presents How to S.E.A.R.C.H. for the Right MS Therapy for You! G Live Webinar October 19, 2016
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1 presents How to S.E.A.R.C.H. for the Right MS Therapy for You! G Live Webinar October 19, 2016
2 How to S.E.A.R.C.H. for the Right MS Therapy for You! Guest Presenter Carrie M. Hersh, DO, MS MS Neurologist Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, NV
3 Acknowledgements MSAA would like to take this opportunity to thank the supporters of this program. This webinar, along with the recently revised S.E.A.R.C.H. booklet and patient workbook, have been made possible with the support of EMD Serono and Sanofi Genzyme. MSAA is solely responsible for the development of S.E.A.R.C.H. and its content.
4 Providing Information... Toll-free Helpline at (800) Online response forums via Chat feature and option at Free mobile phone application - My MS Manager Finding Answers... Comprehensive website: mymsaa.org Award-winning publications, videos, and webinars S.E.A.R.C.H. initiative Programs and Services Easing Daily Life... Equipment distribution Cooling program MRI Access Fund Staying Connected... In-person educational events New online peer community My MSAA Community Social media presence via Facebook, Twitter, YouTube, etc.
5 How to S.E.A.R.C.H. for the Right MS Therapy for You! Webinar Objectives Explore the changing landscape of MS, looking at current and future treatments Emphasize the importance of treatment adherence and compliance Look at today s doctor-patient relationship and how both sides can work together Learn about MSAA s S.E.A.R.C.H. program which can help your decision to choose the right MS therapy for YOU!!!
6 The Changing Landscape of MS Prior to 1993, the MS landscape looked fairly barren There were no FDA-approved treatments for MS Limited approach to treating symptoms and managing the disease No consistent use of rehabilitation services
7 The Changing Landscape of MS Because of such limited options at the time, advice to many MS patients included statements such as... Go home and rest try not to do too much Don t get exposed to the heat You may want to consider not having children
8 The Changing Landscape of MS Since 1993, this barren desert has been transformed into a fertile, growing landscape flourishing with... More than a dozen FDA-approved treatments for MS with more under development A more comprehensive approach to treating and managing the disease, with an increased focus on rehabilitation and wellness
9 The Changing Landscape of MS Current FDA-Approved MS Disease Modifying Therapies (DMTs) Self-Injected Medications Infused Medications Oral Medications Avonex Lemtrada Aubagio Betaseron Novantrone Gilenya Copaxone Tysabri Tecfidera Extavia Glatopa Plegridy Rebif Zinbryta
10 The Changing Landscape of MS New Long-Term Treatments on the Horizon Ocrelizumab - a humanized monoclonal antibody that functions similarly to another therapy commonly used for autoimmune conditions, Rituximab - First disease modifying therapy of its kind to demonstrate positive benefit in patients with primary progressive MS - Administered via intravenous infusion every 6 months - Clinical trials showed excellent reduction of clinical relapses and new MRI lesions compared to a standard injectable MS therapy - Expected to be available for commercial use in 2017
11 The Changing Landscape of MS New Long-Term Treatments on the Horizon Siponimod - an oral treatment strategy with similar structure and function as fingolimod - Potential treatment option for patients with secondary progressive MS - Recently announced at ECTRIMS 2016 in London, England to demonstrate positive benefit in delaying disability progression in patients with secondary progressive MS in a phase 3 clinical trial compared with placebo
12 The Changing Landscape of MS New Long-Term Treatments on the Horizon Ofatumumab - a fully human monoclonal antibody that functions similarly to Rituximab and Ocrelizumab - Expected to be well tolerated given its human structure - In phase 2 clinical trials, Ofatumumab demonstrated significant reduction in number of relapses and new MRI lesions, and no unexpected safety findings were reported - Ofatumumab, administered as a once monthly injection underneath the skin, is entering a phase 3 clinical trial that will be investigating its efficacy and safety in a larger population of patients with relapsing forms of MS
13 Importance of Adherence SIMPLE FACT: Research has proven that most MS patients with relapsing forms of MS who start and continue using a DMT treatment accumulate less disability over time, and at a slower rate than patients who are non-compliant.
14 Having a Good Doctor-Patient Relationship Your appointment with the doctor is at 11:15, but his appointment with you is at 12:15. Give it to me straight, Doc. How long do I have to ignore your advice? The Cartoon Bank/Condé Nast Publications Inc.
15 Having a Good Doctor-Patient Relationship Given the complexity of MS, the doctor and patient must work together to understand the problems and find successful solutions Establishing open and honest doctor-patient communication will help foster: - mutual trust - enhanced accuracy of diagnosis and treatment - improved adherence and compliance - increased patient satisfaction, reduced complaints - the best possible health and overall quality of life
16 Ways to Help Be proactive and take charge of your healthcare - Use credible Internet sites to research information - Keep a journal or use MSAA s mobile phone app (My MS Manager ) - Maintain other healthcare needs and appointments Understand the reduced time doctors have to spend with their patients and come prepared Use MSAA s S.E.A.R.C.H. model to discuss your MS treatment options and make an informed decision
17 What is S.E.A.R.C.H. MSAA s S.E.A.R.C.H. An easy acronym that helps you remember, organize, and prioritize important questions to discuss with your doctor or healthcare team Each letter represents key areas that need to be considered when searching for the most appropriate MS treatment S.E.A.R.C.H. stands for: S AFETY E FFECTIVENESS A CCESS R ISKS C ONVENIENCE H EALTH OUTCOMES (overall wellness and quality of life)
18 MSAA s S.E.A.R.C.H. Safety Suggested Questions: Specific to the MS therapies you are considering... What are the long-term safety profiles of these FDA-approved DMTs? What tests are required prior to taking or while receiving certain DMTs? How will DMTs interact with my current medical treatments, other medical conditions, and any complementary and alternative medicines? What are the concerns about pregnancy or breast feeding while taking one of these DMTs?
19 MSAA s S.E.A.R.C.H. Effectiveness Suggested Questions: Specific to the MS therapies you are considering... How effective are these DMTs in reducing MS relapses, disability, and MRI activity? What are my realistic expectations regarding the effectiveness of these DMTs? How can I tell if my DMT is working? When should I consider using a different DMT?
20 MSAA s S.E.A.R.C.H. Access Access to DMTs and the ability to switch therapies can vary greatly depending on your insurance provider, coverage levels and other restrictions. MSAA has a comprehensive website section titled, My Health Insurance Guide, to help people better understand and utilize their health insurance. Suggested Questions: Specific to the MS therapies you are considering... Which DMTs are covered by my insurance carrier? What are their Tier Levels and how does that affect cost? Are there assistance programs through the pharmaceutical companies, government or charities?
21 MSAA s S.E.A.R.C.H. Risk Suggested Questions: Specific to the MS therapies you are considering... What are the risks of side effects with these DMTs? How frequent and severe are the side effects? How soon do they subside? Can these side effects be managed? How do you balance the risks?
22 MSAA s S.E.A.R.C.H. Convenience Suggested Questions: Specific to the MS therapies you are considering... How are the DMTs administered? How often do I take these DMTs? Must I have regular tests or visits to other healthcare providers to monitor the effects of my treatment?
23 MSAA s S.E.A.R.C.H. Health Outcomes Suggested Questions: Specific to the MS therapies you are considering... How will my general health and quality of life be affected by these DMTs? What will my MS look like in five or 10 years? Will taking a DMT lower my immune system and cause other problems? Can these DMTs assist with my mobility, cognition, and other health factors?
24 S.E.A.R.C.H. Tools MSAA has produced a variety of informational tools to help maximize your success with S.E.A.R.C.H. Current tools available at mymsaa.org include: S.E.A.R.C.H. Booklet with laminated Reference Card S.E.A.R.C.H. Patient Workbook to write notes and organize questions for the doctor MS Disease Modifying Therapy Chart of currently approved treatments MS Resource Guide listing MS organizations and pharmaceutical assistance programs mymsaa.org/healthinsurance with information on the Affordable Care Act and Medicare
25 Remaining Adherent Once a DMT is initiated, evidence suggests that treatment needs to be ongoing for benefits to persist. Non-adherence and gaps in treatment have been associated with an increased rate of relapses and progression in disability. Understandably, adherence can present certain challenges over time. Fortunately many of these challenges can be managed to keep people on course.
26 Remaining Adherent Some Helpful Strategies to Help Build Toward Ongoing Treatment Adherence include: Managing Side Effects - Take over-the-counter medications to manage temporary flu-like symptoms; ice-down and rotate injection sites; use an auto injector Understanding Expectations - Discuss realistic expectations with your doctor; give the DMT 1 yr. to have an effect; realize if you don t see results then it might be working Learning to Adjust - Set a schedule and use calendar reminders or sticky notes to help remember to take your medication; receive proper training if needed on self-injection techniques; if problems arise, don t just stop taking your DMT talk to your doctor!
27 To Summarize Take-home messages: View MS as an ever-changing landscape that holds great promise for the future Recognize that being adherent to an MS DMT will help reduce attacks and lessen disability over time Be proactive in managing your healthcare Strive to have a good doctor-patient relationship Use S.E.A.R.C.H. to help discuss MS medications with your doctor and select the therapy that is right for YOU!
28 Thank You This concludes MSAA s Webinar: How to S.E.A.R.C.H. for the Right MS Therapy for You! This webinar will be available soon on MSAA s website: MSAA would like to thank Dr. Hersh for her excellent presentation on multiple sclerosis and the S.E.A.R.C.H. initiative, as well as supporters EMD Serono and Sanofi Genzyme. Thank you for participating in MSAA s webinar.
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