Safety Data Sheet according to (EC) No. 1907/2006 Day of issue: 25 November 1994 Day of revision: 7. December 2017

Transcription

1 Safety Data Sheet according to (EC) No. 1907/2006 Day of issue: 25 November 1994 Day of revision: 7. December 2017 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier: OPD Tablets- 2 mg -Fizzing Buffer, ph 5, cat. No Relevant identified uses of the substance or mixture and uses advised against: For research and analysis. Restricted to professional users Details of the supplier of the safety data sheet: See below. Responsible person for the safety data sheet ( ): Altox a/s (altox@altox.dk) 1.4. Emergency telephone number: UK NHS: Dial 111 or SECTION 2: Hazards identification 2.1. Classification of the substance or mixture: Environmentally harmful tablets that may harm the unborn child, impair fertility and cause an allergic reaction. Suspected of causing cancer and genetic defects. CLP (1272/2008): Skin Sens. 1;H317 Muta. 2;H341 Carc. 2;H351 Repr. 1B;H360FD Aquatic Chronic 3;H Label elements: Contains: o-phenylenediamine dihydrochloride and boric acid. Hazard statements: DANGER H317: May cause an allergic skin reaction. H341: Suspected of causing genetic defects. H351: Suspected of causing cancer. H360: May damage fertility or the unborn child. H412: Harmful to aquatic life with long lasting effects. Precautionary statements: P201: Obtain special instructions before use. P281: Use personal protective equipment as required. P308+P310: IF exposed or concerned: Immediately call a POISON CENTER or doctor/physician. P280: Wear protective gloves/protective clothing/eye protection/face protection. P273: Avoid release to the environment Other hazards: None known. PBT/vPvB: No ingredients are PBT/vPvB, according to the criteria in REACH Annex XIII.

2 SECTION 3: Composition/Information on ingredients 3.2. Mixtures: % w/w Substance name CAS-no. EC-no. Index-no. REACH Classification reg.-no. ~ 2 o-phenylene Carc. 2;H351 diamine Muta. 2;H341 dihydrochloride Acute Tox. 4;H312+H332 Skin Sens. 1;H317 Acute Tox. 3;H301 Eye Irrit. 2;H319 Aquatic Acute 1;H400 Aquatic Chronic 1;H Boric acid Repr. 1B;H360FD Wording of hazard statements - see section 16. SECTION 4: First-aid measures 4.1. Description of first aid measures: Inhalation: Go to fresh air. Keep at rest. If person feels queasy/discomfort: Seek medical advice. Skin contact: Remove all contaminated clothing and wash subsequently with water and soap. If person feels queasy/discomfort: Seek medical advice. Eye contact: Flush thoroughly with water or physiological salt water, holding eyelids open. Remember to remove contact lenses, if any. If irritation persists: Seek medical advice. Ingestion: Rinse mouth and drink plenty water. Do not induce vomiting. If vomiting occurs, keep the head down to prevent vomit getting into the lungs. Call an ambulance Most important symptoms and effects, both acute and delayed: May harm the unborn child, impair fertility, and cause an allergic reaction. Suspected of causing cancer and genetic defects Indication of any immediate medical attention and special treatment needed: Show this safety data sheet to a physician or emergency ward. SECTION 5: Fire-fighting measures 5.1. Extinguishing media: Use water, dry chemical, foam or carbon dioxide Special hazards arising from the substance or mixture: At fire, the product may form hazardous decomposition products such as: Oxides of carbon and nitrogen and corrosive hydrogen chloride. Remove containers if possible Advice for firefighters: When extinguishing fires use breathing apparatus with an independent source of air. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment - see section 8. Provide adequate ventilation Environmental precautions: Avoid empty into drains. If large amounts of the mixture contaminates sewages, inform appropriate authorities in accordance with local regulations Methods and material for containment and cleaning up: Collect spilled material and place spillage in a plastic container. Subsequently wash area with plenty of water. Further handling of spillage - see section Reference to other sections: See references above. SECTION 7: Handling and storage 7.1. Precautions for safe handling: Organize and perform all work to prevent any contact with the tablets. Work in fume hood. If necessary, use plastic forceps. DO NOT use metal forceps (see section 10). Avoid all contact with skin, eyes and clothes. Avoid breathing dust. Wash with soap and water if skin and clothes are contaminated. Required access to water and eye wash fountain.

3 SECTION 7: Handling and storage (continued) 7.2. Conditions for safe storage, including any incompatibilities: In a well-closed container, protected against moisture. Do not remove the included drying capsule. Store at 2-8 C (short time storage). For long time storage: at -20 C Specific end use(s): See section 1. SECTION 8: Exposure controls/personal protection 8.1. Control parameters: o-phenylenediamine: 0.1 mg/m 3 (ACGIH) DNEL/PNEC: No CSR Exposure controls: Appropriate engineering controls: Provide adequate ventilation - Work in fume hood. Personal protective equipment: Inhalation: Not required if used at proper ventilation (working in fume hood). Skin: Not required when forceps is used. Otherwise, use gloves of nitrile rubber. Breakthrough time: Unknown - change gloves by exposure. Eyes: Wear close-fitting safety goggles when risk of dust formation or splashes during manufacture of solution. Environmental exposure controls: None particular. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties: Appearance: Fizzing tablet(s) Odour: None Odour threshold: ph: 5.2 (water solution) Melting point / freezing point ( C): Initial boiling point and boiling range ( C): Decomposition temperature ( C): Flash point ( C): Evaporation rate: Flammability (solid, gas): Upper/lower flammability or explosive limits (vol.-%): Vapour pressure (hpa, 20 C): Not relevant Vapour density (air=1): Not relevant Relative density (g/cm 3, 20 C): Solubility: Soluble in water Partition coefficient: n-octanol/water, Log Kow: Auto-ignition temperature ( C): Viscosity: Explosive properties: Oxidising properties: 9.2. Other information: None relevant SECTION 10: Stability and reactivity Reactivity: Chemical stability: Combustible. Stable Possibility of hazardous reactions: None known Conditions to avoid: Avoid heating and moisture (will initiate the fizzing process) Incompatible materials: Avoid contact with combustible materials and metals (e.g. metal forceps) or metallic ions (metal works as catalysts for the oxidation process) Hazardous decomposition products: At fire, the product may form hazardous decomposition products such as: Oxides of carbon and nitrogen and corrosive hydrogen chloride.

4 SECTION 11: Toxicological information Information on toxicological effects: Hazard class Data Test Data source Acute toxicity: Inhalation LC50 (rat) = 3.6 mg/l/4h (o-phenylenediamine) No info Supplier Dermal LD50 (rat) > 5000 mg/kg (o-phenylenediamine) No info Supplier Oral LD50 (rat) = 510 mg/kg (o-phenylenediamine) No info Supplier Corrosion/ Irritation, eyes. No irritation, skin(o-phenylenediamine) OECD irritation: 405/404 Sensitization: Skin sensitization (o-phenylenediamine) Patch/GPMT CMR: Carcinogen effect (rats) (o-phenylenediamine) Mutagen effect (o-phenylenediamine) Reproduction toxic effects: Reduced fertility and sterility, also malformation of the skeleton and other impacts on the foetus (Boric acid) No info AMES, Chrom. No info Information on likely routes of exposure: Skin, inhalation and ingestion. Symptoms: Inhalation: Inhalation of tablet-dust may give irritation with coughing and shortness of breath and symptoms as mentioned under Ingestion. Skin: May cause irritation. o-phenylenediamine may be absorbed through the skin and cause symptoms as mentioned under Ingestion. Eyes: Ingestion: May cause irritation. Irritation of the gastrointestinal tract and in large doses: Dizziness, abdominal pain, neurological disorders and jaundice. Chronic effects: May impair fertility and cause harm to the unborn child. o-phenylenediamine can cause an allergic reaction and might cause cancer and genetic defects. SECTION 12: Ecological information Toxicity: o-phenylenediamine is very toxic to aquatic life. Aquatic Data (o-phenylenediamine) Test (Media) Data source Fish LC50 (Danio rerio, 96 h) = 24 mg/l No info.(fw) Crustacean EC50 (Daphnia magna, 48 h) = 0.87 mg/l No info.(fw) Algae IC50 (Sc. subspicatus, 72 h) = 4 mg/l No info.(fw) Persistence and degradability: o-phenylenediamine is not readily biodegradable Bioaccumulative potential: o-phenylenediamine: Log KOW = 0.15 little bioaccumulative potential Mobility in soil: No available or applicable data Results of PBT and vpvb assessment: No ingredients are PBT/vPvB, according to the criteria in REACH Annex XIII Other adverse effects: None known. SECTION 13: Disposal considerations Waste treatment methods: Waste should not be disposed of by release to sewers. The chemical must be treated as hazardous waste. Disposal should be according to local, state or national legislation. EWC-code:

5 SECTION 14: Transport information UN-no.: UN proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (o-phenylenediamine dihydrochloride) Transport hazard class(es): Packing group: III Environmental hazards: MP Special precautions for user: None Transport in bulk according to Annex II of MARPOL and the IBC Code: Not relevant. SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture: The employer shall assess the working conditions and, if there is any risk to the safety or health and any effects on the pregnancy or breastfeeding of workers, take the necessary measures to adjust the working conditions (Directive 92/85/EEC). Restricted use: Must not be used by persons under 18 years of age Chemical Safety Assessment: No CSR. SECTION 16: Other information Hazard statements mentioned in section 3: H301: Toxic if swallowed. H312+H332: Harmful in contact with skin or if inhaled. H317: May cause an allergic skin reaction. H319: Causes serious eye irritation. H341: Suspected of causing genetic defects. H351: Suspected of causing cancer. H360FD: May damage fertility or the unborn child. H400: Very toxic to aquatic life. H410: Very toxic to aquatic life with long lasting effects. Abbreviations: CMR = Carcinogenicity, mutagenicity and reproductive toxicity. CSR = Chemical Safety Report DNEL = Derived No-Effect Level EC50 = Effect Concentration 50 % FW = Fresh Water LC50 = Lethal Concentration 50 % LD50 = Lethal Dose 50 % PBT = Persistent, Bioaccumulative, Toxic PNEC = Predicted No-Effect Concentration vpvb = very Persistent, very Bioaccumulative Literature: RTECS = Register of Toxic Effects of Chemical Substances. = International Uniform ChemicaL Database Information IARC = International Agency for Research on Cancer (monograph, resumé) Training advice: No special training is required. However, the user should be well instructed in the execution of his/her task, be familiar with this Safety Data Sheet and have normal training in the use of personal protective equipment. Edition no.: 9-1 (Revision) Date: 7. December 2017 Changes since the previous edition: 14 Prepared by: Altox a/s Tonsbakken DK-2740 Skovlunde Phone / AP - Quality control: PW