S-14-1 Bioavailability of Vitamins-An Overview
|
|
- Bathsheba Wood
- 5 years ago
- Views:
Transcription
1 S-14-1 Bioavailability of Vitamins-An Overview M.MINO,1 A.MURATA,2 K.YASUDA,3 and Y.ITOKAWA4 1. Department of Pediatrics, Osaka Medical College, Takatsuki, 569, Japan 2. Department of Applied Biological Sciences, Saga Unioversity, Saga, 840, Japan 3. Department of Clinical Pathology, Faculty of Medicine, Teikyo University, Itabashi, Tokyo, 173, Japan 4. Department of Hygiene, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan I. Introduction To maintain a healthy state for a long life, many healthy people in developed countries prefer to continually take vitamins. In past, there have been many reports on the bioavailability of individual vitamins at a large dose and single administration. These are however unsuitable for understanding the efficacy and bioavailabilities of individual vitamins in view of recent real situation of general vitamin intakes. Usually, several vitamins are together taken as a multivitamin-preparation continuously over a long period. When considering single vitamin intake for a long period, it is useful to know whether the baseline of blood vitamin levels changes, and whether a dose response appears. In addition, it may be important to know the problem of individuals with intakes of vitamin preparations with regard to the assessment of the nutritional status of vitamins. This also includes the danger of toxicity regarding the fat soluble vitamins A, D and E. However, there have been no reports, to our knowledge, on the bioavailablities of the usual daily dose of vi-in preparations over a long period. From the above view, Takeda Chemical Industries who sponsor this symposium, promoted an investigation on the bioavailabilities of vitamins with long term intake of a multivitamin preparation for 44 weeks. Some of results of this study will be here. II. Experirnentals: The multivitamin preparation used listed in Table 1. The content of each vitamin was not high compared with the RDA values. This paper will show vitamins C, B6, nicotinamide, vitamins A and E. A randomized, placebo-controlled study on the bioavailavilities of vitamins with long-term intake of a mutivitamin preparation for 44 weeks was carried out. Two dose levels and a placebo were examined to understand the dose responses. The pre-administration and postadministration study were also performed. Table 1. Multivitamin Tablet Composition >>Sugar-coated Tablet (Panvitan(R)-Hi; Takeda Chemical << Ind., Ltd.) III. Results and Discussion To understand difference in bioavailability of a vitamin, the same dose was taken either as a single vitamin preparation or together with other vitamins as a multivitamin preparation, a study was undertaken on vitamin C as
2 Symposium (14) Bioavailability an example[1]. No differences were observed in the bioavailablity between two forms of vitamin C. The ongoing study was then performed using only the multivitamin perparation. 1. Vitamin C [2]: Fig 1 shows the vitamin C changes in plasma and urine during Fig.1 Changes in plasma concentration and daily urinary excretion rate of vitamin C after administration administration. There were marked increases in the plasma concentration and urinary excretion at 4 weeks, followed by further gradual increases during the experimental period at both doses. These levels were significantly and effectively higher than in the placebo group. Dose-dependent differences in plasma concentrations and urinary excretion among the three groups were statistically significant by linear regression analysis. In this examination, no withdrawal effect was observed. Body saturation of vitamin C has been proposed at plasma level of 1.4mg/100ml. From the results of this study, body saturation maybe reached with a dialy dose of 500 mg in addition to dietary intake. In the preliminary study [3] (data not shown), the time course of blood vitamin level was examined after single administration and daily dministration for one week. This result shows that the profile of plasma vitamin C changes was observed in a similar pattern after administration of a single dose and the 7th day of administration in daily intake. However, the baseline level of plasma vitamin C was increased on the 7th day, as compared with the initial level. This was confirmed again in this study. Urinary excretion increased on the 7th day, reflecting the plasma baseline levels. The above finding indicates that the body must be saturated with vitamin C after repeated intake of the vitamin. Seasonal nutrition survey of the dietary intake of vitamins A, B1, B2, nicotinamide and C was performed in this study. No significant changes in dietary intake of these vitamins were observed throughout the experimnetal period. 2. Vitamin B6 [4]: A similar pattern to vitamin C was observed for vitamin B6. Plasma levels increased during the first 4 to 12 weeks of intake which were follwed by a plateau level during further administration, while urinary excretion of 4-pyridoxic acid, a metabolite of vitamin B6, slightly increased throughout the adminiatration periods. Since the requirement of vitamin B6 depends on protein intake, it was assumed to be about 2 mg/day for a Japanese adult [5]. The doses in this study corresponded to 3.4 times (in group of 9 mg/day) and 6.7 times (in group of 18 mg/day) higher than the level of the vitamin B6 requirement. The body pool of vitamin B6 is thought to saturate as the plasma vitamin B6 level reaches a steady state. Dose-dependent differences
3 M.MINO et al. 431 were also statistically siginificant in plasma concentrations and urinary excretion among the three groups. From the results of this study, the body pool of vitamin B6 may be increased by increasing doses because of the finding of only a slight increase in urinary excretion of vitamin B6 with continuous intake of the vitamin. In addition, the ordinary doses of vitamin B6 as shown in group of 9 mg/day, will be recommended because general intake of vitamin B6 from the diet, did not seem to satisfy RDA in several reports [6] and there may be many common drugs usually used including contraceptives which contribute to an abnormality of vitamin B6 metabolism. 3. Nicotinamide [4]: Nicotinamide in whole blood shows a different pattern from vitamins C and B6. No significant changes occurred in the whole blood level Fig 2. Changes in plasma nicotinamide levels and urinary excretion of N1- methyl nicotinamide after administration throughout the administration period at both doses. The urinary excretion of N1-methyl nicotinamide, a metabolite of nicotinamide, increased after administration and the value slightly increased throughout the administration period and fell rapidly to the baseline level one week after cessation. A dose response was clearly found in urinary excretion while it was not seen in the whole blood levels. As previously shown in our preliminary study [7], the metabolic turnover rate of nicotinamide was found to be enhanced by repeated intake. The urinary excretion indicates enhancement of nicotimamide metabolism rate during continuous administration. In this study, nicotinamide for metabolism comes from intake of the vitamin itself and metabolically from tryptophan in ingested foos. From the nutritional survey, we can calculate the nicotinamide levels from ingested tryptophan. A correlation between total cotinamide from the preparation and from tryptophan, and excretion levels ni of N1-methyl nicotinamide was then studied. A linear correlation bound to 0 point was observed. From this finding based on excretion of nicotinamide, the levels of ingested nicotinamide used in this experiment shows similar bioavailability at both doses. 4. Vitamin A: Vitamin A is known to cause toxicity such as hypervitaminosis A, in which the plasma retinyl ester level is reported to increase [8]. In RDA research, the vitamin A requirement is known to depend on liver storage of the vitamin [9]. In this study, the plasma retinol level showed no changes with daily intake of 4,000 IU other than dietary intakes. In addition, no peaks corresponding to retinyl ester in HPLC patterns were observed. Therefore, no danger of toxicity was observed during the experimental period indicating that the nutritional status of vitamin A will be enhanced, since liver storage of retinyl ester will probably increase to a non-dangerous level. 5. Vitamin E: Differing from the retinal pattern, plasma alpha-tocopherol
4 432 Symposium (14) Bioavailability levels increased with daly intake of 20 mg, but not the 10 mg of dl-alpha-tocopheryl acetate, the dose of which was accompanied by slight lowering of the gamma tocopherol level, while no difference was observed between the placebo nistration group andthe group. If 10 mg admi- alpha-tocopherol levels become sufficient, plasma gamma-tpocopherol is known to decrease accompanied with an increase in the plasma alphatocopherol level (10). This indicates that in daily ingestion of 20 mg dl-alpha-tocopheryl acetate the vitamin E status in the body will improve without adverse effects. 6. Side effects and toxicity: Standard clinical screening tests were designed to examine hepatic function, renal sufficiency, the neuromuscular system and hematologic normality. On the basis of this result, it must be concluded that no signs of toxicity were demonstrated in this study. IV. Conclusions: Recently, from the prospective survey of human nutrition Fig 3. Changes in plasma alpha-and gammatocopherol levels after administration. and diseases in the eldery, it has been emphasized that prevention of development of aging diseases including ischemic heart diseases and cancer might be closely related to enhancement of the nutritional status of these vitamins A, C and E [12]. A significant enhancement of the nutritional status of vitamins C, B6 and E was assessed in a 44 weeks administration study using a daily dose of mg vitamin C, 9-18 mg vitamin B6 and 20 mg vitamin E. Plasma retinol levels at daily doses of 2,000 and 4,000 IU in addition to dietary intake during the experimental periods did not change and stayed the recommended adequate level. This may assist the goal of enhancement of vitamin A status. The metabolic turnover of nicotinamide was accelerated with a daily doses of mg. Neither side effects nor toxicity were documented in all the volunteers including the placebo group on the basis of the finding of the questionnaire and the clinical screening test. References: 1) Murata A, Baba R, Matsuoka M, Otsuka H, Takeuchi T, Itokawa Y.(1989): Plasma level and urinary excretion of vitamin C after oral administration of vitamin C preparations in healthy male adult. Vitamin (Japanese) 63, 1" q 2) Murata A, Kobayashi T, Matsuoka M, Otska H, Kitagawa M, Mino M, Kimura M, Itokawa Y.(1991): Changes in the pplasma concentration and urinary excretion of vitamin C in healthy male adults during long-term ingestion of a multivitamin preparation. Vitamin (Japanese) 65, in press. 3) Murata A, Baba R, Matsuoka M, Otsuka H, Takeuchi T, Itokawa Y.(1990): Changes in plasma levels and urinary excretion of vitamin C after dialy oral administration of a multivitamin preparation for one week in healthy
5 M.MINO et al 433 adult males. Vitamin (Japanese) 64, ) Yasuda K, Shimada T, Mino M, Kitagawa M, Itokawa Y, Kimura M, Matsuoka M, Otsuka H.(1991): Changes of blood total vitamin B6 and nicotinamide levels and urinary excretion of their metabolite in normal subjects after longterm administration of a multivitamin preparation. Vitamin (Japanese) 65, in press. 5) Recommended Dieatry Allowances, 10th ed. by National Research Council, National Acad Press, Washington,(1989): Vitamin B6, pp ) Kant AK, Block G.(1990): Dietary vitamin B-6 intake and food source in the US population: NHANES II, Am J Clin Nutr ) Yasuda K, Shomada 5, Itokawa Y, Takeuchi T, Matsuoka M, Otsuka H.(1989): Changes of blood concentrations of vitamin B6 and nicotinic acid and also urinary excretion of their metabolites after administation of three kinds of B-vitmain (B1, B2, B12) or multivitamin preparations. Vitamin (Japanese), ) Olson JA.(1986): Recommended dietary intakes (RDI) of vitamin A in humans. AM J Clin Nutr 45, ) Smith MB, Goodman DS.(1976): Vitamin A transport in human vitamin A toxicity. New Engl J Med 294, ) Baker H, Handelman GY, Short S, Machlin LJ, Bhagavan HN, Dratz EA, Frank.(1986): Comparison of plasma alpha-and gamma-tocopherol levels O following chronic oral administration of either all-rac-alpha-tocopheryl acetate or RRR-alpha-tocopheryl acetate in normal adult male subjects. Am J Clin Nutr 43, ) Kitagawa M, Mino M.(1989): Effects of elevated d-alpha(rrr)-tocopherol dosage in man. J Nutr Sci Vitaminol 35, ) Gey KF, Brubacher GB, Staehelin HB. (1987): Plasma level of antioxidant vitamins in realtion to ischemic heart disease and cancer. Am J Clin Nutr 45,
Effects of Elevated d-alpha(rrr)-tocopherol
J. Nutr. Sci. Vitaminol., 35, 133-142, 1989 Effects of Elevated d-alpha(rrr)-tocopherol Dosage in Man Makoto KITAGAWA and Makoto MIND 1 Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka
More informationE#ects of Excess Folic Acid on Growth and Metabolism of Water-soluble Vitamins in Weaning Rats
February 2008 51 19 8 2 E#ects of Excess Folic Acid on Growth and Metabolism of Water-soluble Vitamins in Weaning Rats Tsutomu FJ@JL6I6G> and Katsumi S=>76I6 Laboratories of Food Science and Nutrition,
More informationLifePak Health Benefits. LifePak is optimum supplementation for:
LifePak What is LifePak? Our comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being. LifePak Health
More informationEffects of Dietary Vitamin E Level and Source on Sow, Milk, and Piglet Concentrations of α-tocopherol 1
Effects of Dietary Vitamin E Level and Source on Sow, Milk, and Piglet Concentrations of α-tocopherol N. W. Shelton, J. L. Nelssen, M. D. Tokach, S. S. Dritz 2, R. D. Goodband, J. M. DeRouchey, H. Yang
More informationSection 5.2: Pharmacokinetic properties
Section 5.2: Pharmacokinetic properties SmPC training presentation Note: for full information refer to the European Commission s Guideline on summary of product characteristics (SmPC) SmPC Advisory Group
More informationPure Encapsulations. Updates to the Supplement Facts Panel: What, Why and When. Andrew Halpner, PhD Vice President, Science & Technical Services
Pure Encapsulations Updates to the Supplement Facts Panel: What, Why and When Andrew Halpner, PhD Vice President, Science & Technical Services Webinar Disclosure Seminars, teleconferences and webinars
More informationMaximization of Vitamin A, Folic Acid, and Other Essential Micronutrient Utilization in the Body
Maximization of Vitamin A, Folic Acid, and Other Essential Micronutrient Utilization in the Body Michael I McBurney, PhD Twitter: @MIMcBurney IFT, Las Vegas, NV June 25, 2017 Utilization of Essential Nutrients
More informationPure Encapsulations. Updates to the Supplement Facts Panel: What, Why and When. Andrew Halpner, PhD Vice President, Science & Technical Services
Pure Encapsulations Updates to the Supplement Facts Panel: What, Why and When Andrew Halpner, PhD Vice President, Science & Technical Services Webinar Disclosure Seminars, teleconferences and webinars
More informationHealth-E Maximum Strength Vitamin E
Health-E Maximum Strength Vitamin E 400% more potent Horse Vitamin E and half the cost of what you are currently using Is This Your Horse? Neurological issues (EPM, EDM, Motor Neuron) Muscle soreness Tie-up
More informationDEKAs in Cholestatic Liver Disease
DEKAs in Cholestatic Liver Disease All-in-one Multivitamin Food for Special Medical Purposes with Enhanced Absorption for the Dietary Management of Cholestatic Liver Disease Roberto Jongejan, MD, PhD Gus
More informationPHA Second Exam Fall On my honor, I have neither given nor received unauthorized aid in doing this assignment.
PHA 5127 Second Exam Fall 2013 On my honor, I have neither given nor received unauthorized aid in doing this assignment. Name Question/Points Set I 20 pts Set II 20 pts Set III 20 pts Set IV 20 pts Set
More informationUnit title: Human Health and Nutrition
Unit title: Human Health and Nutrition Unit code: F/601/0234 QCF level: 5 Credit value: 15 Aim This unit provides an understanding of the fundamental role of nutrients in maintaining health in relation
More informationCommodity Provision Method Principle Type Infant Formula. Turbidimetric Formula. Total B12 as cyanocobalamin
Agenda Item 3 JOINT FAO/WHO FOOD STANDARDS PROGRAMME CODEX COMMITTEE ON METHODS OF ANALYSIS SAMPLING Thirty-seventh th Session Budapest, Hungary, 22 26 February 2016 (information prepared by vice-chair
More informationEffects of Methionine and Cystine on the Cholesterol Concentrations in the Serum and Liver of Cholesterol-Fed
Effects of Methionine and Cystine on the Cholesterol Concentrations in the Serum and Liver of Cholesterol-Fed Chicks Hiroshi UEDA and Wataru FUKUI College of Agriculture, Ehime University, Matsuyama-shi
More informationCetirizine Proposed Core Safety Profile
Cetirizine Proposed Core Safety Profile Posology and method of administration Elderly subjects: data do not suggest that the dose needs to be reduced in elderly subjects provided that the renal function
More informationEffects of dietary Vitamin E level and source on sow, milk, and piglet concentrations of α- tocopherol
Kansas Agricultural Experiment Station Research Reports Volume 0 Issue 0 Swine Day (968-204) Article 268 202 Effects of dietary Vitamin E level and source on sow, milk, and piglet concentrations of α-
More informationEffects of Oral Administration of Erythritol on Patients with Diabetes
REGULATORY TOXICOLOGY AND PHARMACOLOGY 24, S303 S308 (1996) ARTICLE NO. 0112 Effects of Oral Administration of Erythritol on Patients with Diabetes MASASHI ISHIKAWA,* MINORU MIYASHITA, YUKIKO KAWASHIMA,
More informationIn a recent meta-analysis of randomized clinical trials, Miller
Brief Communication: The Prevalence of High Intake of Vitamin E from the Use of Supplements among U.S. Adults Earl S. Ford, MD, MPH; Umed A. Ajani, MBBS, MPH; and Ali H. Mokdad, PhD Article Background:
More informationDEKAs in Cystic Fibrosis
DEKAs in Cystic Fibrosis All-in-one Multivitamin & Mineral Dietary Supplement with Enhanced Absorption Roberto Jongejan, MD, PhD Gus Papas, MD, MPH Vitamin Malabsorption in Cystic Fibrosis In cystic fibrosis,
More informationEquilibrium Intakes of Calcium and Magnesium within an Adequate and Limited Range of Sodium Intake in Human
J Nutr Sci Vitaminol, 52, 402 406, 2006 Equilibrium Intakes of Calcium and Magnesium within an Adequate and Limited Range of Sodium Intake in Human Mamoru NISHIMUTA 1, Naoko KODAMA 1,2, Eiko MORIKUNI 1,
More informationThe Necessity of Niacin in Rats Fed on a High Protein Diet
Biosci. Biotechnol. Biochem., 69 (2), 273 279, 2005 The Necessity of Niacin in Rats Fed on a High Protein Diet Naoko KIMURA, Tsutomu FUKUWATARI, Ryuzo SASAKI, and Katsumi SHIBATA y Laboratories of Food
More informationLeaving Certificate Notes
Leaving Certificate Notes VITAMINS Sources of vitamins Functions of vitamins Effects of vitamin deficiencies Recommended dietary allowances (RDA s) Properties of all the FAT-SOLUBLE & WATER-SOLUBLE vitamins
More informationMumps is a disease caused by a virus. Mumps vaccine is usually given to children as part of the MMR vaccine.
Mumps is a disease caused by a virus. Mumps vaccine is usually given to children as part of the MMR vaccine. What diseases, other than mumps, does the MMR vaccine protect against? Mumps vaccines contain
More informationRecommended nutrient intakes
introduction chapter 2 Recommended nutrient intakes Each country should use recommended nutrient intakes for infants and young children, based on international scientific evidence, as the foundation of
More informationRecent Change in the Annual Incidence of Childhood Type 2 Diabetes in the Tokyo Metropolitan Area
Clin Pediatr Endocrinol 2007; 16(2), 53-58 Copyright 2007 by The Japanese Society for Pediatric Endocrinology Original Article Recent Change in the Annual Incidence of Childhood Type 2 Diabetes in the
More informationRelationship between Twenty-four Hour Urinary Creatinine Excretion and Weight, or Weight and Height of Japanese Children
J. Nutr. Sci. Vitaminol., 33, 185-193, 1987 Relationship between Twenty-four Hour Urinary Creatinine Excretion and Weight, or Weight and Height of Japanese Children Masaki MORIYAMA, Hiroshi SAITO,1 and
More informationBASIC PHARMACOKINETICS
BASIC PHARMACOKINETICS MOHSEN A. HEDAYA CRC Press Taylor & Francis Croup Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business Table of Contents Chapter
More informationObjectives: by reading this topic; the student would be able to:
Objectives: by reading this topic; the student would be able to: 1. Describe the structure, dietary sources, and metabolism of fat soluble vitamins. 2. Identify the biochemical role of fat soluble vitamins.
More informationAROMASIN 25mg (Tablets)
APPROVED PACKAGE INSERT AROMASIN SCHEDULING STATUS: S4 PROPRIETARY NAME AND DOSAGE FORM: AROMASIN 25mg (Tablets) COMPOSITION: Each sugar-coated tablet contains 25 mg exemestane. Preservative: methyl p-hydroxybenzoate
More informationD. Vitamin K -- Group of naphthoquinones having antihemorrhagic activity.
D. Vitamin K -- Group of naphthoquinones having antihemorrhagic activity. 1. Structures VITAMIN K1; Phytonadione; 2-Methyl-3-phytyl-1,4-naphthoquinone VITAMIN K2; Menaquinone-6 and 7; N=6,7 n 2. Function
More informationEFFECT OF AN EXCESS INTAKE OF LEUCINE, WITH AND WITHOUT ADDITIONS OF VITAMIN B6 AND/OR NIACIN, ON TRYPTOPHAN AND NIACIN METABOLISM IN RATS
J. Nutr. Sci. Vitaminol., 23, 535-548, 1977 EFFECT OF AN EXCESS INTAKE OF LEUCINE, WITH AND WITHOUT ADDITIONS OF VITAMIN B6 AND/OR NIACIN, ON TRYPTOPHAN AND NIACIN METABOLISM IN RATS Itsiro NAKAGAWA and
More informationContinuing Education for Pharmacy Technicians Dietary Supplements: Calcium and Vitamin D
1 Continuing Education for Pharmacy Technicians Dietary Supplements: Calcium and Vitamin D Ashley Elliott, PharmD candidate Julie N. Bosler, PharmD McWhorter School of Pharmacy Birmingham, AL Objectives:
More informationregulates the opening of blood vessels, important for unhindered blood flow.
Vitamin E AT A GLANCE Introduction The term vitamin E describes a family of eight related, fat-soluble molecules. Among these, alphatocopherol has the highest biological activity and is the most abundant
More informationVITAMINS-FAT SOLUBLE [LIPPINCOTT S ] Deeba S. Jairajpuri
VITAMINS-FAT SOLUBLE [LIPPINCOTT S 381-394] Deeba S. Jairajpuri VITAMIN A othe term retinoids includes both natural and synthetic forms of vitamin A essential for vision, reproduction, growth and maintenance
More informationJorge Flechas MD, MPH Hendersonville, NC IODINE AND OTHER NUTRITIONAL TREATMENTS OF THYROID DYSFUNCTION
Jorge Flechas MD, MPH Hendersonville, NC 28792 IODINE AND OTHER NUTRITIONAL TREATMENTS OF THYROID DYSFUNCTION Factors That Affect Thyroid Function Factors That Affect Thyroid Function See www.nahypothyroidism.org
More informationUse of DRIs at the U.S. Food and Drug Administration
Use of DRIs at the U.S. Food and Drug Administration Paula R. Trumbo, PhD Nutrition Programs Office of Nutrition and Food Labeling Center for Food Safety and Applied Nutrition U.S. Food and Drug Administration
More informationNEW MK-7 SELECT INTRODUCTION
NEW MK-7 SELECT INTRODUCTION As we have all known for several years now, the presence of optimal amounts of vitamin D is essential for maintaining optimal bone health and bone calcification, as noted by
More informationVitamin D. Vitamin functioning as hormone. Todd A Fearer, MD FACP
Vitamin D Vitamin functioning as hormone Todd A Fearer, MD FACP Vitamin overview Vitamins are organic compounds that are essential in small amounts for normal metabolism They are different from minerals
More informationDietary Protein as a Factor Affecting Vitamin B6 Requirement. Mitsuko OKADA, *Mayumi SHIBUYA, 1 Tomoko AKAZAWA, Hitomi MUYA and Yoko MURAKAMI
J Nutr Sci Vitaminol, 1998, 44, 37-45 Dietary Protein as a Factor Affecting Vitamin B6 Requirement Mitsuko OKADA, *Mayumi SHIBUYA, 1 Tomoko AKAZAWA, Hitomi MUYA and Yoko MURAKAMI Faculty of Health and
More informationPlasma Retinol and ƒ -Tocopherol Concentrations. in Supplemented and Unsupplemented Multiple
J. Clin. Biochem. Nutr., 5, 81-85, 1988 Plasma Retinol and ƒ -Tocopherol Concentrations in Supplemented and Unsupplemented Multiple Sclerosis Patients Keb GHEBREMESKEL,1, * Glynne WILLIAMS,1 Laurenee S.
More informationMicronutrients: History of the Word Vitamin. INE: Micronutrients - Vitamins: Introduction to Vitamins.
Micronutrients: Dr. Ritamarie Loscalzo Medical Disclaimer: The information in this presentation is not intended to replace a one onone relationship with a qualified health care professional and is not
More informationDietary Reference Intakes Definitions
Definitions Estimated Average Requirement (EAR) The EAR is the median daily intake value that is estimated to meet the requirement of half the healthy individuals in a life-stage and gender group. At this
More informationOral contraceptives and ascorbic acid
Oral contraceptives and ascorbic Jen y M. Rivers,2 Ph.D. ABSTRACF Plasma, heukocyte, and platelet ascorbic levels are decreased in women ingesting oral contraceptive steroids. Studies have shown that it
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE MEDICINAL PRODUCT Colecalciferol Meda 800 IU tablet 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains colecalciferol (vitamin D 3 ) 800 IU
More informationEffect of Dietary Amino Acid Balance on the Excretion of Urinary N Compounds and their Ratios* By SHUHACHI KIRIYAMA and HIROYUKIWAO
1 [Agr. Biol. Chem., Vol. 28, No. 5, p. 307-312, 1964] Effect of Dietary Amino Acid Balance on the Excretion of Urinary N Compounds and their Ratios* By SHUHACHI KIRIYAMA and HIROYUKIWAO The National Institute
More informationEffect of Excess of Individual Essential Amino Acids in Diets on Chicks
135 Effect of Excess of Individual Essential Amino Acids in Diets on Chicks Jun-ichi OKUMURA and Kiyoto YAMAGUCHI Laboratory of Animal Nutrition, Faculty of Agriculture, Nagoya University, Nagoya-shi 464
More informationD.K.M COLLEGE FOR WOMEN (AUTONOMOUS) VELLORE-1 DEPARTMENT OF FOODS AND NUTRITION ESSENTIAL OF MICRO NUTRIENTS
D.K.M COLLEGE FOR WOMEN (AUTONOMOUS) VELLORE-1 DEPARTMENT OF FOODS AND NUTRITION ESSENTIAL OF MICRO NUTRIENTS Class: II M.Sc Subject Code: 15CPFN3A Unit - I (6 Marks Questions) 1. Write a note on performed
More informationWho Needs Dietary Supplements? Almost Everyone.
Who Needs Dietary Supplements? Almost Everyone. Even the most conscientious consumers find it difficult to get all the nutrients they need from food alone, and dietary supplements can help fill nutrient
More informationChromium is a mineral that is primarily found in two forms: trivalent (chromium 3+) and
Chelsea Rice KNH 413: Medical Nutrition Therapy II April 21, 2014 Nutrient: Chromium 1. What is the nutrient? Chromium is a mineral that is primarily found in two forms: trivalent (chromium 3+) and hexavalent
More informationLatest Press Release. pink roulette where the boys come out and play
corp@stantec.com Latest Press Release pink roulette where the boys come out and play S Oxycodone is a strong narcotic pain-reliever and cough suppressant similar to morphine, codeine, and hydrocodone.
More informationComparison of Vitamin E Levels in Human Plasma, Red Blood Cells, and Platelets Following Varying Intakes of Vitamin E
J. Clin. Biochem. Nutr., 12, 59-68, 1992 Comparison of Vitamin E Levels in Human Plasma, Red Blood Cells, and Platelets Following Varying Intakes of Vitamin E Morio SAITO,1,* Kenichi NAKATSUGAWA,2 Akira
More informationNew Studies Continue to Reveal the Health Benefits of Colostrum
New Studies Continue to Reveal the Health Benefits of Colostrum by Barbara L. Minton (see all articles by this author) (NaturalNews) Colostrum is the thin yellowish fluid produced during the first few
More informationABSORPTION, UTILIZATION AND CLINICAL EFFECTIVENESS OF ALLITHIAMINES COMPARED TO
J. Nutr. Sci. Vitaminol., 22 (Suppl.), 63-68, 1976 ABSORPTION, UTILIZATION AND CLINICAL EFFECTIVENESS OF ALLITHIAMINES COMPARED TO WATER-SOLUBLE THIAMINES Herman Baker and Oscar Frank Departments of Medicine
More informationA critical review of the antioxidant controversy/safety issues for fatsoluble
A critical review of the antioxidant controversy/safety issues for fatsoluble vitamins Hans K. Biesalski MD PhD Dept. Biological Chemistry and Nutrition University Stuttgart-Hohenheim More than hundred
More informationDietary Reference Intakes for Japanese
1 Dietary Reference Intakes for Japanese -2010- The summary report from the Scientific Committee of Dietary Reference intakes for Japanese National Institute of Health and Nutrition Department of Nutritional
More informationJournal of Epidemiology Vol. 13, No. 1 (supplement) January 2003
Journal of Epidemiology Vol. 13, No. 1 (supplement) January 2003 Validity of a Self-administered Food Frequency Questionnaire Used in the 5-year Follow-up Survey of the JPHC Study Cohort I to Assess Carotenoids
More informationBODY CHEMISTRY TEST. Sample Report
BODY CHEMISTRY TEST * Sample Report Ver. 1.0, Date created: Nov 5, 2017 Disclaimer: VitaminLab is for informational purposes only. lease discuss your results or concerns with your health care professional
More informationChallenges in setting Dietary Reference Values. Where to go from here? Inge Tetens & Susan Fairweather-Tait
Challenges in setting Dietary Reference Values. Where to go from here? Inge Tetens & Susan Fairweather-Tait EFSA symposium on DRVs at FENS Berlin, 22 October 2015 Conflict of interest regarding this presentation:
More informationUCLA Nutrition Bytes. Title. Permalink. Journal ISSN. Author. Publication Date. The Effect of Beta-Carotene Intake on Lung Cancer Development
UCLA Nutrition Bytes Title The Effect of Beta-Carotene Intake on Lung Cancer Development Permalink https://escholarship.org/uc/item/1mp7t40p Journal Nutrition Bytes, 12(1) ISSN 1548-601X Author Brar, Rondeep
More informationSelenium and Vitamin E Cancer Prevention Trial (SELECT): Questions and Answers. Key Points
CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Selenium and Vitamin E
More informationThe Order of Limiting Amino Acids in Ladino Clover Leaf Protein Concentrate Fed to Chicks
227 The Order of Limiting Amino Acids in Ladino Clover Leaf Protein Concentrate Fed to Chicks Hiroshi UEDA and Mitsuaki OHSHIMA Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa-ken 761-07 From
More informationComposition: Each tablet contain. Levocetirizine. Each 5ml contains. Montelukast. Pharmacokinetic properties:
Composition: Each tablet contain Montelukast Levocetirizine 10mg 5mg Each 5ml contains Montelukast Levocetirizine 4mg 2.5mg Pharmacokinetic properties: Peak plasma concentrations of montelukast are achieved
More informationDietary Supplement Guide
Vitamin E Function Vitamin E is a fat-soluble vitamin with the main function as a fat-soluble antioxidant. Vitamin E is important for: - Protecting cell membranes and fats in LDL particles from oxidation
More informationCUTTING THROUGH LABELING CONFUSION
esha presents CUTTING THROUGH LABELING CONFUSION A GUIDE FOR UNDERSTANDING THE FDA'S CHANGES TO NUTRIENTS, DAILY VALUES, AND FORMATTING OF NUTRITION FACTS LABELS An ebook from esha RESEARCH CONTENTS What
More informationazilsartan medoxomil
azilsartan medoxomil edarbi 40mg Tablet 80mg Tablet ANTIHYPERTENSIVE Angiotensin II Receptor Antagonist FORMULATION: Each tablet contains 40mg Azilsartan medoxomil (as potassium) Each tablet contains 80mg
More informationM6ller, McIntosh and Van Slyke (5) has been employed. The cases. changes in functional activity. Indications suggesting that such changes
STUDIES OF UREA EXCRETION. VIII. THE EFFECTS ON THE UREA CLEARANCE OF CHANGES IN PROTEIN AND SALT CONTENTS OF THE DIET BY CUTHBERT L. COPE I (From the Hospital of the Rockefeller Institute for Medical
More informationMulti-Vitamin PART OF YOUR ESSENTIALS PACK
Supplement Details Multi-Vitamin PART OF YOUR ESSENTIALS PACK A perfectly balanced all rounder. Our high quality multivitamin gives you a well balanced daily dose of a plethora of essential vitamins and
More informationUrinary Excretion of Hippuric Acid After Administration of Sodium Benzoate (Biological Monitoring 1)
June 1991 177 Urinary Excretion of Hippuric Acid After Administration of Sodium Benzoate (Biological Monitoring 1) (Received August 2, 1990) Toshiko FUJII*1, Toyonori OMORI*2, Toyohiro TAGUCHI*3 and Masana
More informationChapter 13. Water soluble Vitamins 10/27/ substances
Chapter 13 9 substances Most are cofactors for enzymes in energy producing pathways Amino acid metabolism, DNA synthesis, RBC synthesis Synthesis of other compounds Small amounts stored in the body Excreted
More informationStudies on Digestibility, Biological Value and Metabolizable Energy of Single Cell Protein Sources for the Chicken
Studies on Digestibility, Biological Value and Metabolizable Energy of Single Cell Protein Sources for the Chicken Hiro-omi YOKOTA1, Jun-ichi OKUMURA1, and Yukishige SASA2 1Laboratory of Animal Nutrition,
More informationJournal of Epidemiology Vol. 13, No. 1 (supplement) January 2003
Journal of Epidemiology Vol. 13, No. 1 (supplement) January 2003 Food and Nutrient Intakes Assessed with Dietary Records for the Validation Study of a Self-administered Food Frequency Questionnaire in
More informationRegulation of Enzyme Activity
Regulation of Enzyme Activity Enzyme activity must be regulated so that the proper levels of products are produced at all times and places This control occurs in several ways: - biosynthesis at the genetic
More informationANTIHYPERLIPIDEMIA. Darmawan,dr.,M.Kes,Sp.PD
ANTIHYPERLIPIDEMIA Darmawan,dr.,M.Kes,Sp.PD Plasma lipids consist mostly of lipoproteins Spherical complexes of lipids and specific proteins (apolipoproteins). The clinically important lipoproteins, listed
More informationA. van Leeuwenhoeklaan MA Bilthoven Postbus BA Bilthoven KvK Utrecht T F
A. van Leeuwenhoeklaan 9 3721 MA Bilthoven Postbus 1 372 BA Bilthoven www.rivm.nl KvK Utrecht 3276683 T 3 274 91 11 F 3 274 29 71 info@rivm.nl The habitual micronutrient intake of Dutch adults (VCP 27-21)
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT Fexofenadine Cipla 120 mg film-coated tablets 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains 120 mg fexofenadine
More informationVitamin Sources for Swine Diets
SWINE NUTRITION GUIDE GENERAL NUTRITION PRINCIPLES Vitamin Sources for Swine Diets Vitamins are required for normal metabolism in physiological functions such as growth, development, maintenance, and reproduction.
More informationCOMPOSITION. A film coated tablet contains. Active ingredient: irbesartan 75 mg, 150 mg or 300 mg. Rotazar (Film coated tablets) Irbesartan
Rotazar (Film coated tablets) Irbesartan Rotazar 75 mg, 150 mg, 300 mg COMPOSITION A film coated tablet contains Active ingredient: irbesartan 75 mg, 150 mg or 300 mg. Rotazar 75 mg, 150 mg, 300 mg PHARMACOLOGICAL
More informationModification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C
https://helda.helsinki.fi Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C Hemilä, Harri 2009 Hemilä, H & Kaprio, J 2009, ' Modification
More informationDietary intake in male and female smokers, ex-smokers, and never smokers: The INTERMAP Study
(2003) 17, 641 654 & 2003 Nature Publishing Group All rights reserved 0950-9240/03 $25.00 www.nature.com/jhh ORIGINAL ARTICLE Dietary intake in male and female smokers, ex-smokers, and never smokers: The
More informationnumber Done by Corrected by Doctor Nafeth
number 38 Done by Omar Odeh Corrected by Doctor Nafeth 1 Micronutrients: Vitamins Chapter 28 lipp. In the end of this course, we will talk about fat soluble vitamins. We took water soluble vitamins last
More informationTHE FAT-SOLUBLE VITAMINS 100 YEARS LATER: WHERE ARE WE NOW? William S. Blaner. Department of Medicine, College of Physicians and Surgeons,
THE FAT-SOLUBLE VITAMINS 100 YEARS LATER: WHERE ARE WE NOW? William S. Blaner Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032 Running Title: Vitamin
More informationSCIENTIFIC OPINION. Calcium sulphate for use as a source of calcium in food supplements 1
The EFSA Journal (2008) 814, 1-9 SCIENTIFIC OPINION Calcium sulphate for use as a source of calcium in food supplements 1 Scientific Panel on Food Additives and Nutrient Sources added to food (Question
More informationCreatinine Height Index in a Sample of Japanese Adults under Sedentary Activities. Tsuguyoshi SuzuKI, Tsukasa INAOKA, and Toshio KAWABE1
J. Nutr. Sci. Vitaminol., 30, 467-473, 1984 Creatinine Height Index in a Sample of Japanese Adults under Sedentary Activities Tsuguyoshi SuzuKI, Tsukasa INAOKA, and Toshio KAWABE1 Department of Human Ecology,
More informationEMULSIFIED PRODUCTS EMULSIFIED FAT-SOLUBLE NUTRIENTS
EMULSIFIED PRODUCTS EMULSIFIED FAT-SOLUBLE NUTRIENTS All emulsions are NOT created equal! A.D.P. Product Number: 1101 A.D.P. is a proven effective, patented formula. Utilizing micro-emulsification and
More informationEach tablet contains:
Composition: Each tablet contains: Tolvaptan 15/30mg Pharmacokinetic properties: In healthy subjects the pharmacokinetics of tolvaptan after single doses of up to 480 mg and multiple doses up to 300 mg
More informationOfficial Journal of the European Communities
L 52/19 COMMISSION DIRECTIVE 2001/15/EC of 15 February 2001 on substances that may be added for specific nutritional purposes in foods for particular nutritional uses (Text with EEA relevance) THE COMMISSION
More informationPACKAGE LEAFLET: Information for the patient VITAMINE E Sugar coated tablets 10 mg (Alpha tocopherol acetate)
PACKAGE LEAFLET: Information for the patient VITAMINE E Sugar coated tablets 10 mg (Alpha tocopherol acetate) Read all of this leaflet carefully before you start taking this medicine. - Keep this leaflet.
More informationCreating Healthier Lives. Cholesterol Reduction Complex Lower Your Cholesterol Naturally
Cholesterol Reduction Complex Lower Your Cholesterol Naturally 1 DID YOU KNOW? About 40% of Canadian adults have high cholesterol. 2 DID YOU KNOW? YOU ARE AT RISK FOR HIGH CHOLESTEROL If you have a poor
More informationThe usual dose is 40 mg daily with amoxycillin 1.5 g (750 mg b.d.) for 2 weeks. Up to 2 g/day of amoxycillin has been used in clinical trials.
Name Gasec - 2 Gastrocaps Composition Gasec-20 Gastrocaps Each Gastrocaps contains: Omeprazole 20 mg (in the form of enteric-coated pellets) Properties, effects Proton Pump Inhibitor Omeprazole belongs
More informationNote Urinary Excretion of Water-Soluble Vitamins Increases in Streptozotocin-Induced Diabetic Rats without Decreases in Liver or Blood Vitamin Content
J Nutr Sci Vitaminol, 58, 54 58, 2012 Note Urinary Excretion of Water-Soluble Vitamins Increases in Streptozotocin-Induced Diabetic Rats without Decreases in Liver or Blood Vitamin Content Eri IMAI, Mitsue
More informationNatural Medicines Comprehensive Database VITAMIN E
3120 West March Lane - Stockton, California 95219 www.naturaldatabase.com - Email: mail@naturaldatabase.com PH (209) 472-2244 - Fax (209) 472-2249 Also Known As: VITAMIN E Acétate d'alpha Tocophérol, Acétate
More informationSafety and Pharmacokinetics of CS-834, a New Oral Carbapenem Antibiotic, in Healthy Volunteers
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Dec. 1997, p. 2664 2669 Vol. 41, No. 12 0066-4804/97/$04.00 0 Copyright 1997, American Society for Microbiology Safety and Pharmacokinetics of CS-834, a New Oral
More informationEffects of Vitamin A Supplementation on Plasma Retinol Concentrations, Fertility and Milk Yield of Dairy Cows
Effects of Vitamin A Supplementation on Plasma Retinol Concentrations, Fertility and Milk Yield of Dairy Cows Graduate School for International Development and Cooperation, Hiroshima University, Higashihiroshima-shi
More informationAntihyperlipidemic Drugs
Antihyperlipidemic Drugs Lipid disorders: Disorders of lipid metabolism are manifest by elevation of the plasma concentrations of the various lipid and lipoprotein fractions (total and LDL cholesterol,
More informationFortisip Powder A high energy, high protein, nutritionally complete, powder supplement that can be mixed to desired energy concentration
A high energy, high protein, nutritionally complete, powder supplement that can be mixed to desired energy concentration Features Flexibility to prepare to various energy concentrations: 1kcal/ml, 1.5kcal/ml
More informationPHA Second Exam. Fall On my honor, I have neither given nor received unauthorized aid in doing this assignment.
PHA 5127 Second Exam Fall 2010 On my honor, I have neither given nor received unauthorized aid in doing this assignment. Name Put all answers on the bubble sheet TOTAL /200 pts 1 Question Set I (True or
More informationLeucovorin Calcium Tablets USP, 5 mg, 10 mg, 15 mg, and 25 mg
Leucovorin Calcium Tablets USP, 5 mg, 10 mg, 15 mg, and 25 mg Rx only DESCRIPTION Leucovorin Calcium Tablets USP contain either 5 mg, 10 mg, 15 mg or 25 mg leucovorin as the calcium salt of N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]
More informationFoods, nutrients and dietary patterns for healthy aging
Foods, nutrients and dietary patterns for healthy aging Katherine L Tucker, PhD Professor of Nutritional Epidemiology University of Massachusetts Lowell Changes in dietary needs with aging Lower energy
More informationNutritional need versus optimal intake. Hemilä, Harri O.
https://helda.helsinki.fi Nutritional need versus optimal intake Hemilä, Harri O 1984 Hemilä, H O 1984, ' Nutritional need versus optimal intake ' Medical Hypotheses, vol 14, no. 2, pp. 135-139. DOI: 10.1016/0306-9877(84)90051-3
More information