Heart Rhythm Disorders. How do you quantify risk?
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- Abigayle Burns
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1 Heart Rhythm Disorders How do you quantify risk?
2 Heart Rhythm Disorders Scale of the Problem 1/2 population will have an episode of transient loss of consciousness (T-LOC) at some stage in their life. Palpitations = 1/3 all referrals to cardiology 1% all A&E attendances due to T-LOC
3 Heart Rhythm Disorders Scale of the Problem 1/2 population will have an episode of transient loss of consciousness (T-LOC) at some stage in their life. Palpitations = 1/3 all referrals to cardiology 1% all A&E attendances due to T-LOC Benign Fatal (Cardiac Arrest)
4 Recurrent Transient Loss of Consciousness T-LOC Cerebral Hypoperfusion Transient LOC Loss of postural tone Syncope
5 Syncope Transient loss of consciousness due to cerebral hypoperfusion Postural BP 20% > 90% patients with cardiac syncope have a benign condition with a normal life expectancy Reflex 70% Cardiac 10% Tachycardia Bradycardia Mechanical Obstruction < 10% patients with cardiac syncope have a potentially life-threatening condition
6 Prognosis Framingham Heart Study No Syncope - Reflex Cardiac Adapted from Soteriades E et al. NEJM 2002; 347:
7 Prognosis Framingham Heart Study No Syncope - Reflex Cardiac Adapted from Soteriades E et al. NEJM 2002; 347:
8 Palpitations An abnormal awareness of the heart beat
9 Palpitations An abnormal awareness of the heart beat Paroxysmal Sustained Tachycardias AV node dependent tachycardias Atrial tachyarrhythmias Ventricular tachyarrhythmias Ectopics
10 Palpitations An abnormal awareness of the heart beat Paroxysmal Sustained Tachycardias Ectopics AV node dependent tachycardias (Curable!) Atrial tachyarrhythmias Ventricular tachyarrhythmias
11 Palpitations An abnormal awareness of the heart beats Paroxysmal Sustained Tachycardias AV node dependent tachycardias Atrial tachyarrhythmias Ventricular tachyarrhythmias Ectopics
12 CHADS-VASc Score and Stroke Risk Lip G et al. The Euro Heart Survey on AF. Chest 2010; 137:
13 Danish National Registry CHADS-VASc n(%) Thromboembolism / Score 121,280 (100) 100 person years (8.4) (12.0) (18.2) (23.0) (18.7) (11.7) (5.7) (1.9) (0.4) (0.1) 23.6 Olsen J. BMJ On-line First 2011
14 Assessing Risk in Atrial Tachyarrhythmias (AT, AFL, Afib) CHADSVASc Score = Annual stroke risk Oral anticoagulation reduces risk by 2/3 Aspirin confers little benefit (20% reduction)
15 Danish National Registry CHADS-VASc n(%) Thromboembolism / Score 121,280 (100) 100 person years (8.4) (12.0) (18.2) (23.0) (18.7) (11.7) (5.7) (1.9) (0.4) (0.1) 23.6 Warfarin 2% Olsen J. BMJ On-line First 2011
16 Palpitations An abnormal awareness of the heart beat Paroxysmal Sustained Tachycardias AV node dependent tachycardias Atrial tachyarrhythmias Ventricular tachyarrhythmias - Scar related VT - Normal Heart VT Ectopics
17 Ventricular Tachycardia (Scar Related VT)
18 Conduction Velocity dependent on Fibre orientation
19 Reentry Scar related VT Peri-infarct Zone
20 Peri-Infarct Zone
21 VT initiation *
22 VT initiation
23 Reentry Scar related VT
24 Atherosclerosis Pathophysiology of Cardiac Arrest Myocardial Infarction SCAR Pulseless VT/VF Cardiac Arrest
25 Atherosclerosis Myocardial Infarction Pathophysiology of Cardiac Arrest 100,000 deaths per year 12% all natural deaths SCAR Q waves on ECG Scar inversely proportional to Ejection fraction EF < 35% - Consider primary prevention ICD Pulseless VT/VF Cardiac Arrest
26 Atherosclerosis Pathophysiology of Cardiac Arrest Myocardial Infarction SCAR Syncopal VT Pulseless VT/VF Cardiac Arrest
27 Atherosclerosis Pathophysiology of Cardiac Arrest Myocardial Infarction SCAR A patient with unexplained syncope and significant structural heart disease should be considered to have survived a life threatening event until proven otherwise Syncopal VT Pulseless VT/VF Cardiac Arrest 10%/yr
28 Palpitations An abnormal awareness of the heart beats Paroxysmal Sustained Tachycardias AV node dependent tachycardias Atrial tachyarrhythmias Ventricular tachyarrhythmias Ectopics
29 Ventricular Ectopics Benign or Marker of Disease?
30 Prior MI Myocarditis DCM Alcohol Pathophysiology of Cardiac Arrest SCAR Ventricular ectopics Non-sustained VT Pulseless VT/VF Cardiac Arrest Scar burden? Ischaemic burden?
31 Ectopics Risk stratification Morphology Low Unifocal RVOT focus Higher Multifocal Timing Rest On exercise Frequency Single < 10% Couplets Triplets (NSVT) > 10% Exercise Suppresses Increased frequency Exercise capacity Normal Reduced Echocardiogram Normal Abnormal ECG Normal Abnormal FHx ICC No Yes
32 Causes of SCD by age # Deaths per million/yr CAD Cardiomyopathy Channelopathy Age (yrs) Dr Joe Galvin, Mater Hospital
33 Causes of SCD under 30 years 300 # Deaths per million/yr CAD Cardiomyopathy Channelopathy Other Age (yrs) The majority of sudden unexplained deaths < 30 years are due to inherited cardiac conditions ~ 400/year in England
34 Heart Rhythm Disorders Unexplained T-LOC, undocumented tachycardias or ectopic beats Who is low risk? Structurally normal heart Normal 12 lead ECG No FHx sudden death < 35 years
35 Heart Rhythm Disorders Unexplained T-LOC, undocumented tachycardias or ectopic beats Who is high risk? Significant structurally normal heart Relevant 12 lead ECG abnormality FHx sudden death < 35 years
36 Low Risk Zero Risk
37 Inherited Cardiac Conditions How do you Quantify Risk? Case 1 Case 2 32 year old female 32 year old female Father died suddenly aged 44 Father still alive 56yrs Brother died suddenly aged 12 No FHx sudden death Gene + Gene + QTc = 465ms QTc = 540ms Phenotype expression determines individual risk
38 Prevent Sudden Death
39 External Defibrillator -999 First responder AED
40 Public Access Defibrillator
41 Implantable Cardioverter Defibrillator 6v battery Delivers 700v shock Defibrillates within 15s onset resulting in a success rate of 99.9% PG battery typically lasts 8 years
42 ICD implantation Day case procedure Local anaesthesia Conscious sedation
43 Rating a Patient with CAD and Prior MI Case 1 54 year old man 1 vessel disease Occluded Mid LAD Apical infarct EF = 45%
44 Rating a Patient with CAD and Prior MI Case 1 54 year old man 1 vessel disease Occluded Mid LAD Apical infarct EF = 45% Life rating + 150
45 Rating a Patient with CAD and Prior MI Case 1 54 year old man 1 vessel disease Occluded Mid LAD Apical infarct EF = 45% Life rating Case 2 54 year old cardiac arrest survivor 1 vessel disease Occluded mid LAD Apical infarct EF = 45% ICD in situ > 12 months Decline!
46 Rating a Patient with CAD and Prior MI Case 1 54 year old man 1 vessel disease Occluded Mid LAD Apical infarct EF = 45% Life rating At risk of future cardiac arrest Case 2 54 year old cardiac arrest survivor 1 vessel disease Occluded mid LAD Apical infarct EF = 45% ICD in situ > 12 months Decline! 99.9% protection from arrhythmic death
47 Conclusions Heart rhythm disorders very common & vast majority are benign (> 90% syncope) Heart rhythm disorders cause sudden death which is usually both predictable and preventable Atrial tachyarrhythmias should be rated on the basis of CHADSVASc score + anticoagulation status Cardiac arrest risk Scar Burden
48 Conclusions Diagnosing heart rhythm problems can be challenging In contrast risk stratification is easy! Phenotype not genotype determines individual risk Tachycardias are curable. Incurable life-threatening tachycardias can be treated with 99.9% effectiveness Low risk Zero risk and we frequently assess using suboptimal & incomplete data
49 Case Presentation 54 year old bus driver T-LOC x 1 RTA - Little warning, motionless x 2 min No other cardiac symptoms No FHx ICC DHx Nil SHX Smokes 20/day O/E NAD ECG Subtle Brugada changes & subtle pre-excitation
50 Case Presentation CT brain scan NAD Neurology Likely to be cardiac not neurological Echocardiogram Normal Diagnostic angiogram Normal Adenosine test Ve (No accessory pathway) Ajmaline test No Brugada ECG Prolonged inpatient monitoring NAD CCTV from the bus!
51 Incidence of Ventricular Premature Beats 60% 50% > 0 PVCs > 50 PVCs > 100 PVCs 40% 30% 20% 10% 0% Age Data from Kostis JB. Circulation. 1981;63(6):1353.
52 Sajadieh et al Am J Cardiol 2006;97:
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