I graduated from School of Pharmacy at the Tehran University of Medical Sciences in April 1988 with Pharm D. I was

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1 Masoumeh Jorjani Pharm. D., Ph.D. Academic Appointments: Professor, Pharmacology, Neuroscience Administrative Appointment: Director, Neurobiology Research Center, Address: Department of Pharmacology & Neurobiology Research Center, School of Medicine, Shahid Beheshti. University of Medical Sciences, koodakyar street, Daneshjoo Boulevard, Velenjak, Chamran Exp. Way, Tehran - IRAN Phone: Fax: Lab: (Ext. 120) Personal History: I graduated from School of Pharmacy at the Tehran University of Medical Sciences in April 1988 with Pharm D. I was then employed 2 years as a lecturer in Department of Pharmacology, School of Medicine at the Shahid Beheshti University of Medical Sciences (SBMU) in Tehran, where I received my PhD in November I worked there as an Assistant Professor and was promoted to Associate Professor in December From , I was vice chancellor for research at the Shahid Beheshti University of Medical Sciences. I received my professorship in April From Dec Jul. 2008, I received an appointment as Visiting Prof. in the Department of Physiology, Baltimore School of Medicine at the university of Maryland, USA. I have been General Secretariat for Iranian society of Physiology and Pharmacology (ISPP) from November February 2018 and in March 2018, I was elected as president of ISPP. In December 2013, I was appointed to the role

2 of Director of Neurobiology Research Center at SBMU and became Dean of SBMU Medical School from In addition to my career as an academic faculty, I was also Editor in-chief for Pejouhandeh research journal for ten years, member of academy of medical sciences in IRAN, member of Iranian board of pharmacology(since 2014, member of the International Association for the study of pain, International Brain Research Organization, Society for Iranian Pharmacist and Iranian Society of Neuroscience. I am currently Director of Neurobiology Research Center and serving as Director Secretariat of faculty promotional affairs and Shahid Beheshti Univ. Med. Sci, Tehran, IRAN. Research Interests: I have been interested on sex differences in pain perception and pain signaling pathways in the CNS. We have investigated the influence of steroid hormones on the pain mechanisms and neurotransmitter release in different brain regions. Over the last decade, we have focused on mechanisms underlying central neuropathic pain induced by spinal cord injuries and pain modulation by steroids. We found that Estradiol as a multi-active agent protects the neurons and prevents the progress of neurodegeneration. We think that local steroid production is an endogenous mechanism for repair of neural tissue and improvement of somatosensory functions including central pain during CNS damage. We also investigate to find out new targets for the treatment of sensory-motor dysfunction following SCI. Currently, we concerned on stem cell therapy in combination with neuroprotective agents on SCI functional recovery. Lab Techniques: We use a broad range of techniques, from behavioral analysis to the molecular level. Behavioral tests include tests of acute and chronic pain models and motor activity. We also measure the gene expression and detect the interested proteins in the spinal or brain tissues by RT PCR, Real time PCR, Immunocytochemistry, Western blot, ELIZA and other molecular techniques. We also study the neurotransmitter release in different regions of CNS by using brain and spinal micro dialysis in anesthetized or freely moving rodents. We use HPLC and other analytical techniques to detect the concentration of molecules of interest in dialysate and other biological samples. Laboratory Personnel: Sina Asadi, Clinical scientist resident Fatemeh Abbaszadeh - Research Assistant/ PhD student Fatemeh Maboubifard, PhD student Leila Mohaghegh, PhD student Safura Pournajaf, PhD student

3 Sedighe Talebi, PhD student Publications: Search all of my publications in PubMed Selected Publications Fakhri S, Abbaszadeh F, Dargahi L, Jorjani M. Effects of Astaxanthin on Sensory-Motor Function in a Compression Model of Spinal Cord Injury: Involvement of ERK and AKT Signaling Pathway. Eur J Pain Nov 14. doi: /ejp PMID: Fakhri S, Abbaszadeh F, Dargahi L, Jorjani M. Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury. Brain Res Bull Oct; 143: doi: /j.brainresbull PMID: Fakhri S, Abbaszadeh F, Dargahi L, Jorjani M. Astaxanthin: A Mechanistic review on its biological activities and health benefits.pharmacol Res Oct; 136:1-20. doi: /j.phrs Masoudi A., Darghahi L.,Abbaszadeh F., Pourgholami MH., AsgaryA., Manoochehri M. Jorjani M, Neuroprotective effects of astaxanthin in a rat model of spinal cord injury Bahv. Brain Res. 2017; 329: doi: /j.bbr PMID: Salehi M.,Ardeshirylajimi A., Mossahebi-Mohammadi M., Kondori Z., Jorjani M., Oligodendrocyte progenitor cells differentiation of nuclear transferred mouse embryonic stem cells. Cell Mol Biol May 16; 61(2):56-9., PMID: Ahadi R., khodagholi F.,Daneshi A., Vafaee A, Mafi A., Jorjani M. Diagnostic value of serum level of GFAP, NF-H and NSE compared with clinical findings in severity assessment of human traumatic spinal cord injury. Spine (Phila Pa 1976) Jul 15; 40(14):E doi: /BRS , PMID: Ghorbanpoor S., Garcia-Segura LM., Haeri-Rohani A.,Khodagholi F., Jorjani M. Aromatase inhibition exacerbates pain and reactive gliosis in the dorsal horn of the spinal cord of female rats caused by spinothalamic tract injury. Endocrinology 2014, 155: 11): doi: /en Epub 2014 Aug 8. Ghanbari A., Asgari A. R., Kaka G. R, Falahatpishe H. R., Naderi A., Jorjani M. In vivo microdialysis of glutamate in ventroposterolateral nucleus of thalamus following electrolytic lesion of spinothalamic tract in rats. Exp. Brain Res. (2014) 232:

4 Saghaei S., abbaszadeh f., Naseri K., ghorbanpour S. Haeri A., Jorjani M. Estradiol Attenuates Spinal Cord Injury-Induced Pain by Suppressing Microglial Activation in Thalamic VPL Nuclei of rats. Neurosci. Res.(2013) 7(4): Naseri k., Saghaei E., Abbaszadeh F., Afhami N., Haeri A., Rahimi F., Jorjani M. Role of Microglia and Astrocyte in Central Pain Syndrome Following Electrolytic Lesion at the Spinothalamic Tract.in Rats. J Mol Neurosci (2013) 49: Niknejad H., Peirovi H., Jorjani M., Ahmadiani A., Ghanavi J., Seifalian AM. Properties of the amniotic membrane for potential use in tissue engineering. Eur. Cell Material, (2008) 15: Mousavi Z.,Shafaghi B.,Kobarfard F.,Jorjani M. Sex differences and role of gonadal hormones on glutamate level in the nucleus accumbens in morphine tolerant rats: A microdialysis study. Eur. J. Pharmacol. (2007) 554: Sajedianfard J.,., Khatami Sh., Semnanian S., Naghdi N., Jorjani M. In vivo measurement of noradrenaline in the locus coerulus of rats during the formalin test: A microdialysis study. Eur. J. Pharmacol (2005)512:

5 Departments and organisations Pharmacology: Neuropharmacology, Neurosceince Dean s Neurobiology Research Center School of Medicine Shahid Beheshti University of Medical Sciences Biography Prof. Masoumeh Jorjani graduated from School of Pharmacy at the Tehran University of Medical Sciences in April 1988 with Pharm D. She was then employed 2 years as a lecturer in Department of Pharmacology, School of Medicine at the Shahid Beheshti University of Medical Sciences in Tehran where she received her Ph.D in November She worked there as an Assistant Professor and was promoted to Associate Professor in December From , she was vice chancellor for research at the Shahid Beheshti University of Medical Sciences. She received her professorship in April From Dec Jul. 2008, she received an appointment as Visiting Prof. in the Department of Physiology, Baltimore School of Medicine at the university of Maryland, USA. Form November 2007-March 2018, she was General Secretariat for Iranian society of Physiology and Pharmacology of ISPP and in March 2018 she was elected as the president. In December 2013, she was appointed to the role of Director of Neurobiology Research Center at SBMU and then, she was Dean of SBMU Medical School from In addition to her career as an academic faculty,she was also Editor in-chief for Pejouhandeh research journal for ten years, member of academy of medical sciences in IRAN, member of Iranian board of pharmacology(since 2014, member of the International Association for the study of pain, International Brain Research Organization, Society for Iranian Pharmacist and Iranian Society of Neuroscience. She is currently Director of Neurobiology Research Center and serving as Director Secretariat of faculty promotional affairs and Shahid Beheshti Univ. Med. Sci, Tehran, IRAN. Click here to view her C.V.

6 دکتر معصومه جرجانی گروه آموزشی و دانشگاه محل خدمت فارماکولوژی: نوروفارماکولوژی و علوم اعصاب استاد و رییس مرکز تحقیقات نوروبیولوژی دانشکده پزشکی دانشگاه علوم پزشکی شهید بهشتی بیوگرافی دکتر هعص ه جرجب ی دارای درج دکتری دار سبزی از دا طگب عل م پسضکی ت راى) 7631 ( دکتری تخصصی فبرهبک ل شی از دا طکذ پسضکی دا طگب عل م پسضکی ض یذ ب طتی ت راى) 7611 ( ب د از تیر هب 7631 تب ک ى عض یبت علوی گر فبرهبک ل شی دا طکذ پسضکی دا طگب عل م پسضکی ض یذ ب طتی هییببضذ. ی در سبل 7611 ب درج دا طیبری در سبل 7616 ب درج استبدی ارتقب یبفت. ایطبى در طی د ر خذهت هسئ لیت بی هختلفی وچ ى هعب ى پس طی دا طگب ) ( رییس هرکس تحقیقبت ر بی ل شی) از آببى هب 7631 تب ک ى( دبیر ا جوي فیسی ل شی فبرهبک ل شی ب هذت 1 سبل قبئن هقبم هرکس تحقیقبت عل م اعصبة سردبیری طری پس ذ را ب هذت 3 سبل ریبست دا طکذ پسضکی دا طگب عل م پسضکی ض یذ ب طتی ) ( را ع ذ دار ب د است. ی ع اى پص طگر و از س ی زارت ب ذاضت درهبى آه زش پسضکی در سبل 7617 عض هوتبز یئت علوی در سبل 7611 بب ی برتر ضبغل در استبى در سبل 7611 دریبفت طبى درج یك ضبیستگی از دا طگب عل م پسضکی ض یذ ب طتی بع اى هذیر و در سبل 7611 دبیری یبت هوتح ارزضیببی رضت فبرهبک ل شی را از آببى هب 7636 عض یت ابست در گر آه زش فر گستبى عل م پسضکی از سبل 7633 تبک ى را در کبر به خ د دارد. ی در حبل حبضر استبد گر فبرهبک ل شی دبیر یبت هویس رییس هرکس تحقیقبت ر بی ل شی دا طگب عل م پسضکی ض یذ ب طتی یس رییس ا جوي فیسی ل شی فبرهبک ل شی ایراى است. ا تطبر 17 هقبل تحقیقبتی ذایت 37 پبیبى به در هقبطع هختلف دکتری دار سبزی پسضکی عو هی کبرض بسی ارضذ پی اچ دی اجرای 56 طرح تحقیقبتی هطبرکت در تبلیف 6 د ر دار به رسوی

7 ایراى بخص دار درهب ی کتبة جبهع ک دکبى بخطی از فعبلیت بی علوی ایطبى در ط ل د راى خذهت هیببضذ