Updates and best practices in the management of gastric cancer
|
|
- Violet Osborne
- 5 years ago
- Views:
Transcription
1 Updates and best practices in the management of gastric cancer Olatunji B. Alese, MD Gastrointestinal Oncology, Winship Cancer Institute of Emory University July 28,
2 Incidence 3rd leading cause of cancer death globally; 723k deaths (lung million deaths, liver - 745k deaths) Estimated 28,000 diagnoses (17,750 in men and 10,250 in women) in 2017 About 10,960 deaths (6,720 men and 4,240 women) 1/3 arise in proximal stomach (cardia, GEJ) Average age of onset 55years Globocan 2012 (IARC), Cancer facts and figures 2017 (ACS) 2
3 Bad news EGJ adenoca has been increasing at 5-10% incidence annually since the mid-1970s Most rapidly increasing cancer in many Western countries 5-6x increase in incidence of gastric cardia cancers in the US optimal multimodality treatment for EGJ adenoca has been difficult e.g. lack of trials that focus on the EGJ Etiology Gastric tumors - H. pylori infection, chronic gastritis, and low acid production EGJ tumors - obesity, high acid production, GERD, inversely associated with H. pylori Blot WJ, et al. JAMA. 1991;265(10):
4 Anatomy Minimum of 15 LNs required for staging D1 Dissection pericardial or perigastric LN D2 Dissection Celiac Left gastric artery Splenic artery Hepatic artery D3 Dissection Para-Aortic/Iliac nodes 4
5 Molecular subtypes of gastric cancer Cancer Genome Altas Research Network. Nature.2014;513(7517):
6 Perioperative/Adjuvant therapy 6
7 Al-Batran S-E, et al. J Clin Oncol. 2017;35(suppl): Abstract
8 Al-Batran S-E, et al. J Clin Oncol. 2017;35(suppl): Abstract
9 Baseline characteristics Baseline 1 Al-Batran S-E, et al. J Clin Oncol. 2017;35(suppl): Abstract
10 Chemotherapy related Toxicity Al-Batran S-E, et al. J Clin Oncol. 2017;35(suppl): Abstract
11 Chemotherapy related Toxicity Al-Batran S-E, et al. J Clin Oncol. 2017;35(suppl): Abstract
12 Al-Batran S-E, et al. J Clin Oncol. 2017;35(suppl): Abstract
13 Advanced/Metastatic 13
14 Targeted Therapies In Advanced Gastric/GEJ Cancer Pathway Agent Clinical Trial Randomization Patients MET HER2 EGFR Angiogenesis Ornartuzumab Rilotumumab Pertuzumab Trastuzumab TDM-1 Lapatinib Panitumumab Cetuximab Ramucirumab Ramucirumab METGASTRIC RILOMET JACOB HELOISE GATSBY TyTAN REAL-3 EXPAND REGARD RAINBOW FOLFOX +/- ornatuzumab ECX +/- rilotumumab XP-T +/- pertuzumab XP-T (standard) vs. XP-T (high dose) TDM-1 vs taxane (2 nd line) Paclitaxel +/- lapatinib (2 nd line) EOX +/- panitumuamb XP +/- cetuximab Ramucirumab vs. BSC (2 nd line) 355 Paclitaxel +/- Ramucirumab (2 nd line) 665 Immune therapy pembrolizumab, avelumab, durvalumab and atezolizumab Multiple early phase trials - - Table courtesy of Manish Shah 14
15 Targeted Therapies In Advanced Gastric/GEJ Cancer Pathway Agent Clinical Trial Randomization Patients MET HER2 EGFR Angiogenesis Ornartuzumab Rilotumumab Pertuzumab Trastuzumab TDM-1 Lapatinib Panitumumab Cetuximab Ramucirumab Ramucirumab METGASTRIC RILOMET JACOB HELOISE GATSBY TyTAN REAL-3 EXPAND REGARD RAINBOW FOLFOX +/- ornatuzumab ECX +/- rilotumumab XP-T +/- pertuzumab XP-T (standard) vs. XP-T (high dose) TDM-1 vs taxane (2 nd line) Paclitaxel +/- lapatinib (2 nd line) EOX +/- panitumuamb XP +/- cetuximab Ramucirumab vs. BSC (2 nd line) 355 Paclitaxel +/- Ramucirumab (2 nd line) 665 Immune therapy pembrolizumab, avelumab, durvalumab and atezolizumab Multiple early phase trials - - Table courtesy of Manish Shah 15
16 ToGA Trial 3803 Pts Screened 810 HER2+ (22.1%) IHC 3+ FISH Pts R a n d o m i z e d 5FU or capecitabine + Cisplatin (n=290) 5FU or capecitabine + Cisplatin + trastuzumab (n=294) Bang YJ, et al. Lancet. 2010;376(9742): , 16
17 ToGA Trial Median Overall Survival Chemotherapy: 11.1 mos Chemo+traztuzumab: 13.8 mos HR 0.74 ( , p=0.0046) Median Progression Free Survival Chemotherapy: 5.5 months Chemo + traz: 6.7 months HR 0.71( ,p=0.0002) Bang YJ, et al. Lancet. 2010;376(9742): , 17
18 Beyond progression Makiyama A, et al. J Clin Oncol. 2017;35(suppl 4): Abstract
19 Makiyama A, et al. J Clin Oncol. 2017;35(suppl 4): Abstract
20 Palle J, et al. J Clin Oncol. 2017;35(suppl 4): Abstract
21 Palle J, et al. J Clin Oncol. 2017;35(suppl 4): Abstract
22 Muro K, et al. J Clin Oncol. 2015;33(suppl): Abstract 3. Muro K, et al. Lancet Oncol. 2016;17(6):
23 KEYNOTE-012 Muro K, et al. J Clin Oncol. 2015;33(suppl): Abstract 3. Muro K, et al. Lancet Oncol. 2016;17(6):
24 KEYNOTE-012: Best Overall Response Best Overall Response, RECIST v1.1 Muro K, et al. J Clin Oncol. 2015;33(suppl): Abstract 3. Muro K, et al. Lancet Oncol. 2016;17(6):
25 KEYNOTE-012 Muro K, et al. J Clin Oncol. 2015;33(suppl): Abstract 3. Muro K, et al. Lancet Oncol. 2016;17(6):
26 KEYNOTE-059 Efficacy and safety of pembrolizumab (pembro) monotherapy in previously treated advanced Gastric Cancer (cohort 1) Fuchs CS, et al. ASCO Abstract Fuchs CS, et al. J Clin Oncol. 2017;35(suppl): Abstract
27 KEYNOTE-059 Fuchs CS, et al. J Clin Oncol. 2017;35(suppl): Abstract
28 KEYNOTE-059 Fuchs CS, et al. J Clin Oncol. 2017;35(suppl): Abstract
29 KEYNOTE-059: Cohort 3 N=31 ORR 25.8% ( ) CR 3.2% Median DOR NR ( ) Median PFS 3.3 mos ( ) Median OS NR (9.2 NE) 6 mo OS 72.9% 12 mo OS 61.7% Fuchs CS, et al. J Clin Oncol. 2017;35(suppl): Abstract
30 CheckMate 032 Nivolumab ± Ipilumumab in advanced chemorefractory gastric, esophageal, or GEJ cancer Janjigian YY, et al. J Clin Oncol. 2017;35(suppl): Abstract
31 CheckMate 032 Nivolumab ± Ipilumumab in advanced chemorefractory gastric, esophageal, or GEJ cancer Janjigian YY, et al. J Clin Oncol. 2017;35(suppl): Abstract ORR: 12% vs. 24% vs. 8% PD-L1+: 19% vs. 40% vs. 23% 31
32 Targeted therapy in gastric cancer Wadwa R, et al. Nat Rev Clin Oncol. 2013;10(11):
33 Conclusions Platinum-5FU backbone as frontline gastric/gej tumors; FLOT as new standard of perioperative care Trastuzumab is indicated in patients with HER-2 overexpression; benefit in continuation beyond progression? Promising activity for PD-1/PDL-1 inhibitors Role of PDL-1 as biomarker is evolving 33
34 Thank you 34
NOVITA IN TEMA DI CARCINOMA GASTRICO ROSA BERENATO
NOVITA IN TEMA DI CARCINOMA GASTRICO ROSA BERENATO ONCOLOGIA MEDICA 1 FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI MILANO PROGRESS AGAINST METASTATIC GC OS in first-line palliative setting Little progress
More informationGastric: 16% 18% 27% Esophageal: 5% 10% 19%
2.5% of all cancers Median age 68 years Decline in gastric cancer incidence Increase in esophageal, GEJ, cardia adenocarcinoma OS improvement, 1975-77, 1984-86, 1999-2006 Gastric: 16% 18% 27% Esophageal:
More informationNew experimental targets for gastric cancer Andrés Cervantes
New experimental targets for gastric cancer Andrés Cervantes Professor of Medicine Outline Acquired capabilities of Cancer IGFR pathway PI3K-AKT-m-TOR pathway MET pathway FGFR pathway Check point inhibitors
More informationThe following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only.
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only. If you have any ques7ons, please contact Imedex via email at:
More informationSystemic treatment in early and advanced gastric cancer
Systemic treatment in early and advanced gastric cancer Andrés Cervantes Professor of Medicine Classical approach to localised gastric cancer n Surgical resection n Pathology assessment and estimation
More informationIMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS
IMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS Dr Elizabeth Smyth Cambridge University Hospitals NHS Foundation Trust ESMO Gastric Cancer Preceptorship Valencia 2018 DISCLOSURES Honoraria for advisory role
More informationCurrent Standard of Care of Gastric Cancer:
Current Standard of Care of Gastric Cancer: Andrés Cervantes Professor of Medicine Classical approach to localised gastric cancer Surgical resection Pathology assessment and estimation of risk Treatment
More informationCurrent Standard of Care of Gastro- Esophageal Cancer
Current Standard of Care of Gastro- Esophageal Cancer Andrés Cervantes Professor of Medicine Classical approach to localised gastric cancer Surgical resection Pathology assessment and estimation of risk
More informationBIOLOGICAL TARGETED AGENTS
BIOLOGICAL TARGETED AGENTS (INCLUDING HER2, EGFR, ANGIOGENESIS) Dr Elizabeth Smyth Royal Marsden Hospital ESMO GI Cancer Preceptorship Singapore 2017 DISCLOSURES Honoraria for advisory role Five Prime
More informationCurrent standards of care in gastric cancer
Current standards of care in gastric cancer Prof Eric Van Cutsem, MD, PhD Digestive Oncology Leuven, Belgium Eric.VanCutsem@uzleuven.be Outline Resectable gastric cancer: the role of neoadjuvant and adjuvant
More informationHighlights STOMACH CANCER
UPDATES and NEWS from the Gastrointestinal Cancers Symposium in San Francisco Roma, 10-11 Febbraio 2017 Highlights STOMACH CANCER Lorenzo Fornaro, MD Unit of Medical Oncology 2 Azienda Ospedaliero-Universitaria
More informationCa Cardias e Stomaco: le diversita e le terapie
XXII Riunione Nazionale I.T.M.O. Ca Cardias e Stomaco: le diversita e le terapie Maria Di Bartolomeo s.s. Oncologia Medica Gastroenterologica Fondazione IRCCS Istituto Nazionale Tumori Milano OUTLINE History
More informationUpdated Apr 2017 by Dr. Ko (Medical Oncologist, Abbotsford Cancer Centre)
Metastatic Esophagogastric Cancer Summary Updated Apr 2017 by Dr. Ko (Medical Oncologist, Abbotsford Cancer Centre) Reviewed by Dr. Yoo-Joung Ko (Medical Oncologist, Sunnybrook Odette Cancer Centre, University
More informationAdvances in gastric cancer: Biology and Treatment for advanced disease
Advances in gastric cancer: Biology and Treatment for advanced disease Andrés Cervantes Professor of Medicine Outline Molecular classification Pathology Classification after gene expression The Cancer
More informationGetting to the Bottom of Treatment: An Update in the Management of Esophagogastric Cancers
Getting to the Bottom of Treatment: An Update in the Management of Esophagogastric Cancers Disclosures None Cindy L. O Bryant, PharmD, BCOP, FCCP, FHOPA Professor, University of Colorado Skaggs School
More informationWhere Are We with Check-Point Inhibitors in Gastric Cancer?
21 June 2018, Barcelona Session VII: Metastatic Gastric Cancer Where Are We with Check-Point Inhibitors in Gastric Cancer? Kei Muro, MD. kmuro@aichi-cc.jp Department of Clinical Oncology Aichi Cancer Center
More informationMetastatic NSCLC: Expanding Role of Immunotherapy. Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian
Metastatic NSCLC: Expanding Role of Immunotherapy Evan W. Alley, MD, PhD Abramson Cancer Center at Penn Presbyterian Disclosures: No relevant disclosures Please note that some of the studies reported in
More informationESMO Preceptorship Targeted Therapy for Gastric Cancer
ESMO Preceptorship Targeted Therapy for Gastric Cancer Professor Dr. Florian Lordick Professor of Oncology Director University Cancer Center Leipzig (UCCL) Disclosure Florian Lordick declares honoraria
More informationPCPA Advanced Trainee Program Upper GI Cancers. Dr N Singhal Medical Oncologist Royal Adelaide Hospital
Upper GI Cancers Dr N Singhal Medical Oncologist Royal Adelaide Hospital Localised disease PCPA Advanced Trainee Program 2018 Submucosal PCPA Advanced Trainee Program 2018 Work up EUS- 90% sensitivity
More informationChemotherapy for Advanced Gastric Cancer
Chemotherapy for Advanced Gastric Cancer Andrés Cervantes Professor of Medicine DISCLOSURE OF INTEREST Employment: None Consultant or Advisory Role: Merck Serono, Roche, Beigene, Bayer, Servier, Lilly,
More informationTumores esófago-gástricos, tiene algo que decir la inmunoterapia? Dr. Fernando Rivera Herrero Hospital Universitario Marqués de Valdecilla.
Tumores esófago-gástricos, tiene algo que decir la inmunoterapia? Dr. Fernando Rivera Herrero Hospital Universitario Marqués de Valdecilla. Santander Finantial disclosure Consultor: CELGENE Research fundings:
More informationManagement of advanced Gastric Cancer in the era of targeted therapy
Management of advanced Gastric Cancer in the era of targeted therapy Osman M.Mansour Prof. Medical Oncology, NCI, Cairo University BGO: 28-3 October 215 Gastric Cancer: A Significant Problem in Some Countries
More informationEsophageal and GEJ Cancers. Case Presentations
Esophageal and GEJ Cancers Case Presentations Locally Advanced GEJ Cancer (Case 1) A 55 year old man with longstanding GERD presents with increasing solid food dysphagia. EGD reveals a 3 cm mass in the
More informationMedical Treatment of Advanced Lung Cancer
Medical Treatment of Advanced Lung Cancer Oncology for Scientists April 26, 2018 Edwin Yau, MD., Ph.D. Assistant Professor of Oncology Department of Medicine Department of Cancer Genetics and Genomics
More informationESMO 2017, Madrid, Spain Dr. Loredana Vecchione Charite Comprehensive Cancer Center, Berlin HIGHLIGHTS ON CANCERS OF THE UPPER GI TRACT
ESMO 2017, Madrid, Spain Dr. Loredana Vecchione Charite Comprehensive Cancer Center, Berlin HIGHLIGHTS ON CANCERS OF THE UPPER GI TRACT DOCETAXEL, OXALIPLATIN AND FLUOROURACIL/LEUCOVORIN (FLOT) FOR RESECTABLE
More informationThe following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only.
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only. If you have any ques7ons, please contact Imedex via email at:
More informationEducational Objectives. Worldwide Incidence. Agenda. Gastric Adenocarcinoma: Risk Factors. Gastric Cancer Statistics
Educational Objectives Evaluate the current evidence across multiple lines of therapy and appropriately sequence therapies for gastric and gastroesophageal (GEJ) cancers Mitigate toxicities associated
More informationIMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS
IMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS Dr Elizabeth Smyth Royal Marsden Hospital ESMO Colorectal Cancer Preceptorship Valencia 2018 DISCLOSURES Honoraria for advisory role Servier, Celgene, BMS, Five
More informationChemotherapy for metastatic gastric cancer
ESMO Asia GI Preceptorship 2018 Chemotherapy for metastatic gastric cancer Sun Young Rha, MD, PhD Yonsei Cancer Center, Institute for Cancer Research, Yonsei University College of Medicine Disclosures
More informationSystemic therapy for esophagogastric cancer: targeted therapies
Review Article on Esophagus Cancer Page 1 of 16 Systemic therapy for esophagogastric cancer: targeted therapies Tomas G. Lyons, Geoffrey Y. Ku Gastrointestinal Oncology Service, Department of Medicine,
More informationPerioperative chemotherapy: individualized therapy or same treatment for all? Prof. Dr. med. Salah-Eddin Al-Batran
Perioperative chemotherapy: individualized therapy or same treatment for all? Prof. Dr. med. Salah-Eddin Al-Batran Institute of Clinical Cancer Research Krankenhaus Nordwest UCT - University Cancer Center
More informationNeo- and adjuvant treatment for gastric cancer: The role of chemotherapy
Anna Dorothea Wagner, PD & MER Department of Oncology University of Lausanne Neo- and adjuvant treatment for gastric cancer: The role of chemotherapy Structure 1. Background and overview 2. Adjuvant chemotherapy:
More informationIncorporating Immunotherapy into the treatment of NSCLC
Incorporating Immunotherapy into the treatment of NSCLC Suresh S. Ramalingam, MD Roberto C. Goizueta Chair for Cancer Research Assistant Dean for Cancer Research Deputy Director, Winship Cancer Institute
More informationASCO 2017 updates in Colorectal and Gastric Cancers. May Cho, M.D.
ASCO 2017 updates in Colorectal and Gastric Cancers May Cho, M.D. Relevant financial relationships in the past twelve months by presenter or spouse/partner: None The speaker will directly disclosure the
More informationGenomics and Genetics in BC: Precise selection for chemotherapy and Immunotherapy. Raanan Berger MD PhD Sheba Medical Center, Israel
Genomics and Genetics in BC: Precise selection for chemotherapy and Immunotherapy Raanan Berger MD PhD Sheba Medical Center, Israel Disclosures Honoraria, Ad board BMS, MSD, Pfizer, Astra Zeneca, Bayer,
More informationTargeted Therapies in Gastric Cancer : Where Do We Stand Today. Yoon-Koo Kang Asan Medical Center, University of Ulsan Seoul, Korea
Targeted Therapies in Gastric Cancer : Where Do We Stand Today Yoon-Koo Kang Asan Medical Center, University of Ulsan Seoul, Korea Chemotherapy is the standard of care in advanced gastric cancer Median
More informationImmunotherapy for Upper GI Cancers
Immunotherapy for Upper GI Cancers Esophageal Adenocarcinoma GE Junction Adeno Gastric Carcinoma Ahmed Zakari MD Medical Director of GI Cancer Program, Florida Hospital Cancer Institute Associate Professor
More informationOverview on Gastric Cancer
Chapter 1 Targeted Therapy and Immunotherapy Daniel da Motta Girardi * Department of oncology, Hospital Sirio-Libanês, Brasília, Brazil. *Correspondense to: Daniel da Motta Girardi, Department of oncology,
More informationLargos Supervivientes, Tenemos datos?
Largos Supervivientes, Tenemos datos? Javier Puente, MD, PhD Medical Oncology Department. Hospital Clinico San Carlos Associate Professor of Medicine. Complutense University of Madrid. Summary Snapshot
More informationImmunotherapy for the Treatment of Head and Neck Cancers. Robert F. Taylor, MD Aurora Health Care
Immunotherapy for the Treatment of Head and Neck Cancers Robert F. Taylor, MD Aurora Health Care Disclosures No relevant financial relationships to disclose I will be discussing non-fda approved indications
More informationImmune Checkpoint Inhibitors for Lung Cancer William N. William Jr.
Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr. Diretor de Onco-Hematologia Hospital BP, A Beneficência Portuguesa Non-Small Cell Lung Cancer PD-1/PD-L1 Inhibitors in second-line therapy
More informationConcept to Practice: New Advances in the Treatment of GI Cancers
Concept to Practice: New Advances in the Treatment of GI Cancers 2016 Community Oncology Alliance Conference Orlando, FL Thomas George, MD, FACP Director, GI Oncology Program Director, Experimental Therapeutics
More informationConversations in Oncology. November Kerry Hotel Pudong, Shanghai China
Conversations in Oncology November 12-13 Kerry Hotel Pudong, Shanghai China Immunotherapy of Lung Cancer Professor Caicun Zhou All materials are for scientific exchanges. Afatinib and nintedanib are not
More informationTranslational Research in Upper GI Cancers: Gastroesophageal Cancer Cholangiocarcinoma
Translational Research in Upper GI Cancers: Gastroesophageal Cancer Cholangiocarcinoma Daniel Catenacci, MD Developmental Therapeutics Symposium April 20, 2018 Disclosure Information 23 rd Annual Developmental
More informationCurrent therapeutic landscape for advanced gastroesophageal cancers
Review Article Page 1 of 19 Current therapeutic landscape for advanced gastroesophageal cancers Anthony Lopez 1,2, Kazuto Harada 1, Dilsa Mizrak Kaya 1, Jaffer A. Ajani 1 1 Department of Gastrointestinal
More informationWhich Treatment Approach is Most Appropriate for Primary Therapy of Gastric Cancer: Neoadjuvant Chemotherapy
Which Treatment Approach is Most Appropriate for Primary Therapy of Gastric Cancer: Neoadjuvant Chemotherapy Joseph Chao, M.D. Assistant Clinical Professor Department of Medical Oncology & Therapeutics
More informationUpdates in Immunotherapy for Urothelial Carcinoma
Updates in Immunotherapy for Urothelial Carcinoma Andrew J Armstrong MD ScM FACP DUA 2018 Copyright 2006 SciMed. Talk Outline Immunotherapy progress in 2017: 5 new approved PD-1/PD-L1 inhibitory agents
More informationEsophageal and GEJ Adenocarcinoma: Chemo + RT is the Preferred Treatment
Esophageal and GEJ Adenocarcinoma: Chemo + RT is the Preferred Treatment David H. Ilson, MD, PhD Gastrointestinal Oncology Service Memorial Sloan-Kettering Cancer Center Preop Therapy in Esophageal and
More informationImmune checkpoint blockade in lung cancer
Immune checkpoint blockade in lung cancer Raffaele Califano Department of Medical Oncology The Christie and University Hospital of South Manchester, Manchester, UK Outline Background Overview of the data
More informationConflicts of Interest GI Malignancies: An Update on Current Treatment Options
Conflicts of Interest GI Malignancies: An Update on Current Treatment Options Nothing to disclose Trevor McKibbin, PharmD, MS, BCOP Clinical Specialist, Hematology/Oncology Winship Cancer Institute of
More informationOptions for first-line cisplatin-eligible patients
The Past Options for first-line cisplatin-eligible patients Metastatic urothelial cancer Cisplatin-eligible Gemcitabine/ cisplatin MVAC or high-dose intensity MVAC Paclitaxel/ cisplatin/ gemcitabine Bellmunt
More informationGastric and Colon Cancer. Dr. Andres Wiernik 2017
Gastric and Colon Cancer Dr. Andres Wiernik 2017 GASTRIC CANCER Gastric Cancer Classification Epidemiology General principles of Management 25% GE Junction Gastric Cancer 75% Gastric Cancer Epidemiology
More informationImmunotherapy for the Treatment of Head and Neck Cancers. Barbara Burtness, MD Yale University
Immunotherapy for the Treatment of Head and Neck Cancers Barbara Burtness, MD Yale University Disclosures AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim, Bristol-Myers Squibb, Merck & Co., Inc.,
More information(Neo-) adjuvant Treatment of Gastric Cancer. - The European View
(Neo-) adjuvant Treatment of Gastric Cancer - The European View Florian Lordick, MD Professor of Oncology Director of the University Cancer Center Leipzig (UCCL) University of Leipzig, Germany My Conflict
More informationInternational Course on Theranostics and Molecular Radiotherapy ImmunoPET in Breast Cancer
International Course on Theranostics and Molecular Radiotherapy ImmunoPET in Breast Cancer Geraldine Gebhart Jules Bordet Institute 5/10/2017 PLAN OF THE TALK Increasing role of antibodies in anti-cancer
More informationThe Rationale for Immunotherapy as an Adjuvant Treatment for Locally Advanced BC
The Rationale for Immunotherapy as an Adjuvant Treatment for Locally Advanced BC Seth P. Lerner, MD, FACS Professor, Scott Department of Urology Beth and Dave Swalm Chair in Urologic Oncology Baylor College
More informationBodoky G, Gil-Delgado M, Cascinu S, Lipatov ON, Cunningham D, Van Cutsem E, Muro K, Chandrawansa K, Liepa AM, Carlesi R, Ohtsu A, Wilke H
Characterizing Tumor Responses From RAINBOW, a Randomized Phase III Trial of Ramucirumab (RAM) Plus Paclitaxel (PAC) vs Placebo (PBO) Plus PAC in Patients (pts) With Previously Treated Advanced Gastric
More informationBiologic therapy in esophageal and gastric malignancies: current therapies and future directions
Review Article Biologic therapy in esophageal and gastric malignancies: current therapies and future directions Pamela Samson 1, A. Craig Lockhart 2 1 Division of Cardiothoracic Surgery, 2 Division of
More informationESMO Asia 2016 Industry Satellite Symposium December 2016, Singapore. Advances in gastric cancer
ESMO Asia 2016 Industry Satellite Symposium 16 19 December 2016, Singapore Advances in gastric cancer Chair: Ian Chau With Mitsuru Sasako, Kei Muro and Yung-Jue Bang Saturday 17th December, 12:45-14:15
More informationIndication for- and timing of cytoreductive nephrectomy Kidney- and bladder cancer: Immunotherapy
Indication for- and timing of cytoreductive nephrectomy Kidney- and bladder cancer: Immunotherapy Axel Bex, MD, PhD The Netherlands Cancer Institute Oslo, September 4, 2018 Financial and Other Disclosures
More informationICLIO National Conference
ICLIO National Conference Immuno-oncology In The Clinic Today Lee Schwartzberg, MD, FACP Executive Director, West Cancer Center Chief, Division of Hematology/Oncology University of Tennessee Health Science
More informationII sessione. Immunoterapia oltre la prima linea. Alessandro Tuzi ASST Sette Laghi, Varese
II sessione Immunoterapia oltre la prima linea Alessandro Tuzi ASST Sette Laghi, Varese AGENDA Immunotherapy post-chemo ( true 2/3L ) Immunotherapy in oncogene addicted NSCLC (yes/no? when?) Immunotherapy
More informationSquamous Cell Carcinoma Standard and Novel Targets.
Squamous Cell Carcinoma Standard and Novel Targets. Mohamed K. Mohamed, MD, PhD Director of Thoracic Oncology Cone Health Cancer Center Greensboro, NC 1 Mohamed Mohamed, MD, PhD Squamous Cell Carcinoma:
More informationMedicina Personalizada de Precisión en el Abordaje del Cáncer Gástrico. Dra Desamparados Roda Pérez Hospital Clínico de Valencia Incliva, CIBERONC
Medicina Personalizada de Precisión en el Abordaje del Cáncer Gástrico Dra Desamparados Roda Pérez Hospital Clínico de Valencia Incliva, CIBERONC Gastric cancer Epidemiology Gastric cancer is an important
More informationProstate cancer Management of metastatic castration sensitive cancer
18 th Annual Advances in Oncology - 2017 Prostate cancer Management of metastatic castration sensitive cancer Urothelial carcinoma Non-muscle invasive urothelial carcinoma Updates in metastatic urothelial
More informationColon Cancer ASCO Poster Review
Rome, February 11 th 2017 AIOM POST ASCO GI Review Colon Cancer ASCO Poster Review Lisa Salvatore UOC Oncologia Policlinico GB Rossi Azienda Ospedaliero Universitaria Integrata di Verona Me Before Me After
More informationTargeted therapy in gastroesophageal cancers: past, present and future
Gastroenterology Report, 3(4), 2015, 316 329 doi: 10.1093/gastro/gov052 Advance Access Publication Date: 27 October 2015 Review REVIEW Targeted therapy in gastroesophageal cancers: past, present and future
More informationINMUNOTERAPIA EN CÁNCER GÁSTRICO Y DE LA UGE: DÓNDE ESTAMOS? Maria Alsina Maqueda, MD, PhD Hospital Universitario Vall d Hebron, Barcelona
INMUNOTERAPIA EN CÁNCER GÁSTRICO Y DE LA UGE: DÓNDE ESTAMOS? Maria Alsina Maqueda, MD, PhD Hospital Universitario Vall d Hebron, Barcelona Outline The Immune System Rational to develop immunotherapy in
More informationImmunotherapeutic Advances in the Treatment of Metastatic Non-Small Cell Lung Cancer
Immunotherapeutic Advances in the Treatment of Metastatic Non-Small Cell Lung Cancer Srinivasa R. Sanikommu, MD, and Kathryn F. Mileham, MD Abstract Lung cancer remains the leading cause of cancer-related
More informationNSCLC: immunotherapy as a first-line treatment. Paolo Bironzo Oncologia Polmonare AOU S. Luigi Gonzaga Orbassano (To)
NSCLC: immunotherapy as a first-line treatment Paolo Bironzo Oncologia Polmonare AOU S. Luigi Gonzaga Orbassano (To) The 800-pound gorilla Platinum-based chemotherapy is the SOC for 1st-line therapy in
More informationOut of 129 patients with NSCLC treated with Nivolumab in a phase I trial, the OS rate at 5-y was about 16 %, clearly higher than historical rates.
6th Meeting on external quality assessment in molecular pathology, Naples, May 12-13, 2017 Overview of clinical development of checkpoint inhibitors in solid tumors Pr Jaafar BENNOUNA University of Nantes
More informationA Giant Leap in the Treatment Options for Advanced Bladder Cancer
A Giant Leap in the Treatment Options for Advanced Bladder Cancer Yohann Loriot, MD, PhD Department of Cancer Medicine & INSERM U981 Gustave Roussy Villejuif, France Clinical Features of Bladder Cancer
More informationThe following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only.
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only. If you have any ques7ons, please contact Imedex via email at:
More informationImmunotherapy for NSCLC: Current State of the Art and Future Directions. H. Jack West, MD Swedish Cancer Institute Seattle, Washington, United States
Immunotherapy for NSCLC: Current State of the Art and Future Directions H. Jack West, MD Swedish Cancer Institute Seattle, Washington, United States Which of the following statements regarding immunotherapy
More informationImmunotherapies for Advanced NSCLC: Current State of the Field. H. Jack West Swedish Cancer Institute Seattle, Washington
Immunotherapies for Advanced NSCLC: Current State of the Field H. Jack West Swedish Cancer Institute Seattle, Washington Nivolumab in Squamous NSCLC Chemo-pretreated (1 st line) Adv squamous NSCLC N =
More informationAtezolizumab Is a Humanized Anti-PDL1 Antibody That Inhibits the Binding of PD-L1 to PD-1 and B7.1
Phase II, Single-Arm Trial (BIRCH) of Atezolizumab as First-Line or Subsequent Therapy for Locally Advanced or Metastatic PD-L1-Selected Non-Small Cell Lung Cancer (NSCLC) Abstract 16LBA Besse B, Johnson
More informationNon-Small Cell Lung Cancer Webinar. Thursday, September 13, p.m. EDT
Non-Small Cell Lung Cancer Webinar Thursday, September 13, 2018 1 2 p.m. EDT 1 2 Webinar Faculty Julie R. Brahmer, MD Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Patrick Forde, MD Johns
More informationNovel Molecularly Targeted Therapies and Biomarkers in Advanced Colorectal Cancer. Objectives
Novel Molecularly Targeted Therapies and Biomarkers in Advanced Colorectal Cancer Michael S. Lee, MD Assistant Professor of Medicine University of North Carolina Objectives Discuss important clinicopathologic
More informationMy name is Dr. David Ilson, Professor of Medicine at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center in New York, New York.
Welcome to this CME/CE-certified activity entitled, Integrating the Latest Advances Into Clinical Experience: Data and Expert Insights From the 2016 Meeting on Gastrointestinal Cancers in San Francisco.
More informationRecent Advances in Lung Cancer: Updates from ASCO 2017
Recent Advances in Lung Cancer: Updates from ASCO 2017 Charu Aggarwal, MD, MPH Assistant Professor of Medicine Division of Hematology-Oncology Abramson Cancer Center University of Pennsylvania 6/15/2017
More informationFabienne Warmerdam Zuyderland
GE Fabienne Warmerdam Zuyderland Disclosure ASCO 2017 travelgrant Pfizer CRC ADJUVANT Less is more? More is More! 1 Less is more? Perspectief INT-0035 stadium III (niets vs 5-FU) 6.5-jaars OS 46% vs. 60%
More informationLung Cancer Immunotherapy
Lung Cancer Immunotherapy Luis E. Raez MD FACP FCCP Chief of Hematology/Oncology & Medical Director Memorial Cancer Institute/Memorial Health Care System Clinical Professor of Medicine Herbert Wertheim
More informationChemotherapy for advanced gastric cancer: future perspective in Japan
Gastric Cancer (2017) 20 (Suppl 1):S102 S110 DOI 10.1007/s10120-016-0648-7 REVIEW ARTICLE Chemotherapy for advanced gastric cancer: future perspective in Japan Kohei Shitara 1 Received: 21 August 2016
More informationResectable locally advanced oesophagogastric cancer
Resectable locally advanced oesophagogastric cancer Clinical Case Discussion Florian Lordick University Cancer Center Leipzig University Clinic Leipzig Leipzig, Germany esmo.org DISCLOSURES Honoraria for
More informationand neck cancers, 2018
Emerging systemic treatments for head and neck cancers, 2018 A. DIMITRIOS COLEVAS, MD PROFESSOR OF MEDICINE (ONCOLOGY) AND, BY COURTESY, OF OTOLARYNGOLOGY - HEAD AND NECK SURGERY AT THE STANFORD UNIVERSITY
More informationINMUNOTERAPIA I. Dra. Virginia Calvo
INMUNOTERAPIA I Dra. Virginia Calvo LBA62. Health-related quality of life (HRQoL) for Pembrolizumab or placebo plus Carboplatin and Paclitaxel or nab-paclitaxel in patients with metastatic squamous NSCLC:
More informationChemotherapy for metastatic gastric cancer
ESMO Asia GI Preceptorship 2017 Sun Young Rha, MD, PhD Yonsei Cancer Center, Institute for Cancer Research, Yonsei University College of Medicine Chemotherapy for metastatic gastric cancer Disclosures
More informationPatient Selection: The Search for Immunotherapy Biomarkers
Patient Selection: The Search for Immunotherapy Biomarkers Mark A. Socinski, MD Executive Medical Director Florida Hospital Cancer Institute Orlando, Florida Patient Selection Clinical smoking status Histologic
More informationBiomarkers in Imunotherapy: RNA Signatures as predictive biomarker
Biomarkers in Imunotherapy: RNA Signatures as predictive biomarker Joan Carles, MD PhD Director GU, CNS and Sarcoma Program Department of Medical Oncology Vall d'hebron University Hospital Outline Introduction
More informationSystemic Treatments for Esophagogastric and Pancreas Cancer in the Adjuvant and Metastatic Settings
Systemic Treatments for Esophagogastric and Pancreas Cancer in the Adjuvant and Metastatic Settings Peter C. Enzinger, MD Dana-Farber Cancer Institute & Harvard Medical School 2017 Master Class Course
More informationNOVITA IN TEMA DI TERAPIA DEL CARCINOMA DEL COLON-RETTO
Congresso AIOM Giovani Perugia, 9 luglio 2016 NOVITA IN TEMA DI TERAPIA DEL CARCINOMA DEL COLON-RETTO Carlotta Antoniotti Polo Oncologico Azienda Ospedaliero-Universitaria Pisana Università di Pisa What
More informationPresentation Number: LBA18_PR. Lecture Time: 09:15-09:27. Speakers: Heinz-Josef J. Lenz (Los Angeles, US) Background
LBA18_PR - Durable Clinical Benefit With Nivolumab (NIVO) Plus Low-Dose Ipilimumab (IPI) as First-Line Therapy in Microsatellite Instability-High/Mismatch Repair Deficient (MSI-H/dMMR) Metastatic Colorectal
More informationRecent Advances in Lung Cancer: Updates from ASCO Updates from ESMO, AACR and ASCO
Recent Advances in Lung Cancer: Updates from ASCO 2018 Updates from ESMO, AACR and ASCO Charu Aggarwal, MD, MPH Assistant Professor of Medicine Division of Hematology-Oncology Abramson Cancer Center University
More informationUpdate on the development of immune checkpoint inhibitors
Update on the development of immune checkpoint inhibitors Jean-Pascal Machiels Department of Medical Oncology Laboratory of Medical Oncology Cliniques universitaires Saint-Luc Université catholique de
More informationUrothelial Cancers- New Strategies. Sandy Srinivas.MD Stanford University
Urothelial Cancers- New Strategies Sandy Srinivas.MD Stanford University Relevant financial relationships in the past twelve months by presenter or spouse/partner. Consultant: Genentech, Astra Zeneca The
More informationPractice changing studies in lung cancer 2017
1 Practice changing studies in lung cancer 2017 Rolf Stahel University Hospital of Zürich Cape Town, February 16, 2018 DISCLOSURE OF INTEREST Consultant or Advisory Role in the last two years I have received
More informationIl ruolo di PD-L1 (42%) tra la prima e la seconda linea di trattamento
Il ruolo di PD-L1 (42%) tra la prima e la seconda linea di trattamento Alessia Pochesci Divisione di Oncologia Toracica Istituto Europeo di Oncologia, Milano Tutor: Prof.ssa Silvia Novello Dott.ssa Chiara
More informationRecent Therapeutic Advances for Thoracic Malignancies
Recent Therapeutic Advances for Thoracic Malignancies Developed in collaboration Learning Objectives Upon completion, participants should be able to: Interpret new developments in the use of radiation
More informationPlotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma
Pieter E. Postmus University of Liverpool Liverpool, UK Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma Disclosures Advisor Bristol-Myers Squibb AstraZeneca
More informationCheckMate 012: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer
CheckMate 12: Safety and Efficacy of First Line Nivolumab and Ipilimumab in Advanced Non-Small Cell Lung Cancer Abstract 31 Hellmann MD, Gettinger SN, Goldman J, Brahmer J, Borghaei H, Chow LQ, Ready NE,
More information