3. (((fatty or fat or steato*) adj3 (liver* or hepat*)) or steatohepat* or (visceral adj2 steato*)).ti,ab

Transcription

1 Search strategy for MEDLINE Steatosis: 1. fatty liver/ 2. non-alcoholic fatty liver disease/ 3. (((fatty or fat or steato*) adj3 (liver* or hepat*)) or steatohepat* or (visceral adj2 steato*)).ti,ab 4. (nafl* or nash).ti,ab. 5. or/ letter/ 7. editorial/ 8. news/ 9. exp historical article/ 10. anecdotes as topic/ 11. comment/ 12. case report/ 13. (letter or comment*).ti. 14. or/ randomized controlled trial/ or random*.ti,ab not animals/ not humans/ 18. exp animals, laboratory/ 19. exp animal experimentation/ 20. exp models, animal/ 21. exp rodentia/ 22. (rat or rats or mouse or mice).ti. 23. or/ not

2 26. limit 24 to English language 27. alanine transaminase/ 28. aspartate aminotransferases/ 29. gamma-glutamyltransferase/ 30. (test* or measure* or level* or ratio*).ti,ab. 31. or/ and ((alanine transaminase* or alt or aspartate aminotransferase* or ast or gamma glutamyltransferase* or gamma gt or gammagt or ggt) adj4 (test* or measure* or level* or ratio*)).ti,ab. 34. (fatty liver ind* or fli).ti,ab. 35. (steatotest or steato test).ti,ab. 36. liver fat scor*.ti,ab. 37. ultrasonography/ or exp ultrasonography, doppler/ 38. (ultrasound* or ultrason* or sonograph* or echograph*).ti,ab. 39. magnetic resonance imaging/ 40. magnetic resonance spectroscopy/ 41. (mri or mrs or ((magnetic or mr) adj2 (imag* or spectroscop*))).ti,ab. 42. controlled attenuation parameter.ti,ab. 43. elasticity imaging techniques/ 44. alanine transaminase/ 45. or/ and exp "sensitivity and specificity"/ 48. (sensitivity or specificity).ti,ab. 49. ((pre test or pretest or post test) adj probability).ti,ab. 50. (predictive value* or ppv or npv).ti,ab. 51. likelihood ratio*.ti,ab.

3 52. likelihood function/ 53. (roc curve* or auc).ti,ab. 54. (diagnos* adj3 (performance* or accurac* or utilit* or value* or efficien* or effectiveness)).ti,ab. 55. gold standard.ab. 56. or/ and limit 57 to yr="2015 -Current" Fibrosis: 1. fatty liver/ 2. non-alcoholic fatty liver disease/ 3. (((fatty or fat or steato*) adj3 (liver* or hepat*)) or steatohepat* or (visceral adj2 steato*)).ti,ab. 4. (nafl* or nash).ti,ab. 5. or/ letter/ 7. editorial/ 8. news/ 9. exp historical article/ 10. anecdotes as topic/ 11. comment/ 12. case report/ 13. (letter or comment*).ti. 14. or/ randomized controlled trial/ or random*.ti,ab not animals/ not humans/ 18. exp animals, laboratory/ 19. exp animal experimentation/

4 20. exp models, animal/ 21. exp rodentia/ 22. (rat or rats or mouse or mice).ti. 23. or/ not limit 24 to english language 26. biological markers/ 27. alanine transaminase/ 28. exp aspartate aminotransferases/ 29. keratin-18/ 30. ferritin/ 31. or/ (test* or measure* or level* or diagnos* or ratio or score*).ti,ab and (fibro test* or fibro-test* or fibrometer or fibroscan or fib4 or fib-4).ti,ab. 35. ((nafld or bard or ferritin* or fibrosis) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 36. ((glutamic-pyruvic transaminase or glutamic-oxaloacetic transaminase or sgot or sgpt or alt or ast) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 37. (aspartate adj2 (aminotransferase or apoaminotransferase or transaminase) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 38. (alanine adj2 (aminotransferase or transaminase) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 39. ((ast-to-platelet ratio index or apri or elf or enhanced liver fibrosis or nash) adj4 (test* or measure* or level* or score*)).ti,ab. 40. ((biomarker* or marker*) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 41. exp magnetic resonance spectroscopy/ 42. exp diffusion magnetic resonance imaging/ 43. (elastogra* or sonoelastogra* or elasticity imag* or sheer wave).ti,ab. 44. (acoustic radiation force impulse or arfi).ti,ab.

5 45. ((diffusion or weighted) adj2 (imag* or mri)).ti,ab. 46. (mrs or ((nmr or magnetic or mr) adj2 spectroscop*)).ti,ab. 47. or/ and exp "sensitivity and specificity"/ 50. (sensitivity or specificity).ti,ab. 51. ((pre test or pretest or post test) adj probability).ti,ab. 52. (predictive value* or ppv or npv).ti,ab. 53. likelihood ratio*.ti,ab. 54. likelihood function/ 55. (roc curve* or auc).ti,ab. 56. (diagnos* adj3 (performance* or accurac* or utilit* or value* or efficien* or effectiveness)).ti,ab. 57. gold standard.ab. 58. or/ and limit 59 to yr="2015 -Current" Search strategy for EMBASE Steatosis 1. nonalcoholic fatty liver/ 2. (((fatty or fat or steato*) adj3 (liver* or hepat*)) or steatohepat* or (visceral adj2 steato*)).ti,ab. 3. (nafl* or nash).ti,ab. 4. or/ letter.pt. or letter/ 6. note.pt. 7. editorial.pt. 8. case report/ or case study/ 9. (letter or comment*).ti.

6 10. conference*.pt. 11. or/ randomized controlled trial/ or random*.ti,ab not animal/ not human/ 15. nonhuman/ 16. exp animal experiment/ 17. exp experimental animal/ 18. animal model/ 19. exp rodent/ 20. (rat or rats or mouse or mice).ti. 21. or/ not limit 22 to english language 25. *alanine aminotransferase/ 26. *aspartate aminotransferase/ 27. *gamma glutamyltransferase/ 28. or/ (test* or measure* or level* or ratio*).ti,ab and ((alanine transaminase* or alt or aspartate aminotransferase* or ast or gamma glutamyltransferase* or gamma gt or gammagt or ggt) adj4 (test* or measure* or level* or ratio*)).ti,ab. 32. (fatty liver ind* or fli).ti,ab. 33. (steatotest or steato test).ti,ab. 34. liver fat scor*.ti,ab. 35. *echography/ or *doppler echography/

7 36. (ultrasound* or ultrason* or sonograph* or echograph*).ti,ab. 37. *nuclear magnetic resonance imaging/ 38. *nuclear magnetic resonance spectroscopy/ 39. (mri or mrs or ((magnetic or mr) adj2 (imag* or spectroscop*))).ti,ab. 40. controlled attenuation parameter.ti,ab. 41. *elastography/ 42. or/ and exp "sensitivity and specificity"/ 45. (sensitivity or specificity).ti,ab. 46. ((pre test or pretest or post test) adj probability).ti,ab. 47. (predictive value* or ppv or npv).ti,ab. 48. likelihood ratio*.ti,ab. 49. likelihood function/ 50. (roc curve* or auc).ti,ab. 51. (diagnos* adj3 (performance* or accurac* or utilit* or value* or efficien* or effectiveness)).ti,ab. 52. gold standard.ab. 53. or/ and limit 54 to yr="2015 -Current" Fibrosis: 1. nonalcoholic fatty liver/ 2. (((fatty or fat or steato*) adj3 (liver* or hepat*)) or steatohepat* or (visceral adj2 steato*)).ti,ab. 3. (nafl* or nash).ti,ab. 4. or/ letter.pt. or letter/ 6. note.pt.

8 7. editorial.pt. 8. case report/ or case study/ 9. (letter or comment*).ti. 10. or/ randomized controlled trial/ or random*.ti,ab not animal/ not human/ 14. nonhuman/ 15. exp animal experiment/ 16. exp experimental animal/ 17. animal model/ 18. exp rodent/ 19. (rat or rats or mouse or mice).ti. 20. or/ not limit 21 to english language 23. biological marker/ 24. alanine aminotransferase/ 25. exp aspartate aminotransferases/ 26. cytokeratin 18/ 27. ferritin/ 28. or/ (test* or measure* or level* or diagnos* or ratio or score*).ti,ab and (fibro test* or fibro-test* or fibrometer or fibroscan or fib4 or fib-4).ti,ab. 32. ((nafld or bard or ferritin* or fibrosis) adj4 (test* or measure* or level* or ratio or score*)).ti,ab.

9 33. ((glutamic-pyruvic transaminase or glutamic-oxaloacetic transaminase or sgot or sgpt or alt or ast) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 34. (aspartate adj2 (aminotransferase or apoaminotransferase or transaminase) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 35. (alanine adj2 (aminotransferase or transaminase) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 36. ((ast-to-platelet ratio index or apri or elf or enhanced liver fibrosis or nash) adj4 (test* or measure* or level* or score*)).ti,ab. 37. ((biomarker* or marker*) adj4 (test* or measure* or level* or ratio or score*)).ti,ab. 38. exp nuclear magnetic resonance spectroscopy/ 39. exp diffusion weighted imaging/ 40. (elastogra* or sonoelastogra* or elasticity imag* or sheer wave).ti,ab. 41. (acoustic radiation force impulse or arfi).ti,ab. 42. ((diffusion or weighted) adj2 (imag* or mri)).ti,ab. 43. (mrs or ((nmr or magnetic or mr) adj2 spectroscop*)).ti,ab. 44. or/ and exp "sensitivity and specificity"/ 47. (sensitivity or specificity).ti,ab. 48. ((pre test or pretest or post test) adj probability).ti,ab. 49. (predictive value* or ppv or npv).ti,ab. 50. likelihood ratio*.ti,ab. 51. (roc curve* or auc).ti,ab. 52. (diagnos* adj2 (performance* or accurac* or utilit* or value* or efficien* or effectiveness)).ti,ab. 53. diagnostic accuracy/ 54. diagnostic test accuracy study/ 55. gold standard.ab. 56. or/ and 56

10 58. limit 57 to yr="2015 -Current" Search strategy for Cochrane library collection Steatosis: #1 [mh ^"fatty liver"] #2 MeSH descriptor: [Non-alcoholic Fatty Liver Disease] this term only #3 (((fatty or fat or steato*) near/3 (liver* or hepat*)) or steatohepat* or (visceral near/2 steato*)):ti,ab #4 (nafl* or nash):ti,ab #5 {or #1-#4} #6 [mh ^"alanine transaminase"] #7 [mh ^"aspartate aminotransferases"] #8 [mh ^gamma-glutamyltransferase] #9 {or #2-#4} #10 (test* or measure* or level* or ratio*):ti,ab #11 #5 and #6 #12 ((alanine next transaminase* or alt or aspartate next aminotransferase* or ast or gamma next glutamyltransferase* or gamma next gt or gammagt or ggt) near/4 (test* or measure* or level* or ratio*)):ti,ab #13 (fatty next liver next ind* or fli):ti,ab #14 (steatotest or steato next test):ti,ab #15 liver next fat next scor*:ti,ab #16 [mh ^ultrasonography] #17 [mh "ultrasonography, doppler"] #18 (ultrasound* or ultrason* or sonograph* or echograph):ti,ab #19 [mh ^"magnetic resonance imaging"] #20 [mh ^"magnetic resonance spectroscopy"] #21 (mri or mrs or ((magnetic or mr) near/2 (imag* or spectroscop*))):ti,ab #22 controlled attenuation parameter:ti,ab #23 [mh ^"elasticity imaging techniques"]

11 #24 {or #11-#23} #25 #4 and #24 Publication Year from 2015 to 2017 Fibrosis #1 [mh ^"fatty liver"] #2 MeSH descriptor: [Non-alcoholic Fatty Liver Disease] this term only #3 (((fatty or fat or steato*) near/3 (liver* or hepat*)) or steatohepat* or (visceral near/2 steato*)):ti,ab #4 (nafl* or nash):ti,ab #5 {or #1-#4} #6 MeSH descriptor: [Biomarkers] this term only #7 MeSH descriptor: [Alanine Transaminase] explode all trees #8 MeSH descriptor: [Keratin-18] this term only #9 MeSH descriptor: [Ferritins] this term only #10 {or #2-#6} #11 (test* or measure* or level* or ratio or diagnos* or score*):ti,ab #12 #7 and #8 #13 (fibro test* or fibro-test* or fibrometer or fibroscan or fib4 or fib-4):ti,ab #14 ((nafld or bard or ferritin* or fibrosis) near/4 (test* measure* or level* or ratio or score*)):ti,ab #15 ((glutamic-pyruvic transaminase or glutamic-oxaloacetic transaminase or sgot or sgpt or alt or ast) near/4 (test* or measure* or level* or ratio or score*)):ti,ab #16 (aspartate near/2 (aminotransferase or apoaminotransferase or transaminase) near/4 (test* or measure* or level* or ratio or score*)):ti,ab #17 (alanine near/2 (aminotransferase or transaminase) near/4 (test* or measure* or level* or ratio or score*)):ti,ab #18 ((ast-to-platelet raio index or apri or elf or enhanced liver fibrosis or nash) near/4 (test* or measure* or level* or score*)):ti,ab #19 ((biomarker* or marker*) near/4 (test* or measure* or level* or ratio or score*)):ti,ab #20 MeSH descriptor: [Magnetic Resonance Spectroscopy] explode all trees #21 MeSH descriptor: [Diffusion Magnetic Resonance Imaging] explode all trees

12 #22 (elastogra* or sonoelastogra* or elasticity imag* or sheer wave):ti,ab #23 (acoustic radiation force impulse or arfi):ti,ab #24 ((diffusion or weighted) near/2 (imag* or mri)):ti,ab #25 (mrs or ((nmr or magneetic or mr) near/2 spectroscop*)):ti,ab #26 {or #12-#25} #27 #10 and #26 #28 #5 and #27 Publication Year from 2015 to 2017 Science Index Expanded Steatosis 1 (TS=(fatty liver OR nonalcoholic fatty liver OR non-alcoholic fatty liver disease*)) AND LANGUAGE: (English) 2 (TS=((fatty OR fat or steato*)near(liver* or hepat*))) AND LANGUAGE: (English) 3 (TS=(steatohepat* OR (visceral NEAR steato*))) AND LANGUAGE: (English) 4 (TS=("NAFLD" OR NAFL* OR NASH)) AND LANGUAGE: (English) 5 (#4 OR #3 OR #2 OR #1) AND LANGUAGE: (English) 6 (DT=(conference* OR letter* OR editorial* OR news* or historical* OR comment* OR case*)) AND LANGUAGE: (English) 7 (TS=(RCT OR randomi$ed controlled trial)) AND LANGUAGE: (English) 8 (#6 NOT #7) AND LANGUAGE: (English) 9 (TS=(animal* or animal model* or animal experimentation OR rodentia OR animals laboratory)) AND LANGUAGE: (English) 10 (TI=(rat* or mouse or mice)) AND LANGUAGE: (English) 11 (TS=(animal* NOT human*)) AND LANGUAGE: (English) 12 #11 OR #10 OR #9 13 (#5 NOT #12) AND LANGUAGE: (English) 14 (TS=(alanine transaminase* OR ALT)) AND LANGUAGE: (English) 15 (TS=(aspartate aminotransferase* OR AST)) AND LANGUAGE: (English) 16 (TS=(gamma-glutamyltransferase* or gamma glutamyltransferase* or GGT)) AND LANGUAGE: (English)

13 17 (TS=(test* or measure* or level* or ratio*)) AND LANGUAGE: (English) 18 #16 OR #15 OR #14 19 #18 AND #17 20 (TS=(fatty liver ind* OR "fatty liver index" OR fli)) AND LANGUAGE: (English) 21 (TS=(steatotest OR steato test)) AND LANGUAGE: (English) 22 (TS=(liver fat scor*)) AND LANGUAGE: (English) 23 (TS=(ultrasonograph* OR ultrasound* OR sonograph* or echograph*)) AND LANGUAGE: (English) 24 (TS=(magnetic resonance imaging* OR magnetic resonance spectroscop* OR MRI OR MRS)) AND LANGUAGE: (English) 25 (TS=((controlled attenuation parameter NEAR "CAP") OR elasticity imaging technique*)) AND LANGUAGE: (English) 26 (#25 OR #24 OR #23 OR #22 OR #21 OR #20 OR #19) AND LANGUAGE: (English) 27 #26 AND #13 28 (TS=( sensitivity and specificity)) AND LANGUAGE: (English) 29 (TS=(predictive value* or ppv or npv or likelihood ra tio* or roc curve* or auc)) AND LANGUAGE: (English) 30 (TS=(diagnostic accuracy OR diagnostic test accuracy study)) AND LANGUAGE: (English) 31 (TS=(diagnos* NEAR (performance* OR accurac* or utilit* or value* or efficien* or effectiveness))) AND LANGUAGE: (English) 32 (TS=(biops* AND gold standard)) AND LANGUAGE: (English) 33 #32 OR #31 OR #30 OR #29 OR #28 34 #33 AND #27 Indexes=SCI-EXPANDED Timespan= Fibrosis 1 (TS=(fatty liver OR nonalcoholic fatty liver OR non-alcoholic fatty liver disease*)) AND LANGUAGE: (English) 2 (TS=((fatty OR fat or steato*)near(liver* or hepat*))) AND LANGUAGE: (English) 3 (TS=(steatohepat* OR (visceral NEAR steato*))) AND LANGUAGE: (English) 4 (TS=("NAFLD" OR NAFL* OR NASH)) AND LANGUAGE: (English) 5 (#4 OR #3 OR #2 OR #1) AND LANGUAGE: (English)

14 6 (DT=(conference* OR letter* OR editorial* OR news* or historical* OR comment* OR case*)) AND LANGUAGE: (English) 7 (TS=(RCT OR randomi$ed controlled trial)) AND LANGUAGE: (English) 8 (#6 NOT #7) AND LANGUAGE: (English) 9 (TS=(animal* or animal model* or animal experimentation OR rodentia OR animals laboratory)) AND LANGUAGE: (English) 10 (TI=(rat* or mouse or mice)) AND LANGUAGE: (English) 11 (TS=(animal* NOT human*)) AND LANGUAGE: (English) 12 #11 OR #10 OR #9 13 (#5 NOT #12) AND LANGUAGE: (English) 14 (TS=(alanine transaminase* OR ALT)) AND LANGUAGE: (English) 15 (TS=(aspartate aminotransferase* OR AST)) AND LANGUAGE: (English) 16 TS=(gamma-glutamyltransferase* or gamma glutamyltransferase* or GGT or keratin?18 or ferritin or biological marker* or biomarker*) 17 TS=(test* or measure* or level* or ratio* or diagnos*) 18 #16 OR #15 OR #14 19 #18 AND #17 20 TS=((fibro test* or fibro-test* or fibrometer or fibroscan or fib4 or fib-4 or glutamic-pyruvic transaminase or glutamic-oxaloacetic transaminase or sgot or sgpt or nafld or bard or ferritin* or fibrosis or ast-to-platelet ratio OR apri or elf or "enhanced liver fibrosis" or nash or biomarker* or marker*) AND (test* or measure* or level* or ratio or score* or index)) 21 TS=((aspartate OR alanine) AND (aminotransferase OR apoaminotransferase or transaminase) AND (test* or level* or measure* or ratio or score*)) 22 TS=(magnetic resonance spectroscop* OR MRS OR "magnetic resonance imaging" OR MRI) 23 TS=(ultrasonograph* OR ultrasound* OR sonograph* or echograph* OR sonoelastogra* or elasticity imag* or "sheer wave" or acoustic radiation force impulse OR arfi) 24 TS=((diffusion or weighted) AND (imag* or mri)) 25 TS=(MRS OR (NMR or magnetic or mr)near spectroscop*) 26 (#25 OR #24 OR #23 OR #22 OR #21 OR #20 OR #19) AND LANGUAGE: (English) 27 #26 AND #13 28 (TS=( sensitivity and specificity)) AND LANGUAGE: (English)

15 29 (TS=(predictive value* or ppv or npv or likelihood ra tio* or roc curve* or auc)) AND LANGUAGE: (English) 30 (TS=(diagnostic accuracy OR diagnostic test accuracy study)) AND LANGUAGE: (English) 31 (TS=(diagnos* NEAR (performance* OR accurac* or utilit* or value* or efficien* or effectiveness))) AND LANGUAGE: (English) 32 (TS=(biops* AND gold standard)) AND LANGUAGE: (English) 33 #32 OR #31 OR #30 OR #29 OR #28 34 #33 AND #27 Indexes=SCI-EXPANDED Timespan=