Inappropriate electrical shocks: Tackling the beast
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1 ESC Paris 2011 Inappropriate electrical shocks: Tackling the beast Gerhard Hindricks University of Leipzig Heart Center Dept. of Electrophysiology
2 ESC Paris 2011 Inappropriate electrical shocks: Tackling the beast Presenter disclosure information: Gerhard Hindricks has received honoraria for lectures from Biosense, Stereotaxis, St. Jude Medical, Biotronik Gerhard Hindricks is a member of the Advisory Board / consultant for Biosense, St. Jude Medical, Biotronik, Stereotaxis, Cyberheart
3 Impact of ICD shocks SCD HeFT showed of 33% incidence of ICD shocks appropriate shocks resulted in a 5-fold increased risk of death inappropriate shocks increased risk of death 2-fold median time to death days after appropriate shock days after inappropriate shock leading cause of death: progressive heart failure
4 Impact of ICD shocks inappropriate shocks are a frequent problem of ICD therapy and account for 10 24% of ICD discharges clinical characteristics of pts. with inappropriate shocks: - tend to be younger - more likely to have / develop atrial fibrillation - more advanced heart failure incidence of inappropriate shocks causes of inappropriate shocks solutions for patients with inappropriate shocks and prevention
5 Impact of ICD shocks inappropriate shocks are a frequent problem of ICD therapy and account for 10 24% of ICD discharges clinical characteristics of pts. with inappropriate shocks: - tend to be younger - more likely to have / develop atrial fibrillation - more advanced heart failure incidence of inappropriate shocks causes of inappropriate shocks solutions for patients with inappropriate shocks and prevention
6 How common are ICD shocks?
7 Impact of ICD shocks inappropriate shocks are a frequent problem of ICD therapy and account for 10 24% of ICD discharges clinical characteristics of pts. with inappropriate shocks: - tend to be younger - more likely to have / develop atrial fibrillation - more advanced heart failure incidence of inappropriate shocks causes of inappropriate shocks solutions for patients with inappropriate shocks and prevention
8 Causes of inappropriate shocks 1. Atrial arrhythmias 2. Ventricular oversensing of cardiac signals 3. Lead fracture 4. Electromagnetic interference
9 Causes of inappropriate shocks 133/600 patients (22.6 %) 4% 5% 23% 25% 5% 39% Afib Aflut ST SVT NSVT Oversen. 74 % of inappropriate therapy due to different forms of SVT Weber et al. Z Kardiol 1996;85:809
10 Recurrent shocks in 49 year old man 46 year old male received an ICD for primary prevention of SCD according to MADIT II criteria after 3 years he suddenly experienced 3 shocks during a period of mild palpitations. Subsequent hospital admission showed the following ECG: in the ICU, the patient received another inappropriate shock
11 Inappropriate shocks due to AF
12 Inappropriate shocks due to AF: acute management device interrogation diagnosis / ECG documentation appropriate treatment - betablocker / Ca antagonist - AA-drugs - external cardioversion Braunschweig et al., Europace 2010
13 ICD response to magnets Braunschweig et al., Europace 2010
14 Inappropriate shocks due to AF: options improve device programming, active appropriate algorithms adopt medical treatment with betablockers in adequate dosage antiarrhythmic drug therapy to suppress AF AV nodal ablation catheter ablation of AF
15 Inappropriate shocks due to AF: options improve device programming, active appropriate algorithms adopt medical treatment with betablockers in adequate dosage antiarrhythmic drug therapy to suppress AF AV nodal ablation catheter ablation of AF
16 Inappropriate shocks due to AF: enhanced programming Sudden Onset Activate! - discriminates sinus tachycardia from VT - cave: AFL, AF, AVNRT have also sudden onset - cave: slow VT during sinus tachycardia may be non-sudden Stability Activate! - discriminates atrial fibrillation from VT - cave: sinus tachycardia, AFL, AVNRT also regular - cave: irregular VTs Ventricular EGM Morphology Activate if it works! - cave: SVT with aberrancy Sustained Rate Duration Deactivate (or 5 min)! Activate up to 200 bpm
17 Inappropriate shocks due to AF: enhanced programming Braunschweig et al., Europace 2010
18 Inappropriate shocks: enhanced detection criteria ASTRID Studie n = 149 Dorian et al., Heart Rhythm 2004;1:540-7
19 Inappropriate shocks due to AF: follow-up no further inappropriate shocks for 6 months then another shock during exercise, again due to AF with fast ventricular response. antiarrhythmic drug therapy to suppress AF? AV nodal ablation? catheter ablation of AF?
20 Inappropriate shocks due to AF: follow-up no further inappropriate shocks for 6 months then another shock during exercise, again due to AF with fast ventricular response. antiarrhythmic drug therapy to suppress AF? AV nodal ablation? catheter ablation of AF?
21 Inappropriate shocks due to AF: AF ablation
22 Inappropriate shocks: oversensing 1. Cardiac Signals - T Wave Oversensing - R Wave Double Counting - P Wave Farfield Sensing 2. Body Signals - Pectoral Muscle Potentials - Diaphragmatic Potentials 3. Electromagnetic Interference 4. Electrode Fracture/Insulation Defect
23 Inappropriate shocks: T wave oversensing shock therapy for nsvt combined with T wave oversensing
24 Inappropriate shocks: avoid T wave oversensing large R waves at implantation dedicated programming options R-T ratio: If stable, may be detected by algorithm
25 Inappropriate shocks: T wave oversensing accounting for inappropriate shocks in 3% can be transient, triggered by exercise or electrolyte imbalances can often be corrected by device reprogramming / change in sensitivity / adjustment of refractory period when the device is less sensitive, defibrillation testing may be recommended T-wave oversensing that can not be overcome by reprogramming may require lead repositioning or a new pace sense lead
26 Inappropriate shocks: lead integrity problems patient with 8 consecutive shocks in 2 hours
27 Inappropriate shocks: extracardiac sensing defects skeletal myopotentials electromagnetic interference mechanical lead problems - fracture - dislodgement - insulation break lead fracture (1-4%) should be suspected in patients presenting with multiple shocks in rapid succession interrogation reveals change in lead impedance, failure to sense or capture, however, defects may be transient. often lead revision or replacement necessary
28 Inappropriate shocks: lead integrity alert 76 % of patients with electrode fracture would have received alert 3 days before inappropriate shock Swerdlow et al., Circulation 2008;118:2122-9
29 Inappropriate shocks due to lead fracture: prevention Data from 15,970 patients with Sprint Fidelis electrodes (121 fractures) Swerdlow et al., Circulation 2008;118:2122-9
30 General management of patients with ICD shocks Mishkin JD et al., JACC 2011
31 General rules to minimize unnecessary or inappropriate shocks use detection zones appropriately - upper boundary for slow VT 188 bpm (320 ms) in SHD - fast VT 188 to 250 bpm ( ms) in SHD - VF zone above 200 in SHD consider monitoring zone for slow VT apply individual programming in pts. without SHD adequate rate control in AF pts. (betablocker + amiodarone) adequate rhythm control (catheter ablation) activate discrimination algorithms according to specific device programming options
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