Dr. Linda D. Lee Chief Science Officer VidaShield

Transcription

1 Dr. Linda D. Lee Chief Science Officer VidaShield Room-based active UV-C technology reduces the amount of bacteria and/or fungus in the air and improves indoor air quality.

2 1. Describe at least three instances of healthcare acquired infections that were associated with contaminated air. 2. Describe settings where air decontamination with UV technology can be used safely and effectively. 3. Describe an innovative product that can be used in healthcare facilities to filter and decontaminate air with ultraviolet light technology. 4. Describe the use of ultraviolet light technology to reduce air and environmental contamination in healthcare settings.

3 Air is up to 8 times more contaminated than surfaces Walking sends 100,000 particles per step into the air How pathogens travel on air to surfaces; direct and indirect transmission Surface contamination is directly affected by the air.

4 Bacteria in the air contribute to surface contamination & non-respiratory infections Abundance of human bacteria in the air 2 Hospital air is a potential route of transmission of bacteria like staph and C. Diff 3,4 MRSA and C. diff have been shown to survive for months on hospital surfaces 1,5 1 Best, EL, Fawley, WN, Parnell P, Wilcox MH (2010) The potential for airborne dispersal of clostridium difficile from symptomatic patients, Clin Infect Dis 50(11): doi: / Hospodsky D, Qian J, Nazaroff WW, Yamamoto N, Bibby K, et. al, (2012) Human Occupancy as a Source of Indoor Bacteria, PLoS One 7(4): e34867 doi: /journal.pone Seyed Hamed Mirhoseini PhD, Mahnaz Nikaeen PhD, Zahra Shamsizadeh MS, Hossein Khanahmad PhD. (2016) Hospital air: A potential route for transmission of infections caused by β-lactam resistant bacteria, American Journal of Infection Control doi: /j.ajic E.A. Hathway, C.J. Noakes, P.A. Sleigh, L.A. Fletcher (2011) CFD simulation of airborne pathogen transport due to human activities. Building and Environment, 46 (12) King, M.F., Noakes, C.J., Sleigh, P.A., Camargo-Valero, M.A. (2012) Bioaerosol deposition in single and two-bed hospital rooms: A numerical and experimental study. Building and Environment, 59,

5 High-touch surfaces Pathogen Survival Rates C. difficile 200 days 2,7,8 MRSA 300 days 1,5,10 VRE 200 days 2,3,4 E. Coli 480 days 7,9 Klebsiella 900 days 6,7 Acinetobacter 300 days 7,11 Mycobacterium TB 120 days 7 Candida albicans 120 days 7 1. Beard-Pegler et al J Med Microbiol. 26: BIOQUELL trials, unpublished data. 3. Bonilla et al Infect Cont Hosp Epidemiol. 17: Boyce J Hosp Infect. 65: Duckworth and Jordens J Med Microbial. 32: French et al ICAAC. 7. Kramer et al BMC Infect Dis. 6: Otter and French J Clin Microbial. 47: Smith et al J Med. 27: Wagenvoort et al J Hosp Infect. 45: Wagenvoort and Joosten J Hosp Infect. 52:226-7.

6 Low-touch surfaces Pathogen Survival Rates C. difficile 200 days 2,7,8 MRSA 300 days 1,5,10 VRE 200 days 2,3,4 E. Coli 480 days 7,9 Klebsiella 900 days 6,7 Acinetobacter 300 days 7,11 Mycobacterium TB 120 days 7 Candida albicans 120 days 7 1. Beard-Pegler et al J Med Microbiol. 26: BIOQUELL trials, unpublished data. 3. Bonilla et al Infect Cont Hosp Epidemiol. 17: Boyce J Hosp Infect. 65: Duckworth and Jordens J Med Microbial. 32: French et al ICAAC. 7. Kramer et al BMC Infect Dis. 6: Otter and French J Clin Microbial. 47: Smith et al J Med. 27: Wagenvoort et al J Hosp Infect. 45: Wagenvoort and Joosten J Hosp Infect. 52:226-7.

7 Martinez 1 VRE 2.6x Huang 2 VRE prior room occ. 1.6x MRSA prior room occ. 1.3x Drees 3 VRE cultured w/i room 1.9x VRE prior room occ. 2.2x VRE prior room 2 weeks 2.0x Shaughnessy 4 C. diff prior room occ. 2.4x Nseir 5 A. Baumannii prior room 3.8x P. aeruginosa prior room 2.1x 1 Martinez et al. Arch Intern Med 2003; 163: Huang et al. Arch Intern Med 2006; 166: Drees et al. Clin Infect Dis 2008; 46: Shaughnessy. ICAAC/IDSA Abstract K Nseir et al. Clin Microbiol Infect 2010 (in press).

8 Major components of an infection control program A Bundled Approach to Achieve Maximum Results Surface Cleaning Hand Hygiene Air Purification PPE Note: VidaShield is not intended to treat HAIs and does not claim to reduce HAIs. Treatment

9 UV has a history in healthcare Upper room air disinfection Biological safety cabinet Air handlers & air conditioning units UV robots UV lamps in water treatment

10 UV-C Air Purification How It Works Draws room air into UV-C Neutralizes bacteria and fungi Recirculates treated air back into the room Works continuously Benefits Operates 24/7 Staff did not have to operate it Installed in hospital room during occupation Once patient leaves, maintenance consists of changing filters Reduces bacteria and fungi in treated air Reduces settling of bacteria and fungi in treated air onto surfaces

11 Study location % Reduction in airborne bacteria Notes Desert Springs Hospital 80% Surface bacteria reduced 66% Kentucky Hospital patient room 46% Hospital-reported infections reduced 53% Lowell General ICU 69% Surface bacteria reduced 51% Lowell General OR Break Room 70% Surface bacteria reduced 48% Tennessee Nursing Home 51% Nursing Home-reported infections reduced 28% Staff reported air felt fresh and clean, odors were reduced and allergies were minimized. Hospital, Kentucky 53% reduction in infection rates+ +Infection rate data supplied by institution. HAI incident rate due to multiple factors. Nursing Home, Tennessee 28% reduction in infection rates

12 HAI-causing bacteria are located on surfaces. Airborne bacteria contributes to surface contamination. Reducing airborne bacteria, reduces surface bacteria. Studies reported up to 80% reduction in airborne bacteria in occupied rooms, up to 66% reduction in surface bacteria. Kentucky Hospital reported their infection rate was reduced by over 50% after installing air purification system.

13 Dr. Linda D. Lee Chief Science Officer Any Questions?