A receptor for infectious and cellular prion protein

Transcription

1 Brazilian Journal of Medical and Biological Research (1999) 32: A receptor for infectious and cellular prion protein ISSN X 853 A receptor for infectious and cellular prion protein Fundação Antônio Prudente, São Paulo, SP, Brasil Correspondence Fundação Antônio Prudente Rua Prof. Antônio Prudente, 109/4A São Paulo, SP Brasil Presented at the I International Symposium on Signal Transduction and Gene Expression in Cell Proliferation and Differentiation, São Paulo, SP, Brasil, August 31-September 2, Publication supported by FAPESP. Received November 26, 1998 Accepted January 19, 1999 Abstract a a Key words Prion Transmissible spongiform encephalopathies PrPc Receptor Introduction

2 854 Characteristics of the infectious agent a a Infection mechanism Inter-species barrier

3 A receptor for infectious and cellular prion protein 855 Human prion diseases Normal function of PrPc

4 856 g A PrPc/PrPsc receptor protein Peripheral blood cell participation in prion infection

5 A receptor for infectious and cellular prion protein 857 What is next? PrPc PrPsc receptor Figure 1 - Proposed mechanism of action for PrPc/PrPsc receptor in the normal (A and B) and infectious processes (C). In the normal cell, PrPc and receptor from the same cell (A) or from different cells (B) can interact and promote signal transduction, triggering their physiological function. The infectious agent should use the same receptor (C) which allows its internalization, facilitating the interaction with PrPc and the conformational changes, leading to PrPsc accumulation and cell death. References 1. Gordon WS (1946). Advances in veterinary research. Veterinary Record, 58: Prusiner SB (1991). Molecular biology of prion diseases. Science, 252: Prusiner SB (1993). Genetic and infectious prion diseases. Archives of Neurology, 50: Grifft JS (1967). Self replication and scrapie. Nature, 215: Prusiner SB (1982). Novel proteinaceous infectious particles cause scrapie. Science, 216: Bolton DC, McKinley MP & Prusiner SB (1982). Identification of a protein that purifies with the scrapie prion. Science, 218: Prusiner SB, Groth DF, Bolton DC, Kent

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