BONE HEALTH Dr. Tia Lillie. Exercise, Physical Activity and Osteoporosis

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1 BONE HEALTH Dr. Tia Lillie Exercise, Physical Activity and Osteoporosis

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3 Food for thought... How old would you be if you didn t know how old you were?

4 DEFINITION: Osteoporosis Osteoporosis (OP) is a disease characterized by low bone mass & microarchitectural deterioration of bone tissue leading to enhanced bone fragility & in risk fracture. Consensus Development Conference, 1991

5 Osteoporosis 28 million Americans 80-90% are women 18 million Americans have low bone mass & are at risk for developing Osteoporosis 50% of all women will develop osteoporosis Osteoporosis accounts for more than 1.5 million fractures 700,000 vertebral 300,000 hip 250,000 wrist 300,000 other sites

6 Bone Physiology Bone a living tissue Undergoes a continuous cycle of bone building by osteoblasts & bone resorption by osteoclasts. Remodeling Cycle: Process of resorption & formation One cycle completed - 4 months

7 Bone Remodeling Cycle

8 Measures of bone integrity 1. Bone mass 2. Bone mineral content Calcium Phosphorous Magnesium 3. Bone mineral density Calcium or minerals/unit volume of bone

9 Screening for osteoporosis

10 Criteria for Assessing Disease Severity Normal > -1.0 std Osteopenia BMD SD below the mean Osteoporosis BMD < SD below the mean Severe Osteoporosis BMD < SD below the mean with Fracture

11 Risk of hip fracture per 1000/year

12 INTACT Normal Loading Normal Ca++ Loading Initial stages of Osteoporosis Normal loading Deficient Ca++ Loading Osteoporosis Unloaded Deficient Ca++ Loading (Lanyon & Rubin, 1986)

13 Bone Growth Children Old bone is resorbed but because new bone is formed at a faster rate, total bone linearly with 40-70% in bone mass during puberty. Bone continues to until peak bone mass is achieved around age 30 for both males & females.

14 Stages Bone Growth Resorption < formation Between 25 & 35 Resorption = formation After 40 Resorption > formation

15 Bone Loss Women attain peak bone mass that is generally 10% less than males. Bone loss of approximately.7% - 1% a year occurs up until age of 50 for both genders Bone loss for women to about 2%-3% / year beg. at menopause & continues for 5-10yrs. On average women lose 1/3-1/2 of the BMD during menopause.

16 BMD in Women

17 Demographics of Osteoporosis Gender: Women affected more than men Lower peak bone mass Rapid bone loss with declining estrogen levels Longer lifespan Race / Ethnicity(compared to Caucasians) African descent: higher bone mass Asian: lower bone mass Hispanic: same bone mass

18 Peak Bone Mineral Density (BMD) What factors would influence peak bone mass?

19 Extended bed rest is associated with increased Ca++ excretion Ca++ Excretion Days in Bed

20 Factors Affecting Bone Mineral Density (BMD) Lifestyle Factors: Dietary Ca + Vitamin D Weight bearing PA levels Smoking Alcohol Consumption Aging Factors: Estrogen levels [Menopause or amenorrhea] Testosterone Levels in males

21 Post-Menopausal Women: Hormone replacement therapy will help maintain BMD in post-menopausal women. (RISKS?)

22 Osteoporotic Fractures in Women, Compared With Other Diseases 2,000,000 Annual Incidence 1,500,000 1,000, ,000 1,200, , , , Osteoporotic Fractures Heart Attack Stroke Breast Cancer 1 National Osteoporosis Foundation, Available at: 2 American Heart Association. Heart & Stroke Facts: 1999 Statistical Supplement. 3 American Cancer Society. Breast Cancer Facts & Figures

23 Factors affecting BMD Cont. Health-related Factors Long-term usage of corticosteroid Oral Glucocorticosteroid ( bone formation & in bone resorption) Genetics 70-80% of biologic potential is genetic

24 Oral Glucocorticosteroid Dose Strongly Correlates to Fracture Risk 6 Hip Spine Relative Risk <2.5 mg/d mg/d >7.5 mg/d Daily Oral Glucocorticosteroid Dose

25 3 Common sites Fractures

26 Wrist & Vertebral Fractures WRIST: Pain, reduced ROM 50-70% recover within 6 months VERTEBRAL: Deformity, postural abnormality Pain Functional impairment

27 Hip Fractures HIP: BAD NEWS! 275,000 annually due to osteoporosis 20% die with 6 months of the fracture 20% require long term institutionalization 20% face permanent disability

28 OUTCOMES: Fractures Economic Consequences Projected cost of $45.2 BILLION over the next 10 years Based on: Current costs 3 fracture sites # of women over 45 yrs

29 Fracture Potential If applied load is > than structural capacity the fracture will occur. What determines the structural capacity? Porosity Mineral content Bone matrix

30 Applied Load Magnitude and Direction of load falls. Lateral less than 2% of lateral falls result in hip fracture Backwards 40-60% of vertebral fractures due to backward falls.

31 ARE THERE CULTURAL DIFFERENCES? Race Education Ethnicity SES Gender

32 Athletes: Cross country runners had 20% higher BMC in appendicular skeleton than non-exercisers. Matched for age, height and weight (MALE).

33 Lumbar Density: Athletes Row Volleyball Basketball Swim Run Weights Drinkwater, 1994

34 BMC of women runners & untrained women who are amenorrheic (AM) & eumenorrheic (EU) Bone mineral content (mg/cm3) AM Untrained AM Runners EU Untrained EU Runners

35 Power/Strength vs. Endurance [Runners, Gymnasts & Controls] BMD (mg/cm3) AM Runners EU Runners AM Gymnasts EU Gymnasts EU Controls

36 Cross Sectional Data Summary: Weight bearing physical activity is beneficial & dependent upon body weight. Excessive physical activity may be detrimental, especially in association with amenorrhea. High impact physical activity appear to confer > BMD benefit. Muscle inactivity will result in both muscle & bone atrophy.

37 Post-menopausal Women: Resistance training? Nursing home studies have reported BMD with weight-bearing exercise in VERY old women. Generally will only slow the rate of loss, NOT reverse the process

38 RESEARCH SUMMARY It appears that strenuous aerobic exercise & strength training may be beneficial for maintaining Bone Mineral Density. Mild general exercise such as walking may NOT be effective in preventing post-menopausal bone loss or enhancing bone mass in younger individuals.

39 RECOMMENDATIONS FOR OPTIMAL BONE HEALTH For developing peak bone mass (young) Weight-bearing, bone-stressing physical activity Diet adequate in Ca + Pre-menopausal adults Physical activity to maintain bone mass Diet adequate in Ca + Post-menopausal adults Physical activity to slow bone loss Diet adequate in Ca +

40 Reduction of Fall Risk: Fractures often associated with falls. ~90% of hip fractures ~40-50% of vertebral fractures 100% of radial fractures Fall risk due to: Lower body weakness Reduced power Balance disturbances Polypharmacy

41 Three target periods for intervention Enhance peak bone mass in developing years 2. Maintain peak bone mass in young adult years 3. Minimize loss of bone mass in postmenopausal years Physical activity may positively affect bone health during each phase!

42 If that is the case EXERCISE PRESCRIPTION

43 Minimal Essential Strain (MES) Threshold stimulus that initiates new bone growth. Forces that reaches or exceeds this threshold & is repeated will signal osteoblasts to migrate to the region to lay down matrix protein in the strength of the bone in that area. Osteoblast Secrete collagen to build new bone.

44 Training Concepts for Stimulating New Bone Formation Specificity of loading Proper exercise selection Progressive overload Variation

45 Exercise Selection Multiple muscle groups Isolation of a single muscle group by stabilizing the rest of the body Example: knee extension vs. back squat

46 Progressive Overload a steady gradual increase. WANT TO AVOID INJURY & OVERTRAINING

47 Training Variation Forces on Different areas of the body

48 Exercises to Prevent Falls Increase lower body strength & power Challenge linear movement patterns Stepping up and laterally Incorporating Weights Tai Chi-type movements

49 SUMMARY Movement is good! Bone responds most favorably to: High forces Young bodies (lifetime physical activity) Optimal Ca + intake Adequate reproductive hormones Reducing fall risk is essential!

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51 References Spirduso,, W. W., Francis, K. L., & MacRae,, P. G. (2005). Physical Dimensions of Aging (2nd Ed.). Champaign, IL: Human Kinetics. Corbin, C.B., Welk,, G.J., Corbin, W.R., Welk,, K.A. (2008). Concepts of Physical Fitness: Active Lifestyles for wellness (14th ed.). New York, NY: McGraw-Hill Publishers. Baechle, T.R., & Earle, R.W. (Eds.). (2008). Essentials of Strength Training and Conditioning. Champaign, IL: Human Kinetics