Measuring autonomic activity Heart rate variability Centre for Doctoral Training in Healthcare Innovation
|
|
- Luke Lambert
- 5 years ago
- Views:
Transcription
1 Measuring autonomic activity Heart rate variability Centre for Doctoral Training in Healthcare Innovation Dr. Gari D. Clifford, University Lecturer & Director, Centre for Doctoral Training in Healthcare Innovation, Institute of Biomedical Engineering, University of Oxford
2 Autonomic regulation HRV metrics Time domain Spectral Nonstationary Short term PRSA, HRT Long term wavelet scaling Dealing with noise in the time series Resampling issues Removing abnormal beats ECG-derived respiration (EDR) Physical Autonomic
3 Rest & Digest Fight & Flight
4 ANS autoregulates heart through SA node So measure HRV to gain insight into how autoregulation is working Why? To provides a metric of health by looking for departures form normality (given demographics)
5 Sequence of RR intervals is called Tachogram 60/.RR interval = Instantaneous HR Plot (t,rr) (time vs differential of time!) Now you can employ signal processing on the data! Data taken from PhysioNet;
6 Oscillations in RR tachogram from: Simple example: RSA Also changes due to blood pressure Myogenic changes? Smooth muscle Diurnal variations (temp, sleep, activity) Sudden changes ectopy, arrhythmia
7 ECG, HR and Respiration: HR and respiration highly correlated Resp rate is highest Freq component ~ Hz
8 HRV is a quantification of variation of the beat-to-beat intervals Frequency domain analysis is traditionally split into 4 frequency bands (ULF, VLF, LF & HF) representing the 4 (approx. distinct) time scales over which cardiovascular variations are thought to occur HF ( Hz): Vagal/parasympathetic variations over seconds (e.g. respiration) LF ( Hz): Sympatheticover minutes (BP, Meyer waves) VLF ( Hz): Myogenic? Variations over hours, e.g. temp. ULF ( Hz):Circadian e.g. activity nonstationarities
9 Sympathetic & parasympathetic braches of CNS act in opposition Think of it like 2 pedals in a car both are accelerators AND breaks (innervate / inhibit) The sympathetic brake/accelerator is less sticky Fight/flight response = rapid sympathetic innervation, and slower parasympathetic inhibition (note that parasympathetic action leads to higher frequency oscillations in RR tachogram why?) LF HF The ratio of the LF & HF power reflects the autonomic balance between these continuously interacting inhibitory and innervating actions of the CNS Small values indicate you are relaxing Large values indicate a highly active system e.g. when you are running Elevated values when you are relaxing indicate health problem
10 Record ECG Detect Peaks Calculate RR interval (time between each R peak) Remove RR intervals associated with noise & non-sinus beats (& following N beats?) Interpolate through missing data (insert phantom beats) if using cubic spline? [or cut data] (why do we remove non-sinus beats?) Resample / interpolate time series WHY?
11 Data is unevenly sampled! Nyquist not strictly defined
12 Data is unevenly sampled! Nyquist not strictly defined Nyquist frequency = 1/mean(RR) Hz (generally 0.5Hz for 60 BPM) Some frequencies above this, so you can beat Nyquist through uneven sampling But the accuracy at higher frequencies depends on number of samples with corresponding intervals
13 Data courtesy of PhysioNet;
14 Non-sinus beats are not reflective of SA node activity They lead to nonstationarities in time series so we remove a few following beats Insert phantom beats to create stability for nonlinear interp Resample to make an evenly sampled time series Generally you remove any RR intervals which change by more than 20% on the previous RR interval Example with linear interpolation Note phantom beat is interpolated with linear interp so phantom not needed here
15 Depends on task. Is (average) Nyquist the right resampling frequency? Smallest RR interval possible?? Hz For respiration, what s the fastest rate?? Hz Autonomic information up to? Hz
16 Depends on task. There are frequencies above average Nyquist! Smallest RR interval possible? 200ms 10 Hz But HRV only for sinus beats: <160 BPM ~6 Hz Fastest respiration rate? 60 RPM 2 Hz Autonomic information up to 1 Hz 2 Hz (In reality you need to sample a bit faster than Nyquist)
17 Many measures, some parametric, some nonparametric. Work over many scales Some deal with non-stationarities, some do not
18 Sine wave, with standard deviation calculated over different lengths Eventually it tends to a limit, but local measures can be unrepresentative
19 Time domain (assumes stationarity) Standard frequency domain (assumes stationarity) Scaling over 24 hours Nonlinear measures (sample entropy) Multi-scale entropy
20 Recap: Moments of a distribution Continuous Discrete approx Mean Var General:
21 x
22 Gaussians are mesokurtic with κ =3 SubGaussian SuperGaussian x
23 Approximations of distributions: AVNN: SDNN: SDANN: Average of all NN intervals Standard deviation of all NN intervals Standard deviation of the averages of NN intervals in all 5-minute segments of a 24-hour recording SDNNIDX: Mean of the standard deviations of NN intervals in all 5-minute segments of a 24-hour recording rmssd: Square root of the mean of the squares of differences between adjacent NN intervals pnn50: Percentage of differences between adjacent NN intervals that are > 50 ms. This is one member of the larger pnnx family
24 LF, HF, LF/HF, VLF, ULF Why these bands? Chemical experiments provide evidence HF ( Hz): Vagal/parasympathetic variations over seconds (e.g. respiration) LF ( Hz): Sympathetic- over minutes (BP, Meyer waves) VLF ( Hz): Myogenic? Variations over hours, e.g. temp. ULF ( Hz):Circadian e.g. activity nonstationarities
25 Tachogram has many states with similar means or variances HRi Length of state varies minutes (weakly stationary) Movements between states have brief accelerations in RR interval new mean and/or variance. Time (40 mins)
26 24 hour spectrum of RR intervals exhibits 1/f β scaling β indicates type of long term correlation β=2 : Brownian motion β=1 : Pink (natural) noise β=0 : White noise (no long-term correlation) Measure of fractal properties? (Probably not) Scaling should be not too white, or too brown. Pink is normal for humans How do we measure β since HRV is not stationary? Hint: not with Fourier.
27 Entropy kln(w) is a measure of disorder the more random the time series, the more disorder HRV should have some randomness, but not too much. (c.f. scaling) More info at:
28
29 Only short segments of data required Unit-free - no scaling issues Thought to reflect the sympathovagal balance
30 HRV changes significantly in different sleep cycles and for different conditions: Wakefulness Light Sleep Deep Sleep REM (Dream) Sleep
31 Activity : LF/HF ratio : Spontaneous Breathing Controlled Breathing (15 rpm) Controlled Breathing (18 rpm) Silent Reading Reading Aloud Free Talking Performing mentally stressful tasks silently (e.g. arithmetic) Performing mentally stressful tasks aloud Changes can be larger than inter-patient differences with different pathologies (Bernardi et al.)
32 HRT Heart rate turbulence a cardiovascular response to ectopy PRSA Phase rectified signal averaging the normal response of HR accelerations and decelerations
33 Data courtesy of PhysioNet;
34 SA node response to ectopic beat; short HR acceleration then deceleration. Maintain BP; rapid parasympathetic withdrawal? Then parasympathetic innervation baseline Credit: R. Schneider:
35 Ectopic beats disturb RR tachogram stationarity Disturbance lasts beats HRT quantifies this disturbance using 2 metrics: TO: Turbulence Onset TS: Turbulence Slope
36 Credit: Bauer A, Barthel P, Schneider R, Schmidt G. Dynamics of Heart Rate Turbulence. Circulation 2001b; Vol. 104; No. 17; Supplement; II-339, 1622.
37 (+ index intervals after ectopic, - index before) Percentage difference between mean of each pair of NN intervals on either side of ectopic pair Must average the TO over >> 10 ectopics
38 Find steepest slope for each possible sequence of 5 consecutive normal intervals from RR +2 RR +16 Usually average time series first then calculate one TS on the average time series! Outlier Rejection Important: (See Notes)
39 Run: Figure Credit: Mäkikallio et al., Eur. Heart J., April 2005; 26:
40 TO < 0 and TS > 2.5 are normal (a healthy response to PVCs is a strong sinus acceleration followed by a rapid deceleration)
41
42 An independent predictor of late mortality after acute MI [Schmidt 1999, Ghuran 2002, Wichterle 2004, Watanabe 2005, Baur 2006] Abnormal HRT Predicts Initiation of Ventricular Arrhythmias [Iwasa 2005] HRT indices appear to correlate better with EF than SDNN in Chagas disease [Tundo2005] HRT Predicts Cardiac Death in Patients Undergoing CABG [Cygankiewicz 2003] Prognostic Marker in Patients with Chronic Heart Failure [Kayama 2002] Risk Predictors in Patients With Diabetes Mellitus [Barthel 2000 Barthel 2002] LF/HF ratio indicates stress [Healey others] LF/HF ratio separates normal and sleep apneoic patients (with sleep stage) [Clifford 2003] LF/HF ratio used to screen patients who are responsive to sleep treatments [Campana 2011]
43 HRV is scale dependent short and long term metrics exist Some metrics appropriate only to short scales Can deal with nonstationarities by using: Perturbation analysis Signal averaging Short term boxing Nonstationary measures e.g. wavelets. Can also measure how HRV changes over scale Must be careful to remove noise from data first Choose resample rate based on task! (Always true of all pre-processing there s no magic pre-processing unit) Try to use a smooth resampler if you must or avoid resampling (advanced) HRV very useful in risk stratification, but often need to use some other measure univariate analysis is limited
44
45
46 SNA: Sympathetic Nerve Activity (recorded from peroneal nerve)
47 What if there is noise in the data (or ectopy)?
48 Abnormal or Non-sinus beats (ectopics) generally appear earlier (or sometimes later) than when a sinus beat is expected Ectopic beats usually replace the sinus beat and are followed by a compensatory pause. Their frequency is on average about 1 per hour for the NSRDB Artefacts occur are additional and occur independently of the phase of the sinus rhythm with a recording method-dependent distribution.
49 Linear/cubic interpolation of RR intervals then perform FFT Over-estimation of LF and under-estimation of HF Use Lomb-Scargle periodogram to avoid interpolation
50 Spectral estimation of unevenly sampled data without resampling Variable integration step size Equivalent to least squares fitting of sines to data! Scargle, J. D. (1982). "Studies in astronomical time series analysis. II - Statistical aspects of spectral analysis of unevenly spaced data". Astrophysical Journal 263: 835. doi: /160554
Ectopic Beats, Activity Effects and Heart Rate Turbulence
HRV 2006 Ectopic Beats, Activity Effects and Heart Rate Turbulence Gari Clifford gari@mit.edu www.mit.edu/~gari/ Harvard-MIT Division of Health Sciences & Technology Outline Overview of Cardiovascular
More informationHeart Rate Variability in Heart Failure and Sudden Death
Heart Rate Variability in Heart Failure and Sudden Death Phyllis K. Stein, PhD Washington University School of Medicine St. Louis, MO Outline Effect of erratic rhythm and sinus bigemeny on HRV. Traditional,
More informationHeart-rate Variability Christoph Guger,
Heart-rate Variability Christoph Guger, 10.02.2004 Heart-rate Variability (HRV) 1965 Hon & Lee Fetal distress alterations in interbeat intervals before heart rate (HR) changed 1980 HRV is strong and independent
More informationHRV ventricular response during atrial fibrillation. Valentina Corino
HRV ventricular response during atrial fibrillation Outline AF clinical background Methods: 1. Time domain parameters 2. Spectral analysis Applications: 1. Evaluation of Exercise and Flecainide Effects
More informationSegmenting cardiac-related data using sleep stages increases separation between normal subjects and apnœic patients
INSTITUTE OF PHYSICS PUBLISHING Physiol. Meas. 25 (2004) N27 N35 PHYSIOLOGICAL MEASUREMENT PII: S0967-3334(04)85195-5 NOTE Segmenting cardiac-related data using sleep stages increases separation between
More informationHeart Rate Variability Analysis Using the Lomb-Scargle Periodogram Simulated ECG Analysis
Page 1 of 7 Heart Rate Variability Analysis Using the Lomb-Scargle Periodogram Simulated ECG Analysis In a preceding analysis, our focus was on the use of signal processing methods detect power spectral
More informationCHAPTER 3 HEART RATE VARIABILITY
15 CHAPTER 3 HEART RATE VARIABILITY 3.1 INTRODUCTION Basics of HRV are introduced. Sources of HRV are given. Time domain methods, combined time domain and frequency domain methods and nonlinear methods
More informationSignal Processing Methods For Heart Rate Variability Analysis
Signal Processing Methods For Heart Rate Variability Analysis Gari D. Clifford St Cross College Doctor of Philosophy Michaelmas term 2002 Heart rate variability (HRV), the changes in the beat-to-beat heart
More informationHRV and Risk Stratification: Post-MI. Phyllis K. Stein, Ph.D. Washington University School of Medicine St. Louis, MO
HRV and Risk Stratification: Post-MI Phyllis K. Stein, Ph.D. Washington University School of Medicine St. Louis, MO Outline Research vs. clinical Holter scanning. Caveats in interpretation of published
More informationHeart rate variability
European Heart Journal (1996) 17, 354-381 Guidelines Heart rate variability Standards of measurement, physiological interpretation, and clinical use Task Force of The European Society of Cardiology and
More informationHeart rate variability
European Heart Journal (1996) 17, 354-381 Guidelines Heart rate variability Standards of measurement, physiological interpretation, and clinical use Task Force of The European Society of Cardiology and
More informationAdvanced Methods and Tools for ECG Data Analysis
Advanced Methods and Tools for ECG Data Analysis Gari D. Clifford Francisco Azuaje Patrick E. McSharry Editors ARTECH HOUSE BOSTON LONDON artechhouse.com Preface XI The Physiological Basis of the Electrocardiogram
More informationArbolishvili GN, Mareev VY Institute of Clinical Cardiology, Moscow, Russia
THE VALUE OF 24 H HEART RATE VARIABILITY IN PREDICTING THE MODE OF DEATH IN PATIENTS WITH HEART FAILURE AND SYSTOLIC DYSFUNCTION IN BETA-BLOCKING BLOCKING ERA Arbolishvili GN, Mareev VY Institute of Clinical
More informationDisclosures: Dr. Malhotra has consulting and/or research income from Philips, Ethicon,
1 1 2 Phase Rectified Signal Averaging as a Sensitive Index of Autonomic Changes with Aging 3 4 Campana LM 1,4, Owens RL 4,5. Clifford GD 2,4,5, Pittman SD 3, Malhotra A 4,5. 5 6 7 8 Boston University
More informationTime-Frequency Analysis of Heart Rate Variability Signal in prognosis of Type 2 Diabetic Autonomic Neuropathy
2011 International Conference on Biomedical Engineering and Technology IPCBEE vol.11 (2011) (2011) IACSIT Press, Singapore Time-Frequency Analysis of Heart Rate Variability Signal in prognosis of Type
More informationResearch Article Increase of Short-Term Heart Rate Variability Induced by Blood Pressure Measurements during Ambulatory Blood Pressure Monitoring
Hindawi Computational and Mathematical Methods in Medicine Volume 217, Article ID 5235319, 5 pages https://doi.org/1.1155/217/5235319 Research Article Increase of Short-Term Heart Rate Variability Induced
More informationCOMPARISON OF LINEAR AND NON-LINEAR ANALYSIS OF HEART RATE VARIABILITY IN SEDATED CARDIAC SURGERY PATIENTS
COMPARISON OF LINEAR AND NON-LINEAR ANALYSIS OF HEART RATE VARIABILITY IN SEDATED CARDIAC SURGERY PATIENTS I. Korhonen 1, L.T. Mainardi 2, H.Yppärilä 3, T. Musialowicz 4 1 VTT Information Technology, Tampere,
More informationAnalysis of Heart Rate Variability Linked with Autonomic Nervous System
www.ijemr.net ISSN (ONLINE): 50-0758, ISSN (PRINT): 394-696 Volume-6, Issue-5, September-October 016 International Journal of Engineering and Management Research Page Number: 418-46 Analysis of Heart Rate
More informationMeasures of heart rate variability in women following a meditation
1 de 6 06/02/2011 19:45 Journal List > Int J Yoga > v.3(1); Jan Jun 2010 Int J Yoga. 2010 Jan Jun; 3(1): 6 9. doi: 10.4103/0973-6131.66772. PMCID: PMC2952123 Copyright International Journal of Yoga Measures
More informationChapter 2 Quality Assessment for the Electrocardiogram (ECG)
Chapter 2 Quality Assessment for the Electrocardiogram (ECG) Abstract In this chapter, we review a variety of signal quality assessment (SQA) techniques that robustly generate automated signal quality
More informationAt the Core of Medical Technology INTRODUCTION SA3000P
At the Core of Medical Technology www.medi-core.com INTRODUCTION SA3000P Stress is the root of almost disease. 2 Diagnosis area 1. Stress assessment 2. Assessment of ANS function 3. Predictor of cardiovascular
More informationDesign of the HRV Analysis System Based on AD8232
207 3rd International Symposium on Mechatronics and Industrial Informatics (ISMII 207) ISB: 978--60595-50-8 Design of the HRV Analysis System Based on AD8232 Xiaoqiang Ji,a, Chunyu ing,b, Chunhua Zhao
More informationHeart Rate Variability in Athletes
Heart rate variability in athletes. AE Aubert, B Seps and F Beckers. Sports Medicine 33(12):889-919, 2003 1 Heart Rate Variability in Athletes A.E. Aubert, B. Seps and F. Beckers Laboratory of Experimental
More informationHEART RATE VARIABILITY MEASUREMENTS DURING EXERCISE TEST MAY IMPROVE THE DIAGNOSIS OF ISCHEMIC HEART DISEASE
HEART RATE VARIABILITY MEASUREMENTS DURING EXERCISE TEST MAY IMPROVE THE DIAGNOSIS OF ISCHEMIC HEART DISEASE J. Mateo 1, P. Serrano 2, R. Bailón 1, J. García 1, A. Ferreira 2, A. Del Río 2, I. J. Ferreira
More informationHRV in Diabetes and Other Disorders
HRV in Diabetes and Other Disorders Roy Freeman, MD Center for Autonomic and Peripheral Nerve Disorders Beth Israel Deaconess Medical Center Harvard Medical School Control Propranolol Atropine Wheeler
More informationG. D. Clifford. (gari AT mit DOT edu) Harvard-MIT Division of Health Science and Technology.
Supplementary Material for: Ectopic Beats, Activity Effects and Heart Rate Turbulence, HRV2006, Boston MA, April 2006. G. D. Clifford. (gari AT mit DOT edu) Harvard-MIT Division of Health Science and Technology.
More informationEffect of Physical Contact (Hand-Holding) on Heart Rate Variability
Effect of Physical Contact (Hand-Holding) on Heart Rate Variability T. Pishbin, S.M.P. Firoozabadi, N. Jafarnia Dabanloo, F. Mohammadi and S. Koozehgari Abstract Heart s electric field can be measured
More informationMAX PULSE RESULT INTERPRETATION GUIDE PROVE CLINICAL EFFICACY IMPROVE CLINICAL OUTCOMES IMPROVE PATIENT ADHERENCE
MAX PULSE RESULT INTERPRETATION GUIDE PROVE CLINICAL EFFICACY IMPROVE CLINICAL OUTCOMES IMPROVE PATIENT ADHERENCE PLETHYSMOGRAPHY VOLUME CAPACITY PG ON FINGERTIP VELOCITY PG (1ST DIFFERENTIATION) APG (2ND
More informationHRV - DANTEST. Introduction. Heart Rate Variability (HRV)
1 HRV - DANTEST Introduction http://www.dantest.com/ Heart Rate Variability (HRV) Heart rate variability (HRV), or the beat-to-beat alterations in heart rate, is an accurate and reliable reflection of
More informationAssociation of Arg16Gly Polymorphism of the Beta-2 Adrenergic receptor with Baroreflex Sensitivity and Indices of Autonomic Cardiovascular Modulation
Association of Arg16Gly Polymorphism of the Beta-2 Adrenergic receptor with Baroreflex Sensitivity and Indices of Autonomic Cardiovascular Modulation Ochoa JE 1,2, Correa M 1,5, Gallo J 3,5, McEwen J 1,3,
More informationElectrocardiography Biomedical Engineering Kaj-Åge Henneberg
Electrocardiography 31650 Biomedical Engineering Kaj-Åge Henneberg Electrocardiography Plan Function of cardiovascular system Electrical activation of the heart Recording the ECG Arrhythmia Heart Rate
More informationFrequency Domain Analysis of Heart Rate Variability (HRV) Among the Resident Population of North Eastern Hilly Regions of West Bengal
Indian Journal of Biomechanics: Special Issue (NCBM 7-8 March 9) Frequency Domain Analysis of Heart Rate Variability (HRV) Among the Resident Population of North Eastern Hilly Regions of West Bengal Ankur
More informationEstimating Mental Stress Using a Wearable Cardio-Respiratory Sensor
Estimating Mental Stress Using a Wearable Cardio-Respiratory Sensor Jongyoon Choi and Ricardo Gutierrez-Osuna Department of Computer Science and Engineering Texas A&M University, College Station, TX {goonyong,
More informationHeart Rate Variability Saga. N.I.Yabluchansky
Heart Rate Variability Saga N.I.Yabluchansky History tribute HRV is a well - known phenomenon and the up-to-date technology. Prognostic value since the Meyer s waves discovery. Physiological mechanisms
More informationFeature extraction by wavelet transforms to analyze the heart rate variability during two meditation technique
6th WSEAS International Conference on CIRCUITS, SYSTEMS, ELECTRONICS,CONTROL & SIGNAL PROCESSING, Cairo, Egypt, Dec 29-31, 2007 374 Feature extraction by wavelet transforms to analyze the heart rate variability
More informationKeywords: Gyrosonics, Moving sound, Autonomic nervous system, Heart rate variability
Gyrosonics a Novel Stimulant for Autonomic Nervous System S. K. Ghatak 1, S.S.Ray 2,R.Choudhuri 3 & S.Banerjee 3 1 Department of Physics & Meteorology, 2 School of Medical Science & Technology Indian institute
More informationLithuanian University of Health Sciences, Academy of Medicine, Institute of Cardiology, Lithuania 4
960. Heart rhythm fluctuation in peloidotherapy Giedrė Taletavičienė, Kęstutis Ramanauskas, Gediminas Jaruševičius, Alfonsas Vainoras Giedrė Taletavičienė 1, Kęstutis Ramanauskas 2, Gediminas Jaruševičius
More informationCLASSIFICATION OF CARDIAC SIGNALS USING TIME DOMAIN METHODS
CLASSIFICATION OF CARDIAC SIGNALS USING TIME DOMAIN METHODS B. Anuradha, K. Suresh Kumar and V. C. Veera Reddy Department of Electrical and Electronics Engineering, S.V.U. College of Engineering, Tirupati,
More informationCANINE HOLTER MONITORING REPORT
CANINE HOLTER MONITORING REPORT Copyright NorthEast Monitoring Inc. 1993-217. All data printed in the reports should be reviewed by a qualified physician. HOLTER MONITOR REPORT Patient Name: Fields, Diamond
More informationA point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability
Am J Physiol Heart Circ Physiol 88: H44 H435, 005. First published September 16, 004; doi:10.115/ajpheart.0048.003. A point-process model of human heartbeat intervals: new definitions of heart rate and
More informationESTECK Status Report [Abridged]
Back www.geoffbond.com ESTECK Status Report [Abridged] WARNING! The ES Teck system [] does not replace any existing other medical examinations. The ES Teck system[] is not used for diagnosis. It is intended
More informationPSD Graph. The HRV spectral analysis of ECG signal
PSD Graph The HRV spectral analysis of ECG signal BTL CardioPoint - PSD Graph 3 BURN-OUT syndrome, chronic fatigue, sleep disorders and their diagnostics using the PSD graph The burn-out syndrome significantly
More informationEffect of Postural Changes on Baroreflex Sensitivity: A study on the EUROBAVAR data set
Effect of Postural Changes on Baroreflex Sensitivity: A study on the EUROBAVAR data set Younhee Choi University of Rhode Island Department of ECE Kingston, RI 02881 USA choi.younhee@gmail.com Seok-Bum
More informationnervous system calculation of Heart Rate Variability
#1 Introduction to the autonomic nervous system 1 The science of variability 3 Heart Rate Variability 5 Applications of Heart Rate Variability 7 Methods of measurement and calculation of Heart Rate Variability
More informationDifferentiating mental and physical stressusing a wearable ECG-device
Department of Biomedical Engineering Linköping University Master Thesis Differentiating mental and physical stressusing a wearable ECG-device Linnea Nordvall June 16, 2015 LiTH-IMT/BIT30-A-EX 15/523 SE
More informationCANINE HOLTER MONITORING REPORT
CANINE HOLTER MONITORING REPORT Copyright NorthEast Monitoring Inc. 1993-216. All data printed in the reports should be reviewed by a qualified physician. HOLTER MONITOR REPORT Patient Name: Vandervoort,
More informationComplexity of cardiovascular control in amyotrophic lateral sclerosis patients is related to disease duration
Complexity of cardiovascular control in amyotrophic lateral sclerosis patients is related to disease duration 1,2, Laura Dalla Vecchia 1, Kalliopi Marinou 1, Gabriele Mora 1, Alberto Porta 3,4 ¹ IRCCS
More informationThe mortality of high-risk patients surviving myocardial
Arrhythmia/Electrophysiology Prevalent Low-Frequency Oscillation of Heart Rate Novel Predictor of Mortality After Myocardial Infarction Dan Wichterle, MD; Jan Simek, MD; Maria Teresa La Rovere, MD; Peter
More informationDevelopment of four stress levels in group stroop colour word test using HRV analysis.
Biomedical Research 07; 8 (): 98-0 ISSN 0970-98X www.biomedres.info Development of four stress levels in group stroop colour word test using HRV analysis. Vanitha L *, Suresh GR, Chandrasekar M, Punita
More informationKubios HRV Heart Rate Variability Analysis Software
Kubios HRV Heart Rate Variability Analysis Software Mika Tarvainen, PhD CEO, Kubios Oy MATLAB EXPO 2018 15.5.2018 Helsinki What is HRV Regulation of heart rate Autonomic nervous system (ANS) To preserve
More informationLinear Analysis Variability of Signal
Linear Analysis Variability of Signal Albert C. Yang, M.D., Ph.D. Beth Israel Deaconess Medical Center Harvard Medical School, Boston, USA Aug 6, 2018 cyang1@bidmc.harvard.edu 中醫對於脈象變異的觀察 十難 論一脈十變 十難曰
More informationInner Balance Assessment Using Methods of the Heart Rate Variability Analysis
Inner Balance Assessment Using Methods of the Heart Rate Variability Analysis Practical Use Manual 2000 2009 Biocom Technologies. All Rights reserved. Biocom Technologies makes no claims that its products
More informationTesting the Accuracy of ECG Captured by Cronovo through Comparison of ECG Recording to a Standard 12-Lead ECG Recording Device
Testing the Accuracy of ECG Captured by through Comparison of ECG Recording to a Standard 12-Lead ECG Recording Device Data Analysis a) R-wave Comparison: The mean and standard deviation of R-wave amplitudes
More informationOn the Importance of Performing HRV Analysis on Subjects Using Narcotic Drugs.
Case Report. On the Importance of Performing HRV Analysis on Subjects Using Narcotic Drugs. Elio Conte (1), Rich Norman (1), Leonardo Mendolicchio (1,2), Franco Orsucci (3), Francesco Casciaro Losito (1,4),
More informationDepartment of Electronics and Communication Engineering, MNM Jain Engineering College, Chennai, India. Abstract
Biomedical Research 2017; 28 (2): 689-694 ISSN 0970-938X www.biomedres.info Statistical analysis of pulse rate variability quantified through second derivative photoplethysmogram (SDPPG) and its compatibility
More informationBiomedical Signal Processing
DSP : Biomedical Signal Processing What is it? Biomedical Signal Processing: Application of signal processing methods, such as filtering, Fourier transform, spectral estimation and wavelet transform, to
More informationSelecting Features of Single Lead ECG Signal for Automatic Sleep Stages Classification using Correlation-based Feature Subset Selection
www.ijcsi.org 139 Selecting Features of Single Lead ECG Signal for Automatic Sleep Stages Classification using Correlation-based Feature Subset Selection Ary Noviyanto 1, Sani M. Isa 2, Ito Wasito 3 and
More informationSupplemental Material
Supplemental Material Supplemental Results The baseline patient characteristics for all subgroups analyzed are shown in Table S1. Tables S2-S6 demonstrate the association between ECG metrics and cardiovascular
More informationTIME-FREQUENCY ANALYSIS OF HEART RATE VARIABILITY FOR NEONATAL SEIZURE DETECTION
Australas. Phys. Eng. Sci. Med. Vol. 9, No 1, 06 TIME-FREQUENCY ANALYSIS OF HEART RATE VARIABILITY FOR NEONATAL SEIZURE DETECTION MB Malarvili, Mostefa Mesbah and Boualem Boashash Signal Processing Research
More informationCARE. A Dissertation. presented to. the Faculty of the Graduate School. at the University of Missouri. In Partial Fulfillment
SHORT-TERM HEART RATE VARIABILITY AS A GENERAL INDICATOR OF HEALTH ESTIMATED BY BALLISTOCARDIOGRAPHY USING A HYDRAULIC BED SENSOR IN ELDER CARE A Dissertation presented to the Faculty of the Graduate School
More informationHHS Public Access Author manuscript Heart Rhythm. Author manuscript; available in PMC 2016 July 01.
Subcutaneous nerve activity is more accurate than the heart rate variability in estimating cardiac sympathetic tone in ambulatory dogs with myocardial infarction Yi-Hsin Chan, MD 1,2, Wei-Chung Tsai, MD
More informationApproaches to the Autonomic Nervous System in Female Athletes
Health Topics for Tokyoites Juntendo Medical Journal 2017. 63(2), 83-87 Approaches to the Autonomic Nervous System in Female Athletes NOBUHIRO SUETAKE *,HIROYUKI KOBAYASHI * *Department of Hospital Administration,
More informationKernel Dimensionality Reduction on Sleep Stage Classification using ECG Signal
IJCSI International Journal of Computer Science Issues, Vol. 8, Issue, No 2, July 2011 ISSN (Online): 19-081 www.ijcsi.org 115 Kernel Dimensionality Reduction on Sleep Stage Classification using ECG Signal
More informationHow to Analyze Stress from Heart Rate & Heart Rate Variability: A Review of Physiology
How to Analyze Stress from Heart Rate & Heart Rate Variability: A Review of Physiology STRESS AFFECTS THE AUTONOMIC NERVOUS SYSTEM TERMINOLOGY Heart rate (HR): heartbeat frequency as beats per minute (bpm)
More informationBRAIN IN THE HEART. Eternity In Our Hearts
BRAIN IN THE HEART Rediscovering the Biblical Significance of the Heart Eternity In Our Hearts He has made everything beautiful (appropriate) in its time. He has also set eternity in their heart, yet so
More informationPatient Name : Wollmann, Martin J Page 1 of 13. CardioTech Monitoring Systems 138 Cambridge Drive Lynden, WA PATIENT DEMOGRAPHICS
Patient Name : Wollmann, Martin J Page of Last Name Wollmann First Name Martin Middle Initial J ID Number 45789 Date Of Birth 7/5/978 Sex M Source Physician Office Name Billing Code Recorder Format Philips
More informationFigure removed due to copyright restrictions.
Harvard-MIT Division of Health Sciences and Technology HST.071: Human Reproductive Biology Course Director: Professor Henry Klapholz IN SUMMARY HST 071 An Example of a Fetal Heart Rate Tracing Figure removed
More informationEstimation of sleep recovery in shift working long-haul truck drivers A heart rate variability based study
PARUTHI PRADHAPAN Estimation of sleep recovery in shift working long-haul truck drivers A heart rate variability based study MASTER OF SCIENCE THESIS Subject approved by Department Council 8 th May 2013
More informationThought Technology Ltd.
Thought Technology Ltd. 8205 Montreal/ Toronto Blvd. Suite 223, Montreal West, QC H4X 1N1 Canada Tel: (800) 361-3651 ۰ (514) 489-8251 Fax: (514) 489-8255 E-mail: mail@thoughttechnology.com Webpage: http://www.thoughttechnology.com
More informationA new telemedical system for application in the cosmos and on Earth
A new telemedical system for application in the cosmos and on Earth Moscow Vienna Prof. Joachim Schlund Office Park Headquarters Telovital GmbH Vienna Director Telovital GmbH Vienna Professor of Telemedicine
More informationA Review on Sleep Apnea Detection from ECG Signal
A Review on Sleep Apnea Detection from ECG Signal Soumya Gopal 1, Aswathy Devi T. 2 1 M.Tech Signal Processing Student, Department of ECE, LBSITW, Kerala, India 2 Assistant Professor, Department of ECE,
More informationEustress or Distress: An Empirical Study of Perceived Stress in Everyday College Life
Eustress or Distress: An Empirical Study of Perceived Stress in Everyday College Life Chun-Tung Li Department of Computing The Hong Kong Polytechnic University Hong Kong, China csctli@comp.polyu.edu.hk
More informationarxiv:physics/ v1 4 Jun 2004
NOTE Open-source software for generating electrocardiogram signals arxiv:physics/0406017 v1 4 Jun 2004 Patrick E. McSharry and Gari D. Clifford Department of Engineering Science, University of Oxford,
More informationIOP Conference Series: Earth and Environmental Science PAPER OPEN ACCESS
IOP Conference Series: Earth and Environmental Science PAPER OPEN ACCESS Study of Regulatory Mechanisms of Activity of Cardiovascular System by Method of Mathematical Analysis of Heart Rhythm in Workers
More informationWavelet Decomposition for Detection and Classification of Critical ECG Arrhythmias
Proceedings of the 8th WSEAS Int. Conference on Mathematics and Computers in Biology and Chemistry, Vancouver, Canada, June 19-21, 2007 80 Wavelet Decomposition for Detection and Classification of Critical
More informationAutonomic nervous system, inflammation and preclinical carotid atherosclerosis in depressed subjects with coronary risk factors
Autonomic nervous system, inflammation and preclinical carotid atherosclerosis in depressed subjects with coronary risk factors Carmine Pizzi 1 ; Lamberto Manzoli 2, Stefano Mancini 3 ; Gigliola Bedetti
More informationDesign and Analysis of Electrocardiograph (ECG) Signal for long term continuous heart rate monitoring system
Volume 119 No. 15 2018, 99-110 ISSN: 1314-3395 (on-line version) url: http://www.acadpubl.eu/hub/ http://www.acadpubl.eu/hub/ Design and Analysis of Electrocardiograph (ECG) Signal for long term continuous
More informationECG SIGNAL ACQUISITION, FEATURE EXTRACTION AND HRV ANALYSIS USING BIOMEDICAL WORKBENCH
International Journal of Advanced Research in Engineering and Technology (IJARET) Volume 9, Issue 3, May June 2018, pp. 84 90, Article ID: IJARET_09_03_012 Available online at http://www.iaeme.com/ijaret/issues.asp?jtype=ijaret&vtype=9&itype=3
More informationTHE MOST IMPORTANT FUNCTION of the heart is to pump
10.1515/msr-2015-0027 MEASUREMENT SCIENCE REVIEW, Volume 15, No. 4, 2015 Comparison of the Effects of Cross-validation Methods on Determining Performances of Classifiers Used in Diagnosing Congestive Heart
More informationDiscrimination of the Healthy and Sick Cardiac Autonomic Nervous System by a New Wavelet Analysis of Heartbeat Intervals
Discrimination of the Healthy and Sick Cardiac Autonomic Nervous System by a New Wavelet Analysis of Heartbeat Intervals Y. Ashkenazy a,b,m.lewkowicz c,a,j.levitan c,a, H. Moelgaard d, P.E. Bloch Thomsen
More informationCoronary Artery Disease
Coronary Artery Disease Carotid wall thickness Progression Normal vessel Minimal CAD Moderate CAD Severe CAD Coronary Arterial Wall Angina Pectoris Myocardial infraction Sudden death of coronary artery
More informationAccuracy of Beat-to-Beat Heart Rate Estimation Using the PulseOn Optical Heart Rate Monitor
Accuracy of Beat-to-Beat Heart Rate Estimation Using the PulseOn Optical Heart Rate Monitor Abstract Wrist photoplethysmography allows unobtrusive monitoring of the heart rate (HR). Even if it is frequently
More informationExperimental Study of Heart Rate Variability by Wrist-Pulse Wave
Experimental Study of Heart Rate Variability by Wrist-Pulse Wave Ming Luo a, Liangguang Peng b School of Electronics Engineering, Chongqing University of Posts and Telecommunications, Abstract Chongqing
More informationSpeed - Accuracy - Exploration. Pathfinder SL
Speed - Accuracy - Exploration Pathfinder SL 98000 Speed. Accuracy. Exploration. Pathfinder SL represents the evolution of over 40 years of technology, design, algorithm development and experience in the
More informationIntroduction EHRA POSITION PAPER
Europace (2015) 17, 1341 1353 doi:10.1093/europace/euv015 EHRA POSITION PAPER Advances in heart rate variability signal analysis: joint position statement by the e-cardiology ESC Working Group and the
More informationCHAPTER 5 WAVELET BASED DETECTION OF VENTRICULAR ARRHYTHMIAS WITH NEURAL NETWORK CLASSIFIER
57 CHAPTER 5 WAVELET BASED DETECTION OF VENTRICULAR ARRHYTHMIAS WITH NEURAL NETWORK CLASSIFIER 5.1 INTRODUCTION The cardiac disorders which are life threatening are the ventricular arrhythmias such as
More informationEmotional State Recognition via Physiological Measurement and Processing
APPLICATION NOTE 42 Aero Camino, Goleta, CA 93117 Tel (805) 685-0066 Fax (805) 685-0067 info@biopac.com www.biopac.com Application Note 276: Emotional State Recognition via Physiological Measurement and
More informationEFFICIENT MULTIPLE HEART DISEASE DETECTION SYSTEM USING SELECTION AND COMBINATION TECHNIQUE IN CLASSIFIERS
EFFICIENT MULTIPLE HEART DISEASE DETECTION SYSTEM USING SELECTION AND COMBINATION TECHNIQUE IN CLASSIFIERS G. Revathi and L. Vanitha Electronics and Communication Engineering, Prathyusha Institute of Technology
More informationNote: At the end of the instructions, you will find a table which must be filled in to complete the exercise.
Autonomic Nervous System Theoretical foundations and instructions for conducting practical exercises carried out during the course List of practical exercises 1. Deep (controlled) breath test 2. Cold pressor
More informationIn the 2002 American College of Cardiology/American
Risk Stratification After Acute Myocardial Infarction by Heart Rate Turbulence Petra Barthel, MD; Raphael Schneider, Dipl Ing; Axel Bauer, MD; Kurt Ulm, PhD; Claus Schmitt, MD; Albert Schömig, MD; Georg
More informationBiomedical. Measurement and Design ELEC4623. Lectures 15 and 16 Statistical Algorithms for Automated Signal Detection and Analysis
Biomedical Instrumentation, Measurement and Design ELEC4623 Lectures 15 and 16 Statistical Algorithms for Automated Signal Detection and Analysis Fiducial points Fiducial point A point (or line) on a scale
More informationKey words: HRV db, Family history of Hypertension, Heart Rate, Blood pressure
(14) EFFECT OF DEEP BREATHING ON HEART RATE VARIABILITY IN NORMOTENSIVE MALE OFFSPRING S OF HYPERTENSIVE PARENTS Dr. H. C. Veena 1, Dr. Vijayanath Itagi 2, Dr. R. H. Takalikar 3, Dr. R. S. Patil 4 1. Post
More informationS. Rangsungnoen, 1 P. Chanbenjapipu, 1 N. Mathuradavong, 2 and K. Suwanprasert Introduction
Medical Engineering Volume 2016, Article ID 9823026, 6 pages http://dx.doi.org/10.1155/2016/9823026 Research Article A Hybrid Signal Processing of RR Intervals from QTc Variation Searching Arrhythmia and
More informationVital Responder: Real-time Health Monitoring of First- Responders
Vital Responder: Real-time Health Monitoring of First- Responders Ye Can 1,2 Advisors: Miguel Tavares Coimbra 2, Vijayakumar Bhagavatula 1 1 Department of Electrical & Computer Engineering, Carnegie Mellon
More informationModule 1: Introduction to ECG & Normal ECG
Module 1: Introduction to ECG & Normal ECG Importance of Correct anatomical positions Measurements & Morphologies ONLY accurate if Precise anatomical positions adhered to Standardised techniques are used
More information2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media,
2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising
More informationTime-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set
Appendix II 95 Appendix II Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set B.E. Westerhof, J. Gisolf, W.J. Stok, K.H. Wesseling and J.M. Karemaker, J Hypertens
More informationEffect of Meditation on Time and Frequency Domain Parameters of Heart Rate Variability
Effect of Meditation on Time and Frequency Domain Parameters of Heart Rate Variability Original Research Article Sudhanshu Kacker 1, Neha Saboo 2*, Sonali Sharma 3, Mahima Sharma 4, Mohit Sharma 5, Jitender
More informationReceived November 19, 2012; revised December 20, 2012; accepted December 27, 2012
Journal of Behavioral and Brain Science, 2013, 3, 26-48 doi:10.4236/jbbs.2013.31004 Published Online February 2013 (http://www.scirp.org/journal/jbbs) Heart Rate Variability, Standard of Measurement, Physiological
More information20 ng/ml 200 ng/ml 1000 ng/ml chronic kidney disease CKD Brugada 5 Brugada Brugada 1
Symposium 39 45 1 1 2005 2008 108000 59000 55 1 3 0.045 1 1 90 95 5 10 60 30 Brugada 5 Brugada 80 15 Brugada 1 80 20 2 12 X 2 1 1 brain natriuretic peptide BNP 20 ng/ml 200 ng/ml 1000 ng/ml chronic kidney
More information