Establishment of Reference Intervals for Thyroid- Stimulating Hormone and Free Thyroxine in Amniotic Fluid Using the Bayer ADVIA Centaur
|
|
- Irene Banks
- 6 years ago
- Views:
Transcription
1 Clinical Chemistry / THYROID HORMONES IN AMNIOTIC FLUID Establishment of Reference Intervals for Thyroid- Stimulating Hormone and Free Thyroxine in Amniotic Fluid Using the Bayer ADVIA Centaur Nikola A. Baumann, PhD *, and Ann M. Gronowski, PhD Key Words: Reference intervals; Thyroid hormone; Amniotic fluid DOI: 1.139/69A5AV266W23AUA Abstract: Thyroid hormone concentrations in amniotic fluid (AF) can aid in the diagnosis of fetal hypothyroidism. However, the availability of reference intervals for thyroid hormones in AF using current methods is limited. The purpose of this study was to validate the Bayer ADVIA Centaur (Bayer Healthcare, Tarrytown, NY) third-generation thyroid-stimulating hormone (TSH), total thyroxine (T 4 ), and free thyroxine ( ) assays for use with AF and establish reference intervals for these thyroid hormones in AF. Third-trimester AF samples were assayed for TSH, T 4, and. Reference intervals were calculated using nonparametric analyses. The reference intervals were as follows: TSH (n = 131),.4 to.51 µiu/ml ( miu/l), with a median of.1 µiu/ml (.1 miu/l); (n = 133), less than.1 to.77 ng/dl ( pmol/l), with a median of.26 ng/dl (3.35 pmol/l). T 4 in AF was undetectable using the Centaur assay, reinforcing the importance of validating different manufacturers immunoassays for use with nonserum specimens. These reference intervals represent the first study performed to date using a third-generation TSH assay and a sensitive assay. When thyroid disease arises during pregnancy, the mother can be evaluated by using maternal serum. Evaluation of the fetus for suspected thyroid abnormalities is far more difficult. Proper fetal diagnosis is especially important because thyroid disorders can lead to growth retardation and possible intrauterine death. Approximately 3% of fetal thyroid disorders are associated with goiter, 1 which can cause neck dystocia and respiratory distress. Evaluating thyroid abnormalities in the fetus is clinically difficult; yet, because in utero treatment is available, proper diagnosis is important. Although a fetal goiter can be distinguished during ultrasound examination, ultrasound does not differentiate between hyperthyroidism and hypothyroidism. For knowledge of specific thyroid derangements, direct sampling of cord blood in utero can be performed, but percutaneous umbilical blood sampling is a technically demanding procedure that poses risk of fetal bradycardia, hemorrhage, and possible fetal death. 2 Although the risk of fetal death is low, reported as.5% to 1% or less, 3 amniocentesis is a far simpler and safer procedure, with less risk to the fetus. Studies indicate that from the 12th week of gestation onward, there are steady increases in the fetal serum concentrations of total thyroxine (T 4 ), free thyroxine ( ), thyroidstimulating hormone (TSH), and thyroxine-binding globulin. 2,4 The increasing concentrations of fetal cord blood thyroid hormones correlate with increasing concentrations of amniotic fluid TSH and. 5 Furthermore, these increases are independent of maternal concentrations of the same hormones, indicating that there is no significant transplacental passage of TSH and thyroxine. 2,5 A previous study from this laboratory established reference intervals for thyroid hormones in amniotic fluid using the 158 Am J Clin Pathol 27;128: Downloaded 158 from DOI: 1.139/69A5AV266W23AUA
2 Clinical Chemistry / ORIGINAL ARTICLE Abbott AxSym method for TSH, total T 4, and. 6 In that study, clinical case reports from the literature were also examined, and in all cases of fetal hypothyroidism, the amniotic fluid TSH and concentrations were outside the newly established reference intervals. The data supported the use of thyroid hormone concentrations in amniotic fluid as an aid in the diagnosis of fetal hypothyroidism. However, that study was limited because it used a secondgeneration TSH assay. Today, more sensitive third-generation TSH assays and more sensitive assays are routinely used. Furthermore, it is important to establish and/or validate reference intervals when changing assay methods or when assessing different patient populations. Recent studies comparing automated TSH methods have shown that TSH methods do not provide comparable results across the analytic measurement range. 7 The present study expands on previous studies, establishing amniotic fluid reference intervals for TSH, T 4, and using more sensitive assays on the ADVIA Centaur automated immunoassay analyzer (Bayer Healthcare, Tarrytown, NY). Materials and Methods Samples Leftover amniotic fluid samples sent to the Barnes- Jewish Hospital chemistry laboratory (St Louis, MO) for fetal lung maturity testing from July 22 through November 25 and stored at 2 C were used. All samples were visually inspected for the presence of blood. Amniotic fluid specimens with visible blood contamination were excluded from the study. The study was approved by the Washington University Human Studies Committee (St Louis). Validation of Assays for Use With Amniotic Fluid The ADVIA Centaur automated immunoassay analyzer was used for all thyroid hormone measurements. The ADVIA TSH assay is a sandwich immunoassay with an analytic sensitivity of.2 µiu/ml (.2 miu/l). The ADVIA total T 4 assay is a competitive immunoassay with an analytic sensitivity of.3 µg/dl (3.87 nmol/l). The ADVIA assay is a competitive immunoassay with an analytic sensitivity of.1 ng/dl (1.29 pmol/l). This assay cannot be diluted, and our laboratory has established linearity in plasma to 4.5 ng/dl (58.1 pmol/l). Validation of the ADVIA Centaur thyroid hormone assays using amniotic fluid as a matrix was performed. Serum (2% vol/vol) with a known concentration of TSH, total T 4, or was added to amniotic fluid and then serially diluted using amniotic fluid with a low concentration of TSH, total T 4, or as the diluent. Samples were analyzed in duplicate, and recovery was calculated. As expected, because of binding protein equilibrium, cannot be accurately recovered from diluted specimens. Precision Studies Intra-assay precision for the TSH and assays was determined by measuring amniotic fluid samples 1 consecutive times. Precision was established at 2 concentrations of TSH and. Analyte Stability Studies The effect of the freeze-thaw process on the stability of TSH and was determined by measuring the hormones in 9 specimens before (within 24 hours of collection) and after freezing (24-48 hours) at 2 C. Results obtained before and after freezing were analyzed by using the t test. A P value of less than.5 was considered statistically significant. Calculation of Reference Intervals Thorough chart review for all cases was performed, and samples were excluded if there was a patient history of fetal anomalies, multiple gestations, or any evidence of thyroid disease. Gestational ages ranged from 31.3 to 39.4 weeks (median, 36 weeks). The level of TSH was measured in 131 specimens and of in 133 specimens. Central 95% reference intervals for TSH and were calculated using nonparametric analysis. 8 This process ranks data according to numeric value and calculates percentiles as a function of these ranked numbers. The concentrations at the 2.5 and 97.5 percentiles provide an estimate of the central 95% reference interval for the population based on the given set of data. Results The ADVIA Centaur TSH assay was validated for use with amniotic fluid. Recovery of serum TSH diluted in amniotic fluid was measured at 12 concentrations in the range between.8 µiu/ml (.8 miu/l) and 37 µiu/ml (37 miu/l) Figure 1A. The TSH concentrations (µiu/ml; to convert to miu/l, multiply by 1.) and percentages of recovery were as follows, respectively:.8 and 13%;.1 and 111%;.13 and 127%;.21 and 11%;.35 and 19%;.64 and 18%; 1.22 and 88%; 2.37 and 86%; 4.68 and 78%; 9.3 and 84%; 18.5 and 94%; and 37. and 89%. The mean ± SD recovery of serum TSH was 99% ± 15%. Recovery of serum T 4 when diluted in amniotic fluid is shown in Figure 1B. The T 4 concentrations (µg/dl; to convert to nmol/l, multiply by 12.9) and percentages of recovery were as follows, respectively:.9 and 182%; 1.8 and 164%, Downloaded from Am J Clin Pathol 27;128: DOI: 1.139/69A5AV266W23AUA 159
3 Baumann and Gronowski / THYROID HORMONES IN AMNIOTIC FLUID A B Observed TSH (µiu/ml) Observed T 4 (µg/dl) Expected TSH (µiu/ml) Expected T 4 (µg/dl) Figure 1 Recovery of serum thyroid-stimulating hormone (TSH; A) and total thyroxine (T 4 ; B) in amniotic fluid. Serum (2% vol/vol) with a known concentration of TSH or T 4 was added to amniotic fluid and then serially diluted using amniotic fluid as the diluent. The dashed line represents a slope of 1. A, Slope =.99; y-intercept =.12. Inset graph shows recovery in the low TSH concentration range. Samples were analyzed in duplicate. B, Slope = 1.518; y-intercept =.22. Values are given in conventional units; to convert to Système International units, for TSH (miu/l), multiply by 1.; for T 4 (nmol/l), multiply by and 158%; 3.5 and 159%; and 4.3 and 158%. The mean ± SD recovery of serum T 4 was 164% ± 1%. The recovery data demonstrated overrecovery of T 4, suggesting that the amniotic fluid matrix may affect the measurement of serum T 4 with this assay. in serum (2% vol/vol) was diluted into amniotic fluid, and recovery was measured using the ADVIA Centaur assay. recovery was 195% in this sample. This indicates that serum can be recovered and measured in amniotic fluid using the ADVIA Centaur assay. However, as expected, detailed recovery studies could not be performed because cannot be diluted and accurately measured owing to the effect of dilution on binding protein equilibrium. 9 Intra-assay precision studies were performed on patient amniotic fluid samples. The coefficients of variation (CVs) for the TSH and assays were less than 1%. The intra-assay CVs for the TSH assay in 1 samples were 9.% and 4.1% at TSH concentrations of.6 µiu/ml (.6 miu/l) and.11 µiu/ml (.11 miu/l), respectively. The assay had intraassay CVs of 9.6% and 9.8% at concentrations of.34 ng/dl (4.39 pmol/l) and.52 ng/dl (6.71 pmol/l), respectively (n = 1). It is interesting that we found that T 4 could not be detected in any patient amniotic fluid samples using the ADVIA Centaur method. This did not seem to be simply a matrix effect because serum T 4 could be diluted into amniotic fluid and measured (Figure 1B). This inability to measure amniotic fluid T 4 was further confirmed with 1 amniotic fluid samples that were measured using the ADVIA Centaur and the Abbott AxSym (Abbott Laboratories, Abbott Park, IL) instruments. Amniotic fluid samples analyzed using the Abbott AxSym total T 4 assay gave results between 1.8 and 2.9 µg/dl ( nmol/l), whereas all samples had undetectable T 4 (<1. µg/dl [12.9 nmol/l]) by the ADVIA Centaur assay. Amniotic fluid specimens were stored frozen ( 2 C) before analysis. Thus, it was necessary to determine the stability of TSH and after specimens were subjected to a freeze-thaw cycle. We analyzed 9 amniotic fluid specimens before (within 24 hours of collection) and after freezing (24-48 hours) at 2C. A single freeze-thaw cycle did not have a significant effect on thyroid hormone concentrations in amniotic fluid. Postfreeze TSH and results were within a mean ± SD of 21% ± 27% (P =.22) and 11% ± 21% (P =.8) of the original result, respectively Figure 2. Samples from 133 patients met selection criteria (see the Materials and Methods section) and were subsequently thawed and assayed immediately for TSH and (not all samples could have both assays performed owing to insufficient sample volume). The frequencies of amniotic fluid TSH and results are shown in Figure 3. Central 95% reference intervals, median values, and ranges for TSH and were calculated and are given in Table Am J Clin Pathol 27;128: Downloaded 16 from DOI: 1.139/69A5AV266W23AUA
4 Clinical Chemistry / ORIGINAL ARTICLE A.5 B TSH (µiu/ml).3.2 (ng/dl) TSH Prefreeze TSH Postfreeze. Prefreeze Postfreeze Figure 2 Stability of thyroid-stimulating hormone (TSH; A) and free thyroxine ( ; B) in amniotic fluid. Amniotic fluid specimens were assayed for TSH (A) and (B) before (within 24 hours of collection) and after freezing (24-48 hours) at 2 C. Values are given in conventional units; to convert to Système International units, for TSH (miu/l), multiply by 1.; for free T 4 (pmol/l), multiply by A 4 B Frequency 2 1 Frequency TSH (µiu/ml) (ng/dl) Figure 3 Frequencies of amniotic fluid thyroid hormone results. A, Thyroid-stimulating hormone (TSH). B, Free thyroxine ( ). Values are given in conventional units; to convert to Système International units, for TSH (miu/l), multiply by 1.; for free T 4 (pmol/l), multiply by Table 1 Reference Intervals for TSH and Free T 4 Calculated Using Nonparametric Analysis * No. of Samples Median Range Central 95% Reference Interval TSH (µiu/ml) Free T 4 (ng/dl) < < TSH, thyroid-stimulating hormone; T 4, thyroxine. * Values are given in conventional units; to convert to Système International units, for TSH (miu/l), multiply by 1.; for free T 4 (pmol/l), multiply by Discussion We established normal amniotic fluid reference intervals for TSH and. To our knowledge, this is the first study that has established these reference intervals using the ADVIA Centaur automated immunoassay analyzer. Our reference intervals for TSH and compare favorably with those in previous third-trimester studies. 5,6,1-12 An interesting and unexpected result from this study was the observation that amniotic fluid T 4 cannot be measured using the ADVIA Centaur. This does not seem to be simply a Downloaded from Am J Clin Pathol 27;128: DOI: 1.139/69A5AV266W23AUA 161
5 Baumann and Gronowski / THYROID HORMONES IN AMNIOTIC FLUID matrix effect of the fluid because serum with a known concentration of total T 4 can be recovered when diluted into amniotic fluid (recovery approximately 16%). Furthermore, 1 samples with undetectable total T 4 concentrations using the ADVIA Centaur had detectable T 4 concentrations using the Abbott AxSym analyzer. This observation could be the result of failure of the protein binding inhibitor used in the Centaur assay to release T 4 bound to proteins in amniotic fluid. This observation highlights the potential obstacles in adapting assays for use with a novel matrix such as amniotic fluid. It also emphasizes the importance of validating reference intervals before transferring them between platforms and methods. In addition, because of the inability to dilute specimens and perform in-depth validation experiments and the lack of information available on T 4 binding capacity in amniotic fluid or available information on amniotic fluid binding proteins, we believe that TSH is the preferred analyte for assessment of thyroid status in amniotic fluid when using the ADVIA Centaur immunoassay platform. Total T 4 has been shown to be a useful analyte using other manufacturer s assays; however, all assays must be validated before specimens are analyzed for diagnostic purposes. It is also possible that the ADVIA Centaur T 4 assay does not recognize sulfated T 4, which is a metabolite of T 4 in neonates and amniotic fluid. 13,14 This finding reinforces the importance of validating different manufacturers immunoassays for use with nonserum specimens. The samples used in this study were obtained from a population of women undergoing amniocentesis for fetal lung maturity analysis and do not necessarily represent a normal healthy population. Although this is important, we believe that the reference intervals are still useful as supported by a previous study. 6 Six specimens from women with known thyroid anomalies were excluded. All 6 of these women had amniotic fluid TSH and concentrations within our established reference intervals and, to the best of our knowledge, delivered normal infants. This supports the idea that amniotic fluid thyroid hormone concentrations reflect the thyroid status of the fetus and are independent of the thyroid status of the mother. A potential limitation of the present study is that amniotic fluid specimens were stored frozen for up to 3 years before analysis. However, we demonstrated that TSH and were not significantly affected by a freeze-thaw cycle (Figure 2). Previous studies 15 have also reported that TSH and thyroxine are stable in serum for up to 5 years at 2 C, lending support to the idea that these analytes are stable in specimens stored frozen for extended periods. The usefulness of thyroid hormone measurement in amniotic fluid lies in its use not only for diagnosis but also for management. Many authors have treated cases of fetal hypothyroid goiter with intrauterine thyroxine, using ultrasound examination to show regression of fetal goiter and amniotic fluid to show decreases in amniotic fluid TSH and/or increases in amniotic fluid T 4 levels. Application of our amniotic fluid reference intervals may provide a more relevant end point for therapy than ultrasound monitoring because the regression of goiter does not necessarily confer a euthyroid state. In addition, amniotic fluid is a simple sample to obtain in this setting because it is readily accessible when intrauterine thyroxine injections are performed. Fetal hyperthyroidism is currently diagnosed through findings of fetal goiter, tachycardia, advanced bone maturation, and abnormal cord serum testing. The usefulness of the amniotic fluid thyroid hormone reference ranges for diagnosing hyperthyroidism is unclear. We know of no published case reports of fetal hyperthyroidism in which amniotic fluid thyroid tests were performed. It is not possible to know how useful amniotic fluid TSH and measurements are in diagnosing and monitoring fetal hyperthyroidism until several cases of fetal hyperthyroidism are reported. We established reference intervals for TSH and in third-trimester amniotic fluid by using the ADVIA Centaur. This work expands on previous studies demonstrating that reference intervals for thyroid hormones (especially TSH) in amniotic fluid can be of significant use in the diagnosis and management of fetal hypothyroidism, reducing the need for umbilical blood sampling. From the Department of Pathology and Immunology, Division of Laboratory Medicine, Washington University School of Medicine St Louis, MO, Supported in part by Bayer Healthcare by supplying reagents. Presented in part at the American Association for Clinical Chemistry Annual Meeting; July 25; Orlando, FL. Address reprint requests to Dr Baumann: Dept of Pathology, University of Illinois Medical Center at Chicago, 84 S Wood St, Room 21-G, Chicago, IL Acknowledgment: We thank Mark H. Wener, MD, University of Washington, Seattle, for testing samples using the Abbott AxSym instrument. * Dr Baumann is currently with the Department of Pathology, University of Illinois Medical Center at Chicago. References 1. Volumenie JL, Polak M, Guibourdenche J, et al. Management of fetal thyroid goiters: a report of 11 cases in a single perinatal unit. Prenat Diagn. 2;2: Thorpe-Beeston JG, Nicolaides KH, McGregor AM. Fetal thyroid function. Thyroid. 1992;2: Daffos F. Fetal blood sampling. Annu Rev Med. 1989;4: Ballabio M, Nicolini U, Jowett T, et al. Maturation of thyroid function in normal human foetuses. Clin Endocrinol (Oxf). 1989;31: Yoshida K, Sakurada T, Takahashi T, et al. Measurement of TSH in human amniotic fluid: diagnosis of fetal thyroid abnormality in utero. Clin Endocrinol (Oxf). 1986;25: Am J Clin Pathol 27;128: Downloaded 162 from DOI: 1.139/69A5AV266W23AUA
6 Clinical Chemistry / ORIGINAL ARTICLE 6. Singh PK, Parvin CA, Gronowski AM. Establishment of reference intervals for markers of fetal thyroid status in amniotic fluid. J Clin Endocrinol Metab. 23;88: Rawlins ML, Roberts WL. Performance characteristics of six third-generation assays for thyroid-stimulating hormone. Clin Chem. 24;5: Solberg HE. Establishment and use of reference values. In: Burtis CA, Ashwood ER, eds. Tietz Textbook of Clinical Chemistry. Philadelphia, PA: Saunders; ADVIA Centaur Assay Manual. Tarrytown, NY: Bayer Healthcare; Kourides IA, Heath CV, Ginsberg-Fellner F. Measurement of thyroid-stimulating hormone in human amniotic fluid. J Clin Endocrinol Metab. 1982;54: Kourides IA, Berkowitz RL, Pang S, et al. Antepartum diagnosis of goitrous hypothyroidism by fetal ultrasonography and amniotic fluid thyrotropin concentration. J Clin Endocrinol Metab. 1984;59: Hollingsworth DR, Alexander NM. Amniotic fluid concentrations of iodothyronines and thyrotropin do not reliably predict fetal thyroid status in pregnancies complicated by maternal thyroid disorders or anencephaly. J Clin Endocrinol Metab. 1983;57: Chopra IJ, Santini F, Hurd RE, et al. A radioimmunoassay for measurement of thyroxine sulfate. J Clin Endocrinol Metab. 1993;76: Polk DH. Thyroid hormone metabolism during development. Reprod Fertil Dev. 1995;7: Vasiliades J, Hilgers T, Gentrup B. Long term stability of hormones in serum [abstract]. Clin Chem. 1995;41(suppl):S Perelman AH, Johnson RL, Clemons RD, et al. Intrauterine diagnosis and treatment of fetal goitrous hypothyroidism. J Clin Endocrinol Metab. 199;71: Bruner JP, Dellinger EH. Antenatal diagnosis and treatment of fetal hypothyroidism: a report of two cases. Fetal Diagn Ther. 1997;12: Perrotin F, Sembely-Taveau C, Haddad G, et al. Prenatal diagnosis and early in utero management of fetal dyshormonogenic goiter. Eur J Obstet Gynecol Reprod Biol. 21;94: Abuhamad AZ, Fisher DA, Warsof SF, et al. Antenatal diagnosis and treatment of fetal goitrous hypothyroidism: case report and review of the literature. Ultrasound Obstet Gynecol. 1995;6: Downloaded from Am J Clin Pathol 27;128: DOI: 1.139/69A5AV266W23AUA 163
Antenatal Diagnosis and Treatment of a Dyshormonogenetic Fetal Goiter
Case Report Antenatal Diagnosis and Treatment of a Dyshormonogenetic Fetal Goiter Kathleen A. Mayor-Lynn, MD, Henry J. Rohrs, III, MD, Amelia C. Cruz, MD, Janet H. Silverstein, MD, Douglas Richards, MD
More informationIntra-amniotic thyroxine to treat fetal goiter
Case Report Obstet Gynecol Sci 2016;59(1):66-70 http://dx.doi.org/10.5468/ogs.2016.59.1.66 pissn 2287-8572 eissn 2287-8580 Intra-amniotic thyroxine to treat fetal goiter Min-Jung Kim 1, Yong-Hwa Chae 2,
More informationPerformance Characteristics of Eight Estradiol Immunoassays
Clinical Chemistry / EVALUATION OF EIGHT ESTRADIOL IMMUNOASSAYS Performance Characteristics of Eight Estradiol Immunoassays David T. Yang, MD, 1 William E. Owen, MT(ASCP), 2 Carol S. Ramsay, 3 Hui Xie,
More informationComparison of Five Automated Serum and Whole Blood Folate Assays
Clinical Chemistry / FIVE AUTOMATED FOLATE ASSAYS Comparison of Five Automated Serum and Whole Blood Folate Assays William E. Owen, MT(ASCP), 1 and William L. Roberts, MD, PhD 2 Key Words: Hemolysate;
More informationPrevalence of thyroid disorder in pregnancy and pregnancy outcome
Original Research Article Prevalence of thyroid disorder in pregnancy and pregnancy outcome Praveena K.R. 1, Pramod Kumar K.R. 2*, Prasuna K.R. 3, Krishna Kumar TV 4 1 Assistant Professor, Department of
More informationThis supplementary material has been provided by the authors to give readers
Supplementary Online Content LI D, Radulescu A, Shrestha RT, et al. Association of biotin ingestion with performance of hormone and nonhormone assays in healthy adults. JAMA. doi:1.11/jama.217.1375 efigure
More informationThyroid Stimulating Hormone (TSH) ELISA Catalog No. GWB , legacy id (96 Tests)
For Research Use Only. Not for use in Diagnostic Procedures. INTENDED USE The GenWay, Inc. TSH ELISA Kit is intended for the quantitative measurement of TSH in human serum or plasma. For research use only.
More informationLothian Guidance for Diagnosis and Management of Thyroid Dysfunction in Pregnancy
Lothian Guidance for Diagnosis and Management of Thyroid Dysfunction in Pregnancy Early diagnosis and good management of maternal thyroid dysfunction are essential to ensure minimal adverse effects on
More informationMaternal thyroid function at weeks of gestation in fetal trisomies 21 and 18
PRENATAL DIAGNOSIS Prenat Diagn 2011; 31: 33 37. Published online in Wiley Online Library (wileyonlinelibrary.com).2659 Maternal thyroid function at 11 13 weeks of gestation in fetal trisomies 21 and 18
More informationThyroid disorders in antenatal women in a rural hospital in central India
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Mahajan KS et al. Int J Reprod Contracept Obstet Gynecol. 2016 Jan;5(1):62-67 www.ijrcog.org pissn 2320-1770 eissn 2320-1789
More informationHeterophile Antibody Interference with Thyroid Assay
CASE REPORT Heterophile Antibody Interference with Thyroid Assay KekPengChin 1 and Yeo Chin Pin 2 Abstract Immunoassays are one of the main methods of measuring thyroid hormones. They are prone to interference.
More informationTable 1: Thyroid panel. Result (reference interval) TSH 89.5 miu/l ( ) Total T4 5.2 µg/dl ( ) T3 uptake 39% (22-35)
Introduction Thyroid disease is the second most common endocrine disorder (behind diabetes), and its prevalence increases with increasing age. The incidence of newly diagnosed thyroid cancer is increasing
More informationLothian Guidance for Diagnosis and Management of Thyroid Dysfunction in Pregnancy.
Lothian Guidance for Diagnosis and Management of Thyroid Dysfunction in Pregnancy. Early diagnosis and good management of maternal thyroid dysfunction is essential to ensure minimal adverse effects on
More informationFree hormone estimates. Never ending story.
Free hormone estimates Never ending story. Roger Ekins (1926-2016) - saturation analysis - comp. immunoassay - microarray - RIA (T4, B12) - Free T4 (never really succeeded) Free hormone hypothesis Law
More informationIDEXX Catalyst One Chemistry Analyzer for In-house Measurement of Total Thyroxine (TT 4 ) Concentration in Serum from Dogs and Cats
IDEXX Catalyst One Chemistry Analyzer for In-house Measurement of Total Thyroxine (TT 4 ) Concentration in Serum from Dogs and Cats Authors: Kate Cote, Ph.D., Graham Bilbrough, MA, VetMB, CertVA, MRCVS,
More informationIntellectual Development in Children Whose Mothers Received Propylthiouracil During Pregnancy
THE YALE JOURNAL OF BIOLOGY AND MEDICINE 51 (1978), 151156 Intellectual Development in Children Whose Mothers Received Propylthiouracil During Pregnancy GERARD N. BURROW, ETHELYN H. KLATSKIN, AND MYRON
More informationTransient congenital hypothyroidism (TCH) may occur because of iodine deficiency, iodine overload, transplacental
Transient Neonatal Hypothyroidism is Associated with Elevated Anti-Thyroglobulin Antibody Levels in Newborns and Their Mothers ARASH ORDOOKHANI, MD, PARVIN MIRMIRAN, PHD, PAUL G. WALFISH, CM, MD, AND FEREIDOUN
More informationSENSITIVE THYROID STIMULATING HORMONE (U-TSH) ENZYME IMMUNOASSAY TEST KIT Catalog Number: EA100970
SENSITIVE THYROID STIMULATING HORMONE (U-TSH) ENZYME IMMUNOASSAY TEST KIT Catalog Number: EA197 Enzyme Immunoassay for the Quantitative Determination of Thyroid Stimulating Hormone (TSH) in Human Serum
More informationMeasurement of total thyroxine concentration in serum from dogs and cats by use of various methods Objective Sample Population Procedure Results
Measurement of total thyroxine concentration in serum from dogs and cats by use of various methods Robert J. Kemppainen, DVM, PhD, and Jeremy R. Birchfield, DVM Objective To compare results obtained from
More informationChapter 2. High-sensitivity C-reactive protein methods examined
Chapter High-sensitivity C-reactive protein methods examined Snježana Rothkrantz-Kos, Maria PJ Schmitz, Otto Bekers, Paul PCA Menheere, Marja P van Dieijen-Visser Clin Chem ;48:359-6 3 Chapter Abstract
More informationEliKine Free Thyroxine (ft4) ELISA Kit
EliKine Free Thyroxine (ft4) ELISA Kit Booklet Item NO. KET0005 Product Name EliKine Free Thyroxine (ft4) ELISA Kit ATTENTION For laboratory research use only. Not for clinical or diagnostic use TABLE
More informationTriiodothyronine (T3) ELISA
For Research Use Only. Not for use in Diagnostic Procedures. INTENDED USE The GenWay, Inc. Triiodothyronine (T3) ELISA Kit is intended for the detection of total T3 in human serum or plasma. For research
More informationThyroid Function TSH Analyte Information
Thyroid Function TSH Analyte Information 1 2013-05-01 Thyroid-stimulating hormone (TSH) Introduction Thyroid-stimulating hormone (thyrotropin, TSH) is a glycoprotein with molecular weight of approximately
More informationThyroid Function Test Ordering Pattern in a Tertiary Care Hospital in Western Uttar Pradesh, India.
Research and Reviews: Journal of Medical and Health Sciences Thyroid Function Test Ordering Pattern in a Tertiary Care Hospital in Western Uttar Pradesh, India. Rajni Dawar Mahajan *, Tabassum Yasmin,
More informationThyrotoxicosis in Pregnancy: Diagnose and Management
Thyrotoxicosis in Pregnancy: Diagnose and Management Yuanita Asri Langi email: meralday@yahoo.co.id Endocrinology & Metabolic Division, Internal Medicine Department, Prof.dr.R.D. Kandou Hospital/ Sam Ratulangi
More informationSang Ling Wu, MD, Wei Li, MD, PhD, Alice Wells, MT(ASCP), and Amitava Dasgupta, PhD
Clinical Chemistry / DIGOXIN-LIKE AND DIGITOXIN-LIKE IMMUNOREACTIVE SUBSTANCES IN ELDERLY PEOPLE Digoxin-Like and Digitoxin-Like Immunoreactive Substances in Elderly People Impact on Therapeutic Drug Monitoring
More informationNEWBORN FEMALE WITH GOITER PAYAL PATEL, M.D. PEDIATRIC ENDOCRINOLOGY FELLOW FEBRUARY 12, 2015
NEWBORN FEMALE WITH GOITER PAYAL PATEL, M.D. PEDIATRIC ENDOCRINOLOGY FELLOW FEBRUARY 12, 2015 CHIEF COMPLAINT 35 6/7 week F with goiter, born to a mother with Graves disease (GD) HPI 35 6/7 week F born
More informationLow concentrations of maternal thyroxin during early gestation: a risk factor of breech presentation?
BJOG: an International Journal of Obstetrics and Gynaecology September 2004, Vol. 111, pp. 925 930 DOI: 10.1111/j.1471-0528.2004.00213.x Low concentrations of maternal thyroxin during early gestation:
More informationReference Intervals for Children and Adults
for Children and Adults TSH, FT4, FT3, T4, T3, T-Uptake, FT4-index, Anti-TPO, Anti-Tg, Tg Elecsys systems /20 MODULAR ANALYTICS E70 cobas e 4 and cobas e 60 analysers Contents Page Introduction 4 2 Summary
More informationLecture title. Name Family name Country
Lecture title Name Family name Country Nguyen Thy Khue, MD, PhD Department of Endocrinology HCMC University of Medicine and Pharmacy, MEDIC Clinic Hochiminh City, Viet Nam Provided no information regarding
More informationThe Thyroid and Pregnancy OUTLINE OF DISCUSSION 3/19/10. Francis S. Greenspan March 19, Normal Physiology. 2.
The Thyroid and Pregnancy Francis S. Greenspan March 19, 2010 OUTLINE OF DISCUSSION 1. Normal Physiology 2. Hypothyroidism 3. Hyperthyroidism 4. Thyroid Nodules and Cancer NORMAL PHYSIOLOGY Iodine Requirements:
More informationOvert and subclinical hypothyroidism among Bangladeshi pregnant women and its effect on fetomaternal outcome
Bangladesh Med Res Counc Bull 21; : 52-57 Overt and subclinical hypothyroidism among Bangladeshi pregnant women and its effect on fetomaternal outcome Sharmeen M, Shamsunnahar A, Laita TR, Chowdhury SB
More informationThyroid Function. Thyroid Antibodies. Analyte Information
Thyroid Function Thyroid Antibodies Analyte Information - 1-2013-04-30 Thyroid Antibodies Determination of thyroid autoantibodies are, besides TSH and FT4, one of the most important diagnostic parameters.
More informationMonitoring Levothyroxine Dose during Pregnancy: A Prospective Study
American Journal of Infectious Diseases 7 (3): 75-79, 2011 ISSN 1553-6203 2011 Science Publications Monitoring Levothyroxine Dose during Pregnancy: A Prospective Study 1 Juhi Agarwal, 1 Sirimavo Nair and
More informationIodine and Thyroid Hormones
Iodine and Thyroid Hormones Iodine and Thyroid Hormones feed-back Iodine Deficiency Characteristics Iodine Deficiency None Mild Mode Severe Median urine iodine >100 50-99 20-49
More informationHyperthyroïdie et Grossesse
Club Thyroïde, Paris 9 juin 2018 Hyperthyroïdie et Grossesse De la Mère à l Enfant Professeur Juliane Léger Endocrinologie diabétologie Pédiatrique Centre de Référence des Maladies Endocriniennes de la
More informationRat Mullerian Inhibiting Substance/Anti-Mullerian hormone, MIS/AMH ELISA kit
Rat Mullerian Inhibiting Substance/Anti-Mullerian hormone, MIS/AMH ELISA kit Catalog No. E0228r (96 tests) Operating instruction www.eiaab.com FOR RESEARCH USE ONLY; NOT FOR THERAPEUTIC OR DIAGNOSTIC APPLICATIONS!
More informationNIH Public Access Author Manuscript Ther Drug Monit. Author manuscript; available in PMC 2013 April 14.
NIH Public Access Author Manuscript Published in final edited form as: Ther Drug Monit. 2006 February ; 28(1): 8 11. Thyroid Function Testing in Pregnancy and Thyroid Disease: Trimester-specific Reference
More informationHuman Thyroid Stimulating Hormone CLIA kit
Human Thyroid Stimulating Hormone CLIA kit Cat. No.:DEEL0223 Pkg.Size:96 tests Intended use For the direct quantitative determination of Thyroid Stimulating Hormone in human serum by chemiluminescence
More informationINCREASED NEED FOR THYROXINE IN WOMEN WITH HYPOTHYROIDISM DURING ESTROGEN THERAPY
INCREASED NEED FOR THYROXINE IN WOMEN WITH HYPOTHYROIDISM DURING ESTROGEN THERAPY BAHA M. ARAFAH, M.D. ABSTRACT Background Women with hypothyroidism that is being treated with thyroxine often need higher
More informationThyroid Management. Evolving Controversy - Science, Dogma, Opinion. The Ogden Surgical Medical Society May 2016
Thyroid Management Evolving Controversy - Science, Dogma, Opinion The Ogden Surgical Medical Society May 2016 Published Guidelines AACE and ATA - Clinical Practice Guidelines in 2012 Guidelines are neither
More informationTSH (Human) ELISA Kit
TSH (Human) ELISA Kit Catalog Number KA0197 96 assays Version: 03 Intended for research use only www.abnova.com Table of Contents Introduction... 3 Intended Use... 3 Background... 3 Principle of the Assay...
More informationT3 (Total) (Mouse/Rat) ELISA Kit
T3 (Total) (Mouse/Rat) ELISA Kit Catalog Number KA0925 96 assays Version: 02 Intended for research use only www.abnova.com Table of Contents Introduction... 3 Intended Use... 3 Background... 3 Principle
More informationA descriptive study of the prevalence of hypothyroidism among antenatal women and foetal outcome in treated hypothyroid women
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Prasad DR et al. Int J Reprod Contracept Obstet Gynecol. 2016 Jun;5(6):1892-1896 www.ijrcog.org pissn 2320-1770 eissn 2320-1789
More informationMouse/Rat THYROXINE (T4) ELISA Catalog No (96 Tests)
For Research Use Only. Not for use in Diagnostic Procedures. INTENDED USE The GenWay, Inc. Mouse/Rat Thryroxine Kit is intended for the detection of total T4 in mouse/rat serum or plasma. SUMMARY AND EXPLANATION
More informationThyroid profile in geriatric population
Original article: Thyroid profile in geriatric population Dr. Abhijit Pratap, Dr. Mona A. Tilak, Dr. Pradnya Phalak Dept of Biochemistry, Dr. D. Y. Patil Medical College, Pimpri, Pune 18 Corresponding
More informationPATHOLOGY ROUNDS. Falsely Low Serum hcg Level in a Patient With Hydatidiform Mole Caused by the High-Dose Hook Effect CLINICAL
Alice Yoo Joseph Zaccaro CLINICAL PATHOLOGY ROUNDS Falsely Low Serum hcg Level in a Patient With Hydatidiform Mole Caused by the High-Dose Hook Effect Case Presentation A 34-year-old women came to the
More informationResearch. Although thyrotropin (thyroidstimulated
Research www.ajog.org OBSTETRICS Free T4 immunoassays are flawed during pregnancy Richard H. Lee, MD; Carole A. Spencer, PhD; Jorge H. Mestman, MD; Erin A. Miller, BS; Ivana Petrovic, MS; Lewis E. Braverman,
More informationSpecific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester
Barun K Chakrabarty et al ORIGINAL ARTICLE 10.5005/jp-journals-10054-0029 Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women
More informationINFANT OF A MOTHER WITH GRAVES DISEASE. Endorama May 14 th, 2015 Carmen Mironovici, M.D.
INFANT OF A MOTHER WITH GRAVES DISEASE Endorama May 14 th, 2015 Carmen Mironovici, M.D. Chief Complaint Newborn born to a mother with autoimmune hyperthyroidism HPI Male infant born at 39w 2d gestation
More informationStability of Stopped thyroid hormones in Enzyme Linked Immunosorbent Assay
Stability of Stopped thyroid hormones in Enzyme Linked Immunosorbent Assay Kayode J. Adebayo Department of Chemical Pathology, Faculty of Clinical Sciences, College of Medical Sciences Ambrose Alli University
More informationEnz Ag = Enzyme-antigen Conjugate (Constant Quantity) AgAb C.W. = Antigen-Antibody Complex
AccuDiag Free Thyroxine Free T4 ELISA Kit Cat# 3146-15 96 Tests Test Free T4 ELISA Method Enzyme Linked Immunosorbent Assay Principle Competitive Enzyme Immunoassay Detection Range 0-7.40ng/dL Sample 50µL
More informationManagement of Pregestational and Gestational Diabetes Mellitus
Background and Prevalence Management of Pregestational and Gestational Diabetes Mellitus Pregestational Diabetes - 8 million women in the US are affected, complicating 1% of all pregnancies. Type II is
More informationSee external label 96 tests ULTRASENSITIVE THYROID STIMULATING HORMONE (u-tsh) TSH Ultra Sensitive
DIAGNOSTIC AUTOMATION, INC. 21250 Califa Street, Suite 102 and 116, Woodland Hills, CA 91367 Tel: (818) 591-3030 Fax: (818) 591-8383 onestep@rapidtest.com technicalsupport@rapidtest.com www.rapidtest.com
More informationShould every pregnant woman be screened for thyroid disease?
Should every pregnant woman be screened for thyroid disease? Tal Biron-Shental Rinat Gabbay-Benziv Is there a debate? Thyroid screening Guidelines Targeted case finding criteria Age > 30 years Personal
More informationInternational Journal of Health Sciences and Research ISSN:
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Thyroid Status in First Trimester of Pregnancy-A Hospital Based Study Saurabh Borkotoki 1*,
More informationHypothyroidism in pregnancy. Nor Shaffinaz Yusoff Azmi Jabatan Perubatan Hospital Sultanah Bahiyah Kedah
Hypothyroidism in pregnancy Nor Shaffinaz Yusoff Azmi Jabatan Perubatan Hospital Sultanah Bahiyah Kedah Agenda 1. Epidemiology and clinical characteristics of maternal hypothyroidism 2. Prevention and
More informationUpdate on Thyroid Disorders Unrestricted Siemens Healthcare Diagnostics Inc All rights reserved.
Linda Rogers, PhD, DABCC, FACB Update on Thyroid Disorders Objectives 1. Define hypothyroidism and hyperthyroidism and describe the common clinical presentations and the general laboratory diagnosis of
More informationThe Virtues and Pitfalls of Implementing a New Test
The Virtues and Pitfalls of Implementing a New Test James H. Nichols, Ph.D., DABCC, FACB Professor of Clinical Pathology, Microbiology and Immunology Associate Medical Director for Clinical Operations
More informationHbA1c (Human) ELISA Kit
HbA1c (Human) ELISA Kit Cat. No.:DEIA3509 Pkg.Size:96T Intended use GHbA1c (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human GHbA1c. General Description vhemoglobin,
More information39 th Annual Perinatal Conference Vanderbilt University December 6, 2013 IUGR. Diagnosis and Management
39 th Annual Perinatal Conference Vanderbilt University December 6, 2013 IUGR Diagnosis and Management Giancarlo Mari, M.D., M.B.A. Professor and Chair Department of Obstetrics and Gynecology University
More informationJMSCR Vol 04 Issue 03 Page March 2016
www.jmscr.igmpublication.org Impact Factor 5.244 Index Copernicus Value: 5.88 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: http://dx.doi.org/10.18535/jmscr/v4i3.60 Thyroid Dysfunction and Pregnancy Outcome
More informationEVALUATION OF THYROID FUNCTION IN PRE-ECLAMPSIA
EVALUATION OF THYROID FUNCTION IN PRE-ECLAMPSIA K. Sunanda 1, P. Sravanthi 2, H. Anupama 3 1Assistant Professor, Department of Obstetrics & Gynaecology, Gandhi Medical College/Hospital. 2Post Graduate,
More informationEvaluation of the EUROLYSER-SOLO Total T4 assay. for veterinary samples
Evaluation of the EUROLYSER-SOLO Total T4 assay for veterinary samples Dr. rer.-nat. Volker Schlüter Zacherlweg 18 D-82061 Neuried Date: 2011 April 27 th Scope of the study Goal of this study was the validation
More informationCanine Thyroid Stimulating Hormone, TSH ELISA Kit
Canine Thyroid Stimulating Hormone, TSH ELISA Kit Catalog No: E0463c 96 Tests Operating instruction www.eiaab.com FOR RESEARCH USE ONLY; NOT FOR THERAPEUTIC OR DIAGNOSTIC APPLICATIONS! PLEASE READ THROUGH
More informationIn Vitro Diagnostic Glucose Test System
CDRH Final Guidance 2-Page Cover Sheet Guidance for Industry In Vitro Diagnostic Glucose Test System Document issued on: July 6, 1998 U.S. Department Of Health and Human Services Food and Drug Administration
More informationStudy on diurnal variation in TSH and freet4 levels of healthy adults
Original Article Study on diurnal variation in TSH and freet4 levels of healthy adults Liyanage YSH 1, Siriwardhana ID 2, Dissanayake M 3, Dayanath BKPT 4 1 Allied Health Sciences Degree Program, Faculty
More informationScreening Babies at risk of Congenital Hyperthyroidism GL354
1 Screening Babies at risk of Congenital Hyperthyroidism GL354 Approval and Authorisation Approved by Job Title Date Paediatric Clinical Governance Chair of paediatric Clinical Governance March 2016 Change
More informationEnzyme Immunoassay for the Quantitative Determination of Total Thyroxine (T4) in Human Serum
of total T4, TSH, Free T3 and Free T4 by immunoassay are reliable and convenient methods to determine the presence of thyroid disorders in patients.4,5 Increased levels of T4 have been found in hyperthyroidism
More informationDAGNOSIS AND TREATMENT OF THYROID GLAND DISEASES IN PREGNANCY GUIDELINE AND RECOMMENDATIONS
Svetlana Spremovic-Radjenovic 1 DAGNOSIS AND TREATMENT OF THYROID GLAND DISEASES IN PREGNANCY GUIDELINE AND RECOMMENDATIONS The field referred to thyroid gland diseases and pregnancy has recorded the fast
More informationSee external label 2 C-8 C Σ=96 tests Cat # 3171Z. Free Estriol. Cat # 3171Z. Enzyme Linked Immunosorbent Assay
DIAGNOSTIC AUTOMATION, INC. 23961 Craftsman Road, Suite D/E/F, Calabasas, CA 91302 Tel: (818) 591-3030 Fax: (818) 591-8383 onestep@rapidtest.com technicalsupport@rapidtest.com www.rapidtest.com See external
More informationThis is the author s final accepted version.
Carty, D. M., Doogan, F., Welsh, P., Dominiczak, A. F., and Delles, C. (2017) Thyroid stimulating hormone (TSH) 2.5mU/l in early pregnancy: prevalence and subsequent outcomes. European Journal of Obstetrics
More informationThyroid Disease in Pregnancy: The Essentials. Elizabeth N. Pearce, MD, MSc
Thyroid Disease in Pregnancy: The Essentials Elizabeth N. Pearce, MD, MSc None Disclosures Case 1 A 31-year-old woman from Massachusetts is practicing a vegan diet. She is currently planning a pregnancy.
More informationChapter I.A.1: Thyroid Evaluation Laboratory Testing
Chapter I.A.1: Thyroid Evaluation Laboratory Testing Jennifer L. Poehls, MD and Rebecca S. Sippel, MD, FACS THYROID FUNCTION TESTS Overview Thyroid-stimulating hormone (TSH) is produced by the anterior
More informationProduct Datasheet excellence in early discovery research MICRO-EIA T 3 TRIIODOTHYRONINE KIT
Product Datasheet www.leinco.com excellence in early discovery research MICRO-EIA T 3 TRIIODOTHYRONINE KIT For the quantitative determination of triiodothyronine (T 3 ) in human serum. Leinco Technologies,
More informationMaternal outcome in thyroid dysfunction
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Manju VK et al. Int J Reprod Contracept Obstet Gynecol. 2017 Jun;6(6):2361-2365 www.ijrcog.org DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20172313
More informationDevelopment of Quantitative Immunoassay Reagent FUJI DRI-CHEM IMMUNO AU Cartridge vc-tsh and v-cor
Development of Quantitative Immunoassay Reagent FUJI DRI-CHEM IMMUNO AU Cartridge vc-tsh and v-cor Hiroyuki CHIKU* Junichi KATADA* Tomoya OHARA* Noriyuki KASAGI* Atsuhiko WADA* and Kentaro NAKAMURA* Abstract
More informationLABORATORY TESTS FOR EVALUATION OF THYROID DISORDERS
LABORATORY TESTS FOR EVALUATION OF THYROID DISORDERS Maryam Tohidi Anatomical & clinical pathologist Research Institute for Endocrine Sciences THYROID GLAND (15-25 gr), (12-20 gr), 2 lobes connected by
More informationTo evaluate the influence of ferritin on thyroid hormones in second trimester antenatal cases in Perambalur District
Original Research Article To evaluate the influence of ferritin on thyroid hormones in second trimester antenatal cases in Perambalur District Nageshwari A 1, G. Kavitha 2* 1 Final year Postgraduate student,
More informationClinical Study Risk-Based Screening for Thyroid Dysfunction during Pregnancy
Pregnancy Volume 2013, Article ID 619718, 5 pages http://dx.doi.org/10.1155/2013/619718 Clinical Study Risk-Based Screening for Thyroid Dysfunction during Pregnancy Masanao Ohashi, 1 Seishi Furukawa, 2
More informationUpdate on Gestational Thyroid Disease. Aidan McElduff The Discipline of Medicine, The University of Sydney
IADPSG 2016 Update on Gestational Thyroid Disease Aidan McElduff The Discipline of Medicine, The University of Sydney IADPSG 2016 DISCLOSURES and AIM Nil to disclose Aim: to provide an overview 2017 Guidelines
More informationVerification and validation of diagnostic laboratory tests in clinical virology
Journal of Clinical Virology 40 (2007) 93 98 Review Verification and validation of diagnostic laboratory tests in clinical virology Holger F. Rabenau a,, Harald H. Kessler b, Marhild Kortenbusch a, Andreas
More informationSURVEY AND DETECTION OF IODINE DEFICIENCY
SURVEY AND DETECTION OF IODINE DEFICIENCY Anwar Dudin, Annie Rambaud-Cousson, Amin Thalji, Ghaleb Zughayer Pediatric department-makassed Hospital-Jerusalem I-AVAILABLE DATA IN THE SOCIETY 1-NEONATAL SCREENING
More informationNo conflict of interest to report
Ultrasound Findings in Fetal Infection No conflict of interest to report Kim A. Boggess MD Ob Gyn UNC at Chapel Hill Learning Objectives At conclusion, participants will Identify maternal infections that
More informationUSING THE ACCESS AMH ASSAY IN YOUR LABORATORY
INFORMATION BULLETIN USING THE ACCESS AMH ASSAY IN YOUR LABORATORY ///////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////
More informationHuman Thyroid-Peroxidase Antibody, TPO-Ab ELISA Kit
Human Thyroid-Peroxidase Antibody, TPO-Ab ELISA Kit Catalog No: E0442h 96 Tests Operating instruction www.eiaab.com FOR RESEARCH USE ONLY; NOT FOR THERAPEUTIC OR DIAGNOSTIC APPLICATIONS! PLEASE READ THROUGH
More informationThe Effect of Environmental Perchlorate on Thyroid Function in Pregnant Women. from Cordoba, Argentina, and Los Angeles, California
The Effect of Environmental Perchlorate on Thyroid Function in Pregnant Women from Cordoba, Argentina, and Los Angeles, California Elizabeth N. Pearce, MD, MSc, 1 Carole A. Spencer, PhD, FACB, 2 Jorge
More information344 Thyroid Disorders
344 Thyroid Disorders Definition/Cut-Off Value Thyroid dysfunctions that occur in pregnant and postpartum women, during fetal development, and in childhood are caused by the abnormal secretion of thyroid
More informationLow Concentrations of Maternal Thyroxin During Early Gestation :A Risk Factor of Breech Presentation
Negative feedback CONCENTRATIONS THE IRAQI POSTGRADUATE OF MEDICAL MATERNAL JOURNAL THYROXIN Low Concentrations of Maternal Thyroxin During Early Gestation :A Risk Factor of Breech Presentation Nada Salih
More informationDue to the importance of early detection for CH to
of ism Se Hospital K Lu r S 0 Sakinah, FRCP*, B A K Khalid, FRCP*, A Roslan*, A G Zainal*, M L Ng, PhD**, N Adeeb, FRCOG***, "Departments of Medicine, **Biochemistry and Obstetrics and ***Gynaecology,
More informationCME/SAM. An Examination of the Usefulness of Repeat Testing Practices in a Large Hospital Clinical Chemistry Laboratory
Clinical Chemistry / Repeat Testing Practices in Clinical Chemistry An Examination of the Usefulness of Repeat Testing Practices in a Large Hospital Clinical Chemistry Laboratory Carl O. Deetz, MD, PhD,
More informationReal Pregnancy or Uncontrolled Hypothyroidism?
Real Pregnancy or Uncontrolled Hypothyroidism? Christie G. Turin 1,MD; Anisha Gupta 1, MD; Susan Samson 1,2, MD; Mandeep Bajaj 1,2, MBBS Baylor College of Medicine, Houston, TX 1 ; CHI-St. Luke s Episcopal
More informationTHYROID HORMONAL STATUS IN PREGNANCY AND PRE- ECLAMPSIA AND ITS CORRELATION WITH MATERNAL AGE AND PARITY
THYROID HORMONAL STATUS IN PREGNANCY AND PRE- ECLAMPSIA AND ITS CORRELATION WITH MATERNAL AGE AND PARITY *P. Jain and R. Devi Department of Biochemistry, Gauhati Medical College and Hospital, Assam, India
More informationA study of neonatal and maternal outcomes of asthma during pregnancy
International Journal of Research in Medical Sciences Meena BL et al. Int J Res Med Sci. 2013 Feb;1(1):23-27 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Research Article DOI: 10.5455/2320-6012.ijrms20130206
More informationHarmonisation of TFTs
Royal Prince Alfred Hospital and University of Sydney Harmonisation of TFTs Harmonisation Workshop May 2015 Paul Williams Harmonisation May 2015 Talk Outline IFCC initiatives C-STFT (Committee for standardisation
More informationEvaluation of maternal thyroid function during pregnancy: the importance of using gestational age-specific reference intervals
European Journal of Endocrinology (2007) 157 509 514 ISSN 0804-4643 CLINICAL STUDY Evaluation of maternal thyroid function during pregnancy: the importance of using gestational age-specific reference intervals
More informationTransient hyperthyroidism of hyperemesis gravidarum
BJOG: an International Journal of Obstetrics and Gynaecology June 2002, Vol. 109, pp. 683 688 Transient hyperthyroidism of hyperemesis gravidarum Jackie Y.L. Tan a, *, Keh Chuan Loh b, George S.H. Yeo
More informationManagement of Fetal and Neonatal Graves Disease
HORMONE RESEARCH IN PÆDIATRIC S Mini Review Received: September 16, 2016 Accepted: November 3, 2016 Published online: December 16, 2016 Management of Fetal and Neonatal Graves Disease Juliane Léger Service
More informationTHYROID STIMULATING HORMONE (TSH) ENZYME IMMUNOASSAY TEST KIT Catalog Number: EA100969
THYROID STIMULATING HORMONE (TSH) ENZYME IMMUNOASSAY TEST KIT Catalog Number: EA1969 Enzyme Immunoassay for the Quantitative Determination of Thyroid Stimulating Hormone (TSH) in Human Serum FOR IN VITRO
More information