Rowell 30% kcal P< P< ml/min 73 1 : 35-44, 2015

Transcription

1 7 1 : - 44, kcal P<0.0 1 P< ml/min r=0.99, P< r=0.91, P<0.01 Rowell % : : TEL : FAX :

2 SONOS100, HP770A ; Yokogawa - Hewlett - Packard, Tokyo, Japan & California, USA 4 cm 1 cm Fig. 1. MHz 7. MHz ± ±7. cm cm 69.±6.8 kg kg Fig. 1 Schema of three conduit arterial vessels targeted for measurement of blood ow. Blood flow BF measurements were obtained for abdominal aorta Ao above coeliac trunk bifurcation and for bilateral LFA and RFA. BF to abdominal - pelvic organs BFVis was calculated by subtracting blood ows of left femoral artery BFLFA and right femoral artery BFRFA from BFAo. BFVis is comprehensive measurement of total BF supply to splanchnic gastrointestinal blood vessels, primarily coeliac trunk CT and superior SMA and inferior IMA mesenteric arteries, as well as renal arteries RA, internal iliac arteries, and other minor arteries that supply abdominal and pelvic organs. 2

3 : 7 Fig. 2 Experimental protocol. After 10 min rest, subjects ingested solid food with total caloric volume of 800 kcal Calorie mate, Otsuka Pharmaceutical, Tokyo, Japan within min. Blood velocity and vessel diameter measurements in three conduit arteries were performed within 4 min of each other. Measurement points are indicated by black isosceles triangles. Throughout protocol, heart rate and blood pressure were measured simultaneously Doppler spectrogram B Fig Fig kcal 160 g : 16.8 g 44.4 g 81.4 g RBP ; KANDS, Aichi, Japan RadiaPress <4%. Fisher PLSD : : BFLFA BFVis BFAo BFRFA, 1, 0, 4, 6 8 Fisher PLSD P<0.0 ± BFVis = BFAo - BFLFA+BFRFA 6-11

4 ±0.07 cm 0.92±0.07 cm 0.9±0.08 cm 8 Fig. 2. Fig. 4 2,4±691 ml/ min 1,48 -,771 ml/min 2±129 ml/min ml/min 29±122 ml/min ml/min 1,801±28 ml/min 1,084-2,7 ml/ min 1 P= P= P= P= ml/min 1 P= P= P= Fig. r=0.99 P< r=0.91, P= r=0.88, P=0.084 r=0.67, P= kcal ,688±1,144 ml/min 1,801±28 ml/min 1. Fig. Fig. Pre - and post - prandial heart rate and mean blood pressure. Post - prandial heart rate and mean blood pressure were not different from pre - prandial values. Values represent mean standard deviation. 4

5 : 9 Fig. 4 Blood ow values for three conduit arteries and BFVis. Postprandial BFAo and BFVis increased markedly, but blood ow in femoral artery only showed slight increase at, 0, and 6 min after meal. Blood ow BF to abdominal - pelvic organs BFVis, abdominal aorta BFAo, left femoral artery BFLFA, and right femoral artery BFRFA. *P<0.0 compared to pre - meal. Values represent mean standard deviation. Fig. Relationship between blood ow in upper abdominal aorta and abdominal viscera, as well as between blood ow in upper abdominal aorta and femoral artery. Significant positive correlations were observed for BFAo and BFVis r=0.99, P<0.0001, BFAo and BFFAs r=0.91, P=0.0047, and BFAo and BFRFA r=088, P=0.084, represented by regression lines. However, there was no signi cant correlation r=0.67, P= between BFAo and BFLFA. BFFAs : sum of blood ow in both femoral arteries. 4, Qamar Read

6 % 0 60% 4 7% 90 kcal 62% 0 6% 4 29% 60 20% 6 8% 8-20% % Fig. 4, lag phase r=0.99, P< r=0.91, P= half gastric emptying time T1/2 1/ Malagelada kcal Perko Fig Someya

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10 Determining effect of food intake on comprehensive abdominal - pelvic visceral blood ow by Doppler ultrasound Hiroyasu NAGATA, Takuya OSADA, Norio MURASE, Ryotaro KIME, Toshihito KATSUMURA Department of Sports Medicine for Health Promotion, Tokyo Medical University Abstract Aim : Comprehensive arterial blood ow BF in the abdominal - pelvic viscera BFVis can be calculated by subtracting right and left femoral arterial BF BFRFA and BFLFA, respectively from upper abdominal aorta BF BFAo above the coeliac trunk. The aim of the present study was to evaluate the time course in BFVis and its relation to hemodynamic parameters following food intake using pulsed Doppler ultrasound. Method : Pre - and post - prandial BFAo, BFRFA, and BFLFA were determined in 9 healthy subjects at, 1, 0, 4, 6, and 8 min after intake of 800 kcal solid food. The BFVis was calculated by subtracting both BFFAs from BFAo. Blood pressure and heart rate were also measured at each point. Results : An increase was observed in postprandial BFAo at between 1 and 4 min. Postprandial BFRFA increased at 1 min. An increase was observed in postprandial BFVis at min, with the peak value increase of 887 ml/min compared to value at before food intake occurring at 1 min ; further increase was maintained until 4 min, after which it recovered to pre - food intake values at 8 min. A linear correlation was observed between BFAo and BFVis r=0.99, P<0.0001, as well as between BFAo and both femoral arterial BFs r=0.91, P<0.01. There was no postprandial change in BP or HR. Conclusion : The postprandial BFVis was closely related to BFAo. This suggests that a rise in BFVis indicates an increase in stroke volume, and that BF to the coeliac trunk and superior/inferior mesenteric artery increases due to vasodilation in the splanchnic vascular bed. These results indicate that the type of measurements used in this study may serve as a useful indicator in investigating the time course in BFVis due to food intake. Key words : Comprehensive blood ow in abdominal viscera, Food intake, Pulsed Doppler ultrasound 10