Endovenous Thermal vs. Endovenous Chemical Ablation What is the Best for the Patient
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1 Endovenous Thermal vs. Endovenous Chemical Ablation What is the Best for the Patient T. Noppeney, J. Noppeney Center for Vascular Diseases: Outpatient Dept. Obere Turnstrasse, Dept. for Vascular Surgery Martha-Maria Hospital (Academic Teaching Hospital Erlangen University) Nuremberg, Germany
2 Disclosures TN Consultant Medi Bayreuth, Germany
3 Development of Varicose Vein Therapy 1998 CE mark for Radiofrequencyablation (RFA) 1999 CE mark for endovenous laserablation (ELA) 1998 CHIVA 2004 Renaissance of foam sclerotherapy 2007 Stripping without ligation of the SFJ (ASFAL) 2009 Steam ablation 2011 Mechano-chemical ablation (Clarivein ) 2012 Closing the vein with Cyanoacrylat glue (Sapheon )
4 RFA Perioperative Complications Deep Vein Thrombosis, Pulmonary Embolism DVT Closure Plus 0% (Lübke 2008) DVT Closure Plus 0,2% (Noppeney 2008) DVT Closure Fast 0% (Pröbstle 2008) PE Closure Plus 0,2% (Noppeney 2008) PE Closure Fast 0% (Pröbstle 2008)
5 T.M. Pröbstle, B. J. Alm, O. Göckeritz, C. Wentzel, T. Noppeney, C. Lebard, C. Sessa, D. Creton, O. Pichot Five year results from the prospective European multicenter cohort study on radiofrequency segmental thermal ablation for incompetent great saphenous veins Br J Surg 2015; 102: Perioperative Complications and Side Effects follow-up 1 week 1 year 3 years 4 years ecchymosis 5.8% 0.0% 0.0% 0.0% erythema 2.0% 0.0% 0.0% 0.0% hematomas 1.4% 0.0% 0.0% 0.0% paresthesias 3.4% 0.4% 0.4% 0.4% phlebitis 1.0% 0.0% 0.0% 0.0% pigmentation 2.4% 1.0% 0.4% 0.4% thrombus extension, DVT 0.0% 0.0% 0.0% 0.0% 5 years 0.0% 0.0% 0.0% 0.4% 0.0% 0.4% 0.0%
6 Spreafico G, et al Laser saphenous ablations in more than 1,000 limbs with longterm duplex examination follow-up. Ann Vasc Surg 2011; 25: ELA- Perioperative Complications Analysis of 1020 procedures from 11 European and US centers DVT 0,6% Hyp- und paresthesias 2,7% Skin burn 0,9%
7 ELA Perioperative Complications ELA with bare fibers has a higher perioperative complication rate and produces more perioperative pain due to perforations (Doganci S, 2010; Schwarz T, 2010)
8 Luebke T, Gawenda M, Heckenkamp J et al. Metaanalysis of endovenous radiofrequency obliteration of the great saphenous vein in primary varicosis J Endovasc Ther 2008; 15: RFA Return to Work Return to work after RFA significant faster in comparison to stripping
9 Rasmussen LH et al: Randomized clinical trial comparing endovonus laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous veins Br J Surg 2011; 96: Results RCT with 580 legs stripping, ELA, RFA and FS Reflux in the GSV after 1 year STR 4,8% ELA 5,8% RFA 4,8% FS 16,3% (p<0,001)
10 T.M. Pröbstle, B. J. Alm, O. Göckeritz, C. Wentzel, T. Noppeney, C. Lebard, C. Sessa, D. Creton, O. Pichot Five year results from the prospective European multicenter cohort study on radiofrequency segmental thermal ablation for incompetent great saphenous veins Br J Surg 2015; 102: Occlusion Rate of the GSV 91,9 ± 1,8%
11 ELA Results Occlusion Rates Author Study type Follow up months Occlusion Rasmussen 2011 RCT 12 94,2% Rasmussen 2010 RCT 24 99% Christenson 2010 RCT 24 95,6% Rasmussen 2012 RCT 24 82,2% Disselhof 2011 RCT 60 91% Van den Bos 2009 Metanalysis 60 95,4% Rasmussen 2013 RCT 60 82,1% Ravi 2009 Case Series 66 86%
12 T.M. Pröbstle, B. J. Alm, O. Göckeritz, C. Wentzel, T. Noppeney, C. Lebard, C. Sessa, D. Creton, O. Pichot Five year results from the prospective European multicenter cohort study on radiofrequency segmental thermal ablation for incompetent great saphenous veins Br J Surg 2015; 102: Development of the VCSS Score after 5 years 1.3 ± 1.7 (p<0.0001)
13 ELA Venous Disorders, Qualitiy of Life RCT s Significant improvement of VCSS and AVVSS after ELA up to 24 months postoperatively (Darwood 2008, Kalteis 2008, Disselhoff 2008, Almeida 2009) Improvement of quality of life up to 16 months postoperatively (Kalteis 2008, Almeida 2009)
14 Summary RFA and ELA RFA has a standardised procedure protocol, simple to perform, ELA different wave lenghts Perioperative complication rates are very low Pathological reflux can be eliminated securely Fast return to work, significant improvement of venous disorders and QoL Mid- and long term results are good and well documented in the literature
15 van Eekeren RR et al., Postoperative pain and early quality of life after radiofrequency ablation and mechanochemical endovenous ablation of incompetent great saphenous veins J Vasc Surg 2013; 57: MOCA Prospective observational study with 68 patients presenting insufficiency of the GSV, MOCA vs. RFA After MOCA significant less pain 14 d postoperatively (VAS 4,8±9,7 mm vs 18,6±17,0mm; p<0,001) Shorter return to daily activities and to work after MOCA (p=0,02) In both groups significant improvement of quality of life (SF36) and venous disorders (AVVQ)
16 Lane T, Bootun R, Dhamarajiah B Lim CS, Najem M, Renton S, Sritan K, Davies AH A multi-center randomised controlled trial comparing radiofrequency and mechanical occlusion chemically assisted ablation of varicose veins Final results of the Venefit vs Clarivein for varicose veins trial Phlebology 2016; epub ahead MOCA RCT MOCA vs RFA in 170 patients Significant less pain in the MOCA group (p=0.003) Improvement of VCSS, QoL similar in both groups Occlusion rates similar in both groups at 1 and 6 m
17 J Lawson, S Gauw, C van Vlijmen, P Pronk, M Gaastra, M Mooij, C H A Wittens Sapheon: the solution? Phlebology 2013; 28 Suppl 1:2 9 Glue - Cyanoacrylat Studies Almeida E-scope Lawson Zierau Total % GSV or SSV Procedures Occluded 3 months 35/36 65/69 8/8 64/ Occluded 12 months 33/ Paraesthesia DVT Other SAEs Superficial phlebitis
18 Tekin AI, Tuncer ON, Memetoglu ME et al Nonthermal, nontumescent endovenous treatment of varicose veins Ann Vasc Surg 2016; 36: Single center prospective study, n=62 patients with incompetence of GSV Occlusion at 6 m 90.3 %, subtotal occlusion 3.2 %, no occlusion 6.5 %, diameter > 11 mm No compression stockings
19 Bozkurt AK, Yilmaz MF A prospective comparison of a new cyanoacrylate glue and laser ablation for the treatment of venous insufficiency Phlebology 2016; 31: Suppl 1, RCT with 310 patients glue vs. ELA Significant less pain for patients treated with glue (p<0.001) Significant less ecchymosis with glue (p<0.001) Less paresthesias in the glue group (p<0.015) Both groups significant improvement of the VCSS and in the AVVQ Both groups similar occlusion rates at 12 m
20 Comparison Between Different Ablation Techniques Compl. Side effects Pain Effort Occl usion Limita tions Long term results QoL VCSS RFA + ELA + MOCA +? GLUE ++?
21 Summary No final conclusion possible for MOCA and glue, because we dont have sufficient and long term data MOCA and glue seem to be associated with less pain in comparison to other endovenous procedures
22 Meisner MH What is effective care for varicose veins? Phlebology 2016; 31: Suppl 1, Which form of intervention is superior to another? This (question) has largely been driven by patient and physician preferences in the absence of robust evidence that one therapy is truely superior to another
23 Thank You Very Much for Your Attention Center for Vascular Diseases: Outpatient Dept. Obere Turnstrasse, Dept. for Vascular Surgery Martha-Maria Hospital (Academic Teaching Hospital Erlangen University) Nürnberg, Germany
24 Endovenous Thermal vs. Endovenous Chemical Ablation What is the Best for the Patient T. Noppeney, J. Noppeney Center for Vascular Diseases: Outpatient Dept. Obere Turnstrasse, Dept. for Vascular Surgery Martha-Maria Hospital (Academic Teaching Hospital Erlangen University) Nuremberg, Germany
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