Focus on flow: imaging the human microcirculation in perioperative and intensive care medicine Elbers, P.W.G.

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1 UvA-DARE (Digital Academic Repository) Focus on flow: imaging the human microcirculation in perioperative and intensive care medicine Elbers, P.W.G. Link to publication Citation for published version (APA): Elbers, P. W. G. (2010). Focus on flow: imaging the human microcirculation in perioperative and intensive care medicine General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 29 Jan 2019

2 List of Publications and Curriculum Vitae

3 Publications related to this thesis Elbers PW, Wijbenga J, Solinger F, Yilmaz A, van Iterson M, van Dongen EP, Ince C. Direct observation of the human microcirculation during cardiopulmonary bypass: effects of pulsatile perfusion. J Cardiothorac Vasc Anesth 2010; epub ahead of print. Munsterman LD, Elbers PW, Ozdemir A, van Dongen EP, van Iterson M, Ince C. Withdrawing intra-aortic balloon pump support paradoxically improves microvascular flow. Crit Care Aug 25; 14: R161, epub ahead of print. Elbers PW, Ozdemir A, Heijmen RH, Heeren J, van Iterson M, van Dongen EP, Ince C. Microvascular hemodynamics in human hypothermic circulatory arrest and selective antegrade cerebral perfusion. Crit Care Med 2010; 38: Elbers PW, Craenen AJ, Driessen A, Stehouwer MC, Munsterman L, Prins M, van Iterson M, Bruins P, Ince C. Imaging the human microcirculation during cardiopulmonary resuscitation in a hypothermic victim of submersion trauma. Resuscitation 2010; 81: 123. Elbers PW, Atasever B. Quality and consistency in microvascular research. Br J Anaesth 2009; 102: 886. Meinders AJ, Elbers PW. Images in clinical medicine. Leukocytosis and sublingual microvascular blood flow. N Engl J Med 2009; 360: e9. Elbers PW, Ozdemir A, van Iterson M, van Dongen EP, Ince C. Microcirculatory imaging in cardiac anesthesia: ketanserin reduces blood pressure but not perfused capillary density. J Cardiothorac Vasc Anesth 2009; 23: 95. Elbers PW. Fast-track microcirculation analysis. Crit Care 2007; 11: 426. Elbers PW, Ince C. The microcirculation is a vulnerable organ in sepsis; in: Vincent JL (ed): Update on Intensive Care and Emergency Medicine; Vol 44: Abraham E., Singer M (eds): Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery. New York, NY, USA, Springer Verlag 2007: 249. Elbers PW, Ince C. Mechanisms of critical illness--classifying microcirculatory flow abnormalities in distributive shock. Crit Care 2006; 10: 221. Elbers PW, Emons M, Ozekinci H, Schwart LA. PEEP reduces functional capillary density. J Vasc Res 2000; 37 (S1): 30. [152]

4 Other publications Vieleers N, Bosman RJ, Elbers PW, Oudemans-Van Straaten HM. VCO2 based calculation of required caloric intake differes from ESPEN nutritional guidelines. Intensive Care Med; 2010; 36 (S2): S258. Gatz R, Elbers PW. In defence of the Stewart approach to acid-base analysis. Kidney Int 2010; 78: 711. Gatz R, Elbers PW. Albumin is not a buffer in plasma. Blood Transfus 2010; epub ahead of print. Kruyt ND, Biessels GJ, Vriesendorp TM, Devries JH, Hoekstra JB, Elbers PW, Kappelle LJ, Portegies P, Vermeulen M, Roos YB. Subjecting acute ischemic stroke patients to continuous tube feeding and an intensive computerized protocol establishes tight glycemic control. Neurocrit Care 2010; 12: 62. Elbers PW, Gatz R. Acidbase.org: online decision support in complex acid base disorders using the Stewart approach. Crit Care 2009; 13 (Suppl 1): 449. Elbers PW. The perioperative period; in: Kellum JA, Elbers PW (eds): Stewart s Textbook of Acid-Base. AcidBase.org, Amsterdam, The Netherlands 2009; 463. Kellum JA, Elbers PW (eds). Stewart s Textbook of Acid-Base. AcidBase.org, Amsterdam, The Netherlands Elbers PW, de Haan P, Vanicky I, Legemate D, Dzoljic M. Effect of temporary visceral ischemia on spinal cord ischemic damage in the rabbit. Ann Thorac Surg 2006; 81: 910. [153]

5 Curriculum Vitae Paul Willem Gerhard Elbers was born on March 18, 1975 in IJsselstein, The Netherlands. He attended pre-university education at Gymnasium Juvenaat H Hart in Bergen op Zoom. Following graduation, he briefly studied Technical Business Administration at Universiteit Twente, Enschede. After this he spent a year working in Paris, France. In 1994, he started his medical education at Universiteit van Amsterdam. It was here where he first met Prof. dr. ir. Can Ince. This led to a long lasting collaboration. Its results include pioneering research on microvascular imaging, various symposia on Microcirculation and Mitochondrial Dysfunction in Intensive Care Medicine and of course the studies on the human microcirculation that have resulted in this thesis. During his medical studies, he developed a career in computer science. For this, he spent one year in Dublin, Ireland working at Gateway Computers. Another year was spent in The Hague. There he was appointed team leader to work on the millennium problem at the Ministry of Health of The Netherlands. He obtained his M.Sc. in Medicine in During his clinical rotations, he was employed as a research associate at the department of Anesthesiology (head: Prof. dr. Misa Dzoljic) to investigate ischemic spinal cord ischemia. After obtaining his medical degree in 2003 he briefly worked as an intensive care physician at Meander Medisch Centrum, Amersfoort. In 2004, he started training in Anesthesiology at St. Antonius Hospital, Nieuwegein (head: Dr. Eric PA van Dongen). Besides clinical work he participated in implementing a Patient Data Management System in this hospital. In addition, the studies on the human microcirculation described in this thesis were conducted during this residency. In 2009 he was registered as anesthesiologist with special focus on cardiac anesthesiology. During his medical career, he also developed a keen interest in acid-base physiology, especially using the quantitative approach developed by the late Peter A Stewart. This led to the development of the web site which hosts Stewart s classic text. In 2009, together with Prof. John A Kellum (University of Pittsburgh, PA, USA) he published Stewart s Textbook of Acid-Base, which helped revive clinical quantitative acid-base medicine. Large parts of this thesis were written on the island of Curacao, Netherlands Antilles where he resided intermittently after his residency in Anesthesiology. This was alternated with a position as Anesthesiologist at Onze Lieve Vrouwe Gasthuis, Amsterdam (head: Dr. Jasper A Kal). At the end of 2009, he started training in Intensive Care Medicine at Onze Lieve Vrouwe Gasthuis, Amsterdam (heads: Prof. dr. Durk Zandstra and Dr. Peter van der Voort). In 2010, he was registered as anesthesiologist-intensivist. In 2011, he will take up a position as cardiac anesthesiologist and intensivist at Medisch Centrum Leeuwarden. [154]