WHERE NEUROENGINEERING BRIDGES BODY AND MIND.

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1 TECNALIA HEALTH AND AGEING NEUROENGINEERING WHERE NEUROENGINEERING BRIDGES BODY AND MIND.

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3 TECNALIA INSIRING BUSINESS WHERE NEUROENGINEERING BRIDGES BODY AND MIND. WE TRANSFORM TECHNOLOGY INTO VALUE, WEALTH AND FUTURE WE UNDERSTAND NEUROENGINEERING AS A DISCILINE THAT USES ENGINEERING METHODS TO SUORT, IMROVE OR REAIR THE NEURAL SYSTEM. COMENSATE, ACCELERATE, RECOVER AND REHABILITATE TO IMROVE EOLE S LIVES. Under this premise, we are developing advanced medical devices to treat neurological diseases to enable the elderly and disabled as well as the chronically ill or injured persons to compensate or accelerate the recovery of their lost functions (such as mobility) and facilitate personal autonomy while improving their quality of life. We strive to provide healthcare professionals with the best clinical instruments to enable them to improve the assessment and rehabilitation process; for businesses to improve competitiveness in the healthcare market or diversify their offer to include new health realms. We are committed to the creation of an innovative healthcare industry with global presence, meeting both people s needs and market requirements, acting as leverage for our industries competitiveness and enabling access to a sophisticated and high value sector. Did you know? 600 million people need rehabilitation, but only one third receives it. Access to advanced rehabilitation technologies is still quite limited despite the fact that it helps reduce healthcare system costs and greatly improves the therapy results. Neurological disorders affect millions of people around the world and according to WHO, cardiovascular disease, epilepsy, dementia, Alzheimer s disease, obesity or sleeping disorders have the highest prevalence. A compound annual growth rate of 20% has been estimated for the advanced rehabilitation device market. According to the Wintergreen Research report, the rehabilitation robotics, active prostheses and exoskeletons market is expected to increase from $43.3 million (2014) to $1.8 billion by / 4 / 5

4 TECNALIA INSIRING BUSINESS WE DEVELO ADVANCED MEDICAL DEVICES FOR THE TREATMENT OF NEUROLOGICAL DISEASES OUR ACTIVITY FOCUSES ON THE DEVELOMENT OF: New devices for the rehabilitation of motor functions affected by neurological disorders. WE OFFER OUR EXERTISE IN: Neuroprotheses capable of restoring or modulating functions (sensory, motor, cognitive) in persons affected by neural pathologies. Biomechanics and human motor control Electrotherapy (functional electrical stimulation) Rehabilitation systems through implantable devices and brain-machine interfaces applying neuroengineering. Wearable robotics Clinical aspects in neurorehabilitation EMG / EEG technology Wearable biofeedback systems (vital signs / physiological signals) Cognitive aspects of rehabilitation Quantitative assessment of function, activity and participation rostheses and orthopaedic devices for rehabilitation Assessment: Biomarkers and haptic biofeedback Design, organisation, co-ordination and management of clinical trials in the field of (non-invasive and implantable) neural interfaces TO DEVELO: Rehabilitation robots and orthoses Sensor-based rehabilitation Virtual rehabilitation Tele-rehabilitation Implantable devices Brain-machine Interfaces (BMI) Neuroprostheses / 6 / 7

5 TECNALIA INSIRING BUSINESS A RESEARCH EXCELLENCE TEAM TECNALIA researchers are our greatest asset, and their passion is our driving force. Some of the leaders of our neuroengineering team are: Our Neuroengineering Team has achieved high levels of excellence with international recognition in certain technologies. 150 high impact publications 13 awards and recognitions 80 International Conferences (session or conference organizers) Dr. Thierry Keller _ Dr. Ander Ramos _ Dr. Joseph McIntyre _ 20 active patent families Three New Technology-Based Companies were created as a result of the activity in this field Director of the Neurorehabilitation department and resident of the Functional Electrical Stimulation Society (IFESS) has developed various neuroprostheses that help improve the walking and grasp functions in physically impaired subjects. Bio-medical engineer and hd in neuroscience leading neurotechnology and neural interfaces work backed by his international background and several international awards Having studied Engineering, Biology and Neuroscience at Caltech and MIT, has made a career of the interface between human physiology and engineering, helping to build bridges between these two disciplines. Information related to the last 5 years. CANADA / THE USA UNIV. OF TORONTO GERMANY MEDICAL UNIV. OF GÖTTINGEN MEDICAL UNIV. OF TUEBINGEN UNIV. OF BIELEFELD TECHNICAL UNIV. OF MUNICH TECHNICAL UNIV. OF BERLIN TECHNICAL UNIV. OF CHEMNITZ THE NETHERLANDS UNIV. OF TWENTE SWEDEN ABB KUNGLIGA TENKISKA HOEGSKOLAN RISE ACREO AB NORWAY WE ARE CERTAIN THAT TODAY S INNOVATION SHOULD BE OEN. ABALONYX AS DENMARK UNIV. OF AALBORG Therefore, we connect with international knowledge centres, people worldwide and leading companies to accelerate our and their research processes while improving the resources. ORTUGAL. ORTO SERBIA BELGRADE UNIVERSITY HOSITAL BELGRADE UNIVERSITY SWITZERLAND ETH ZURICH HOCOMA AG IDUN TECHNOLOGIES AG SAIN JESÚS USÓN MINIMALLY INVASIVE SURGERY CENTRE DONOSTIA HOSITAL BIODONOSTIA AITA MENNI HOSITAL BIOCRUCES CSIC UM UNITED KINGDOM UNIV. OF SOUTHAMTON CENTRE FOR RESEARCH AND TECHNOLOGY HELLAS FRANCE GREECE SLOVENIA NATIONAL REHABILITATION CENTRE OF SLOVENIA / 8 CEA LIST CNRS KORIAN FOUNDATION CEA LETI UNIV. OF GRENOBLE ALES / 9

6 TECNALIA INSIRING BUSINESS ASSET IELINE: ROTECTED TRANSFERRED ASSET COMANY CREATED CURRENT ASSETS ROOF OF CONCET VALIDATION MARKET ARTNERS REHAND Robot for hand rehabilitation which can be integrated into more complex robotic devices NEUROMOD Closed loop neuromodulation platform BACKSTIM Medical device aimed at treating backpain and scoliosis through electrical stimulation RECODO Active elbow rehabilitation device WIFALL Fall detection and localization device for indoor and outdoor use EQUIMETRIX FES System for functional stability assessment and training Functional Electrical Stimulation (FES) based rehabilitation technology to enable the activation of peripheral nerves and paralysed muscles FES UER Wrist and hand rehabilitation system based on FES technology and aimed at stroke patients FESIA WALK Rehabilitation system based on FES Technology and aimed at stroke patients with foot drop ISMORE Intracranial system for motor rehabilitation of stroke patients MAXSENS Electrode-based stimulation device providing artificial sensory and proprioceptive information to amputees BONESTIM Medical device aimed at treating osteoporosis through electrical stimulation ARMASSIST Comprehensive upper-limb robotic device for neurorehabilitation ISMORE MAXSENS EQUIMETRIX REHAND ARMASSIST FES UER FESIA WALK / 10 / 11

7 TECNALIA INSIRING BUSINESS TECNALIA IS AN ALIED RESEARCH AND TECHNOLOGICAL DEVELOMENT CENTRE SERVICE OFFER UNIVERSITIES AND UBLIC RESEARCH CENTRES COMANIES Advanced technological services specialised in the evaluation and diagnosis of products, processes and materials. ADVANCED TECHNOLOGICAL SERVICES _ YOUR ROJECT INVESTMENT OORTUNITIES Development of technological assets ready to generate new business. R&D AND INNOVATION ROJECTS TECNALIA R&D and innovation projects for the development of new products and processes or for the improvement of existing ones. SCIENTIFIC-TECHNOLOGICAL CHALLENGES Basic Research Applied Research Experimental Development FROM SCIENCE MISSION We transform technology into GD TO MARKET We transform technology into wealth to obtain beneficial visible results for companies, society, our environment and in short, for people. ADVANCED MANUFACTURING New insights for the Industry and Factory of the Future which will be smart and connected, automated and cognitive, flexible as well as sustainable, social and collaborative. DIGITAL AND HYERCONNECTED WORLD We continue to evolve towards an increasingly connected and interactive world. We are working in this context to give due response to the challenges of the Digital Economy and Cyber-hysical Systems. LOW-CARBON ENERGY Clean technologies and renewable energy play a key role in advancing towards a more sustainable and efficient low-carbon society. URBAN HABITAT We are committed to smart places and cities, because we believe in their potential for progress, their innovation catalyst role and their ability to become an economic development driver. HEALTH & AGEING Technology can play a key role in improving the quality of life of many people with physical disabilities or health problems. We are committed to developing new devices, systems and products that encourage business activity in this sector. CLIMATE CHANGE AND SHORTAGE OF RESOURCES Climate change impacts are already a reality. We need to implement solutions and actions to minimise their effects: valorisation of waste and critical materials, emission reduction, circular economy, bioeconomy, etc. / 12 / 13

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9 WE CAN DO SO MUCH TOGETHER Our work is not understood without yours; we want to work together so your company can compete better. Because together, we can develop technologies that transform the present. The future is technological, let's share it! blogs.tecnalia.com TECNALIA arque Científico y Tecnológico de Gipuzkoa Mikeletegi asealekua 2 E Donostia-San Sebastián. Gipuzkoa (Spain) Tel.: salud@tecnalia.com Neurorehabilitation Contact: Dr. Thierry Keller thierry.keller@tecnalia.com Neurotechnology Contact: Dr. Ander Ramos ander.ramos@tecnalia.com Medical Robotics Contact: Dr. Joseph McIntyre joseph.mcintyre@tecnalia.com