Introduction of Assisted Reproductive Technology to Israel Joseph G Schenker MD.FRCOG.FACOG.( HON.)

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1 Introduction of Assisted Reproductive Technology to Israel Joseph G Schenker MD.FRCOG.FACOG.( HON.) President International Academy of Human Reproduction Hebrew University Hadassah Medical Centre Jerusalem,Israel

2 Division of Reproductive Biology University of Pennsylvania Cleavage of human ova in vitro. The purpose of this investigation was to develop an in vitro system in which human follicular oocytes can complete the maturation process, and undergo cleavage following exposure to spermatozoa Seitz HM Jr, Rocha G, Brackett BG, Mastroianni L Jr. Fertil Steril Apr;22(4):255-62

3 l Department Obstetrics Gynecology Infrastructure Bernard Zondek Infertility Clinic International Reputation Academic Achievements Zeev Polishuk Research Laboratories Joseph Schenker

4 1980 Dr. Baruch Modan Director-General of the Israeli Ministry of Health Professor and Chairman OB/G, Hebrew University Hadassah Medical Centre President Medical Association, Jerusalem Deputy Chairman Israel Medical Council Chairman Resident Committee, State of Israel President Israel Society Obstetrics and Gynecology Chairman Advisory Committee to Ministry of Health Elezer Shostak Minister of Health

5 Letter to Chairman Helsinki Committee Introducing IVF 1980

6 MINISTRY OF HEALTH OFFICIAL RESPOND TO THE REQUEST TO START THE PROJECT OF IVF IN ISRAEL

7 Hormone Research Department Weizmann Institute HANS LINDER Research Fellow NERI LAUFER ALEX ZAFRIR

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9 Reproductive Biology Unit at the Royal Women Hospital Melbourne, Australia PREPARATION OF MEDIUM Adding 3 volumes of 5 time redistilled water to one volume of HF-10 medium ORDER - OF ADDING THE DIFFERENT COMPONENTS OF THE MEDIUM

10 Israel's first test-tube baby, a girl, was born CONCEPTION Born Hal U.Kl Birth Cesarean Section - 11 February Jerusalem

11 Israel's first test-tube baby, a girl, was born several... March 5, 1982 TEL AVIV, Israel -- Israel's first test-tube baby, a girl, was born several weeks ago, Hadassah University Hospital in Jerusalem said today. UP Archives (Google) 'There is no difference between her and a normally conceived baby,' the announcement said UP Archives (Google) Out of respect for the parents' privacy, no details about them were given. The implantation was done outside Israel for the birth of Israel's first baby conceived in the 'in vitro' method under which an egg is fertilized with the male's sperm and reimplanted in the female's womb.

12 Odelia 11 February April 2018 Age - 36 and 3 months

13 License - IVF - State of Israel Ministry of Health Committee for Human Experimentation State of Israel Religious Jewish Authorities Leaders Religious Parties in Kneset

14 Leader - Religious Torah Front List, An alliance of Agudat Yisrael and Poalei Agudat Yisrael. Chairman of the Labor and Welfare Committee Menachem Porush Knesset Schenker - Parliamentary Committee Induced Abortion

15 Rebbe Simchah Bunim Alter Gerre Rebbe Menachem Porush Chairman, Agudat Yisrael -

16 Rabbi Ovadia Yosef Sephardi Chief Rabbi of Israel Spiritual leader of the SHAS political party Rabbi Shlomo Goren Rabbi Shlomo Goren Congress - Fetus as a Patient Round table Discussion Ashkenazi Chief Rabbi of Israel,

17 17/11/81 Joseph Schenker Personal License Mashiach Shlomo

18 Criteria for License IVF Units Letter to Director Ministry of Health Prof Baruch Modan (15/7/1984

19 Committee Inspection and License 1984 For IVF Units - State Israel Joseph Schenker - - Chairman Michael Schlesinger Shlomo Machiach

20 Hadassah Ein-Karem - Jerusalem Sheba - Ramat-Gan 17/11/81 Ministry of Health Committee to Grant Certification - IVF Units 3/8/1984 Committee: Joseph Schenker, Chair,Chairman Advisory Committee to Ministry of Health Michael Schlesinger, Chairman, Research and Development authority Hebrew University Jerusalem Shlomo Mashiach, Head Department,Sheba Hospital Criteria : Clinical experience activity Qualified clinical personal Qualified laboratory personal Infrastructure Soroka - Beersheba Sourasky - Tel-AVIV Hasharon - Petach Tikva Rambam - Haifa Carmel - Haifa Beilinson - Petah - Tikva - -

21 EMERGENCY PRE-EMBRYO FREEZING - REQUEST Letter to Prof Dan Michaeli Director Ministry of Health Chairman Helsinki Committee

22 GUIDLINES FOR CRYOPRESERVATION SCHENKER

23 Ultrasonically Quided Percutaneous Aspiration of Follicles in an In Vitro Fertilization Program Comparative study of ultrasonically guided percutaneous aspiration with local anesthesia and laparoscopic aspiration of follicles in an in vitro fertilization program. Lewin A, Margalioth EJ, Rabinowitz R, Schenker JG. Am J Obstet Gynecol Mar 1;151(5):621-5

24 A woman born without ovaries conceived after an ovum... 9 August 1985 JERUSALEM -- A woman born without ovaries conceived after an ovum donated by another woman was fertilized in a test tube and implanted in her uterus, Hadassah Medical Center said Tuesday. The 36-year-old woman is now in her third trimester of pregnancy. The egg was implanted into the woman's uterus 48 hours after it was inseminated with her husband's semen, Hadassah said.the couple was not identified. Hadassah said the woman was born with a congenital defect known as Turner's Syndrome, which is characterized by an absence of both ovaries. Women with this condition do not menstruate and lack the main female hormones. Treatment for the woman began several months ago at Hadassah by a staff of the gynecology department headed by Dr. Joseph Schenker. Hadassah said this is the first time in medical history that a woman in this condition has succeeded in becoming pregnant. She conceived after preparation of her uterus with a special hormonal treatment. Until the advent of in vitro (test tube) fertilization of a donated egg, there was no hope for a woman in this condition of becoming pregnant.

25 OVUM DONATION BIRTH HADASSAH

26 Establishment of Pregnancies in the Absence of Ovaries Hadassah - Hebrew University Jerusalem, Israel N Engl Med ,1986

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28 OOCYTE DONATION SCIENTIFIC Rabbi Mordechai Eliyahu Chief Rabbi of Israel LEGAL RELIGIOUS And she called his name Joseph; and said, The LORD shall add to me another son.(rachel) Genesis 30:24

29 ועדה ציבורית מקצועית לבחינה הפריה חוץ גופית 1991 Committee to examine the Ethical, Halakhic,Legal Aspects of IVF Treatments and Surrogacy Agreemenys S. Aloni District Judge, Tel-Aviv D. Amir - Sociology, Tel-Aviv, University E. Balas - Ministry Social Work D. Hed -, Philosophy,Hebrew University M. Halperin - Ministry of Health L. Lau - Chief Rabbai Tel-Aviv C. Shalev. Law Department,Ministry of Health J. Schenker - Obstetric Gynecology Department, Hebrew University- Hadassah,Jerusalem SURROGACY AGREEMENT LAW 1996

30 Cryopreservation and transplantation of ovarian tissue 1997 Dror Meirow [Cryopreservation and transplantation of ovarian tissue as a means of preserving female fertility]. Meirow D, Schenker JG. Harefuah Mar 15;134(6):461-4

31 Pioneer of Human Embryonic Stem Cell Research Director Human Embryonic Stem Cell Research Center Hadassah Medical Center - Hebrew University Jerusalem 1

32 VI WORLD CONGRESS OF IN VITRO FERTILIZATION Jerusalem 3-7 APRIL 1989

33 CHAIR INTERNATIONAL ETHICAL COMMITTEE International Federation of Gynecology and Obstetrics International Federation Fertility Societies International Academy Perinatal Medicine Asian Societies of Obstetrics and Gynecology

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36 WE ARE PROUD FOR CONTRIBUTION TRAINING IN ASSISTED REPRODUCTION WORLDWIDE

37 Thanks