A clinical study of Shunthyadi churna in the Management of Tamaka shwasa W.S.R. to Bronchial Asthma
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1 Journal of Ayurvedic and Herbal Medicine 2018; 4(2): Clinical Study ISSN: J. Ayu. Herb. Med. 2018; 4(2): , All rights reserved Received: Accepted: A clinical study of Shunthyadi churna in the Management of Tamaka shwasa W.S.R. to Bronchial Asthma Rajnik Jadav 1, Alankruta Dave 2, Jitendra Varsakiya 3 1 PhD Scholar, Department of Kayachikitsa, IPGT and RA, Gujarat Ayurved University Jamnagar, Gujarat, India 2 Associate Professor, Department of Kayachikitsa, IPGT and RA, Gujarat Ayurved University Jamnagar, Gujarat, India 3 Assistant Professor, Department of Kayachiktsa, Chaudhary Brahm Prakash Ayurved Charaka Smasthan, Najafgarh, Khera Dabar, New Delhi, India ABSTRACT In classics Tamaka Shwasa is Pitta Sthana Samudbhava Vhadhi, mainly affected Doshas are Vata and Pitta. In modern science Tamaka Swasa is correlate with bronchil ashtha, Symptoms of Tamaka Swasa is nearly similar to. Bronchial asthma a chronic inflammatory disorder of the airways in which the chronic inflammation causes an associated increase in airway hyperresponsiveness that leads to recurrent episodes of asthmatic exacerbation. Modern science has no permanent cure of Tamaka Swasa, thats why it is necessity to search herbal and herbo-minaral preparations for the treatment of disease. It is safe and effective in asthma. Shunthyadi Churna described in Yogratnakara for the treatment of Shwasa. Aim: Role of Shunthyadi Churna in treatment of Tamaka Shwasa. Materials and Methods: Total 23 patients of Tamaka Shwasa age group of 18 to 60 years fulfilling the inclusion criteria were selected for trial. Disscussion: Properties having Shuthyadi Churna is Tikta Katu Rasa, Laghu and Tikna Guna (light and penetrating properties), Ushna Virya (hot potency) and Vatakaphagna (decrease Vata and Kapha Dosha). Shuthyadi Churna is effective in break down the Samprapti of Tamaka Swasa and effective remedy for the patient of bronchial asthma. Keywords: Ayurveda, Bronchial asthma Shunthyadi Churna, Tamaka Shwasa. INTRODUCTION Research in respiratory diseases is necessity in today s era because of air pollution, dietary habits, crowds, low immunity of peoples etc. It is prior to such option of modality for the management of bronchial asthma. Nowadays bronchial asthma is leading causes of hospitalization among children and adolescents. India has an estimated million asthmatics.in India, rough estimates indicate a prevalence of between 1 and 15% in 5-11 year old children [1]. Actually asthmatic problem is increasing day by day due to environmental smoke and air pollution resulting from urbanization. Modern science has symptomatic relief for this ailment, but not any type of permamnt cure. Ayurveda is great science of life having lots of management for cure and prevent the chronic diseases. Herbal remedy Shuthyadi Churna a polyherbal compound have Shunthi (Zingiber officinale), Marich (piper nigram) Twaka (Cinnamomum zeylanicum) ela (Elettaria cardamomum), and Pippali (Piper longum). These drugs are Ushana Virya (hot potency) and Vata kapha hara properties. i.e Ushana, Tikshna, Katu Rasa. In Tamaka Swasa mainly involved Doshas are Vata and Pitta also disease is Amashaya Samudhbhava, so Shuthyadi Churna by its properties break down Samprapti of disease and cure the ailment [2]. Shunthi Zingiber officinale having broncho-dilatory and anti-inflammatory effect on bronchioles [3]. AIMS AND OBJECTIVE Role of poly herble formulation Shunthyadi Churna in the treatment of Tamaka Shwasa MATERIALS AND METHOD *Corresponding author: Dr. Rajnik Jadav PhD Scholar, Department of Kayachikitsa, IPGT and RA, Gujarat Ayurved University Jamnagar, Gujarat, India jeet12989[at]gmail.com A total of 23 patients of age of 18 to 60 years fulfilling the diagnostic of Tamaka Shwasa were selected and registered in this study from the OPD and IPD of Kayachikitsa department, IPGT and RA, Jamnagar. The study was carried out after obtaining ethical clearance of Institutional Ethics Committee (PGT/7/- A/Ethics/ /1538 dated ). It was also registered with Clinical Trial Registry of India (CTRI) vide CTRI/2016/06/ and prior to registration informed written consent of each patient was taken. For diagnosis, a detailed medical history was taken and physical examination was done in detail according 48
2 to both modern and Ayurvedic clinical methods and was noted down in specially prepared proforma. Inclusion criteria Patients having signs and symptoms of Tamaka Shwasa described in Ayurvedic texts and modern texts will be included. Age group: years Chronicity less than 10 years Uncomplicated cases of Tamaka Shwasa Exclusion criteria Patients of age less than 16 and above 60 years. The patient suffering from tuberculosis, Cardiac complains, Endocrine disorders like Diabetes mellitus, Hypo or Hyperthyroidism, etc Patients having complications like cor-pulmonale, emphysema, pneumonia, malignancy, etc and breathlessness due to severe anaemia, renal failure, etc Trial drug details Drug and posology The details of the trial drug are as given below. Table no-1 Shunthyadi Churna in the dose of 3gm with honey was administered 3 times a day after food for a period of 6 weeks. Pathyapathya was advised to all the patients as per classics [4]. After completion of treatment, patients were asked to follow up for 2 weeks. Shuthyadi Churna were procured from the pharmacy of IPGT and RA, Gujarat Ayurved University, Jamnagar. Criteria of assessment [5] The enrolled volunteers were assessed at baseline (day 0 visit) and then after the end of the trail, that is the 6 weeks of medication. Classical symptomatology of the disease Tamaka Shwasa and cardinal symptoms of Bronchial asthma were taken as subjective criteria of Rogabala for assessment. Laboratory investigations like CBC with Absolute Eosinophil count, PEFR were taken as objective criteria for assessment. in Rogabala along with Deha, Agni & Chetasabala was considered for assessment. Data presentation General data was subjected to suitable statistical analysis such as wilcoxon Signed Rank test for non parametric paired data, unpaired t- test for quantitative unpaired data. After preparing the master chart of all the required data in Microsoft excel work sheet, statistical calculations were made with the help of Sigma stat 3.5 software and in stat 3 software. The results were interpreted as significant p < 0.05, highly significant p < 0.01, very highly Significant p < 0.001, insignificant p>0.05. Considering the relief in major symptoms and improvement in the quantity and quality of semen, the subjects were divided into groups - improvement as no change, < 25 % - improvement as mild positive response, % - improvement as moderate positive response, 51-75% - improvement as marked positive response, 75% improvement as excellent response to assess the total efficacy of each therapy. OBSERVATIONS A total of 23 patients of Tamaka Shwasa were registered in this trial, out of which 21 patients completed the course of the treatment. Maximum patients in this trial from age group of year coming from poorly socio-economically area 66.66%, having urban %lifestyle and poorly educated, they have dusty (76.19) surround residence. Among them % have addiction of smoking tobacco, and 52.38% have family history of asthma (Table no. 3-6 ). As chief complaint Shwasakastata was observed in 10 patients, Kasa in 95.23%, Kaphanishthivanam was found in 52.38% patients, Peenasa was found in 90.47% patients, Parshvashula was observed in 33.33% patients. Maximum numbers of patients included in the trial (48.78%) were suffering from Bronchial asthma for 1 to 5 years. Maximum numbers of patients (72.56%) were taking aerosol PEF ranged <60 was observed in majority of the patients (58.32%) Results In all the symptoms related to Shwasakastata, trial drug showed a remarkably high percentage improvement. Parameters like frequency of Shwasa Vega, duration of attack, Pranavaha Srotodusti Lakshanas and use of emergency medicine were reduced by 61.11%, 39.68%, 74.21% and 87.7 respectively. Kasa and Peenasa was reduced by 46.03% and 56.35% respectively (Table no. 2). The difference of decrease in AEC was statistically significant. (P < 0.01). There was an increase in the P.E.F.R. by 33.33% There was no any statistically significant changes were observed. PEF was improved by %.( Table -3) Effect on other Hematocrits showed that Haemoglobin concentration and Lymphocyte count, absolute Eosinophils count (21.13% ), as well as on ESR (1.26% ), showed very good result on TLC (6.26% ) which was statistically significant, may be better in inflammatory condition. (Table no-4) Effect on other Biochemical Values showed that statistically significant changes were observed in alkaline phosphatage which was reduced by 1.5%. S. Triglyceride, S. Creatinine and S. Uric acid was also reduced percentage wise but no statistically significant. Effect on Spirometry Readings showed that, were mildly improved percentagewise but no any statistically significant change was found. Probable mode of action of Shunthyadi Churna [6] The drug Shunthyadi Churna consists many ingredients which excellently balancing each other in Rasa-panchaka and enhancing the Vata-Kaphahara, Deepana, Pachana and Vatanulomana properties. Vata-Kaphahara property of most of the content alleviates both Vata and Kapha, which are the main Doshas in the pathogenesis of Tamaka Shwasa. The main factor in this disease as in many other diseases is Ama and the Deepana-Pachana properties of the drug will digest the Ama by kindling the Jatharagni as well as Rasagni and Bhutagni. Further the Shothahara Karma of most of the contents will neutralize the Srotorodha in Pranavaha Srotas due to Shotha created by Sama Vata. The Dosha-Prashamana effect (Shunthi, Pippali, Maricha, Nagadala, Tvak) acts on the main Doshas which contribute to the Samprapti viz. Vata and Kapha. Deepana-Pachana Karma (Shunthi, Pippali, Maricha, Nagadala, Sukshaila) digest Ama.Vatanulomana property (Shunthi, Pippali) maintains the normal flow of Vata. Shwasa, Kasa, Shothahara Prabhava of all the ingredients act on the symptoms. Srotorodhnivarana Prabhava (Shunthi, Maricha) removes Srotorodha from the Pranavaha and Rasavaha Srotasas. The pharmacological studies already reported on the individual drugs also favour its effect in disease Bronchial Asthma like Shunthi has antiinflammatory, anti-microbial, immunomodulatory, hypolipidemic, and anti-viral activity [7]. Pippali has anti-inflammatory, anti-asthmatic, antidepressant, anti-bacterial, analgesic, anti-oxidative and immunomodulatory activity [8]. Maricha has anti-asthmatic, antimicrobial, anti-oxidant, anti-inflammatory, Hepato-protective, digestive, anti-depressant, immunomodulatory and effect of piperine on metabolism [9]. Nagadala has anti-allergic, anti-filarial, antibacterial, gastro-protective, anti-oxidant, immunomodulatory and anti- 49
3 asthmatic effect [10]. Tvak has anti-inflammatory, Anti-bacterial, Gastroprotective, Anti-oxidant and lipid peroxidation activity [11]. Ela has antiasthamatic, gastro-protective activity [12]. Table 1: Ingredients of Shunthyadi Churna Drug Name Botanical Name Ratio Part Used Shunthi Zingiber officinale 6 parts Rizome Pippali Piper longum 5 parts Fruit Maricha Piper nigrum 4 parts Fruit Nagadal(Kalkatti) Piper bettle 3 parts Patra Tvaka Cinnamomum zeylanicum 2 parts Tvaka Ela Elettaria cardamomum 1 parts Fruit Sharkara Parts Powder Table 2: General observation in this trial content Detail No of Patients Percentage Age Sex Male Female Education Uneducated Primary to Higher Secondary Graduate to Post Graduate occupation House-wife Service class Labourer Business Surrounding With dust No dust Habitat Urban Rural Desh Vyadhita in brith place Vyadhita in samvrith place Vyadhita after coming Jamnagar Dominancy Madhura Amla Lavana Katu 0 0 All Diet Habit At regular time At irregular time Working place Sitting Physical House wife With dust Addiction Smoking Tobacco chewing No addiction Day Sleep Present
4 Absent Family History Present Absent Vayayma Shakti Pravara 0 0 Madhyama Avara Ahara Guru Amapradosha Vistambhi Sheeta Abhishyandi Vihara Raja Dhuma Pragvata Chinta Precipiating Sheeta Varsha Ushna 0 0 Chief complains Shwaskastata Kasa Kaphanisthivan Peenasa Parshvashula Associate complain Kasa Kasateh Shleshmanirharana Krachhen Bhashitam Lalate Sweda Vishushkasyta Moha Table 3: Effect Therapy on Spirometry Readings of 21 Patients Parameter Mean Score % of Change S.D. S.E. T P BT AT FVC FEV FEV1% PEF Table 4: Effect of therapy on the Haematocrit Values of 21 Patients Parameter Mean Score % of Change S.D. S.E. T P BT AT Hb TLC N L E M PCV RBC Platelets ESR
5 Table 5: Effect on Dehabala and Chetabala Dehabala Balavriddhi HS Swar Varna Yoga S Sharira Upachaya HS Chetasbala Nidra Labho Yathakalam HS Sukhen Cha Pratibodhanam HS Mano Budhi Indriya Avyapatti S Vaikarika Swapna Adarshan NS 70.0 n = % 56.94% % 52.98% ROGABALA AGNIBALA DEHABALA SATVABAL 9. Damanhouri ZA, Ahmad A. A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices. Med Aromat Plants, 2014; 3:161. doi: / Rekha VP, Kollipara M, Gupta BR, Bharath Y, Pulicherla K. A review on Piper betle L.: Nature s promising medicinal reservoir. American Journal of Ethnomedicine. 2014;1(5): Vetal S, Bodhankar SL, Mohan V, Thakurdesai PA. Anti-inflammatory and anti-arthritic activity of type-a procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats. Food Science and Human Wellness. 2013;2(2): Jafri MA, et al. Evaluation of the gastric antiulcerogenic effect of large cardamom (fruits of Amomum subulatum Roxb). Ethnopharmacol. 2001; 75(2-3): HOW TO CITE THIS ARTICLE Jadav R, Dave A, Varsakiya J. A clinical study of Shunthyadi churna in the Management of Tamaka shwasa W.S.R. to Bronchial Asthma. J Ayu Herb Med 2018; 4(2): SC Chart 1: Overall Effect of the Therapy Shuthyadi Churna n = % % 1 Unchanged Mild Moderate Marked Complete Remission SC Chart 2: Overall Assessment REFERENCES 1. accessed date 21/6/ pm. 2. Gabrielian ES, Narimanian MZ, Asianian G. A Placebo controlled double blind study with an Ayurvedic drug Pulmoflex in brochial asthma. Phytomedica. 2004; 5: Khare CP. 1st ed. New york: Spinger Science. Indian medicinal plants -an illustrated disctinary, 2007; pp Charaka Samhita Chakrapani Tika by Dr. Ramharsh Shingh, Chowkhamba Surbharti Prakashana, Varanasi- Chikitsasthana, 17/55-64: Mali Pavan et al. A clinical study on the effect of Shireeshady Avaleha and Virechana Karma in the management of Tamaka Shwasa. MD Thesis, IPGT and RA, Jamnagar, Lakshmipati Shastri. Yogaratnakara edited with Vidhyotini Hindi commentary by Brahmasankara Shastri, published by Chaukhambha Prakashana, Varanasi (2010), Uttar Khanda Shwasa Chikitsa Agrahari P. A brief study on Zingiber officinale -A review. Journal of Drug Discovery and Therapeutics. 2015;3(28). 8. Nisar Ahmad et al. Biological role of Piper nigrum L. (Black pepper): A review. Asian Pacific Journal of Tropical Biomedicine. 2012; S1945-S
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