Sodium±iodide symporter (NIS) gene expression in lymph-node metastases of papillary thyroid carcinomas
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1 European Journal of Endocrinology (2000) ±627 ISSN CLINICAL STUDY Sodium±iodide symporter (NIS) gene expression in lymph-node metastases of papillary thyroid carcinomas F Arturi, D Russo 1, D Giuffrida 2, M Schlumberger 3 and S Filetti Cattedra di Endocrinologia, Dipartimento di Medicina Sperimentale e Clinica, 1 Dipartimento di Scienze Farmacobiologiche, UniversitaÁ di Catanzaro, Catanzaro, Italy, 2 Cattedra di Endocrinologia, UniversitaÁ di Catania, Italy and 3 Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, Villejuif Cedex, France (Correspondence should be addressed to S Filetti, Cattedra di Endocrinologia, Dipartimento di Medicina Sperimentale e Clinica, Via T. Campanella 115, Catanzaro, Italy; letti@tin.it) Abstract Objective: To investigate the molecular mechanisms underlying the in uence of alteration of iodine trapping on the prognosis of metastatic papillary thyroid carcinomas, focusing on the expression of the Na /I symporter (NIS). Design: We evaluated the expression of the NIS gene in a series of 11 enlarged neck lymph-node metastases of papillary thyroid carcinomas, including four patients in whom an enlarged lymph node represented the rst sign of the tumoral disease. Nine lymph nodes, either reactive or metastatic for non-thyroid tumors, were also investigated. Methods: Expression of the NIS gene was evaluated by RT-PCR in material obtained by ne-needle aspiration biopsy. Results: The NIS gene was expressed in eight (73%) of 11 differentiated thyroid cancer metastatic lymph nodes examined. Five of these metastatic lymph nodes were positive at the post-treatment totalbody iodine-131 scan; in the other three, the total-body scan showed no uptake in the metastatic tissues, indicating an alteration downstream to the NIS mrna synthesis causing the loss of iodide uptake. As expected, when the NIS mrna expression was absent, total-body 131 I scan showed no uptake in the metastatic lymph nodes. Conclusions: Our study demonstrates that NIS gene expression may be absent in metastatic differentiated thyroid carcinomas and that different mechanisms, other than loss of NIS transcription, may also be involved in the loss of iodide uptake in metastatic thyroid cells. Study of NIS gene expression in the metastatic lymph nodes, therefore, may provide useful information in the management of patients with thyroid carcinoma. European Journal of Endocrinology ±627 Introduction The ability to transport, concentrate and organify iodide is a property of normally functioning thyroid tissue and the maintenance of such features in thyroid cancer cells is a fundamental prerequisite for using radioiodine in the diagnosis and treatment of patients with differentiated thyroid carcinomas to ablate residual, recurrent or metastatic tumors (1). Several studies, both in vivo and in vitro, have demonstrated the role of thyroid-stimulating hormone (TSH) as the principal regulator of iodide uptake (2), acting through the stimulation of the synthesis of the protein responsible for such a process, the sodium±iodide symporter (NIS). This TSH effect is maintained in most differentiated thyroid tumors, so that periodic withdrawal of the thyroid hormone treatment is required to increase serum thyrotropin concentrations and stimulate thyroid tissue before performing the radioiodine treatment (3). However, in some individuals, differentiated thyroid carcinomas and their metastases concentrate iodide less ef ciently than normal thyroid tissue during interruption of the thyroid hormone-suppressive treatment, rendering the treatment with radioiodide substanstially ineffective. This decrease in iodide concentration is variable from one tumor to another, and no uptake can be detected in 30% of cases (4). The recent cloning of the NIS gene (5, 6) has afforded the possibility of better elucidating the molecular mechanisms underlying the loss/reduction of iodide trapping in thyroid cancer cells, both primary and metastatic (2). A reduction in NIS mrna expression has been reported in primary thyroid tumors in all studies (6±12) except one (13). These data correlate with a reduced NIS protein abundance in thyroid tumor q 2000 Society of the European Journal of Endocrinology Online version via
2 624 F Arturi and others EUROPEAN JOURNAL OF ENDOCRINOLOGY (2000) 143 slices, as assessed by immunohistochemistry (9, 14). In contrast, no data are available about the presence of the NIS transcript in thyroid tumor metastases. In the present study, we analyzed the expression of the NIS gene in a series of enlarged neck lymph-node metastases of papillary thyroid carcinomas. It is noteworthy that, in four patients of our series, the enlarged cervical lymph node represented the rst sign of disease, so that the evaluation of NIS mrna expression was not affected by the pharmacological suppression of TSH concentrations. Patients and methods Patients Twenty enlarged cervical lymph nodes were investigated: seven patients were in follow-up for papillary thyroid carcinomas, 13 patients had one single enlarged node of unknown origin. All patients underwent ne-needle aspiration biopsy under ultrasound guidance; an aspirate aliquot was smeared for cytological examination and another was frozen for subsequent PCR (15). Histopathological diagnosis in multiple sections of excised lymph nodes was assumed to re ect a correct diagnosis. On histological examination, the 20 lymph nodes examined yielded diagnoses of 11 papillary thyroid carcinomas and nine enlarged lymph nodes, either reactive or metastatic from non-thyroid tumors. Therefore, in four of 11 papillary thyroid carcinoma metastases the enlarged cervical lymph nodes represented the rst clinical sign of a differentiated thyroid cancer (Table 1). RNA extraction and RT-PCR Messenger RNA was extracted from the biopsy material with an mrna Puri cation Kit (Amersham Pharmacia Biotech, Milan, Italy) following the manufacturer's instructions, as previously described (16). cdna was synthesized according to the procedure of the manufacturer (Roche Diagnostics SpA, Monza, Italy). The mixture was incubated at 25 8C for 10 min, at 42 8C for 60 min, heated to 99 8C for 5 min, and then stored at 20 8C. PCR ampli cation was performed using 5 ml cdna (of 20 ml mixture), as previously reported (16). Brie y, samples were subjected to 40 cycles of ampli cation and PCR conditions for the NIS gene were as follows: denaturation at 94 8C for 1 min, annealing at 62 8C for 1 min and extension at 72 8C for 1 min. The last cycle was 72 8C for 7 min (one cycle). Ten microliters of the 50 ml of the ampli cation products were then run on 1.5% Tris±borate±EDTA (TBE) agarose gel containing ethidium bromide, and analyzed to con rm a positive or negative outcome. Primer oligonucleotides for the NIS gene were: 5 0 primer, 5 0 -TCTCTCAGTCAACGCCTCT-3 0 and 3 0 primer, 5 0 -ATCCAGGATGGCCACTTCTT-3 0. The ampli cation yielded a 299 base pair DNA product corresponding to fragment 1801±2099 according to the published sequence of the NIS gene (6). Expression of the transcripts of thyrotropin receptor (TSH-R), thyroglobulin (Tg) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a control gene ubiquitously expressed, was also analysed, as previously described (16). The primers for the NIS, Tg and the TSH-R genes spanned exon±intron junctions of the genes, to exclude possibility of genomic DNA contamination. All primers were from Life-Technologies (Milan, Italy). In the negative samples, we performed a radiolabeled PCR by adding 1 ml a 32 P-dNTP (3000 Ci/mmol, Amersham Pharmacia Biotech) to the PCR mixture. The samples were then subjected to 40 cycles of ampli cation, using the same conditions previously described, and 10 ml of the 50 ml of PCR products were run on 10% TBE polyacrylamide electrophoresis gel (BioRad Laboratories Srl, Milan, Italy). The gel was dried Table 1 Clinical ndings in patients with lymph-node metastases of papillary thyroid carcinomas. Age at Tumor Thyroglobulin Patient Sex/age diagnosis diameter Lymph-node NIS gene serum concns² No. (yr) (yr) (mm) metastases expression 131 I Uptake (ng/ml) 1 F/ Recurrent right Positive 18 2 F/ Lower right jugular Positive 42 3 F/ Upper left jugular Negative 15 4 M/ Lower left spinal accessory Negative 22 5 F/ Lower right jugular Negative 35 6 M/ Lower left jugular Positive 13 7* F/ Paratracheal right Negative NA 8* M/ Upper right jugular Positive NA 9* F/ Lower left jugular Negative NA 10* F/ Lower right spinal accessory Negative NA 11 F/ Upper left jugular Positive NA * In these four patients the lymph-node metastasis represented the rst clinical sign of papillary thyroid carcinomas; at the time of biopsy sampling, the thyroid was present and the serum thyrotropin was in normal range. ² Serum thyroglobulin measured at the time of 131 I total-body scan after 6 weeks of thyroid hormone withdrawal (normal value <1 ng/ml). NA, not available.
3 EUROPEAN JOURNAL OF ENDOCRINOLOGY (2000) 143 NIS transcript in thyroid tumor metastases 625 Figure 1 Presence of NIS transcript in lymph-node metastases of papillary thyroid carcinomas. Agarose gel electrophoresis of RT-PCR ampli ed DNA in material obtained by ne-needle aspiration. C+, cdna of human thyroid cells in primary culture (positive control); C, cdna from non-thyroid tissue (colon tumor; negative control). Lanes 1±11: cdna of patients with lymph-node metastases. The expected band is indicated by the black arrow. at 60 8C and subsequently exposed to radiographic lm to con rm a positive or negative outcome. Results All the tumoral specimens presented the GAPDH transcript, indicating the integrity of the mrna and the cdna (data not shown). The NIS gene was expressed in eight (73%) of 11 differentiated thyroid cancer metastatic lymph nodes examined (Fig. 1). Five of eight metastatic lymph nodes positive for NIS mrna expression were also positive at the post-treatment total-body iodine-131 scan (Nos 1, 2, 6, 8 and 11; Table 1); in the other three, the totalbody scan showed no uptake in the metastatic tissues (Nos 4, 5 and 9; Table 1). Three of 11 (27%) thyroid cancer metastatic tissues did not express the NIS transcript (Fig. 1). To exclude the presence of falsenegative results, we performed a radiolabeled PCR (see Methods), a more sensitive method for detection of the mrna expression, which con rmed the results obtained with non-radiolabeled PCR (data not shown). In these three patients, the total-body scan showed no uptake in the metastatic lymph nodes (Nos 3, 7 and 10; Table 1). The expression of NIS mrna was also examined in two of the three primary thyroid carcinomas in which the metastatic tissue was negative for expression of the NIS transcript (Nos 3 and 10; Table 1); in both we found expression of the NIS transcript. In the other patient (No. 7) a micro (occult) carcinoma was found at pathological examination and no tissue specimen was available for genetic examination. All samples from differentiated thyroid carcinoma metastases were positive for Tg and TSH-R transcripts (data not shown). In contrast, the nine reactive and non-thyroid metastatic lymph nodes did not express any of the thyroid-speci c genes examined (data not shown). Discussion Use of radioiodine is the most powerful tool in the management of differentiated thyroid carcinomas, for both diagnostic and therapeutical purposes, in either primary or metastatic disease. Indeed, differentiated thyroid carcinomas generally retain many of the differentiated features of normal thyroid cells, including the ability to concentrate iodine. However, impairment of iodine metabolism, together with variable degrees of reduction in thyroid-speci c transcripts, have frequently been observed in neoplastic thyroid tissues (12, 17). Thirty- ve to sixty percent of differentiated thyroid carcinoma metastases do not take up 131 I (18, 19) and in some patients with increased serum Tg concentrations, total-body iodine-131 scan, even when performed with a high dose of radioiodine, is also negative (20), necessating the use of alternative tools of detection, such as octreoscan, positron emission tomography scan or conventional imaging modalities, but with a poorer prognosis for the patient (2, 3). Several studies have investigated the levels of NIS mrna in thyroid tumors, showing a reduction or loss of NIS gene expression in most differentiated thyroid carcinomas (6±12); only in one study has an increased expression of the NIS gene in papillary thyroid carcinomas been demonstrated (13). In a previous study, using a non-quantitative detection system, we found loss of NIS mrna expression in six primary thyroid tumors ( ve papillary and one follicular thyroid carcinomas) out of 24 differentiated thyroid carcinomas examined (8). In this series, four of eight patients with differentiated thyroid carcinoma with distant metastases and a negative post-treatment totalbody scan exhibited a lack of NIS gene expression in the primary cancer. In some patients, therefore, the absence of NIS appears to be intrinsic to the primary transformed thyroid cell, and not acquired in the metastatic tissues through a further dedifferentiation during the process of tumor progression. In contrast, a decrease in NIS gene expression in lymph-node metastases compared with both normal thyroid and primary tumor tissues was detected in two patients, suggesting that the reduction in NIS gene expression may also be a consequence of cancer progression (8). In a further study, using a quantitative PCR method, NIS gene expression was found to be
4 626 F Arturi and others EUROPEAN JOURNAL OF ENDOCRINOLOGY (2000) 143 decreased in 40 of 43 thyroid carcinomas and more advanced tumor stages were associated with lower expression of the NIS gene (12). In the present study, we examined the expression of the NIS mrna in a series of 11 enlarged neck lymphnode metastases of papillary thyroid carcinomas, including four patients in whom the enlarged lymph node represented the rst sign of the tumoral disease. We found loss of NIS transcript expression in three of 11 thyroid lymph-node metastases examined. The absence of NIS expression correlated with a negative total-body iodine-131 scan. Also, we examined the expression of NIS mrna in two of the three patients with primary thyroid carcinomas whose metastatic tissue was negative for NIS transcript expression and, in both, we found the presence of NIS transcript. This observation con rms our previous nding (8) that loss of NIS gene expression in metastatic tumors may be the result of a dedifferentiation process occurring during the development of metastasis. In contrast, three patients were negative on 131 I scan, even though the NIS transcript was expressed in the metastatic tissue. Thyroglobulin concentrations at the time of the 131 I total-body scan was increased in all patients, clearly indicating the persistence of neoplastic tissue. This suggests the involvment of other mechanisms responsible for the failure to concentrate radioiodine, including a defect (intrinsic, acquired, or both) of the iodide symporter protein structure or activation, or an alteration in the pathway of iodide organi cation. An important issue in the evaluation of tumoral expression of TSH-dependent transcripts is the current treatment of the patient when the tissue sample is collected for the examination; very frequently, the patient is undergoing TSH-suppressive therapy, so that mrna levels of any TSH-dependent gene are affected by this unphysiological condition. In our study, we had the opportunity to investigate four patients presenting an enlarged cervical lymph node as the rst sign of the thyroid disease ± in whom, therefore, no TSH-suppressive treatment was in progress when the biopsy material was collected for examination. Our data show that, even in the absence of suppression of TSH, NIS gene expression may be undetectable in lymph-node metastases of differentiated thyroid carcinomas, as observed in two patients in our series (Table 1). In conclusion, as the iodide symporter system plays a critical role in thyroid tumorigenesis, analysis of the expression of its mrna may offer useful information for the management of and the therapeutic approach to patients with differentiated thyroid carcinoma, especially in the presence of metastases. Acknowledgements We acknowledge the support of Associazione Italiana per la Ricerca sul Cancro (AIRC) (to S F) and MURST PRI '99 (to S F). F A is the recipient of Dottorato di Ricerca in `Basi Molecolari dell'azione Ormonale' at the University of Catania. References 1 Mazzaferri EL. Carcinoma of follicular epithelium: radioiodine and other treatment outcomes. In The Thyroid ± a Fundamental and Clinical Text, edn 7, pp 922±945. Eds. LE Braverman & RD Utiger. Philadelphia: Lippincott-Raven, Filetti S, Bidart JM, Arturi F, Caillou B, Russo D & Schlumberger M. Sodium/iodide symporter: a key transport system in thyroid cancer cell metabolism. European Journal of Endocrinology ± Schlumberger M. Papillary and follicular thyroid carcinoma. New England Journal of Medicine ± Schlumberger M, Challeton C, De Vathaire F, Travagli JP, Gardet P, Lumbroso JD et al. Radioactive iodine treatment and external radiotherapy for lung and bone metastases from thyroid carcinoma. Journal of Nuclear Medicine ± Dai G, Levy O & Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature ± Smanik PA, Liu Q, Furminger L, Ryu KY, Xing S, Mazzaferri EL et al. Cloning of the human sodium iodide symporter. Biochemical and Biophysical Research Communications ± Smanik PA, Ryu KY, Theil KS, Mazzaferri EL & Jhiang SM. Expression, exon±intron organization, and chromosome mapping of the human sodium iodide symporter. Endocrinology ± Arturi F, Russo D, Schlumberger M, Du Villard JA, Caillou B, Vigneri P et al. Iodide symporter gene expression in human thyroid tumors. Journal of Clinical Endocrinology and Metabolism ± Caillou B, Troalen F, Baudin E, Talbot M, Filetti S, Schlumberger M et al. Na + /I symporter distribution in human thyroid tissues: an immunohistochemical study. Journal of Clinical Endocrinology and Metabolism ± Ryu KY, Senokozlieff ME, Smanik PA, Wong MG, Siperstein AE, Duh QY et al. Development of reverse transcription-competitive polymerase chain reaction method to quantitate the expression levels of human sodium iodide symporter. Thyroid ± Venkataraman GM, Yatin M, Marcinek R & Ain KB. Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na + /I symporter gene methylation status. Journal of Clinical Endocrinology and Metabolism ± Lazar V, Bidart JM, Caillou B, MaheÁ C, Lacroix L, Filetti S et al. Expression of the Na + /I symporter gene in human thyroid tumors: a comparison study with other thyroid-speci c genes. Journal of Clinical Endocrinology and Metabolism ± Saito T, Endo T, Kawaguchi A, Ikeda M, Katoh R, Kawaoi A et al. Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas. Journal of Clinical Investigation ± Jhiang S, Cho JY, Ryu KY, DeYoung BR, Smanik PA, McGaughy VR et al. An immunohistochemical study of Na /I symporter in human thyroid tissues and salivary gland tissues. Endocrinology ± Winzer R, Schmutzler C, Jakobs TC, Ebert R, Rendl J, Reiners C et al. Reverse transcriptase-polymerase chain reaction analysis of thyrocyte-relevant genes in ne-needle aspiration biopsies of the human thyroid. Thyroid ± Arturi F, Russo D, Giuffrida D, Ippolito A, Perrotti N, Vigneri R et al. Early diagnosis by genetic analysis of differentiated thyroid cancer metastases in small lymph nodes. Journal of Clinical Endocrinology and Metabolism ± Ohta K, Endo T & Onaya T. The mrna levels of thyrotropin receptor, thyroglobulin and thyroid peroxidase in neoplastic human thyroid tissues. Biochemical and Biophysical Research Communications ±1255.
5 EUROPEAN JOURNAL OF ENDOCRINOLOGY (2000) 143 NIS transcript in thyroid tumor metastases Schlumberger M, Tubiana M, De Vathaire F, Hill C, Gardet P, Travagli JPet al. Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism ± Nemec J, Rohling S, Zamrazil V & Pohunkova D. Comparison of the distribution of diagnostic and thyroablative 131 I in the evaluation of differentiated thyroid cancer. Journal of Nuclear Medicine ± Pineda JD, Lee T, Ain K, Reynolds JC & Robbins J. Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan. Journal of Clinical Endocrinology and Metabolism ±1492. Received 20 January 2000 Accepted 29 June 2000
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