Further, WVHN acknowledges that the person signing this agreement on behalf of WVHN is authorized to execute this agreement on behalf of WVHN.

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Alaris System Data Set Report APPROVED ASPIRUS 7-5-2018 WVHN a(n) corporation (Name) (State Incorporated) (Address) (City, State, Zip) WVHN acknowledges that WVHN's unique data sets (Customized Data

1 Alaris System Data Set Report APPROVED ASPIRUS WVHN a(n) corporation (Name) (State Incorporated) (Address) (City, State, Zip) WVHN acknowledges that WVHN's unique data sets (Customized Data Set) have been developed by WVHN in accordance with WVHN's best practices protocols, for use with Guardrails Safety Software. WVHN acknowledges that it is the owner of the Customized Data Set and, as such, is solely responsible for the development, verification and usage of the Customized Data Set in accordance with WVHN's best practices protocols. At WVHN's request, CareFusion personnel may assist WVHN with the upload of WVHN's Customized Data Sets pursuant to the AARIS SMARTServiceSM Implementation Program or other service agreements. Further, WVHN acknowledges that the person signing this agreement on behalf of WVHN is authorized to execute this agreement on behalf of WVHN. Signature Name Title Date WVHN - 7/5/ :09 Page 1 of 146

2 1. Current Data Set Status Data Set Name ASPIRUS Hospital Name Data Set ID Data Set Status WVHN 022d0d4f4-A Approved ast Changed On 7/5/ :09 Filename C:\Users\b10035\Documents\Guardrails Editor\022c4fd42-R.gre WVHN - 7/5/ :09 Page 2 of 146

3 2. Drug ibrary by Profile 2.1 Ambulatory Oncology /Bolus - Non-Anesthesia Drugs /Bolus - Non-Anesthesia Drugs - Ambulatory Oncology Conc. Dosing Administration Module Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Concentrations Min Max Max Value Min Max Max Value Min Max Max Value AminocaproicINFUSION gram/h gram / 250 m (0.02 gram / m) CMV immunoglobulin YES mg/kg/h mg / - m daratumumab 90 min YES mg/kg/h Bolus - mg / - m mg/kg mg/kg/min fentany mcg/h ,000 mcg / 100 m (20 mcg / m) mcg mcg/min fentany mcg/kg/h ,000 mcg / 100 m (20 mcg / m) mcg mcg/min Flebogamma 10% YES No filter mg/kg/h required 20 gram / 200 m (0.1 gram / m) - gram / - m Gammagard 10% 20 gram / 200 m (0.1 gram / m) - gram / - m Glassia - mg / - m YES mg/kg/h YES mg/kg/min No filter required Aralast rate WVHN - 7/5/ :09 Page 3 of 146

4 Concentrations heparin ACS therapy 25,000 unit / 250 m (100 unit / m) heparin Atrial Fib 25,000 unit / 250 m (100 unit / m) heparin DVT/PE 25,000 unit / 250 m (100 unit / m) heparin Stroke 25,000 unit / 250 m (100 unit / m) insulin Non-anesthesia 150 unit / 150 m (1 unit / m) - unit / - m Iron DETRAN IV /Bolus - Non-Anesthesia Drugs - Ambulatory Oncology Module Conc. Dosing Administration Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Min Max Max Value Min Max Max Value Min Max Max Value nd RN to verify unit/h unit unit/min - mg / - m Kcentra - unit / - m morphine 100 mg / 100 m (1 mg / m) 250 mg / 250 m (1 mg / m) 500 mg / 500 m (1 mg / m) - mg / - m naloxone 0.8 mg / 250 m (0.003 mg / m) 4 mg / 1,000 m (0.004 mg / m) - mg / - m Obinutuzumab 1,000 mg dose 1,000 mg / 250 m (4 mg / m) unit/h unit unit/min unit/h unit unit/min unit/h YES unit/h YES mg/min YES unit/min YES mg/h mg mg/min YES mg/h mg/h nd RN to verify nd RN to verify nd RN to verify Insulin advisory Hypersensitivity Saline only WVHN - 7/5/ :09 Page 4 of 146

5 /Bolus - Non-Anesthesia Drugs - Ambulatory Oncology Conc. Dosing Administration Module Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Concentrations Min Max Max Value Min Max Max Value Min Max Max Value Obinutuzumab 900 mg dose mg/h Saline only 1,000 mg / 250 m (4 mg / m) Ocrelizumab First Dose mg/h Filter 0.22 Micron 300 mg / 250 m (1.2 mg / m) Ocrelizumab Second Dose 300 mg / 250 m (1.2 mg / m) Ocrelizumab Subsequent Doses 600 mg / 500 m (1.2 mg / m) octreotide 1,500 mcg / 500 m (3 mcg / m) - mcg / - m Privigen 10% 20 gram / 200 m (0.1 gram / m) - gram / - m Prolastin-C - mg / - m Zemaira - mg / - m Zidovudine infusion - mg / - m mg/h mg/h YES mcg/h mcg mcg/min YES mg/kg/h YES mg/kg/min YES mg/kg/min YES mg/kg/h Filter 0.22 Micron Filter 0.22 Micron No filter required Proteinase rate note Proteinase rate note /Bolus - Non-Anesthesia Drugs - Concentration imits /Bolus - Non-Anesthesia Drugs - Concentration imits - Ambulatory Oncology Module Concentration imits P S Conc. Hard Soft Soft Dosing Method Units Min Min Max CMV immunoglobulin mg/m daratumumab 90 min mg/m WVHN - 7/5/ :09 Page 5 of 146

6 /Bolus - Non-Anesthesia Drugs - Concentration imits - Ambulatory Oncology Module Concentration imits P S Conc. Hard Soft Soft Dosing Method Units Min Min Max Flebogamma 10% mg/m Gammagard 10% Glassia insulin Non-anesthesia Non Iron DETRAN IV Non Kcentra Non morphine Non naloxone Non octreotide Non Privigen 10% Prolastin-C Zemaira Zidovudine infusion mg/m mg/m unit/m mg/m unit/m mg/m mg/m mcg/m 1 6 mg/m mg/m mg/m mg/m 1 4 WVHN - 7/5/ :09 Page 6 of 146

7 2.1.3 /Bolus - Anesthesia Only Drugs /Bolus - Anesthesia Only Drugs - Ambulatory Oncology Conc. Dosing Administration Clinical Ads. Module Bolus imits Units Rate Name P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Concentrations Min Max Max Value Min Max Max Value Min Max Max Value fentany mcg/kg/h mcg / 1 m (50 mcg / m) mcg mcg/min insulin Anesthesia only unit/h nd RN to verify 150 unit / 150 m (1 unit / m) /Bolus - Anesthesia Only Drugs - Concentration imits No drugs exist in this section Intermittent Drugs Abraxane Acetaminophen pt weight < 50kg Acetaminophen pt weight >= 50kg acyclovir ADO-trastuzumab First Dose ADO-trastuzumab Subsequent Doses albumin 25% albumin 5% alemtuzumab amifostine Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg/m mg / - m 00:20 01:00 00:30 mg/m mg/kg mg / - m 00:10 00:30 00:15 mg/m mg ,000 mg / 100 m (10 mg / m) 00:10 00:30 00:15 mg mg / - m 00:45 02:00 01:00 mg/m mg/kg mg / - m 01:20 02:00 01:30 mg/m Non-PVC mg/kg mg / - m 00:25 02:00 00:30 mg/m Non-PVC gram gram / 50 m (0.25 gram / m) 00:15 01:00 00:30 25 gram / 100 m (0.25 gram / m) 00:20 01:00 00:30 gram gram / 250 m (0.05 gram / m) 00:15 01:00 mg mg / - m 01:45 03:00 02:00 mg/m mg/m mg / - m 00:03 00:30 00:05 mg/m 1 50 Protect From ight WVHN - 7/5/ :09 Page 7 of 146

8 amikacin Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg/kg mg / - m 00:25 02:00 01:00 mg/m 1 6 ampho B (IPOSOMA) mg/kg mg / - m 01:00 04:00 02:00 mg/m amphotericin B.Standard Dosing amphotericin B Blasto load < 100 KG amphotericin B Blasto load >= 100KG amphotericin B Blasto Maintenance ampicillin ampicillin/sulbact arsenic trioxide asparaginase Atezolizumab First Dose Atezolizumab Subsequent Doses ATGAM-lymph horse lg azactidine azithromycin aztreonam bendamustine HCl Bendeka bendamustine HCl Treanda mg mg / - m 00:59 06:00 mg/m mg/kg mg / - m 02:30 03:30 03:00 mg/m mg mg / 500 m (0.1 mg / m) 02:30 03:30 03:00 mg/kg mg / - m 22:00 23:00 25:00 24:00 mg/m gram / 50 m (0.01 gram / m) 00:25 01:00 00:30 1 gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 gram gram / 100 m (0.02 gram / m) 00:25 01:00 00:30 - gram / - m 00:25 01:00 00:30 gram/m gram / 50 m (0.03 gram / m) 00:10 01:00 00:15 3 gram / 100 m (0.03 gram / m) 00:10 01:00 00:15 gram gram / - m 00:10 01:00 00:15 gram/m mg/kg mg / - m 00:55 04:10 mg/m Protect From ight Protect From ight Protect From ight Protect From ight unit/m unit / - m 00:25 01:00 00:30 unit/m Hypersensitivity mg ,200 mg / 250 m (4.8 mg / m) 00:25 01:20 01:00 mg ,200 mg / 250 m (4.8 mg / m) 00:25 01:20 00:30 mg mg / - m 01:45 03:30 12:00 mg/m mg/m mg / - m 00:05 00:40 00:10 mg/m mg gram mg / 250 m (2 mg / m) 00:50 03:00 01:00 - mg / - m 00:50 03:00 01:00 mg/m gram / 100 m (0.01 gram / m) 00:25 01:00 00:30 2 gram / 100 m (0.02 gram / m) 00:25 01:00 00:30 - gram / - m 00:25 01:00 00:30 gram/m mg/m mg / - m 00:08 01:00 00:10 mg/m 1 6 mg/m mg / - m 00:20 01:00 00:30 mg/m WVHN - 7/5/ :09 Page 8 of 146

9 Bevacizumab FIRST bevacizumab subseque 10 mg/kg doses bevacizumab subseque 15 mg/kg doses bevacizumab subseque 5 mg/kg doses bevacizumab subseque 7.5 mg/kg doses bleomycin brentuximab bumetanide Cabazitaxel calcium gluconate CARBOplatin carfilzomib carmustine Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg/kg mg / - m 00:25 03:00 00:30 mg/m 1 25 mg/kg mg / - m 00:25 03:00 00:30 mg/m 1 25 mg/kg mg / - m 00:25 03:00 00:30 mg/m 1 25 mg/kg mg / - m 00:09 01:00 00:15 mg/m 1 25 mg/kg mg / - m 00:12 01:00 00:15 mg/m 1 25 unit/m unit / - m 00:10 01:30 01:00 unit/m mg/kg mg / - m 00:25 00:45 00:30 mg/m mg mg / - m 00:30 03:00 01:00 mg/m Not for continuous mg/m mg / - m 00:45 01:45 01:00 mg/m Non-PVC mg ,000 mg / 50 m (20 mg / m) 00:10 00:15 06:00 01:00 - mg / - m 00:10 00:15 06:00 mg/m mg mg / - m 00:25 01:00 00:30 mg/m mg/m mg / - m 00:04 00:12 00:10 mg/m mg/m mg / - m 01:00 04:00 02:00 mg/m cefazolin 1 gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 2 gram / 50 m (0.04 gram / m) 00:25 01:00 00:30 gram gram / 100 m (0.03 gram / m) 00:25 01:00 00:30 - gram / - m 00:25 01:00 00:30 gram/m cefepime 1 gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 2 gram / 100 m (0.02 gram / m) 00:25 01:00 00:30 gram gram / - m 00:25 01:00 00:30 gram/m cefotaime 1 gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 2 gram / 100 m (0.02 gram / m) 00:25 01:00 00:30 gram gram / - m 00:25 01:00 00:30 gram/m cefoitin gram gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 WVHN - 7/5/ :09 Page 9 of 146

10 Ceftaroline ceftazidime ceftriaone cetuximab oading Dose cetuximab Maintenance Dose chlorothiazide chlorpromazine cidofovir CIPROfloxacin CISplatin cixutumumab cladribine 120 minute infusion cladribine 24 hour Infusion CINDAmycin cyclophosphamide cytarabine INFUSION cytarabine IVPB Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max 2 gram / 50 m (0.04 gram / m) 00:25 01:00 00:30 - gram / - m 00:25 01:00 00:30 gram/m mg mg / 50 m (8 mg / m) 00:05 00:30 00: mg / 50 m (12 mg / m) 00:05 00:30 00:15 1 gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 2 gram / 50 m (0.04 gram / m) 00:25 01:00 00:30 gram gram / - m 00:25 01:00 00:30 gram/m gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 2 gram / 50 m (0.04 gram / m) 00:25 01:00 00:30 gram gram / - m 00:25 01:00 00:30 gram/m mg/m mg / - m 01:45 04:00 02:00 mg/m Filter 0.22 Micron mg/m mg / - m 00:50 01:30 01:00 mg/m Filter 0.22 Micron mg mg / - m 00:15 02:00 00:30 mg/m 1 30 mg mg / 25 m (0.25 mg / m) 00:06 00:15 00: mg / 25 m (0.5 mg / m) 00:12 00:20 00:15 25 mg / 25 m (1 mg / m) 00:25 00:35 00:30 mg/kg mg / - m 00:59 01:30 01:00 mg/m mg mg / 100 m (2 mg / m) 00:50 02:00 01: mg / 200 m (2 mg / m) 00:50 02:00 01:00 mg/m mg / - m 00:30 06:00 01:00 mg/m mg/kg mg / - m 00:50 02:30 01:00 mg/m mg/kg mg / - m 02:00 02:30 02:00 mg/m mg/kg mg / - m 21:00 23:00 25:00 24:00 mg/m mg mg / 50 m (6 mg / m) 00:10 01:00 00: mg / 50 m (12 mg / m) 00:20 01:00 00: mg / 50 m (18 mg / m) 00:20 01:00 00:30 - mg / - m 00:10 01:00 00:30 mg/m 3 18 mg/m mg / - m 00:15 01:30 00:20 mg/m 1 20 mg/m mg / - m 21:00 22:00 25:00 24:00 mg/m mg/m mg / - m 01:45 04:00 02:00 mg/m Filter 0.22 Micron WVHN - 7/5/ :09 Page 10 of 146

11 dacarbazine DAPTOmycin Daratumumab First Dose Daratumumab Second Dose Daratumumab Subsequent Doses Decitabine denileukin desmopressin dexamethasone dexrazoane < 2 m2 CrCl < 40 m/min dexrazoane < 2 m2 CrCl >= 40 m/min dexrazoane >= 2 m2 CrCl < 40 m/min dexrazoane >= 2 m2 CrCl >= 40 m/min diphenhydramine DOCEtaxel dolasetron Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg/m mg / - m 00:20 02:30 00:30 mg/m Protect From ight mg mg / - m 00:25 01:00 00:30 mg/m 2 15 mg/kg mg / - m 05:00 06:30 21:00 20:00 mg/m mg/kg mg / - m 02:30 12:00 10:00 mg/m mg/kg mg / - m 01:30 06:00 mg/m mg/m mg / - m 00:50 03:20 mg/m mcg/kg mcg / - m 00:30 01:30 01:00 mcg/m mcg/kg mcg / - m 00:15 01:00 00:30 mcg/m mg mg / - m 00:10 00:30 00:15 mg/m mg/m mg / - m 01:00 03:00 02:00 mg/m 1 4 mg/m mg / - m 01:00 03:00 02:00 mg/m 1 4 mg mg / - m 01:00 03:00 02:00 mg/m 1 4 mg mg / - m 01:00 03:00 02:00 mg/m 1 4 mg mg / - m 00:10 00:30 00:15 mg/m Filter 0.22 Micron Filter 0.22 Micron Filter 0.22 Micron mg/m mg / - m 00:45 03:00 01:00 mg/m DEHP mg mg / - m 00:10 00:30 00:15 mg/m DOOrubicin INFUSION mg/m mg / - m 21:00 22:00 25:00 24:00 mg/m Vesicant DOOrubicin, liposo mg/m mg / - m 00:30 02:00 mg/m Dextrose only durvalumab Filter 0.22 mg/kg mg / - m 00:50 02:00 01:00 mg/m 1 15 Micron Eculizumab 300 mg / 60 m (5 mg / m) 00:30 02:00 00:35 mg mg / 120 m (5 mg / m) 00:30 02:00 00: mg / 180 m (5 mg / m) 00:30 02:00 00:35 1,200 mg / 240 m (5 mg / m) 00:30 02:00 00:35 ertapenem gram gram / 50 m (0.02 gram / m) 00:25 02:00 00:30 WVHN - 7/5/ :09 Page 11 of 146

12 erythromycin etoposide Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max - gram / - m 00:25 02:00 00:30 gram/m mg / 100 m (2.5 mg / m) 00:30 01:30 01:00 mg mg / 100 m (5 mg / m) 00:30 02:00 01:30 - mg / - m 00:30 02:00 01:30 mg/m 1 5 mg/m mg / - m 00:30 01:30 01:00 mg/m Etoposide CONT INFUS mg/m mg / - m 21:00 22:00 25:00 24:00 mg/m Ferric CARBOymaltos mg ferric gluconate Na fluconazole fludarabine fluorouraci fosaprepitant_emend fosphenytoin GANciclovir gemcitabine gentamicin Dose =< 300 mg gentamicin Dose > 300 mg Golimumab ARIA granisetron IFOSfamide IFOSfamide-MESNA mg mg mg / 250 m (3 mg / m) 00:12 01:00 00:20 - mg / - m 00:12 01:00 00:20 mg/m mg / 100 m (1.25 mg / m) 00:15 01:30 01: mg / 250 m (1 mg / m) 00:30 02:30 02:00 - mg / - m 01:00 03:00 mg/m mg / 50 m (2 mg / m) 00:30 04:00 01: mg / 100 m (2 mg / m) 00:30 04:00 01: mg / 200 m (2 mg / m) 00:30 04:00 02:00 - mg / - m 00:30 04:00 mg/m 1 2 mg/m mg / - m 00:15 01:15 00:30 mg/m mg/m mg / - m 00:05 24:00 00:10 mg/m mg mg / 250 m (0.6 mg / m) 00:16 00:40 00:20 mg mg / 50 m (2 mg / m) 00:10 00:30 00:20 - mg / - m 00:10 00:30 00:20 mg/m mg/kg mg / - m 00:50 02:00 01:00 mg/m 1 10 mg/m mg / - m 00:20 01:00 00:30 mg/m mg mg / 50 m (1.6 mg / m) 00:25 01:20 00:30 - mg / - m 00:25 01:20 00:30 mg/m mg mg / - m 00:35 01:20 01:00 mg/m mg/kg mg / - m 00:25 01:00 00:30 mg/m mg mg / 50 m (0.02 mg / m) 00:10 00:30 00:15 - mg / - m 00:10 00:30 00:15 mg/m mg/m mg / - m 00:30 24:00 mg/m mg/m mg / - m 00:30 25:00 24:00 mg/m 2 29 ow protein binding WVHN - 7/5/ :09 Page 12 of 146

13 infiimab interferon alpha-2b IPIIMumab IRINOtecan 120 minute infusion IRINOtecan 30 minute infusion IRINOtecan 90 minute infusion IRINOtecan liposomal iron sucrose ixabepilone leucovorin levetiracetam levofoacin levoeucovorin levoeucovorin linezolid magnesium sulfate Mannitol IVPB meropenem Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg/kg mg / - m 01:55 25:00 mg/m Hypersensitivity unit/m unit / - m 00:15 60:00 00:20 unit/m unit=1million mg/kg mg / - m 01:15 02:00 01:30 mg/m 1 2 mg/m mg / - m 01:00 01:30 02:30 02:00 mg/m mg/m mg / - m 00:20 00:50 00:30 mg/m mg/m mg / - m 01:00 02:30 01:30 mg/m mg/m mg / - m 01:00 02:30 01:30 mg/m mg mg / 100 m (1 mg / m) 00:06 01:00 00: mg / 100 m (2 mg / m) 00:15 01:00 00: mg / 250 m (1.2 mg / m) 01:00 02:00 01:30 - mg / - m 00:15 05:00 mg/m mg/m mg / - m 02:40 03:20 03:00 mg/m mg/m mg / - m 00:15 03:00 02:00 mg/m mg / 100 m (5 mg / m) 00:10 00:30 00:15 mg ,000 mg / 100 m (10 mg / m) 00:10 00:30 00:15 - mg / - m 00:10 00:30 00:15 mg/m mg / 50 m (5 mg / m) 00:50 02:00 01:00 mg mg / 100 m (5 mg / m) 00:50 02:00 01: mg / 150 m (5 mg / m) 01:15 02:00 01:30 mg/m mg / - m 00:15 03:00 02:00 mg/m mg mg / - m 00:30 00:45 02:00 01:00 mg/m mg mg / 300 m (2 mg / m) 00:45 02:00 01:00 gram gram mg gram / 100 m (0.01 gram / m) 00:25 02:00 01:00 2 gram / 50 m (0.04 gram / m) 00:25 04:00 01:00 4 gram / 100 m (0.04 gram / m) 00:50 08:00 02:00 - gram / - m 00:30 12:00 gram/m gram / 100 m (0.125 gram / m) 00:06 00:15 00:07 25 gram / 140 m (0.179 gram / m) 00:09 00:20 00:10 - gram / - m 00:06 00: mg / 50 m (10 mg / m) 00:25 01:00 00:30 1,000 mg / 50 m (20 mg / m) 00:25 01:00 00:30 Filter 0.22 Micron DHEP and actate WVHN - 7/5/ :09 Page 13 of 146

14 MESNA BOUS MESNA INFUSION methotreate.standard Dosing methotreate High Dose - GRAMS methylprednisolone metronidazoe micafungin mitomycin mitoantrone mycophenoate nafcillin Nelarabine Nivolumab Nivolumab Obinutuzumab-100 mg Olaratumab ondansetron Ondansetron ARCC Oritavancin OAiplatin Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max - mg / - m 00:25 01:00 00:30 mg/m 4 20 mg/m mg / - m 00:10 00:30 00:15 mg/m 4 30 mg/m mg / - m 21:00 22:00 25:00 24:00 mg/m 3 11 mg/m mg / - m 00:15 12:00 mg/m gram/m gram / - m 01:00 25:00 gram/m mg mg / - m 00:15 01:00 mg/m mg mg / 50 m (5 mg / m) 00:25 02:00 00: mg / 100 m (5 mg / m) 00:25 02:00 01:00 - mg / - m 00:50 02:00 01:00 mg/m 2 5 mg mg / - m 00:45 01:30 01:00 mg/m mg/m mg / - m 00:15 00:30 00:20 mg/m Vesicant mg/m mg / - m 00:20 00:45 00:30 mg/m Vesicant mg mg / - m 01:50 04:00 02:00 mg/m gram gram / 50 m (0.02 gram / m) 00:25 01:30 00:30 2 gram / 100 m (0.02 gram / m) 00:25 01:30 01:00 - gram / - m 00:25 01:30 00:30 gram/m mg/m mg / - m 01:45 03:00 02:00 mg/m mg mg / 100 m (2.4 mg / m) 00:25 01:50 00: mg / 100 m (4.8 mg / m) 00:25 01:50 00:30 mg/kg mg / - m 00:25 01:50 00:30 mg/m mg mg / 100 m (1 mg / m) 03:30 04:30 04:00 Saline only mg/kg mg / - m 00:50 02:30 01:00 mg/m Saline only mg mg / - m 00:10 01:00 00:15 mg/m mg mg / 90 m (0.178 mg / m) 00:10 01:00 00:15 mg mg / 1,000 m (0.8 mg / m) 02:30 02:45 04:00 03:00 1,200 mg / 1,000 m (1.2 mg / m) 02:30 02:45 04:00 03:00 Dextrose only mg/m mg / - m 01:45 03:00 02:00 mg/m Oxaliplatin WVHN - 7/5/ :09 Page 14 of 146

15 PACitaxel 1 hour infusion PACitaxel 3 hour infusion Palonosetron pamidronate panitumumab First Dose panitumumab Subsequent Doses pegaspargase Pembrolizumab Pembrolizumab PEMEtrexed peng 2.5 Mill Units peng 5 million units Penicillin G Pertuzumab piperacillin/tazo 30 minute infusion piperacillin/tazo 4 hour infusion potassium chloride Central potassium chloride Peripheral Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg/m mg / - m 00:45 02:00 01:00 mg/m Paclitaxel mg/m mg / - m 02:30 05:00 03:00 mg/m Paclitaxel mg mg / 50 m (0.005 mg / m) 00:10 00:30 00:15 mg mg/kg 3 9 mg/kg mg / 250 m (0.12 mg / m) 00:50 00:55 06:00 01:00 60 mg / 250 m (0.24 mg / m) 00:55 01:45 06:00 02:00 90 mg / 250 m (0.36 mg / m) 02:00 06:00 04:00 - mg / - m 02:00 06:00 04:00 mg/m mg / 100 m (2 mg / m) 00:25 01:30 00:30 - mg / - m 00:50 01:30 01:00 mg/m mg / 100 m (2 mg / m) 00:20 01:30 00:30 - mg / - m 00:20 01:30 00:30 mg/m 5 10 Dedicated IV ine filter low protein filter low protein unit/m unit / - m 00:50 02:30 01:00 unit/m mg mg / 100 m (2 mg / m) 00:20 01:00 00:30 mg/kg mg / - m 00:20 01:00 00:30 mg/m 1 10 mg/m mg / - m 00:08 00:15 00:10 mg/m 3 13 Filter 0.22 Micron Filter 0.22 Micron unit unit / 100 m (0.025 unit / m) 00:25 02:30 01:00 1unit=1million unit unit / 250 m (0.02 unit / m) 00:25 02:30 01:00 1unit=1million unit unit / - m 00:25 02:30 01:00 unit/m unit=1million mg mg / 264 m (1.591 mg / m) 00:20 01:30 00: mg / 278 m (3.022 mg / m) 00:50 01:30 01:00 Pertuzumab 0.75 gram / 50 m (0.015 gram / m) 00:25 01:00 00: gram / 50 m (0.045 gram / m) 00:25 01:00 00:30 gram gram / 50 m (0.067 gram / m) 00:25 01:00 00: gram / 100 m (0.045 gram / m) 00:25 01:00 00:30 - gram / - m 00:25 01:00 00:30 gram gram / 50 m (0.067 gram / m) 03:50 04:10 04:00 - gram / - m 03:50 04:10 04:00 pip-tazo warning 10 meq / 100 m (0.1 meq / m) 00:30 02:00 01:00 20 meq / 50 m (0.4 meq / m) 01:00 03:00 02:00 Central ine meq meq / 100 m (0.2 meq / m) 01:00 03:00 02:00 Only meq/m - meq / - m 00:50 01:00 04: meq meq / 100 m (0.1 meq / m) 00:40 03:00 01:00 20 meq / 100 m (0.2 meq / m) 01:00 06:00 02:00 KC warning WVHN - 7/5/ :09 Page 15 of 146

16 potassium PHOSphate Central potassium PHOSphate Peripheral prochlorperazine Ramucirumab ranitidine rasburicase rifampin rituimab SM/TMP STREPTOzocin temsirolimus Thiamine ticarcillin/clav tigecycine TOBRAmycin Dose =< 300 mg TOBRAmycin Dose > 300 mg Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max - meq / - m 00:50 01:00 04:00 meq/m mmol / 250 m (0.06 mmol / m) 02:00 06:00 03:00 20 mmol / 250 m (0.08 mmol / m) 02:00 06:00 03:00 mmol mmol / 250 m (0.1 mmol / m) 03:00 06:00 04:00 - mmol / - m 03:00 09:00 04:00 mmol/m mmol / 250 m (0.056 mmol / m) 02:00 06:00 03:00 15 mmol / 250 m (0.06 mmol / m) 02:00 06:00 03:00 mmol mmol / 250 m (0.08 mmol / m) 02:00 06:00 03:00 - mmol / - m 02:00 06:00 mmol/m mg mg / - m 00:10 00:30 00:15 mg/m mg/kg mg / - m 00:50 03:00 01:00 mg/m mg mg / 50 m (1 mg / m) 00:10 01:00 00:15 Filter 0.22 Micron mg mg / 50 m (0.06 mg / m) 00:25 00:45 00:30 - mg / - m 00:25 00:45 00:30 mg/m Saline only 300 mg / 250 m (1.2 mg / m) 00:50 03:00 01:00 mg mg / 500 m (1.2 mg / m) 00:50 03:00 01:00 - mg / - m 00:55 03:00 mg/m mg/m mg / - m 01:00 25:00 mg/m Hypersensitivity mg/kg mg / - m 00:45 02:00 01:00 mg/m mg/m mg / - m 00:45 02:00 01:00 mg/m Vesicant mg mg / - m 00:25 01:15 00:30 mg/m Non-PVC mg mg / 50 m (4 mg / m) 00:15 01:00 00: mg / 50 m (6 mg / m) 00:15 01:00 00: mg / 50 m (10 mg / m) 00:25 01:00 00:30 - mg / - m 00:15 01:00 mg/m gram gram / 100 m (0.031 gram / m) 00:25 01:00 00:30 mg mg mg / 50 m (1 mg / m) 00:25 01:00 00:30 Dedicated IV 100 mg / 100 m (1 mg / m) 00:25 01:00 00:30 ine 80 mg / 100 m (0.8 mg / m) 00:25 01:00 00:30 - mg / - m 00:25 01:00 00:30 mg/m mg mg / - m 00:35 01:20 01:00 mg/m WVHN - 7/5/ :09 Page 16 of 146

17 topotecan trastuzumab oading Dose trastuzumab Subsequent Doses VANCOmycin 1,000mg/200mg Wausau VANCOmycin All Facilities vinbastine vincristine vinorebine VORIconazole Vyxeos zidovudine Ziv-aflibercept zoledronic (RECAST) zoledronic (ZOMETA) Intermittent Drugs - Ambulatory Oncology Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg/m mg / - m 00:20 01:00 00:30 mg/m mg/kg mg / - m 01:20 02:00 01:30 mg/m mg/kg mg / - m 00:25 02:00 00:30 mg/m mg ,000 mg / 200 m (5 mg / m) 01:00 02:30 01:30 mg mg / 100 m (5 mg / m) 00:30 01:30 01: mg / 150 m (5 mg / m) 00:30 02:30 01:30 1,000 mg / 250 m (4 mg / m) 01:00 02:30 01:30 1,250 mg / 250 m (5 mg / m) 01:00 03:00 02:00 1,500 mg / 250 m (6 mg / m) 01:30 03:30 02:30 - mg / - m 02:20 04:30 mg/m mg/m mg / - m 00:03 00:12 00:05 mg/m Vesicant mg mg / - m 00:03 00:12 00:10 mg/m Vesicant mg/m mg / - m 00:05 00:11 00:10 mg/m Vesicant mg mg / 250 m (0.8 mg / m) 00:50 02:00 01: mg / 250 m (1.6 mg / m) 01:45 04:00 02:00 - mg / - m 01:45 04:00 mg/m mg/m mg / - m 01:20 02:00 01:30 mg/m mg/kg mg / - m 00:50 01:30 01:00 mg/m 1 4 mg/kg mg / - m 00:45 01:15 01:00 mg/m Non-PVC mg mg / 100 m (0.05 mg / m) 00:15 02:00 00:15 mg mg / 100 m (0.04 mg / m) 00:15 02:00 00:15 - mg / - m 00:15 02:00 00:15 mg/m Fluids Fluid Name Fluids - Ambulatory Oncology Supports Module Rate imits (m/h) Clinical Ads. Name Secondary P S Soft Soft Hard Min Max Max..Maintenance IVF Yes IVF + KC 10 meq/ Yes WVHN - 7/5/ :09 Page 17 of 146

18 Fluids - Ambulatory Oncology Fluid Name Supports Module Rate imits (m/h) Clinical Ads. Name Secondary P S Soft Soft Hard Min Max Max.IVF + KC 20 meq/ Yes IVF + KC 30 meq/ Yes IVF + KC 40 meq/ Yes Maint IVF+Additives Yes Bicarb Drip Yes Blood (FFP) No Dedicated IV ine Blood (platelets) Yes Dedicated IV ine Blood (PRBCs) No Dedicated IV ine Blood Reinfusion No Sodium Chlor 3% Yes TPN No micron filter PCA Drugs fentany PCA Drugs - Ambulatory Oncology Concentrations: 600 mcg / 30 m (20 mcg / m) Concentration imits imits Conc. Units Hard Min Soft Min Soft Max Hard Soft Soft Hard Initial PCA Pause Protocol: Min Min Max Max Value No PCA Dose Dosing Units Dose / h mcg Max Accum. Includes Bolus? oading Dose Yes ockout Interval (minutes) Clinical Advisory Name Max Acc. Dose Range / 4 h nd RN to verify WVHN - 7/5/ :09 Page 18 of 146

19 HYDROmorphone PCA Drugs - Ambulatory Oncology Concentrations: 6 mg / 30 m (0.2 mg / m) Concentration imits imits Conc. Units Hard Min Soft Min Soft Max Hard Soft Soft Hard Initial PCA Pause Protocol: Min Min Max Max Value No PCA Dose Dosing Units Dose / h mg Max Accum. Includes Bolus? oading Dose Yes ockout Interval (minutes) Clinical Advisory Name Max Acc. Dose Range / 4 h 1 5 2nd RN to verify morphine PCA Drugs - Ambulatory Oncology Concentrations: 30 mg / 30 m (1 mg / m) Concentration imits imits Conc. Units Hard Min Soft Min Soft Max Hard Soft Soft Hard Initial PCA Pause Protocol: Min Min Max Max Value No PCA Dose Dosing Units Dose / h mg Max Accum. Includes Bolus? oading Dose Yes ockout Interval (minutes) Clinical Advisory Name Max Acc. Dose Range / 4 h nd RN to verify 2.2 Critical Care WVHN - 7/5/ :09 Page 19 of 146

20 2.2.1 /Bolus - Non-Anesthesia Drugs /Bolus - Non-Anesthesia Drugs - Critical Care Conc. Dosing Administration Module Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Concentrations Min Max Max Value Min Max Max Value Min Max Max Value abciximab.weight under 80Kg YES mg / - m abciximab Weight >= to 80kg mcg/min mg / 250 m (0.029 mg / m) Adenosine (CATH AB) 60 mg / 20 m (3 mg / m) 90 mg / 30 m (3 mg / m) 150 mg / 50 m (3 mg / m) - mg / - m agalsidase beta 65 mg / 100 m (0.65 mg / m) - mg / - m alteplase EKOS infusion 24 mg / 240 m (0.1 mg / m) alteplase MI 67KG or less - mg / - m alteplase MI greater than 67KG 100 mg / 100 m (1 mg / m) alteplase Pulmonary Embolism 100 mg / 100 m (1 mg / m) alteplase Stroke 100kg and up 90 mg / 90 m (1 mg / m) NO mcg/kg YES mg/h mg/h YES mg/kg/h mg mg/min mg/h mg mg/min mg/h mg/h mg mg/min filter low protein WVHN - 7/5/ :09 Page 20 of 146

21 Concentrations alteplase Stroke less 100 kg - mg / - m alteplase Vascular Occlusions 4 mg / 100 m (0.04 mg / m) 10 mg / 50 m (0.2 mg / m) 25 mg / 125 m (0.2 mg / m) - mg / - m AminocaproicINFUSION /Bolus - Non-Anesthesia Drugs - Critical Care Module Conc. Dosing Administration Bolus imits Units Rate P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Min Max Max Value Min Max Max Value Min Max Max Value YES mg/kg/h mg/kg mg/kg/min 5 gram / 250 m (0.02 gram / m) AMINOphyllineINFUSIO 250 mg / 250 m (1 mg / m) 1,000 mg / 1,000 m (1 mg / m) AMIODArone 360 mg / 200 m (1.8 mg / m) 450 mg / 250 m (1.8 mg / m) 900 mg / 500 m (1.8 mg / m) angiotensin II 2.5 mg / 500 m (0.005 mg / m) Aralast - mg / - m argatroban.standard Dosing 50 mg / 50 m (1 mg / m) 125 mg / 125 m (1 mg / m) 250 mg / 250 m (1 mg / m) argatroban Hepatic Dose 50 mg / 50 m (1 mg / m) 125 mg / 125 m (1 mg / m) atracurium 50 mg / 250 m (0.2 mg / m) 100 mg / 500 m (0.2 mg / m) - mg / - m YES mg/h gram/h mg/h mg/min nanogram/kg/min YES mg/kg/min YES Clinical Ads. Name Filter 0.22 Micron Aralast rate nd RN to verify nd RN to verify Neuromuscular BA WVHN - 7/5/ :09 Page 21 of 146

22 Concentrations bivalirudin.standard Dosing 250 mg / 50 m (5 mg / m) bivalirudin Dialysis dosing 250 mg / 50 m (5 mg / m) bivalirudin Renal Dose 250 mg / 50 m (5 mg / m) bumetanide continuos 25 mg / 100 m (0.25 mg / m) 50 mg / 200 m (0.25 mg / m) cisatracurium 200 mg / 200 m (1 mg / m) - mg / - m Clevidipine /Bolus - Non-Anesthesia Drugs - Critical Care Module Conc. Dosing Administration Bolus imits Units Rate P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Min Max Max Value Min Max Max Value Min Max Max Value mg/kg/h mg/kg mg/kg/min 25 mg / 50 m (0.5 mg / m) CMV immunoglobulin - mg / - m cosyntropin 0.5 mg / 100 m (0.005 mg / m) - mg / - m dexmedetomidine 400 mcg / 100 m (4 mcg / m) - mcg / - m mg/kg/h mg/kg mg/kg/min mg/kg/h mg/kg mg/kg/min mg/h YES mg/kg mg/kg/min mg/h YES mg/kg/h YES mcg/h mcg mcg/min YES mcg/kg/h mcg/kg Clinical Ads. Name Neuromuscular BA Hour Tubing WVHN - 7/5/ :09 Page 22 of 146

23 /Bolus - Non-Anesthesia Drugs - Critical Care Conc. Dosing Administration Module Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Concentrations Min Max Max Value Min Max Max Value Min Max Max Value Dextrose - Heparin unit/h Impella advisory 50 unit / 1 m (50 unit / m) diltiazem mg/h mg / 125 m (1 mg / m) DOBUTamine.Standard Dosing YES mg / 250 m (2 mg / m) 1,000 mg / 250 m (4 mg / m) - mg / - m DOBUTamine Stress test 250 mg / 250 m (1 mg / m) DOPamine 400 mg / 250 m (1.6 mg / m) - mg / - m EPINEPHrine 4 mg / 250 m (0.016 mg / m) - mg / - m eptifibatide.standard Dosing 75 mg / 100 m (0.75 mg / m) eptifibatide.weight121kg & above 75 mg / 100 m (0.75 mg / m) eptifibatide Renal Dose 75 mg / 100 m (0.75 mg / m) eptifibatide Renal Dose wt >121kg 75 mg / 100 m (0.75 mg / m) esmolol 2,500 mg / 250 m (10 mg / m) fenoldopam 10 mg / 250 m (0.04 mg / m) 20 mg / 250 m (0.08 mg / m) YES YES mg/h mg/h mcg/kg Stress Test Central ine Only Central ine Only CrCl > 50 m/min CrCl > 50 m/min CrCl < 50 m/min CrCl < 50 m/min WVHN - 7/5/ :09 Page 23 of 146

24 /Bolus - Non-Anesthesia Drugs - Critical Care Conc. Dosing Administration Module Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Concentrations Min Max Max Value Min Max Max Value Min Max Max Value fentany mcg/h ,000 mcg / 100 m (20 mcg / m) mcg mcg/min fentany mcg/kg/h ,000 mcg / 100 m (20 mcg / m) mcg mcg/min Flebogamma 10% YES No filter mg/kg/h required 20 gram / 200 m (0.1 gram / m) - gram / - m FUROSemide 1,000 mg / 100 m (10 mg / m) - mg / - m Gammagard 10% 20 gram / 200 m (0.1 gram / m) - gram / - m Gamunex - C 10% 20 gram / 200 m (0.1 gram / m) - gram / - m Glassia - mg / - m glucagon 10 mg / 100 m (0.1 mg / m) heparin ACS therapy 25,000 unit / 250 m (100 unit / m) heparin Atrial Fib 25,000 unit / 250 m (100 unit / m) YES mg/h YES mg/kg/h YES mg/kg/h YES mg/kg/min mg/h unit/h unit unit/min unit/h unit unit/min No filter required No filter required Aralast rate nd RN to verify nd RN to verify WVHN - 7/5/ :09 Page 24 of 146

25 Concentrations heparin CRRT 25,000 unit / 250 m (100 unit / m) heparin DVT/PE 25,000 unit / 250 m (100 unit / m) heparin Impella 25,000 unit / 250 m (100 unit / m) heparin Stroke 25,000 unit / 250 m (100 unit / m) heparin 2 units/m 1,000 unit / 500 m (2 unit / m) insulin Non-anesthesia 150 unit / 150 m (1 unit / m) - unit / - m isoproterenol 1 mg / 250 m (0.004 mg / m) Kcentra - unit / - m Ketamine 250 mg / 250 m (1 mg / m) 500 mg / 500 m (1 mg / m) - mg / - m labetalol 300 mg / 150 m (2 mg / m) 500 mg / 250 m (2 mg / m) levothyroxine /Bolus - Non-Anesthesia Drugs - Critical Care Module Conc. Dosing Administration Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Min Max Max Value Min Max Max Value Min Max Max Value nd RN to verify unit/h unit unit/min 200 mcg / 500 m (0.4 mcg / m) unit/h unit unit/min unit/h unit unit/min unit/h unit/h YES unit/h mcg/min YES unit/min YES mg/min mcg/h nd RN to verify nd RN to verify nd RN to verify heparin flush bag Insulin advisory WVHN - 7/5/ :09 Page 25 of 146

26 /Bolus - Non-Anesthesia Drugs - Critical Care Conc. Dosing Administration Module Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Concentrations Min Max Max Value Min Max Max Value Min Max Max Value idocaine Cardiac mg/min ,000 mg / 500 m (4 mg / m) ORazepam YES mg/h Filter 0.22 Micron 40 mg / 120 m (0.333 mg / m) - mg / - m mg mg/min midazolam 100 mg / 100 m (1 mg / m) - mg / - m milrinone 20 mg / 100 m (0.2 mg / m) morphine 100 mg / 100 m (1 mg / m) 250 mg / 250 m (1 mg / m) 500 mg / 500 m (1 mg / m) - mg / - m naloxone 0.8 mg / 250 m (0.003 mg / m) 4 mg / 1,000 m (0.004 mg / m) - mg / - m nicardipine 20 mg / 200 m (0.1 mg / m) 25 mg / 250 m (0.1 mg / m) - mg / - m nitrogycerin 25 mg / 250 m (0.1 mg / m) 50 mg / 250 m (0.2 mg / m) nitroprusside 50 mg / 250 m (0.2 mg / m) 100 mg / 250 m (0.4 mg / m) YES mg/h mg mg/min mcg/kg YES mg/h mg mg/min YES mg/h YES mg/h mcg/min Central preferred Protect From ight WVHN - 7/5/ :09 Page 26 of 146

27 NORepinephrine Concentrations 4 mg / 250 m (0.016 mg / m) - mg / - m Ocrelizumab First Dose 300 mg / 250 m (1.2 mg / m) Ocrelizumab Second Dose 300 mg / 250 m (1.2 mg / m) Ocrelizumab Subsequent Doses 600 mg / 500 m (1.2 mg / m) octreotide 1,500 mcg / 500 m (3 mcg / m) - mcg / - m oxytocin /Bolus - Non-Anesthesia Drugs - Critical Care Module Conc. Dosing imits Units Bolus P S Soft Soft Hard Initial Soft Soft Hard Min Max Max Value Min Max Max YES 30 unit / 500 m (0.06 unit / m) Pantoprazole Infusio 80 mg / 100 m (0.8 mg / m) PENTobarbital CI 1,000 mg / 500 m (2 mg / m) - mg / - m PHENYephrine 40 mg / 250 m (0.16 mg / m) - mg / - m Privigen 10% 20 gram / 200 m (0.1 gram / m) - gram / - m procainamide 1,000 mg / 250 m (4 mg / m) 2,000 mg / 500 m (4 mg / m) Prolastin-C - mg / - m mg/h mg/h mg/h YES mcg/h mcg mcg/min milliunit/min mg/h YES mg/kg/h YES YES mg/kg/h mg/min YES mg/kg/min Administration Rate Clinical Ads. Initial Soft Soft Hard Initial Name Value Min Max Max Value Central ine Only Filter 0.22 Micron Filter 0.22 Micron Filter 0.22 Micron Central ine Only No filter required Proteinase rate note WVHN - 7/5/ :09 Page 27 of 146

28 propofol Concentrations 500 mg / 50 m (10 mg / m) 1,000 mg / 100 m (10 mg / m) rituimab ACU 1,000 mg / 500 m (2 mg / m) - mg / - m rocuronium /Bolus - Non-Anesthesia Drugs - Critical Care Module Conc. Dosing Administration Bolus imits Units Rate Clinical Ads. P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Name Min Max Max Value Min Max Max Value Min Max Max Value Hour Tubing 100 mg / 100 m (1 mg / m) tirofiban CrCl < 60 m/min 5 mg / 100 m (0.05 mg / m) 12.5 mg / 250 m (0.05 mg / m) tirofiban CrCl >= 60 m/min 5 mg / 100 m (0.05 mg / m) 12.5 mg / 250 m (0.05 mg / m) TRANexamic acid CV 3,000 mg / 250 m (12 mg / m) Treprostinil 1,250 mcg / 500 m (2.5 mcg / m) - mcg / - m vasopressin 40 unit / 100 m (0.4 unit / m) - unit / - m vecuronium 100 mg / 250 m (0.4 mg / m) - mg / - m YES mg/h mcg/kg mcg/kg mcg/kg mg/kg/h mg/kg mg/kg/min YES nanogram/kg/min YES unit/min NO mcg/kg Hypersensitivity Tirofiban dosing Tirofiban dosing Filter 0.22 Micron Central ine Only Neuromuscular BA WVHN - 7/5/ :09 Page 28 of 146

29 Zemaira Concentrations - mg / - m Zidovudine infusion - mg / - m /Bolus - Non-Anesthesia Drugs - Critical Care Module Conc. Dosing imits Units Bolus P S Soft Soft Hard Initial Soft Soft Hard Min Max Max Value Min Max Max YES mg/kg/min YES mg/kg/h Administration Rate Clinical Ads. Initial Soft Soft Hard Initial Name Value Min Max Max Value Proteinase rate note /Bolus - Non-Anesthesia Drugs - Concentration imits /Bolus - Non-Anesthesia Drugs - Concentration imits - Critical Care Module Concentration imits P S Conc. Hard Soft Soft Dosing Method Units Min Min Max abciximab mcg/m weight under 80Kg agalsidase beta mg/m Non alteplase MI 67KG or less alteplase Stroke less 100 kg alteplase Vascular Occlusions Non Aralast atracurium cisatracurium CMV immunoglobulin cosyntropin mg/m mg/m mg/m mg/m mcg/m mcg/m mg/m mcg/m Non WVHN - 7/5/ :09 Page 29 of 146

30 /Bolus - Non-Anesthesia Drugs - Concentration imits - Critical Care Module Concentration imits P S Conc. Hard Soft Soft Dosing Method Units Min Min Max dexmedetomidine mcg/m DOBUTamine.Standard Dosing DOPamine EPINEPHrine Flebogamma 10% FUROSemide Non Gammagard 10% Gamunex - C 10% Glassia insulin Non-anesthesia Non Kcentra Non Ketamine ORazepam Non midazolam Non morphine mcg/m mcg/m mcg/m mg/m mg/m mg/m mg/m mg/m unit/m unit/m mcg/m mg/m mg/m mg/m Non WVHN - 7/5/ :09 Page 30 of 146

31 /Bolus - Non-Anesthesia Drugs - Concentration imits - Critical Care Module Concentration imits P S Conc. Hard Soft Soft Dosing Method Units Min Min Max naloxone mg/m Non nicardipine Non NORepinephrine octreotide Non PENTobarbital CI PHENYephrine Privigen 10% Prolastin-C rituimab ACU Non Treprostinil vasopressin Non Zemaira Zidovudine infusion mg/m mcg/m mcg/m 1 6 mg/m 1 8 mcg/m mg/m mg/m mg/m nanogram/ m unit/m mg/m mg/m 1 4 WVHN - 7/5/ :09 Page 31 of 146

32 2.2.3 /Bolus - Anesthesia Only Drugs atracurium Concentrations 10 mg / 1 m (10 mg / m) 20 mg / 100 m (0.2 mg / m) 50 mg / 100 m (0.5 mg / m) cisatracurium /Bolus - Anesthesia Only Drugs - Critical Care Conc. Dosing Module Bolus imits Units P S Soft Soft Hard Initial Soft Soft Hard Min Max Max Value Min Max Max YES 2 mg / 1 m (2 mg / m) dantrolene ANESTHESI - mg / - m dantrolene ANESTHESI 20 mg / 60 m (0.333 mg / m) fentany 50 mcg / 1 m (50 mcg / m) insulin Anesthesia only 150 unit / 150 m (1 unit / m) midazolam 1 mg / 1 m (1 mg / m) Propofol ANESTHESIA 10 mg / 1 m (10 mg / m) 500 mg / 50 m (10 mg / m) 1,000 mg / 100 m (10 mg / m) YES mg/kg mg/kg/min YES mg/h mg/kg mg/kg/min mg/kg/h mcg/kg/h mcg mcg/min unit/h mcg/kg mcg/kg Administration Rate Clinical Ads. Name Initial Soft Soft Hard Initial Value Min Max Max Value Neuromuscular BA Neuromuscular BA nd RN to verify WVHN - 7/5/ :09 Page 32 of 146

33 /Bolus - Anesthesia Only Drugs - Critical Care Conc. Dosing Administration Clinical Ads. Module Bolus imits Units Rate Name P S Soft Soft Hard Initial Soft Soft Hard Initial Soft Soft Hard Initial Concentrations Min Max Max Value Min Max Max Value Min Max Max Value protamine sulfate mg/min mg / 1 m (10 mg / m) mg mg/min remifentanil mcg / 1 m (50 mcg / m) mcg/kg rocuronium mg / 1 m (10 mg / m) mcg/kg succinylcholine mg/min mg / 1 m (20 mg / m) mg/kg mg/kg/min SUFentanil mcg/kg/h mcg / 1 m (50 mcg / m) mcg/kg vecuronium Neuromuscular BA 1 mg / 1 m (1 mg / m) mcg/kg /Bolus - Anesthesia Only Drugs - Concentration imits /Bolus - Anesthesia Only Drugs - Concentration imits - Critical Care Module Concentration imits P S Conc. Hard Soft Soft Dosing Method Units Min Min Max WVHN - 7/5/ :09 Page 33 of 146

34 /Bolus - Anesthesia Only Drugs - Concentration imits - Critical Care Module Concentration imits P S Conc. Hard Soft Soft Dosing Method Units Min Min Max dantrolene ANESTHESI mg/m Non Intermittent Drugs Abatacept Acetaminophen pt weight < 50kg Acetaminophen pt weight >= 50kg acetazoamide acetylcysteine First Dose acetylcysteine Second Dose acetylcysteine Third Dose acyclovir albumin 25% albumin 5% amikacin Intermittent Drugs - Critical Care Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg mg / - m 00:25 01:00 00:30 mg/m Protein and filter mg/kg mg / - m 00:10 00:30 00:15 mg/m Acetaminophen doses mg ,000 mg / 100 m (10 mg / m) 00:10 00:30 00:15 mg mg / - m 00:15 01:00 00:30 mg/m gram/kg gram / - m 00:30 02:00 01:00 gram/m gram/kg gram / - m 03:30 05:00 04:00 gram/m gram/kg gram / - m 13:20 18:00 16:00 gram/m Acetylcysteine bolus acetylcysteine 2nd acetylcysteine 3rd mg mg / - m 00:45 02:00 01:00 mg/m gram gram / 50 m (0.25 gram / m) 00:15 01:00 00:30 25 gram / 100 m (0.25 gram / m) 00:20 01:00 00:30 gram gram / 250 m (0.05 gram / m) 00:15 01:00 mg/kg mg / - m 00:25 02:00 01:00 mg/m 1 6 Aminocaproic OAD 5 gram / 250 m (0.02 gram / m) 00:45 01:30 01:00 gram gram / - m 00:45 01:30 01:00 gram/m AMIODArone oading 150 mg / 100 m (1.5 mg / m) 00:08 00:15 00:10 mg mg / - m 00:08 01:00 mg/m 1 3 ampho B (IPOSOMA) mg/kg mg / - m 01:00 04:00 02:00 mg/m amphotericin B.Standard Dosing amphotericin B Blasto load < 100 KG mg mg / - m 00:59 06:00 mg/m mg/kg mg / - m 02:30 03:30 03:00 mg/m Protect From ight Protect From ight WVHN - 7/5/ :09 Page 34 of 146

35 amphotericin B Blasto load >= 100KG amphotericin B Blasto Maintenance ampicillin ampicillin/sulbact ascorbic acid azithromycin aztreonam Belatacept Belimumab bumetanide Bumetanide in HSS calcium chloride calcium gluconate cefazolin cefepime Intermittent Drugs - Critical Care Available As Total Dose imits Module Duration imits Concentration imits Clinical Ads. Dosing Soft Soft Hard Hard Soft Soft Initial Conc. Hard Soft Soft Name Pri. Sec. Units Min Max Max Concentrations P S Min Min Max Value Units Min Min Max mg mg / 500 m (0.1 mg / m) 02:30 03:30 03:00 Protect From ight mg/kg mg / - m 22:00 23:00 25:00 24:00 mg/m Protect From ight 0.5 gram / 50 m (0.01 gram / m) 00:25 01:00 00:30 1 gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 gram gram / 100 m (0.02 gram / m) 00:25 01:00 00:30 - gram / - m 00:25 01:00 00:30 gram/m gram / 50 m (0.03 gram / m) 00:10 01:00 00:15 3 gram / 100 m (0.03 gram / m) 00:10 01:00 00:15 gram gram / - m 00:10 01:00 00:15 gram/m mg ,500 mg / 100 m (15 mg / m) 00:15 01:00 00:30 - mg / - m 00:15 01:00 mg/m 5 20 mg mg / 250 m (2 mg / m) 00:50 03:00 01:00 - mg / - m 00:50 03:00 01:00 mg/m gram / 100 m (0.01 gram / m) 00:25 01:00 00:30 2 gram / 100 m (0.02 gram / m) 00:25 01:00 00:30 gram gram / - m 00:25 01:00 00:30 gram/m mg/kg mg / - m 00:20 00:40 00:30 mg/m ow protein binding mg mg / - m 00:55 03:00 01:00 mg/m Saline only mg mg / - m 00:30 03:00 01:00 mg/m Not for continuous mg mg / 150 m (0.027 mg / m) 00:25 00:45 00:30 Not for 8 mg / 150 m (0.053 mg / m) 00:25 00:45 00:30 continuous - mg / - m 00:25 00:45 00:30 mg/m ,000 mg / 50 m (20 mg / m) 00:08 02:00 01:00 Central ine mg mg / - m 00:08 02:00 01:00 mg/m Only mg ,000 mg / 50 m (20 mg / m) 00:10 00:15 06:00 01:00 - mg / - m 00:10 00:15 06:00 mg/m gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 2 gram / 50 m (0.04 gram / m) 00:25 01:00 00:30 gram gram / 100 m (0.03 gram / m) 00:25 01:00 00:30 - gram / - m 00:25 01:00 00:30 gram/m gram / 50 m (0.02 gram / m) 00:25 01:00 00:30 2 gram / 100 m (0.02 gram / m) 00:25 01:00 00:30 gram gram / - m 00:25 01:00 00:30 gram/m WVHN - 7/5/ :09 Page 35 of 146

Alaris System Profile Report RELEASED. Stepdown. VUMC - 3/18/ :20 Page 1 of 19 VUMC O, 018d997b6-R

Alaris System Profile Report RELEASED Stepdown VUMC - 3/18/2013 09:20 Page 1 of 19 1. Current Data Set Status Data Set Name Hospital Name Data Set ID Data Set Status VUMC 9.4 2013 O VUMC 018d997b6-R Released