WHAT KEEPS OUR BONES STRONG?
|
|
|
- Marion Wilcox
- 5 years ago
- Views:
Transcription
1 WHAT KEEPS OUR BONES STRONG? The role of diet and lifestyle in osteoporosis prevention Thomas Walczyk PhD, Associate Professor Food Science and Technology Programme Department of Chemistry, Faculty of Science Department of Biochemistry, Yong Loo Lin School of Medicine
2 !!! BONE IS NO DEAD MATTER!!!
3 BONE REMODELLING BONE-ACCRETION Osteoblasts Ca Osteoclasts BONE RESORPTION
4 BONE DIET - LIFESTYLE BONE-ACCRETION Genotype Ca Vitamin D Phytoestrogenes Body Weight Physical Activity Alcohol Coffee Salt Intake Protein-Intake Acid/Base Balance Smoking BONE RESORPTION
5 BONE MASS AND AGE BONE MASS PEAK BONE MASS males puberty menopause females AGE (YEARS)
6 BONE MASS AND AGE Lis Roskilde Lis Roskilde Vertebra young female Vertebra old female
7 OSTEOPOROSIS = POROUS BONE A disease characterized by low bone mass and micro-architectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk. World Health Organization (WHO) 199
8 HIDDEN VERTEBRAE FRACTURES 5 years 75 years
9 DANGER ZONES Solvay Pharma Vertebrae 1 in 6 women 1 in 20 men Wrist 1 in 6 women 1 in 0 men Femoral Neck 1 in 6 women 1 in 17 men Fracture Lifetime risk (western populations) 1 in 3 women and 1 in 5 man over 50 years International Osteoporosis Foundation / Kanis et al / Melton 1992
10 PROJECTIONS - FOCAL POINT ASIA International Osteoporosis Foundation
11 CONSEQUENCES OF OSTEOPOROSIS Height loss, chronic pain affects self esteem, depression sleepless nights only 30% of osteoporotic patients fully regain their pre fracture level of independence Constipation, abdominal pain lumbar fractures may alter abdominal anatomy Limited mobility!!! REFERS BOTH TO MALES AND FEMALES!!!
12 SINGAPORE - FACTS AND FIGURES High prevalence among Singaporeans ca. 100,000 women suffer from osteoporosis ca. 800 to 900 osteoporotic hip fractures every year Sharp increase in hip fractures over past 3 decades in men and women (>50 years) 5 times in women from 75 cases to 02 cases per 100,000 populations 1.5 times in men from 103 cases to 152 cases per 100,000 populations High mortality and morbidity rate 1 in Singaporeans suffering an osteoporotic hip fracture die within one year after injury 1 in 3 became wheelchair bound or bedridden Source: International Osteoporosis Foundation (Country Factsheets 2007)
13 OSTEOPOROSIS PREVENTION BETTER CHOICE THAN THERAPY
14 ASSESSMENT OF CHANGES IN BONE METABOLISM Bone Mineral Density double emission X-ray absorptiometry (DEXA) computer-tomography (CT, q-ct, pq-ct, µ-ct) ultrasonic Techniques DXA measurement
15 ASSESSMENT OF CHANGES IN BONE METABOLISM Bone Mineral Density double emission X-ray absorptiometry (DEXA) computer-tomography (CT, q-ct, pq-ct, µ-ct) ultrasonic Techniques Biochemical Markers of Bone Metabolism degradation products of organic bone matrix in urine pyridinoline, desoxy-pyridinoline, telopeptides, sialoprotein compounds involved in bone accretion process osteocalcin, procollagen-polypeptide, alkaline phosphatase
16 LIMITATIONS OF AVAILABLE TECHNIQUES LIMITED SENSITIVITY = long monitoring periods STRONG INTRA-INDIVIDUAL VARIATIONS = large subject numbers
17 NUTRI TRACE SCIENCE (S13) Exploration of mineral and trace element metabolism in humans by stable isotope tracer techniques for development and evaluation of strategies to improve public health through diet and lifestyle operational since 08/2008
18 NUTRI TRACE SCIENCE (S13) CONTROLLED INTERVENTION STUDIES animal + men ASSESSMENT OF NUTRIENT INTAKE METABOLIC STUDIES USING ISOTOPE TECHNIQUES NUTRITIONAL STATUS
19 NUTRI TRACE SCIENCE (S13) CONTROLLED INTERVENTION IRON STUDIES animal + men ASSESSMENT OF NUTRIENT INTAKE CALCIUM METABOLIC STUDIES USING ISOTOPE TECHNIQUES NUTRITIONAL STATUS
20 ISOTOPIC LABELING OF BONE CALCIUM SINGLE ADMINISTRATION OF CALCIUMISOTOPE
21 ISOTOPIC LABELING OF BONE CALCIUM SINGLE ADMINSITRATION OF CALCIUMISOTOPE INCORPORATION OF CALCIUM ISOTOPE INTO BONE MATRIX
22 ISOTOPIC LABELING OF BONE CALCIUM SINGLE ADMINSITRATION OF CALCIUMISOTOPE INCORPORATION OF CALCIUM ISOTOPE INTO BONE MATRIX URINARY TRACER SIGNAL = MEASURE OF BONE CALCIUM BALANCE
23 ISOTOPIC LABELING OF BONE CALCIUM CALCIUMISOTOPE TRACER SIGNAL IN URINE LABELING PHASE TIME
24 ISOTOPIC LABELING OF BONE CALCIUM TRACER SIGNAL IN URINE POSI TI VE EFFECT I NTERVENTI ON
25 ISOTOPIC LABELING OF BONE CALCIUM TRACER SIGNAL IN URINE NEGATI VE EFFECT I NTERVENTI ON
26 ISOTOPIC LABELING OF BONE CALCIUM TRACER SIGNAL IN URINE NEGATI VE EFFECT I NTERVENTI ON
27 WHAT ARE CALCIUM-ISOTOPES? increasing neutron number = increasing mass CALCIUM CALCIUM ISOTOPES = calcium atoms of different mass
28 STABLE VERSUS RADIOACTIVE ISOTOPES mass number abundance CALCIUM % % STABLE ISOTOPES 3 0.1% 2.08% % % 9 Natural calcium = stable isotope mix Isotopic abundances highly constant Highly enriched stable isotopes can be used as tracers No health hazards Outrageous costs
29 STABLE VERSUS RADIOACTIVE ISOTOPES CALCI UM s s % 1 1 1x10 5 a % % 2.08% mass number half-life d RADIOACTIVE ISOTOPES % 7 7.5d % m!!! HEALTH HAZARDS!!!
30 STABLE VERSUS RADIOACTIVE ISOTOPES effective dose < 1/1000 of standard chest x-ray CALCI UM s s % 1 1 1x10 5 a d SEMI-STABLE RADIOACTIVE ISOTOPE 39 ISOTOPES s % 3 0.1% 2.08% % 7 7.5d 7 0.9s 1 very long 163d half-life.5d 1x10 5 a % m 9 8.7m = very slow decay (virtually stable) = very low radio-emission highly sensitive detection = low dosage
31 THE ANALYTICAL CHALLENGE Accelerator Mass Spectrometer ETH Zurich
32 THE ANALYTICAL CHALLENGE 1 Ca/nat. Ca in enriched samples: 10 - to Accelerator Mass Spectrometer ETH Zurich
33 THE ANALYTICAL CHALLENGE SWITZERLAND ETH Zurich, Laboratory of Human Nutrition SWITZERLAND ETH Zurich, Institute of Particle Physics SWITZERLAND Paul Scherrer Institute, Villingen SWITZERLAND University Hospital Zurich, Clinical Pharmacology GERMANY University of Mainz, Institute of Physics ENGLAND Scottish Universities Environmental Research Centre East Killbride IRELAND University of Cork, Food and Nutritional Sciences EU EU Joint Research Center, Institute of Reference Materials and Measurements DENMARK The Danish Food and Veterinary Administration Institute of Food Research and Nutrition USA Lawrence Livermore National Laboratory USA Argonne National Laboratory Accelerator Mass Spectrometer ETH Zurich
34 EFFECT OF BISPHOSPHONATE THERAPY ON Ca- 1 SIGNAL BISPHOSPHONATES = POTENT INHIBITORS OF BONE RESORPTION LABELING PHASE single tracer dose (100 nci) 3 month bisphosphonate treatment 6 post-menopausal women with diagnosed osteopenia intervention
35 EFFECT OF BISPHOSPHONATE THERAPY ON Ca- 1 SIGNAL RESPONSE TO TREATMENT WITHIN WEEKS OF THERAPY IN ALL SUBJECTS evaluation by population based pharmacokinetic modelling techniques
36 EFFECT OF CALCIUM SUPPLEMENTATION 1 Ca/ 0 Ca isotope ratio in urine.e-10 3.E-10 2.E-10 1.E-10 ID 7 ID 8 ID 9 ID E-10.E-10 Pla Ca 3.E-10 2.E-10 1.E-10 ID E-10 5.E-10 Pla Pla Ca Ca 3.E-10 1.E-10 ID ID ID 12 Ca Ca Ca Pla Pla Pla ID 11 Ca Ca Pla Pla ID 1 Ca Pla ID 20 Ca Ca Pla Pla ID 15 Ca Pla E-10 5.E-10 Pla Ca Pla Ca Pla Ca Pla Ca 3.E-10 1.E-10 ID ID ID ID Intervention period [days] 3 month blinded randomized placebo controlled supplementation trial 750 mg/d + 00 IU Vit D; 16 postmenopausal women
37 EFFECT OF CALCIUM SUPPLEMENTATION 1 Ca -55% p<0.001 Plasma P S B 35 mg Alendronate weekly Urine Bone Surface Deep Bone 1 Ca +27% p< % p<0.001 P S B 750 mg Ca daily Effect of intervention resolvable in each individual DIFFERENCES IN MECHANISMS OF ACTION CAN BE IDENTIFIED
38 FOCAL POINTS SINGAPORE GENETIC POLYMORPHISMS ACID BASE BALANCE ETHNIC DIFFERENCES PHYTOESTROGEN ES AND SOY OSTEOPOROSIS CALCIUM INTAKE PHYSICAL ACTIVITY TRACE ELEMENT NUTRITION VITAMIN D STATUS
39 THANK YOU FOR YOUR ATTENTION
Clinician s Guide to Prevention and Treatment of Osteoporosis
Clinician s Guide to Prevention and Treatment of Osteoporosis Published: 15 August 2014 committee of the National Osteoporosis Foundation (NOF) Tipawan khiemsontia,md outline Basic pathophysiology screening
Building Bone Density-Research Issues
Building Bone Density-Research Issues Helping to Regain Bone Density QUESTION 1 What are the symptoms of Osteoporosis? Who is at risk? Symptoms Bone Fractures Osteoporosis 1,500,000 fractures a year Kyphosis
Osteoporosis. Current Trend in Osteoporosis Management for Elderly in HK- Medical Perspective. Old Definition of Osteoporosis
Current Trend in Osteoporosis Management for Elderly in HK- Medical Perspective Dr Dicky T.K. Choy Physician Jockey Club Centre for Osteoporosis Care and Control, CUHK Osteoporosis Global public health
Overview. Bone Biology Osteoporosis Osteomalacia Paget s Disease Cases. People Centred Positive Compassion Excellence
Overview Osteoporosis and Metabolic Bone Disease Dr Chandini Rao Consultant Rheumatologist Bone Biology Osteoporosis Osteomalacia Paget s Disease Cases Bone Biology Osteoporosis Increased bone remodelling
Nutritional Aspects of Osteoporosis Care and Treatment Cynthia Smith, FNP-BC, RN, MSN, CCD Pars Osteoporosis Clinic, Belpre, Ohio
Osteoporosis 1 Nutritional Aspects of Osteoporosis Care and Treatment Cynthia Smith, FNP-BC, RN, MSN, CCD Pars Osteoporosis Clinic, Belpre, Ohio 1) Objectives: a) To understand bone growth and development
Osteoporosis. Overview
v2 Osteoporosis Overview Osteoporosis is defined as compromised bone strength that increases risk of fracture (NIH Consensus Conference, 2000). Bone strength is characterized by bone mineral density (BMD)
Module 5 - Speaking of Bones Osteoporosis For Health Professionals: Fracture Risk Assessment. William D. Leslie, MD MSc FRCPC
Module 5 - Speaking of Bones Osteoporosis For Health Professionals: Fracture Risk Assessment William D. Leslie, MD MSc FRCPC Case #1 Age 53: 3 years post-menopause Has always enjoyed excellent health with
Skeletal Manifestations
Skeletal Manifestations of Metabolic Bone Disease Mishaela R. Rubin, MD February 21, 2008 The Three Ages of Women Gustav Klimt 1905 1 Lecture Outline Osteoporosis epidemiology diagnosis secondary causes
Chapter 39: Exercise prescription in those with osteoporosis
Chapter 39: Exercise prescription in those with osteoporosis American College of Sports Medicine. (2010). ACSM's resource manual for guidelines for exercise testing and prescription (6th ed.). New York:
BONE HEALTH Dr. Tia Lillie. Exercise, Physical Activity and Osteoporosis
BONE HEALTH Dr. Tia Lillie Exercise, Physical Activity and Osteoporosis Food for thought... How old would you be if you didn t know how old you were? DEFINITION: Osteoporosis Osteoporosis (OP) is a disease
To understand bone growth and development across the lifespan. To develop a better understanding of osteoporosis.
Nutrition Aspects of Osteoporosis Care and Treatment t Cynthia Smith, FNP-BC, RN, MSN, CCD Pars Osteoporosis Clinic, Belpre, OH. Objectives To understand bone growth and development across the lifespan.
The Bare Bones of Osteoporosis. Wendy Rosenthal, PharmD
The Bare Bones of Osteoporosis Wendy Rosenthal, PharmD Definition A systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase
Osteoporosis: Who, What, When, Why, and How
Osteoporosis: Who, What, When, Why, and How Doris J. Uh, PharmD, AE-C Pharm 445 September 20, 2005 Objectives define osteoporosis (what) determine high risk groups (who, when) review modifiable, non-modifiable
Calcium Nephrolithiasis and Bone Health. Noah S. Schenkman, MD
Calcium Nephrolithiasis and Bone Health Noah S. Schenkman, MD Associate Professor of Urology and Residency Program Director, University of Virginia Health System; Charlottesville, Virginia Objectives:
AACE/ACE Osteoporosis Treatment Decision Tool
AACE/ACE Osteoporosis Treatment Decision Tool What is Osteoporosis? OSTEOPOROSIS is defined as reduced bone strength leading to an increased risk of fracture. Osteoporosis, or porous bones, occurs when
Osteoporosis. When we talk about osteoporosis, we have to be familiar with the constituents of bone and what it is formed of.
Osteoporosis When we talk about osteoporosis, we have to be familiar with the constituents of bone and what it is formed of. Osteoblasts by definition are those cells present in the bone and are involved
CASE 1 WHY IS IT IMPORTANT TO TREAT? FACTS CONCERNS
4:30-5:15pm Ask the Expert: Osteoporosis SPEAKERS Silvina Levis, MD OSTEOPOROSIS - FACTS 1:3 older women and 1:5 older men will have a fragility fracture after age 50 After 3 years of treatment, depending
Osteoporosis - At a Glance
Published on: 29 Sep 2010 Osteoporosis - At a Glance What Is A Bone? Bone Connective tissue 206 bones Support Function of Bone Protection Assisting in movement Mineral balance Site of blood cell production
Osteoporosis in Men Wendy Rosenthal PharmD. This program has been brought to you by PharmCon
Osteoporosis in Men Wendy Rosenthal PharmD This program has been brought to you by PharmCon Osteoporosis in Men Speaker: Dr. Wendy Rosenthal, President of MedOutcomes, will be the presenter for this webcast.
Bone health. Kirstie Stenhouse, NHS Forth #ACFALLS2018 #SPSP10
Bone health Kirstie Stenhouse, NHS Forth Valley @Kirstieahp At the end of this session you will: Click Be to able edit to Master identify text if the styles individuals you work with are at risk of fragility
1
www.osteoporosis.ca 1 2 Overview of the Presentation Osteoporosis: An Overview Bone Basics Diagnosis of Osteoporosis Drug Therapies Risk Reduction Living with Osteoporosis 3 What is Osteoporosis? Osteoporosis:
Guideline for the investigation and management of osteoporosis. for hospitals and General Practice
Guideline for the investigation and management of osteoporosis for hospitals and General Practice Background Low bone density is an important risk factor for fracture. The aim of assessing bone density
Additional Research is Needed to Determine the Effects of Soy Protein on Calcium Binding and Absorption NDFS 435 3/26/2015. Dr.
Additional Research is Needed to Determine the Effects of Soy Protein on Calcium Binding and Absorption NDFS 435 3/26/2015 Dr. Tessem Osteoporosis is a public health problem in all stages of life. Many
Horizon Scanning Technology Briefing. Zoledronic Acid (Aclasta) once yearly treatment for postmenopausal. National Horizon Scanning Centre
Horizon Scanning Technology Briefing National Horizon Scanning Centre Zoledronic Acid (Aclasta) once yearly treatment for postmenopausal osteoporosis December 2006 This technology summary is based on information
Osteoporosis Update. Greg Summers Consultant Rheumatologist
Osteoporosis Update Greg Summers Consultant Rheumatologist DEFINITION OSTEOPOROSIS is LOW BONE MASS (& micro-architectural deterioration) causing AN INCREASED RISK OF FRACTURE 23 years 82 years 23 y/o
nogg Guideline for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK
nogg NATIONAL OSTEOPOROSIS GUIDELINE GROUP Guideline for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK Produced by J Compston, A Cooper,
Osteoporosis after Spinal Cord Injury
Authors: SCIRE Community Team Reviewed by: Janice Eng, PhD, PT Last updated: Oct 11, 2017 Osteoporosis is a condition that can affect the bones after spinal cord injury (SCI). This page provides information
Updates in Osteoporosis. I have no conflicts of interest. What Would You Do? Mrs. C. What s New in Osteoporosis. Page 1
Updates in Osteoporosis Jeffrey A. Tice, MD Associate Professor of Medicine Division of General Internal Medicine, University of California, San Francisco I have no conflicts of interest What s New in
Management of postmenopausal osteoporosis
Management of postmenopausal osteoporosis Yeap SS, Hew FL, Chan SP, on behalf of the Malaysian Osteoporosis Society Committee Working Group for the Clinical Guidance on the Management of Osteoporosis,
Osteoporosis: An Overview. Carolyn J. Crandall, MD, MS
Osteoporosis: An Overview Carolyn J. Crandall, MD, MS Osteoporosis: An Overview Carolyn J. Crandall, MD, MS Professor of Medicine David Geffen School of Medicine at UCLA Objectives Review osteoporosis
Osteoporosis. Open Access. John A. Kanis. Diseases, University of Sheffield, UK
Journal of Medical Sciences (2010); 3(3): 00-00 Review Article Osteoporosis Open Access John A. Kanis WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, UK incorporated into
Kristen M. Nebel, DO PENN/ LGHP Geriatrics. Temple Family Medicine Review
Kristen M. Nebel, DO PENN/ LGHP Geriatrics 10/3/17 Temple Family Medicine Review OBJECTIVES Define Revised 2017 American College of Physician Recommendations Screening, Prevention and Treatment Application
Learning Objectives. Controversies in Osteoporosis Prevention and Management. Etiology. Presenter Disclosure Information. Epidemiology.
12:45 1:30pm Controversies in Osteoporosis Prevention and Management SPEAKER Carolyn Crandall, MD, MS Presenter Disclosure Information The following relationships exist related to this presentation: Carolyn
Challenging the Current Osteoporosis Guidelines. Carolyn J. Crandall, MD, MS Professor of Medicine David Geffen School of Medicine at UCLA
Challenging the Current Osteoporosis Guidelines Carolyn J. Crandall, MD, MS Professor of Medicine David Geffen School of Medicine at UCLA Whom to screen Which test How to diagnose Whom to treat Benefits
TREATMENT OF OSTEOPOROSIS
TREATMENT OF OSTEOPOROSIS Summary Prevention is the key issue in the management of osteoporosis. HRT is the agent of choice for prevention of postmenopausal osteoporosis. Bisphosphonates and Calcitonin
Fragile Bones and how to recognise them. Rod Hughes Consultant physician and rheumatologist St Peter s hospital Chertsey
Fragile Bones and how to recognise them Rod Hughes Consultant physician and rheumatologist St Peter s hospital Chertsey Osteoporosis Osteoporosis is a skeletal disorder characterised by compromised bone
Objectives: What is Osteoporosis 10/8/2015. Bone Health/ Osteoporosis: BASICS OF SCREENING, INTERPRETING, AND TREATING
Bone Health/ Osteoporosis: BASICS OF SCREENING, INTERPRETING, AND TREATING TIFFANY PAUL, APN, CNP, CCD Objectives: Review the diagnosis of Osteoporosis Describe the basics of a bone density exam Identify
Using the FRAX Tool. Osteoporosis Definition
How long will your bones remain standing? Using the FRAX Tool Gary Salzman M.D. Director Banner Good Samaritan/ Hayden VAMC Internal Medicine Geriatric Fellowship Program Phoenix, Arizona Using the FRAX
Assessment and Treatment of Osteoporosis Professor T.Masud
Assessment and Treatment of Osteoporosis Professor T.Masud Nottingham University Hospitals NHS Trust University of Nottingham University of Derby University of Southern Denmark What is Osteoporosis? Osteoporosis
Interpreting DEXA Scan and. the New Fracture Risk. Assessment. Algorithm
Interpreting DEXA Scan and the New Fracture Risk Assessment Algorithm Prof. Samir Elbadawy *Osteoporosis affect 30%-40% of women in western countries and almost 15% of men after the age of 50 years. Osteoporosis
Osteoporosis. Treatment of a Silently Developing Disease
Osteoporosis Treatment of a Silently Developing Disease Marc K. Drezner, MD Senior Associate Dean Emeritus Professor of Medicine Emeritus University of Wisconsin-Madison Auditorium The Forest at Duke October
Objectives. Discuss bone health and the consequences of osteoporosis on patients medical and disability status.
Objectives Discuss bone health and the consequences of osteoporosis on patients medical and disability status. Discuss the pathophysiology of osteoporosis and major risk factors. Assess the major diagnostic
Vasu Pai FRACS, Nat Board, MCh, M.S
Vasu Pai FRACS, Nat Board, MCh, M.S Composition of bone Mineral 70% Protein 22% Water 8% On osteoclast precurssor On Osteoblast Osteoporosis Dx No clinical lsigns No blood tests Gold standard: Bone
Horizon Scanning Centre March Denosumab for glucocorticoidinduced SUMMARY NIHR HSC ID: 6329
Horizon Scanning Centre March 2014 Denosumab for glucocorticoidinduced osteoporosis SUMMARY NIHR HSC ID: 6329 This briefing is based on information available at the time of research and a limited literature
Helpful information about bone health & osteoporosis Patient Resource
Helpful information about bone health & osteoporosis Patient Resource Every year In the United States, 2.5 million fractures occur due to osteoporosis. Out of these, 330,000 are hip fractures, and half
Diagnosis and Treatment of Osteoporosis. Department of Endocrinology and Metabolism Ajou University School of Medicine.
Diagnosis and Treatment of Osteoporosis Department of Endocrinology and Metabolism Ajou University School of Medicine Yoon-Sok CHUNG WCIM, COEX, Seoul, 27Oct2014 Case 1 71-year old woman Back pain Emergency
New 2010 Osteoporosis Guidelines: What you and your health provider need to know QUESTIONS&ANSWERS
New 2010 Osteoporosis Guidelines: What you and your health provider need to know QUESTIONS&ANSWERS Wednesday, December 1, 2010 1:00 p.m. to 2:00 p.m. ET 1. I m 55 years old. I ve been taking Fosavance
Ca, Mg metabolism, bone diseases. Tamás Kőszegi Pécs University, Department of Laboratory Medicine Pécs, Hungary
Ca, Mg metabolism, bone diseases Tamás Kőszegi Pécs University, Department of Laboratory Medicine Pécs, Hungary Calcium homeostasis Ca 1000g in adults 99% in bones (extracellular with Mg, P) Plasma/intracellular
Prevention and Treatment of OSTEOPOROSIS 骨質疏鬆的預防與治療
Prevention and Treatment of OSTEOPOROSIS 骨質疏鬆的預防與治療 Gwo Jaw Wang, M.D. 王國照教授 University of Virginia (U.S.A.) & National Cheng Kung University (Taiwan) Learning Objectives Pathophysiology of osteoporosis
Aromatase Inhibitors & Osteoporosis
Aromatase Inhibitors & Osteoporosis Miss Sarah Horn Consultant Oncoplastic Breast Surgeon April 2018 Aims Role of Aromatase Inhibitors (AI) in breast cancer treatment AI s effects on bone health Bone health
Forteo (teriparatide) Prior Authorization Program Summary
Forteo (teriparatide) Prior Authorization Program Summary FDA APPROVED INDICATIONS DOSAGE 1 FDA Indication 1 : Forteo (teriparatide) is indicated for: the treatment of postmenopausal women with osteoporosis
The Skeletal Response to Aging: There s No Bones About It!
The Skeletal Response to Aging: There s No Bones About It! April 7, 2001 Joseph E. Zerwekh, Ph.D. Interrelationship of Intestinal, Skeletal, and Renal Systems to the Overall Maintenance of Normal Calcium
Orthopantomogram as an effective tool for the diagnosis of osteoporosis-a study
Original Research Article Comparative Study of Mandibular Cortical Index in Orthopantomogram and Bone Mineral Density of Lumbar Vertebrae in Dual Energy X-Ray Absorptiometry in Postmenopausal Females in
Summary. Background. Diagnosis
March 2009 Management of post-menopausal osteoporosis This bulletin focuses on the pharmacological management of patients with post-menopausal osteoporosis both those with clinically evident disease (e.g.
COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) GUIDELINE ON THE EVALUATION OF NEW MEDICINAL PRODUCTS IN THE TREATMENT OF PRIMARY OSTEOPOROSIS
European Medicines Agency Evaluation of Medicines for Human Use London, 14 December 2005 Doc. Ref. CPMP/EWP/552/95 Rev. 2 COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) DRAFT GUIDELINE ON THE EVALUATION
Product: Denosumab (AMG 162) Clinical Study Report: month Primary Analysis Date: 21 November 2016 Page 1
Date: 21 November 2016 Page 1 2. SYNOPSIS Name of Sponsor: Amgen Inc., Thousand Oaks, CA, USA Name of Finished Product: Prolia Name of Active Ingredient: denosumab Title of Study: Randomized, Double-blind,
OSTEOPOROSIS: PREVENTION AND MANAGEMENT
OSTEOPOROSIS: OVERVIEW OSTEOPOROSIS: PREVENTION AND MANAGEMENT Judith Walsh, MD, MPH Departments of Medicine and Epidemiology and Biostatistics UCSF Definitions Key Risk factors Screening and Monitoring
Bone Disease after Kidney Transplantation
Bone Disease after Kidney Transplantation BTS March 2018 Dr Arif Khwaja PhD, FRCP Sheffield Kidney Institute Clinical case 47 year old female FSGS DBD 2007 egfr 25mls/min. Sirolimus, Azathioprine and prednisolone
ORIGINAL ARTICLE SERUM OSTEOCALCIN, SHALL WE CONSIDER IT AS A BIOCHEMICAL MARKER FOR OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
SERUM OSTEOCALCIN, SHALL WE CONSIDER IT AS A BIOCHEMICAL MARKER FOR OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN V. S. Kalai Selvi 1, K. Prabhu 2, Monika Gupta 3. HOW TO CITE THIS ARTICLE: V. S. Kalai Selvi, K.
DOWNLOAD OR READ : OSTEOPOROSIS IN MEN SECOND EDITION PDF EBOOK EPUB MOBI
DOWNLOAD OR READ : OSTEOPOROSIS IN MEN SECOND EDITION PDF EBOOK EPUB MOBI Page 1 Page 2 osteoporosis in men second edition osteoporosis in men second pdf osteoporosis in men second edition 1 OVERVIEW A
DEVELOPMENT OF A RISK SCORING SYSTEM TO PREDICT A RISK OF OSTEOPOROTIC VERTEBRAL FRACTURES IN POSTMENOPAUSAL WOMEN
October 2-4, Liverpool, UK EURO SPINE 2013 DEVELOPMENT OF A RISK SCORING SYSTEM TO PREDICT A RISK OF OSTEOPOROTIC VERTEBRAL FRACTURES IN POSTMENOPAUSAL WOMEN D. Colangelo, L. A. Nasto, M. Mormando, E.
[If no, skip to question 10.] Y N. 2. Does the member have a diagnosis of Paget s disease of bone? Y N. [If no, skip to question 4.
![[If no, skip to question 10.] Y N. 2. Does the member have a diagnosis of Paget s disease of bone? Y N. [If no, skip to question 4.](/thumbs/86/94943423.jpg "[If no, skip to question 10.] Y N. 2. Does the member have a diagnosis of Paget s disease of bone? Y N. [If no, skip to question 4.")
Pharmacy Prior Authorization AETA BETTER HEALTH EW JERSE (MEDICAID) Zoledronic Acid (Medicaid) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review information,
3. Has bone specific alkaline phosphatase level increased OR does the member have symptoms related to active Paget s?
Pharmacy Prior Authorization AETA BETTER HEALTH VIRGIIA CCC PLUS and MEDALLIO/FAMIS 4.0 Zoledronic Acid (Medicaid) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review
Submission to the National Institute for Clinical Excellence on
Submission to the National Institute for Clinical Excellence on Strontium ranelate for the prevention of osteoporotic fractures in postmenopausal women with osteoporosis by The Society for Endocrinology
Name of Policy: Boniva (Ibandronate Sodium) Infusion
Name of Policy: Boniva (Ibandronate Sodium) Infusion Policy #: 266 Latest Review Date: April 2010 Category: Pharmacology Policy Grade: Active Policy but no longer scheduled for regular literature reviews
This includes bone loss, endometrial cancer, and vasomotor symptoms.
Hello and welcome. My name is Chad Barnett. I m a Clinical Pharmacy Specialist in the Division of Pharmacy at the University of Texas, MD Anderson Cancer Center and I m very pleased today to be able to
9/26/2016. The Impact of Dietary Protein on the Musculoskeletal System. Research in dietary protein, musculoskeletal health and calcium economy
The Impact of Dietary Protein on the Musculoskeletal System Outline A. The musculoskeletal system and associated disorders Jessica D Bihuniak, PhD, RD Assistant Professor of Clinical Nutrition Department
BMD: A Continuum of Risk WHO Bone Density Criteria
Pathogenesis of Osteoporosis Osteoporosis Diagnosis: BMD, FRAX and Assessment of Secondary Osteoporosis AGING MENOPAUSE OTHER RISK FACTORS RESORPTION > FORMATION Bone Loss LOW PEAK BONE MASS Steven T Harris
Osteoporosis. Osteoporosis ADD PICTURE
OSTEOPOROSIS The Silent Thief Chronic, progressive metabolic bone disease marked by Low bone mass Deteriora?on of bone?ssue Leads to increased bone fragility ADD PICTURE Osteoporosis Over 54 million people
Download slides:
Download slides: https://www.tinyurl.com/m67zcnn https://tinyurl.com/kazchbn OSTEOPOROSIS REVIEW AND UPDATE Boca Raton Regional Hospital Internal Medicine Conference 2017 Benjamin Wang, M.D., FRCPC Division
OSTEOPOROSIS IN INDONESIA
OSTEOPOROSIS IN INDONESIA Hana Ratnawati Faculty of Medicine Maranatha Christian University Bandung - Indonesia 5th SBA Conference 2013 1 5th SBA Conference 2013 2 INTRODUCTION Indonesia is an archipelago
Bone Mineral Density and Its Associated Factors in Naresuan University Staff
Naresuan University Journal 2005; 13(3): 13-18 13 Bone Mineral Density and Its Associated Factors in Naresuan University Staff Supawitoo Sookpeng *, Patsuree Cheebsumon, Malinee Dhanarun, Thanyavee Pengpan
Dietary Protein and Bone Health Emphasis: Animal Protein
USDA-ARS Human Nutrition Research Centers Dietary Protein and Bone Health Emphasis: Animal Protein Z.K. (Fariba) Roughead, PhD, RD Research Nutritionist USDA-ARS Grand Forks Human Nutrition Research Center
BAD TO THE BONE. Peter Jones, Rheumatologist QE Health, Rotorua. GP CME Conference Rotorua, June 2008
BAD TO THE BONE Peter Jones, Rheumatologist QE Health, Rotorua GP CME Conference Rotorua, June 2008 Agenda Osteoporosis in Men Vitamin D and Calcium Long-term treatment with Bisphosphonates Pathophysiology
Osteoporosis in Men. Until recently, the diagnosis of osteoporosis. A New Type of Patient. Al s case. How is the diagnosis made?
A New Type of Patient Rafat Faraawi, MD, FRCP(C), FACP Until recently, the diagnosis of osteoporosis in men was uncommon and, when present, it was typically described as a consequence of secondary causes.
BONE HEALTH BASICS. Promoting Healthy Bones: Sorting Out the Science. Learning Objectives. Guest Speaker
Copyright 11 by the Preventive Cardiovascular Nurses Association Promoting Healthy Bones: Sorting Out the Science Guest Speaker Robert P. Heaney, MD, FACP, FASN Professor and Professor of Medicine Creighton
This house believes that HRT should be the first-line prevention for postmenopausal osteoporosis: the case against
This house believes that HRT should be the first-line prevention for postmenopausal osteoporosis: the case against Juliet Compston Professor of Bone Medicine University of Cambridge School of Clinical
Elecsys bone marker panel. Optimal patient management starts in the laboratory
bone marker panel Optimal patient management starts in the laboratory Complete solution for osteoporosis The most complete bone metabolism panel on a single platform bone marker assays are important diagnostic
Silent Killer: Osteoporosis
Special Dedication to the Old Females Silent Killer: Osteoporosis David Goltzman, Discoveries, Drugs and Skeletal Disorders Nature, Volume 1, October 2002, pp784-796 BII Journal Club Wang Zhengyuan 5:00-5:30pm
Bone density scanning and osteoporosis
Bone density scanning and osteoporosis What is osteoporosis? Osteoporosis occurs when the struts which make up the mesh-like structure within bones become thin causing them to become fragile and break
Correlation between Thyroid Function and Bone Mineral Density in Elderly People
IBBJ Spring 2016, Vol 2, No 2 Original Article Correlation between Thyroid Function and Bone Mineral Density in Elderly People Ali Mirzapour 1, Fatemeh Shahnavazi 2, Ahmad Karkhah 3, Seyed Reza Hosseini
Osteoporosis: A Tale of 3 Task Forces!
Osteoporosis: A Tale of 3 Task Forces! Robert A. Adler, MD McGuire Veterans Affairs Medical Center Virginia Commonwealth University Richmond, Virginia, USA Disclosures The opinions are those of the speaker
International Journal of Scientific & Engineering Research Volume 8, Issue 7, July-2017 ISSN ,393
ISSN 2229-5518 2,393 Awareness and Knowledge of Osteoporosis among Saudi Females in Riyadh Leena Al-Ghamdi, Doaa Ismail,, Salwa Bakr, Bushra Al-Garni, Deema Al-Sadoun, ra Al-Suniyn, Mariam AlGhareeb College
Osteoporosis challenges
Osteoporosis challenges Osteoporosis challenges Who should have a fracture risk assessment? Who to treat? Drugs, holidays and unusual adverse effects Fracture liaison service? The size of the problem 1
Efficacy of risedronate in men with primary and secondary osteoporosis: results of a 1-year study
Rheumatol Int (2006) 26: 427 431 DOI 10.1007/s00296-005-0004-4 ORIGINAL ARTICLE J. D. Ringe Æ H. Faber Æ P. Farahmand Æ A. Dorst Efficacy of risedronate in men with primary and secondary osteoporosis:
Page 1. New Developments in Osteoporosis. What s New in Osteoporosis
New Developments in Osteoporosis Eliseo J. Pérez-Stable MD Professor of Medicine Division of General Internal Medicine Department of Medicine July 4, 2013 Declaration of full disclosure: No conflict of
Osteoporosis/Fracture Prevention
Osteoporosis/Fracture Prevention NATIONAL GUIDELINE SUMMARY This guideline was developed using an evidence-based methodology by the KP National Osteoporosis/Fracture Prevention Guideline Development Team
S^t _j4 A-N.1^.^ A _ WE 2
S^t _j4 A-N.1^.^ A _ WE 2 Name of Sponsor: Amgen Inc. Name of Finished Product: Denosumab (AMG 162) Name of Active Ingredient: Fully human monoclonal antibody to RANKL Title of Study: A Randomized Study
ESPEN Congress Cannes Education and Clinical Practice Programme
ESPEN Congress Cannes 2003 Organised by the Israel Society for Clinical Nutrition Education and Clinical Practice Programme Session: Dietitian Symposium: Nutrition throughout the woman life cycle Prevention
Healthy Bones: Osteoporosis Management. Laurel Short, MSN, FNP-C
Healthy Bones: Osteoporosis Management Laurel Short, MSN, FNP-C Disclosure I have no current affiliation or financial interest with any grantor or commercial interests that may have direct interest in
Advanced medicine conference. Monday 20 Tuesday 21 June 2016
Advanced medicine conference Monday 20 Tuesday 21 June 2016 Osteoporosis: recent advances in risk assessment and management Juliet Compston Emeritus Professor of Bone Medicine Cambridge Biomedical Campus
LOVE YOUR BONES Protect your future
www.worldosteoporosisday.org LOVE YOUR BONES Protect your future Know your risk for osteoporosis www.iofbonehealth.org Osteoporosis is a problem worldwide, and in many countries, up to one in three women
All about Osteoporosis symptoms, diagnosis, treatment
Health & Fitness Published : 07 Sep 2017, 14:41 All about Osteoporosis symptoms, diagnosis, treatment By : BD Post Desk Osteoporosis is a bone disease. Its name comes from the Latin for porous bones. The
An audit of osteoporotic patients in an Australian general practice
professional Darren Parker An audit of osteoporotic patients in an Australian general practice Background Osteoporosis is a major contributor to morbidity and mortality in Australia, and is predicted to
Coordinator of Post Professional Programs Texas Woman's University 1
OSTEOPOROSIS Update 2007-2008 April 26, 2008 How much of our BMD is under our control (vs. genetics)? 1 2 Genetic effects on bone loss: longitudinal twin study (Makovey, 2007) Peak BMD is under genetic
Page 1
Osteoporosis Osteoporosis is a condition characterised by weakened bones that fracture easily. After menopause many women are at risk of developing osteoporosis. Peak bone mass is usually reached during
John J. Wolf, DO Family Medicine
John J. Wolf, DO Family Medicine Objectives: 1. Review incidence & Risk of Osteoporosis 2.Review indications for testing 3.Review current pharmacologic & Non pharmacologic Tx options 4.Understand & Utilize
The Better Health News2
October, 2016 Volume11, Issue 10 The Better Health News2 Special Interest Articles: Menopause and Bioflavonoids Osteoporosis and Exercise Bone Health: More than Calcium & Vitamin D Flax Seeds and Menopause
BONE MINERAL DENSITY OF BANGLADESHI PEOPLE
6 DAFFODIL INTERNATIONAL UNIVERSITY JOURNAL OF SCIENCE BANU: BONE AND MINERAL TECHNOLOGY, DENSITY VOLUME OF BANGLADESHI 4, ISSUE 2, JULY PEOPLE 2009 BONE MINERAL DENSITY OF BANGLADESHI PEOPLE Dilruba Akhter
Page: 1 of 12. Bone Turnover Markers for Diagnosis and Management of Osteoporosis and Diseases Associated With High Bone Turnover
Last Review Status/Date: December 2014 Page: 1 of 12 Management of Osteoporosis and Diseases Description Bone turnover markers are biochemical markers of either bone formation or bone resorption. Commercially