SEWPROF Roundtable Spain

Transcription

1 SEWPROF Roundtable Spain John Ramsey TICTAC Communications Ltd St. George s, University of London London SW17 0RE

2 TICTAC s contribution ER Dr. Bram Miserez Discovery and characterisation of NPS Test purchases Amnesty bins Police seizures Prisons Pooled urine collection Dissemination of samples Analysis of results

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4 Typical UK head shop offering April 2013 Rock Stars Tablet 5-MeO-DALT Rockets Capsule Methylone AMT Tablet AMT Dutchy Herb 5F-AKB48, STS-135, MAM-2201 E-Scape Tablet 5-MAPB, 5/6-APB Puff Adder Herb 5F-AKB48, AKB48 Chillem Blue Herb 5F-AKB48, AKB48 Ethylphenidate Poke Powder Methiopropamine, Dimethocaine Dust Till Dawn Powder Benzocaine, Methiopropamine Charly Sheen Powder Lidocaine, Methiopropamine, MDAI Clockwork Orange Herb 5F-AKB48 Gogaine Powder Lidocaine, Methiopropamine, Ethylphenidate Bomb Powder Methiopropamine, Benzocaine Magic Crystals Powder Benzocaine, Caffeine, Ethylphenidate China White Powder Methiopropamine, Benzocaine Barry White Powder Methiopropamine, MDPV, Lidocaine, 2-Aminoindane Blue Genie Tablet Methiopropamine, 5/6-APB Jack and Jills Tablet Ethylphenidate Disco Biscuts Tablet AMT Green Beans Capsule Methiopropamine, 5/6-APB 6APB Capsule Ethylone Blast Tablet 5-MeO-DALT Fury Xtreme Capsule 5/6-APB, Methiopropamine Pink Panters Capsule Methiopropamine Purple Bomb Tablet Ethylphenidate, 5-Meo-DALT, Methiopropamine Jumping Beans Tablet Methiopropamine Matrix Fury Tablet Methoxetamine AMT Methiopropamine Methylone

5 Methylphenidate derivatives Methylphenidate (Ritalin ) Ethylphenidate 3,4-CTMP isopropylphenidate HDMP-28 (methylnaphthidate) Methylphenidate IsoPropylphenidate 3,4-CTMP Methylnaphthidate Ethylphenidate

6 This means that it will be unlawful to supply, possess with intent to supply, produce, and import or export ethylphenidate, 3,4-dichloromethylphenidate, methylnaphthidate (HDMP-28), isopropylphenidate and propylphenidate, and their simple derivatives, except under licence issued by the Home Office.

7 The driver for change new compounds are used as drugs because they fall outside legislation the law catches up The consequence is that vulnerable young people are exposed to a succession of compounds that have never been tested for safety

8 The response? B2 / M1M Propylhexedrine analogue (3,4-methdioxy variant) 1-(hexahydrobenzo[d][1,3]dioxol-5-yl)-N-methylpropan-2-amine 500g B or 1kg B2-2500

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10 Synthetic cannabinoids detected by TICTAC March fluoro NPB-22 5-fluoro AB-PINACA THJ 018 JWH-018 indazole analog SDB fluoro MN-18 FUB-PB-22 EG fluoro AMB URB597 AM2201 benzimidazole analog AB-PINACA ADB-FUBINACA URB754 THJ2201 A MDMB-CHMICA MDMB-CHMINACA

11 MDMB-CHMINACA URB754 endogenous agonist of the central cannabinoid (CB 1 ) receptor A higher affinity for the peripheral CB 2 receptor analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice MDMB-CHMICA 5F-AB-PINACA

12 Data from:- Dr. María Ibáñez Martínez O 5F-AB-PINA O NH NH 2 N [M+H] + N [M+Na] + [M+Na] + [M+H] + C18H25FN4O2 F

13 5F-AB-PINACA single peak by GCMS Internal standards

14 The challenge to SEWPROF is to move faster Monitor market half life of new compounds TN M 1/2 UK Time from first detection to disappearance from the local market Characterise new compound Minimum data set * Pharmacology / Toxicology * Dose * Duration of action Distribute standards Access or guess human/bacterial metabolism Access stability Develop and validate analytical method Implement