Safety Data Sheet acc. to OSHA HCS

Transcription

1 Safety Data Sheet acc. to OSHA HCS Page 1/11 Printing date 09/21/2015 Reviewed on 09/21/ Identification Product identifier Trade name: PROPYLENE OXIDE, ACS REAGENT Article number: 20401, 20411, 20412, CAS Number: EC number: Index number: Relevant identified uses of the substance or mixture and uses advised against No further relevant information available. Application of the substance / the mixture Laboratory chemicals Details of the supplier of the safety data sheet Manufacturer/Supplier: Electron Microscopy Sciences 1560 Industry Road USA-Hatfield, PA Tel: Fax: sgkcck@aol.com Information department: Product safety department Emergency telephone number: ChemTrec Contract CCN Hazard(s) identification Classification of the substance or mixture GHS02 Flame Flam. Liq. 1 H224 Extremely flammable liquid and vapor. GHS06 Skull and crossbones Acute Tox. 3 H311 Toxic in contact with skin. Acute Tox. 3 H331 Toxic if inhaled. GHS08 Health hazard Muta. 1B Carc. 1B H340 May cause genetic defects. H350 May cause cancer. GHS05 Corrosion Eye Dam. 1 H318 Causes serious eye damage. (Contd. on page 2) US

2 Safety Data Sheet acc. to OSHA HCS Page 2/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 1) GHS07 Acute Tox. 4 H302 Harmful if swallowed. Skin Irrit. 2 H315 Causes skin irritation. STOT SE 3 H335 May cause respiratory irritation. Label elements GHS label elements The substance is classified and labeled according to the Globally Harmonized System (GHS). Hazard pictograms GHS02 GHS05 GHS06 GHS07 GHS08 Signal word Danger Hazard-determining components of labeling: propylene oxide Hazard statements Extremely flammable liquid and vapor. Harmful if swallowed. Toxic in contact with skin or if inhaled. Causes skin irritation. Causes serious eye damage. May cause genetic defects. May cause cancer. May cause respiratory irritation. Precautionary statements Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Use explosion-proof electrical/ventilating/lighting/equipment. Avoid breathing dust/fume/gas/mist/vapors/spray Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use only non-sparking tools. Avoid release to the environment. Take precautionary measures against static discharge. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center/doctor Specific measures (see on this label). IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. If skin irritation occurs: Get medical advice/attention. Rinse mouth. In case of fire: Use for extinction: CO2, powder or water spray. Store locked up. (Contd. on page 3) US

3 Safety Data Sheet acc. to OSHA HCS Page 3/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 2) Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations. Classification system: NFPA ratings (scale 0-4) Health = 3 Fire = 4 Reactivity = 0 HMIS-ratings (scale 0-4) HEALTH FIRE REACTIVITY Health = 3 Fire = 4 Reactivity = 0 Other hazards Results of PBT and vpvb assessment PBT: Not applicable. vpvb: Not applicable. 3 Composition/information on ingredients Chemical characterization: Substances CAS No. Description propylene oxide Identification number(s) EC number: Index number: First-aid measures Description of first aid measures General information: Immediately remove any clothing soiled by the product. Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident. Remove breathing apparatus only after contaminated clothing have been completely removed. In case of irregular breathing or respiratory arrest provide artificial respiration. After inhalation: Supply fresh air or oxygen; call for doctor. In case of unconsciousness place patient stably in side position for transportation. After skin contact: Immediately wash with water and soap and rinse thoroughly. After eye contact: Rinse opened eye for several minutes under running water. Then consult a doctor. After swallowing: Immediately call a doctor. Information for doctor: Most important symptoms and effects, both acute and delayed No further relevant information available. Indication of any immediate medical attention and special treatment needed No further relevant information available. US (Contd. on page 4)

4 Safety Data Sheet acc. to OSHA HCS Page 4/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 3) 5 Fire-fighting measures Extinguishing media Suitable extinguishing agents: CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Special hazards arising from the substance or mixture No further relevant information available. Advice for firefighters Protective equipment: Mouth respiratory protective device. 6 Accidental release measures Personal precautions, protective equipment and emergency procedures Wear protective equipment. Keep unprotected persons away. Environmental precautions: Dilute with plenty of water. Do not allow to enter sewers/ surface or ground water. Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust). Dispose contaminated material as waste according to item 13. Ensure adequate ventilation. Reference to other sections See Section 7 for information on safe handling. See Section 8 for information on personal protection equipment. See Section 13 for disposal information. 7 Handling and storage Handling: Precautions for safe handling Ensure good ventilation/exhaustion at the workplace. Open and handle receptacle with care. Prevent formation of aerosols. Information about protection against explosions and fires: Keep ignition sources away - Do not smoke. Protect from heat. Protect against electrostatic charges. Keep respiratory protective device available. Conditions for safe storage, including any incompatibilities Storage: Requirements to be met by storerooms and receptacles: Store in a cool location. Information about storage in one common storage facility: Not required. Further information about storage conditions: Keep receptacle tightly sealed. Do not gas tight seal receptacle. Store in cool, dry conditions in well sealed receptacles. Protect from heat and direct sunlight. Specific end use(s) No further relevant information available. US (Contd. on page 5)

5 Safety Data Sheet acc. to OSHA HCS Page 5/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 4) 8 Exposure controls/personal protection Additional information about design of technical systems: No further data; see item 7. Control parameters Components with limit values that require monitoring at the workplace: propylene oxide PEL Long-term value: 240 mg/m³, 100 ppm REL See Pocket Guide App. A TLV Long-term value: 4.8 mg/m³, 2 ppm DSEN Additional information: The lists that were valid during the creation were used as basis. Exposure controls Personal protective equipment: General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. Store protective clothing separately. Avoid contact with the skin. Avoid contact with the eyes and skin. Breathing equipment: In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air. Protection of hands: Protective gloves The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. Penetration time of glove material The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed. Eye protection: Tightly sealed goggles US (Contd. on page 6)

6 Safety Data Sheet acc. to OSHA HCS Page 6/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 5) 9 Physical and chemical properties Information on basic physical and chemical properties General Information Appearance: Form: Liquid Color: Colorless Odor: Characteristic Odour threshold: Not determined. ph-value: Not determined. Change in condition Melting point/melting range: Boiling point/boiling range: C (-169 F) 34.3 C (94 F) Flash point: -37 C (-35 F) Flammability (solid, gaseous): Not flammable. Ignition temperature: 430 C (806 F) Decomposition temperature: Not determined. Auto igniting: Not determined. Danger of explosion: Product is not explosive. However, formation of explosive air/vapor mixtures are possible. Explosion limits: Lower: 1.9 Vol % Upper: 15 Vol % Vapor pressure at 20 C (68 F): 590 hpa (443 mm Hg) Density at 20 C (68 F): g/cm³ (6.937 lbs/gal) Relative density Not determined. Vapour density Not determined. Evaporation rate Not determined. Solubility in / Miscibility with Water at 20 C (68 F): 405 g/l Partition coefficient (n-octanol/water): Not determined. Viscosity: Dynamic: Not determined. Kinematic: Not determined. Organic solvents: 0.0 % Other information No further relevant information available. 10 Stability and reactivity Reactivity Chemical stability Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. Possibility of hazardous reactions No dangerous reactions known. Conditions to avoid No further relevant information available. Incompatible materials: No further relevant information available. (Contd. on page 7) US

7 Safety Data Sheet acc. to OSHA HCS Page 7/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT Hazardous decomposition products: No dangerous decomposition products known. (Contd. of page 6) 11 Toxicological information Information on toxicological effects Acute toxicity: LD/LC50 values that are relevant for classification: propylene oxide Oral LD mg/kg (rat) Dermal LD mg/kg (rabbit) Primary irritant effect: on the skin: Irritant to skin and mucous membranes. on the eye: Strong irritant with the danger of severe eye injury. Sensitization: No sensitizing effects known. Additional toxicological information: Carcinogenic categories IARC (International Agency for Research on Cancer) propylene oxide 2B NTP (National Toxicology Program) propylene oxide R OSHA-Ca (Occupational Safety Health Administration) Substance is not listed. 12 Ecological information Toxicity Aquatic toxicity: No further relevant information available. Persistence and degradability No further relevant information available. Behavior in environmental systems: Bioaccumulative potential No further relevant information available. Mobility in soil No further relevant information available. Additional ecological information: General notes: Water hazard class 3 (Self-assessment): extremely hazardous for water Do not allow product to reach ground water, water course or sewage system, even in small quantities. Danger to drinking water if even extremely small quantities leak into the ground. Results of PBT and vpvb assessment PBT: Not applicable. vpvb: Not applicable. Other adverse effects No further relevant information available. 13 Disposal considerations Waste treatment methods Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system. (Contd. on page 8) US

8 Safety Data Sheet acc. to OSHA HCS Page 8/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT Uncleaned packagings: Recommendation: Disposal must be made according to official regulations. Recommended cleansing agent: Water, if necessary with cleansing agents. (Contd. of page 7) 14 Transport information UN-Number DOT, ADR, IMDG, IATA UN1280 UN proper shipping name DOT Propylene oxide ADR 1280 Propylene oxide IMDG, IATA PROPYLENE OXIDE Transport hazard class(es) DOT Class 3 Flammable liquids Label 3 ADR, IMDG, IATA Class 3 Flammable liquids Label 3 Packing group DOT, ADR, IMDG, IATA I Environmental hazards: Marine pollutant: No Special precautions for user Warning: Flammable liquids Danger code (Kemler): 339 EMS Number: F-E,S-D Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code Transport/Additional information: Not applicable. DOT Quantity limitations On passenger aircraft/rail: 1 L On cargo aircraft only: 30 L Hazardous substance: 100 lbs, 45.4 kg ADR Excepted quantities (EQ) Code: E3 Maximum net quantity per inner packaging: 30 ml Maximum net quantity per outer packaging: 300 ml (Contd. on page 9) US

9 Safety Data Sheet acc. to OSHA HCS Page 9/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT IMDG Limited quantities (LQ) 0 Excepted quantities (EQ) Code: E3 Maximum net quantity per inner packaging: 30 ml Maximum net quantity per outer packaging: 300 ml UN "Model Regulation": UN1280, Propylene oxide, 3, I (Contd. of page 8) 15 Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture Sara Section 355 (extremely hazardous substances): Substance is listed. Section 313 (Specific toxic chemical listings): Substance is listed. TSCA (Toxic Substances Control Act): Substance is listed. Proposition 65 Chemicals known to cause cancer: Substance is listed. Chemicals known to cause reproductive toxicity for females: Substance is not listed. Chemicals known to cause reproductive toxicity for males: Substance is not listed. Chemicals known to cause developmental toxicity: Substance is not listed. Carcinogenic categories EPA (Environmental Protection Agency) propylene oxide B2 TLV (Threshold Limit Value established by ACGIH) propylene oxide A3 NIOSH-Ca (National Institute for Occupational Safety and Health) Substance is listed. GHS label elements The substance is classified and labeled according to the Globally Harmonized System (GHS). Hazard pictograms GHS02 GHS05 GHS06 GHS07 GHS08 Signal word Danger Hazard-determining components of labeling: propylene oxide (Contd. on page 10) US

10 Safety Data Sheet acc. to OSHA HCS Page 10/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 9) Hazard statements Extremely flammable liquid and vapor. Harmful if swallowed. Toxic in contact with skin or if inhaled. Causes skin irritation. Causes serious eye damage. May cause genetic defects. May cause cancer. May cause respiratory irritation. Precautionary statements Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Use explosion-proof electrical/ventilating/lighting/equipment. Avoid breathing dust/fume/gas/mist/vapors/spray Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use only non-sparking tools. Avoid release to the environment. Take precautionary measures against static discharge. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a poison center/doctor Specific measures (see on this label). IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. If skin irritation occurs: Get medical advice/attention. Rinse mouth. In case of fire: Use for extinction: CO2, powder or water spray. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations. National regulations: Information about limitation of use: Workers are not allowed to be exposed to this hazardous material. Exceptions can be made by the authorities in certain cases. Chemical safety assessment: A Chemical Safety Assessment has not been carried out. 16 Other information This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. Date of preparation / last revision 09/21/2015 / - Abbreviations and acronyms: ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the International Carriage of Dangerous Goods by Road) IMDG: International Maritime Code for Dangerous Goods DOT: US Department of Transportation IATA: International Air Transport Association ACGIH: American Conference of Governmental Industrial Hygienists (Contd. on page 11) US

11 Safety Data Sheet acc. to OSHA HCS Page 11/11 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT EINECS: European Inventory of Existing Commercial Chemical Substances CAS: Chemical Abstracts Service (division of the American Chemical Society) NFPA: National Fire Protection Association (USA) HMIS: Hazardous Materials Identification System (USA) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent Flam. Liq. 1: Flammable liquids, Hazard Category 1 Acute Tox. 4: Acute toxicity, Hazard Category 4 Acute Tox. 3: Acute toxicity, Hazard Category 3 Skin Irrit. 2: Skin corrosion/irritation, Hazard Category 2 Eye Dam. 1: Serious eye damage/eye irritation, Hazard Category 1 Muta. 1B: Germ cell mutagenicity, Hazard Category 1B Carc. 1B: Carcinogenicity, Hazard Category 1B STOT SE 3: Specific target organ toxicity - Single exposure, Hazard Category 3 (Contd. of page 10) US

12 Safety data sheet according to 1907/2006/EC, Article 31 Page 1/10 Printing date Revision: Identification of the substance/mixture and of the company/undertaking Product identifier Trade name: PROPYLENE OXIDE, ACS REAGENT Article number: 20401, 20411, 20412, CAS Number: EC number: Index number: Relevant identified uses of the substance or mixture and uses advised against No further relevant information available. Application of the substance / the mixture Laboratory chemicals Details of the supplier of the safety data sheet Manufacturer/Supplier: Electron Microscopy Sciences 1560 Industry Road USA-Hatfield, PA Tel: Fax: sgkcck@aol.com ProSciTech Pty Ltd 11 Carlton Street, Kirwan QLD 4817 Australia Telephone Number: (07) :30am - 5:00pm, Monday to Friday (excluding Public Holidays) Emergency Contact: (07) :30am - 5:00pm, Monday to Friday (excluding Public Holidays) Emgrid Australia Pty. Ltd. P.O. Box 118 The Patch VIC 3792 Australia Tel: Fax: Website: Further information obtainable from: Product safety department Emergency telephone number: ChemTrec Contract CCN Hazards identification Classification of the substance or mixture GHS02 flame Flam. Liq. 1 H224 Extremely flammable liquid and vapour. GHS06 skull and crossbones Acute Tox. 3 H311 Toxic in contact with skin. Acute Tox. 3 H331 Toxic if inhaled. (Contd. on page 2) AU

13 Safety data sheet according to 1907/2006/EC, Article 31 Page 2/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 1) GHS08 health hazard Muta. 1B Carc. 1B H340 May cause genetic defects. H350 May cause cancer. GHS05 corrosion Eye Dam. 1 H318 Causes serious eye damage. GHS07 Acute Tox. 4 H302 Harmful if swallowed. Skin Irrit. 2 H315 Causes skin irritation. STOT SE 3 H335 May cause respiratory irritation. Label elements GHS label elements The substance is classified and labelled according to the Globally Harmonised System (GHS). Hazard pictograms GHS02 GHS05 GHS06 GHS07 GHS08 Signal word Danger Hazard-determining components of labelling: propylene oxide Hazard statements Extremely flammable liquid and vapour. Harmful if swallowed. Toxic in contact with skin or if inhaled. Causes skin irritation. Causes serious eye damage. May cause genetic defects. May cause cancer. May cause respiratory irritation. Precautionary statements Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Use explosion-proof electrical/ventilating/lighting/equipment. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use only non-sparking tools. Avoid release to the environment. Take precautionary measures against static discharge. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. (Contd. on page 3) AU

14 Safety data sheet according to 1907/2006/EC, Article 31 Page 3/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 2) Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. Specific measures (see on this label). IF INHALED: Remove person to fresh air and keep comfortable for breathing. If skin irritation occurs: Get medical advice/attention. Rinse mouth. In case of fire: Use for extinction: CO2, powder or water spray. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations. Other hazards Results of PBT and vpvb assessment PBT: Not applicable. vpvb: Not applicable. 3 Composition/information on ingredients Chemical characterisation: Substances CAS No. Description propylene oxide Identification number(s) EC number: Index number: SVHC propylene oxide 4 First aid measures Description of first aid measures General information: Immediately remove any clothing soiled by the product. Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident. Remove breathing equipment only after contaminated clothing have been completely removed. In case of irregular breathing or respiratory arrest provide artificial respiration. After inhalation: Supply fresh air or oxygen; call for doctor. In case of unconsciousness place patient stably in side position for transportation. After skin contact: Immediately wash with water and soap and rinse thoroughly. After eye contact: Rinse opened eye for several minutes under running water. Then consult a doctor. After swallowing: Call for a doctor immediately. Information for doctor: Most important symptoms and effects, both acute and delayed No further relevant information available. (Contd. on page 4) AU

15 Safety data sheet according to 1907/2006/EC, Article 31 Page 4/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT Indication of any immediate medical attention and special treatment needed No further relevant information available. (Contd. of page 3) 5 Firefighting measures Extinguishing media Suitable extinguishing agents: CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Special hazards arising from the substance or mixture No further relevant information available. Advice for firefighters Protective equipment: Mouth respiratory protective device. 6 Accidental release measures Personal precautions, protective equipment and emergency procedures Wear protective equipment. Keep unprotected persons away. Environmental precautions: Dilute with plenty of water. Do not allow to enter sewers/ surface or ground water. Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust). Dispose contaminated material as waste according to item 13. Ensure adequate ventilation. Reference to other sections See Section 7 for information on safe handling. See Section 8 for information on personal protection equipment. See Section 13 for disposal information. 7 Handling and storage Handling: Precautions for safe handling Ensure good ventilation/exhaustion at the workplace. Open and handle receptacle with care. Prevent formation of aerosols. Information about fire - and explosion protection: Keep ignition sources away - Do not smoke. Protect from heat. Protect against electrostatic charges. Keep respiratory protective device available. Conditions for safe storage, including any incompatibilities Storage: Requirements to be met by storerooms and receptacles: Store in a cool location. Information about storage in one common storage facility: Not required. Further information about storage conditions: Keep container tightly sealed. Do not seal receptacle gas tight. Store in cool, dry conditions in well sealed receptacles. Protect from heat and direct sunlight. (Contd. on page 5) AU

16 Safety data sheet according to 1907/2006/EC, Article 31 Page 5/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT Specific end use(s) No further relevant information available. (Contd. of page 4) 8 Exposure controls/personal protection Additional information about design of technical facilities: No further data; see item 7. Control parameters Ingredients with limit values that require monitoring at the workplace: propylene oxide NES Long-term value: 48 mg/m³, 20 ppm Additional information: The lists valid during the making were used as basis. Exposure controls Personal protective equipment: General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing Wash hands before breaks and at the end of work. Store protective clothing separately. Avoid contact with the skin. Avoid contact with the eyes and skin. Respiratory protection: In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use self-contained respiratory protective device. Protection of hands: Protective gloves The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. Penetration time of glove material The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed. Eye protection: Tightly sealed goggles AU (Contd. on page 6)

17 Safety data sheet according to 1907/2006/EC, Article 31 Page 6/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 5) 9 Physical and chemical properties Information on basic physical and chemical properties General Information Appearance: Form: Liquid Colour: Colourless Odour: Characteristic Odour threshold: Not determined. ph-value: Not determined. Change in condition Melting point/melting range: C Boiling point/boiling range: 34.3 C Flash point: -37 C Flammability (solid, gaseous): Not applicable. Ignition temperature: 430 C Decomposition temperature: Not determined. Self-igniting: Not determined. Danger of explosion: Product is not explosive. However, formation of explosive air/vapour mixtures are possible. Explosion limits: Lower: 1.9 Vol % Upper: 15 Vol % Vapour pressure at 20 C: 590 hpa Density at 20 C: g/cm³ Relative density Not determined. Vapour density Not determined. Evaporation rate Not determined. Solubility in / Miscibility with water at 20 C: 405 g/l Partition coefficient (n-octanol/water): Not determined. Viscosity: Dynamic: Kinematic: Not determined. Not determined. Solvent content: Organic solvents: 0.0 % VOC (EC) 0.00 % Other information No further relevant information available. 10 Stability and reactivity Reactivity Chemical stability Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. Possibility of hazardous reactions No dangerous reactions known. (Contd. on page 7) AU

18 Safety data sheet according to 1907/2006/EC, Article 31 Page 7/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT Conditions to avoid No further relevant information available. Incompatible materials: No further relevant information available. Hazardous decomposition products: No dangerous decomposition products known. (Contd. of page 6) 11 Toxicological information Information on toxicological effects Acute toxicity LD/LC50 values relevant for classification: propylene oxide Oral LD mg/kg (rat) Dermal LD mg/kg (rabbit) Primary irritant effect: Skin corrosion/irritation Irritant to skin and mucous membranes. Serious eye damage/irritation Strong irritant with the danger of severe eye injury. Respiratory or skin sensitisation No sensitising effects known. CMR effects (carcinogenity, mutagenicity and toxicity for reproduction) Muta. 1B, Carc. 1B 12 Ecological information Toxicity Aquatic toxicity: No further relevant information available. Persistence and degradability No further relevant information available. Behaviour in environmental systems: Bioaccumulative potential No further relevant information available. Mobility in soil No further relevant information available. Additional ecological information: General notes: Water hazard class 3 (German Regulation) (Self-assessment): extremely hazardous for water Do not allow product to reach ground water, water course or sewage system, even in small quantities. Danger to drinking water if even extremely small quantities leak into the ground. Results of PBT and vpvb assessment PBT: Not applicable. vpvb: Not applicable. Other adverse effects No further relevant information available. 13 Disposal considerations Waste treatment methods Recommendation Must not be disposed together with household garbage. Do not allow product to reach sewage system. Uncleaned packaging: Recommendation: Disposal must be made according to official regulations. Recommended cleansing agents: Water, if necessary together with cleansing agents. AU (Contd. on page 8)

19 Safety data sheet according to 1907/2006/EC, Article 31 Page 8/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 7) 14 Transport information UN-Number ADG, IMDG, IATA UN1280 UN proper shipping name ADG 1280 PROPYLENE OXIDE IMDG, IATA PROPYLENE OXIDE Transport hazard class(es) ADG, IMDG, IATA Class 3 Flammable liquids. Label 3 Packing group ADG, IMDG, IATA I Environmental hazards: Marine pollutant: No Special precautions for user Warning: Flammable liquids. Danger code (Kemler): 339 EMS Number: F-E,S-D Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code Transport/Additional information: Not applicable. ADG Limited quantities (LQ) 0 Excepted quantities (EQ) Code: E3 Maximum net quantity per inner packaging: 30 ml Maximum net quantity per outer packaging: 300 ml Transport category 1 Tunnel restriction code D/E IMDG Limited quantities (LQ) 0 Excepted quantities (EQ) Code: E3 Maximum net quantity per inner packaging: 30 ml Maximum net quantity per outer packaging: 300 ml UN "Model Regulation": UN1280, PROPYLENE OXIDE, 3, I 15 Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture Australian Inventory of Chemical Substances Substance is listed. Standard for the Uniform Scheduling of Medicines and Poisons propylene oxide S7 (Contd. on page 9) AU

20 Safety data sheet according to 1907/2006/EC, Article 31 Page 9/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT GHS label elements The substance is classified and labelled according to the Globally Harmonised System (GHS). Hazard pictograms (Contd. of page 8) GHS02 GHS05 GHS06 GHS07 GHS08 Signal word Danger Hazard-determining components of labelling: propylene oxide Hazard statements Extremely flammable liquid and vapour. Harmful if swallowed. Toxic in contact with skin or if inhaled. Causes skin irritation. Causes serious eye damage. May cause genetic defects. May cause cancer. May cause respiratory irritation. Precautionary statements Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Use explosion-proof electrical/ventilating/lighting/equipment. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use only non-sparking tools. Avoid release to the environment. Take precautionary measures against static discharge. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. Specific measures (see on this label). IF INHALED: Remove person to fresh air and keep comfortable for breathing. If skin irritation occurs: Get medical advice/attention. Rinse mouth. In case of fire: Use for extinction: CO2, powder or water spray. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations. Directive 2012/18/EU Named dangerous substances - ANNEX I Substance is not listed. (Contd. on page 10) AU

21 Safety data sheet according to 1907/2006/EC, Article 31 Page 10/10 Printing date Revision: Trade name: PROPYLENE OXIDE, ACS REAGENT National regulations: (Contd. of page 9) Information about limitation of use: Workers are not allowed to be exposed to this hazardous material. Exceptions can be made by the authorities in certain cases. Other regulations, limitations and prohibitive regulations Substances of very high concern (SVHC) according to REACH, Article propylene oxide Chemical safety assessment: A Chemical Safety Assessment has not been carried out. 16 Other information This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. Abbreviations and acronyms: ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreement concerning the International Carriage of Dangerous Goods by Road) IMDG: International Maritime Code for Dangerous Goods IATA: International Air Transport Association EINECS: European Inventory of Existing Commercial Chemical Substances CAS: Chemical Abstracts Service (division of the American Chemical Society) VOC: Volatile Organic Compounds (USA, EU) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent Flam. Liq. 1: Flammable liquids, Hazard Category 1 Acute Tox. 4: Acute toxicity, Hazard Category 4 Acute Tox. 3: Acute toxicity, Hazard Category 3 Skin Irrit. 2: Skin corrosion/irritation, Hazard Category 2 Eye Dam. 1: Serious eye damage/eye irritation, Hazard Category 1 Muta. 1B: Germ cell mutagenicity, Hazard Category 1B Carc. 1B: Carcinogenicity, Hazard Category 1B STOT SE 3: Specific target organ toxicity - Single exposure, Hazard Category 3 AU

22 Safety Data Sheet acc. to OSHA HCS Page 1/10 Printing date 09/21/2015 Reviewed on 09/21/ Identification Product identifier Trade name: PROPYLENE OXIDE, ACS REAGENT Article number: 20401, 20411, 20412, CAS Number: EC number: Index number: Relevant identified uses of the substance or mixture and uses advised against No further relevant information available. Application of the substance / the mixture Laboratory chemicals Details of the supplier of the safety data sheet Manufacturer/Supplier: Electron Microscopy Sciences 1560 Industry Road USA-Hatfield, PA Tel: Fax: sgkcck@aol.com Information department: Product safety department Emergency telephone number: ChemTrec Contract CCN Hazard(s) identification Classification of the substance or mixture GHS02 Flame Flam. Liq. 1 H224 Extremely flammable liquid and vapor. GHS06 Skull and crossbones Acute Tox. 3 Acute Tox. 3 H311 Toxic in contact with skin. H331 Toxic if inhaled. GHS08 Health hazard Muta. 1B Carc. 1B H340 May cause genetic defects. H350 May cause cancer. GHS05 Corrosion Eye Dam. 1 H318 Causes serious eye damage. (Contd. on page 2) CA

23 Safety Data Sheet acc. to OSHA HCS Page 2/10 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 1) GHS07 Acute Tox. 4 Skin Irrit. 2 STOT SE 3 H302 Harmful if swallowed. H315 Causes skin irritation. H335 May cause respiratory irritation. Aquatic Acute 3 H402 Harmful to aquatic life. Aquatic Chronic 3 H412 Harmful to aquatic life with long lasting effects. Classification according to Directive 67/548/EEC or Directive 1999/45/EC Not applicable. Toxic Carc. Cat. 2, Muta. Cat. 2 May cause cancer. May cause heritable genetic damage. Toxic by inhalation and in contact with skin. Harmful Harmful if swallowed. Irritant Irritating to respiratory system and skin. Risk of serious damage to eyes. Extremely flammable Extremely flammable. Information concerning particular hazards for human and environment: Not applicable. Label elements Labelling according to EU guidelines: The product has been classified and marked in accordance with directives on hazardous materials. Code letter and hazard designation of product: Carc. Cat. 2, Muta. Cat. 2 Toxic Extremely flammable Risk phrases: May cause cancer. May cause heritable genetic damage. Extremely flammable. Also harmful if swallowed. Also toxic by inhalation and in contact with skin. Irritating to respiratory system and skin. Risk of serious damage to eyes. Safety phrases: Avoid exposure - obtain special instructions before use. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). This material and its container must be disposed of as hazardous waste. (Contd. on page 3) CA

24 Safety Data Sheet acc. to OSHA HCS Page 3/10 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT Hazard description: WHMIS-symbols: B2 - Flammable liquid D1B - Toxic material causing immediate and serious toxic effects D2A - Very toxic material causing other toxic effects (Contd. of page 2) Classification system: NFPA ratings (scale 0-4) Health = 3 Fire = 4 Reactivity = 0 HMIS-ratings (scale 0-4) HEALTH FIRE REACTIVITY Health = 3 Fire = 4 Reactivity = 0 Other hazards Results of PBT and vpvb assessment PBT: Not applicable. vpvb: Not applicable. 3 Composition/information on ingredients Chemical characterization: Substances CAS No. Description propylene oxide Identification number(s) EC number: Index number: SVHC propylene oxide 4 First-aid measures Description of first aid measures General information: Immediately remove any clothing soiled by the product. Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident. Remove breathing apparatus only after contaminated clothing have been completely removed. In case of irregular breathing or respiratory arrest provide artificial respiration. After inhalation: Supply fresh air or oxygen; call for doctor. In case of unconsciousness place patient stably in side position for transportation. After skin contact: Immediately wash with water and soap and rinse thoroughly. After eye contact: Rinse opened eye for several minutes under running water. Then consult a doctor. (Contd. on page 4) CA

25 Safety Data Sheet acc. to OSHA HCS Page 4/10 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 3) After swallowing: Immediately call a doctor. Information for doctor: Most important symptoms and effects, both acute and delayed No further relevant information available. Indication of any immediate medical attention and special treatment needed No further relevant information available. 5 Fire-fighting measures Extinguishing media Suitable extinguishing agents: CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Special hazards arising from the substance or mixture No further relevant information available. Advice for firefighters Protective equipment: Mouth respiratory protective device. 6 Accidental release measures Personal precautions, protective equipment and emergency procedures Wear protective equipment. Keep unprotected persons away. Environmental precautions: Dilute with plenty of water. Do not allow to enter sewers/ surface or ground water. Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust). Dispose contaminated material as waste according to item 13. Ensure adequate ventilation. Reference to other sections See Section 7 for information on safe handling. See Section 8 for information on personal protection equipment. See Section 13 for disposal information. 7 Handling and storage Handling: Precautions for safe handling Ensure good ventilation/exhaustion at the workplace. Open and handle receptacle with care. Prevent formation of aerosols. Information about protection against explosions and fires: Keep ignition sources away - Do not smoke. Protect from heat. Protect against electrostatic charges. Keep respiratory protective device available. Conditions for safe storage, including any incompatibilities Storage: Requirements to be met by storerooms and receptacles: Store in a cool location. Information about storage in one common storage facility: Not required. Further information about storage conditions: Keep receptacle tightly sealed. Do not gas tight seal receptacle. Store in cool, dry conditions in well sealed receptacles. (Contd. on page 5) CA

26 Safety Data Sheet acc. to OSHA HCS Page 5/10 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT Protect from heat and direct sunlight. Specific end use(s) No further relevant information available. (Contd. of page 4) 8 Exposure controls/personal protection Additional information about design of technical systems: No further data; see item 7. Control parameters Components with limit values that require monitoring at the workplace: propylene oxide EL Long-term value: 2 ppm IARC 2B; S EV Long-term value: 2 ppm Additional information: The lists that were valid during the creation were used as basis. Exposure controls Personal protective equipment: General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. Store protective clothing separately. Avoid contact with the skin. Avoid contact with the eyes and skin. Breathing equipment: In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air. Protection of hands: Protective gloves The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. Penetration time of glove material The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed. Eye protection: Tightly sealed goggles CA (Contd. on page 6)

27 Safety Data Sheet acc. to OSHA HCS Page 6/10 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT (Contd. of page 5) 9 Physical and chemical properties Information on basic physical and chemical properties General Information Appearance: Form: Liquid Color: Colorless Odor: Characteristic Odour threshold: Not determined. ph-value: Not determined. Change in condition Melting point/melting range: C Boiling point/boiling range: 34.3 C Flash point: -37 C Flammability (solid, gaseous): Not flammable. Ignition temperature: 430 C Decomposition temperature: Not determined. Auto igniting: Not determined. Danger of explosion: Product is not explosive. However, formation of explosive air/vapor mixtures are possible. Explosion limits: Lower: 1.9 Vol % Upper: 15 Vol % Vapor pressure at 20 C: 590 hpa Density at 20 C: g/cm³ Relative density Not determined. Vapour density Not determined. Evaporation rate Not determined. Solubility in / Miscibility with Water at 20 C: 405 g/l Partition coefficient (n-octanol/water): Not determined. Viscosity: Dynamic: Not determined. Kinematic: Not determined. Organic solvents: 0.0 % Other information No further relevant information available. 10 Stability and reactivity Reactivity Chemical stability Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. Possibility of hazardous reactions No dangerous reactions known. Conditions to avoid No further relevant information available. Incompatible materials: No further relevant information available. (Contd. on page 7) CA

28 Safety Data Sheet acc. to OSHA HCS Page 7/10 Printing date 09/21/2015 Reviewed on 09/21/2015 Trade name: PROPYLENE OXIDE, ACS REAGENT Hazardous decomposition products: No dangerous decomposition products known. (Contd. of page 6) 11 Toxicological information Information on toxicological effects Acute toxicity: LD/LC50 values that are relevant for classification: propylene oxide Oral LD mg/kg (rat) Dermal LD mg/kg (rabbit) Primary irritant effect: on the skin: Irritant to skin and mucous membranes. on the eye: Strong irritant with the danger of severe eye injury. Sensitization: No sensitizing effects known. Additional toxicological information: Carcinogenic categories IARC (International Agency for Research on Cancer) propylene oxide 2B NTP (National Toxicology Program) propylene oxide R OSHA-Ca (Occupational Safety Health Administration) Substance is not listed. 12 Ecological information Toxicity Aquatic toxicity: No further relevant information available. Persistence and degradability No further relevant information available. Behavior in environmental systems: Bioaccumulative potential No further relevant information available. Mobility in soil No further relevant information available. Additional ecological information: General notes: Water hazard class 3 (Self-assessment): extremely hazardous for water Do not allow product to reach ground water, water course or sewage system, even in small quantities. Danger to drinking water if even extremely small quantities leak into the ground. Results of PBT and vpvb assessment PBT: Not applicable. vpvb: Not applicable. Other adverse effects No further relevant information available. 13 Disposal considerations Waste treatment methods Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system. (Contd. on page 8) CA