 Inappropriate Shocks 3
22
23 ICD with Subcutaneous Leads Advantages No transvenous lead complications Fluoroscopy not required for implant Ultra far field signals for arrhythmia discrimination Disadvantages Post shock pacing only (No Brady, CRT, ATP) No remote monitoring Larger Pulse generator
24 Patient Groups for S-ICD Implantation S-ICD is preferred device Channelopathies (long-qt syndrome, Brugada, hypertrophic cardiomyopathy) No venous access (occluded veins or congenital anomalies) High risk of complications for transvenous systems have (dialysis, pediatric, and immunocompromised) Previous device infections or lead failures History of endocarditis S-ICD should be strongly considered Young patients Life expectancy >10 y Primary prevention indicated patients with ischemic/nonischemic heart failure Prosthetic valves Women (preferred generator placement lateral wall) Selected secondary prevention indicated patients (survivors of out-ofhospital VF, no evidence of monomorphic VT S-ICD should be avoided Systolic heart failure and LBBB who are indicated for CRT
25 What You Should Know About Subcutaneous and Transvenous ICD N. A. Mark Estes III MD Professor of Medicine Tufts University School of Medicine Director, New England Cardiac Arrhythmia Center Tufts Medical Center Boston MA Friday October 27, 2017 HCM Summit Boston, MA
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