Neurobiology of Epileptogenesis
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2 Neurobiology of Epileptogenesis Michael C. Smith, MD Director, Rush Epilepsy Center Professor and Senior Attending Neurologist Rush University Medical Center Chicago, IL
3 Network Milieu Cellular Milieu Synaptic Milieu Molecular Milieu Molecular, Synaptic, and Cellular Effects of Seizures SEIZURE seconds-to-minutes hours-to-days weeks-months-years Intracellular Extracellular Presynaptic Element (Axon Terminals) Postsynaptic Element (Receptors/Channels) Presynaptic- Postsynaptic Functional Unit Ca++ Enzyme Activity Adenosine K+ Glutamate Excitation GABA Inhibition Facilitation PTP LTP Gene Expression Nerve Growth Factors Axon Proliferation, Growth 1 Synaptogenesis Kainate Receptors BZD Receptors Glia Neurons Necrosis Neuron Loss Apoptosis Gliosis Local Circuit Excitation > Inhibition Imbalance Projection Circuit Disconnection Between Regions Lothman EW. Epilepsy: Models, Mechanisms, and Concepts
4 Basic Mechanisms of Seizures Neuronal short-circuit - PDS Paroxysmal Depolarization Shift Neuronal synchronization Gap junctions, ephaptic coupling, electrical fields, ionic concentrations Transition from interictal to ictus Failure of inhibition, excessive excitation
5 Paroxysmal Depolarization Shift Paroxysmal Depolarization Shift (PDS) is described in both experimental animal models of epilepsy and in human tissue obtained in epilepsy surgery Intracellular expression of epileptic spike Well-characterized with micro-electrode studies
6 Na + influx Ca +2 influx Paroxysmal Depolarization Shift Paroxysmal depolarization shift o Vm Vth Vrest -70 mv TIME Voltage dependent K + efflux Ca + 2 dependent 200 msec
7 Paroxysmal Depolarization Shift Pathophysiology of PDS Abnormal ionic conductance (Na + /Ca ++ ) Due to increased number of ionic channels Excessive response to normal input Due to excessive excitatory input Giant EPSP (excitatory post-synaptic potential) Probably a combination of both
8 PDS Origin of Interictal Spike Intracellular recording Extracellular recording Paroxysmal depolarizing shift Wong PK, et al. Prog Brain Res
9 PDS Ionic Conductance A. Interictal PDS within seizure focus B. Basic cortical circuit Feed-forward inhibition Feedback inhibition Westbrook G. Principles of Neuroscience
10 Epileptic Focus Interplay Between Excitatory and Inhibitory Circuitry Westbrook G. Principles of Neuroscience
11 Neurobiology of Absence Seizures A EEG Neuron GABA GABA GABA GABA T-Ca ++ T-Ca ++ T-Ca ++ 1 sec B Cortex Thalamus T R T R Re Nu Dichter MA. Epilepsia
12 Neuronal Synchronization Poorly understood and difficult to study Synchronization is necessary to reach the critical mass of neurons to overwhelm normal surround inhibition for transition to ictus There are multiple mechanisms responsible for neuronal synchronization
13 Neuronal Synchronization Neuronal synchronization may occur at dendritic and axonal levels, but not at cell body Gap junctions on these processes, when blocked, prevent fast ripple potentials that synchronize adjacent neurons Electrical field effects may synchronize adjacent neurons Alterations in extracellular space and ionic concentrations affect neuronal excitability and synchronization Scharfman HE. Curr Neurol Neurosci Rep
14 Interactions Between NMDA Activation, Extracellular Space and Potassium Concentration Spike threshold Burst AHP Depolarization IPSP NMDA receptor NEURONAL FIRING DURING INTERICTAL BURSTS Cell swelling EC space Ephaptic coupling RISE IN BASELINE [K + ] Larger [K + ] transient during interictal burst Seizure
15 Effects of Seizure on Extracellular Space and Ionic Concentration Lothman EW. Epilepsy: Models, Mechanisms, and Concepts
16 Glial Cell - Role in Generation and Spread of Seizures Impaired K + buffering due to reduced gk(ir) in sclerotic epileptic hippocampus Enhanced expression of astroglial gap junction protein supports hypersynchronization Enhanced activation of metabotropic glutamate receptors with increased intracellular Ca ++ Steinhäuser C. Eur J Pharmacol
17 Astrocytic Ionic Regulatory Function Steinhäuser C. Eur J Pharmacol
18 Pathophysiology of Interictal Spike Interictal discharge Originating in temporal lobe Excitatory Center Inhibitory surround Pyramidal Cells Basket cells Synaptic inhibition in surrounding neurons DS Hyperpolarization Dichter MA. Epilepsia
19 Transition to Ictus Imbalance of excitation and inhibition Failure of inhibition: Activity dependent disinhibition Loss of the after hyperpolarization (AHP) Loss of surround inhibition Excessive glutamate stimulation Positive feedback Recurrent excitatory feedback circuitry Staley K. Nat Neurosci. 2015; Scharfman HE. Curr Neurol Neurosci Rep
20 Transition from Interictal State to Ictus Tonic Phase Clonic Phase Seizure Focus Distant Lothman EW. Epilepsy: Models, Mechanisms, and Concepts
21 GABA Desensitization Leading to Inhibitory Failure
22 Glutamate Neurotransmission Dichter MA. Epilepsia
23 Excessive Excitation Breaking Down Inhibition
24 Seizure-induced Change in Neuron Function and Structure Lothman EW. Epilepsy: Models, Mechanisms, and Concepts
25 An 18-month old male has a 25 minute convulsion followed by R-sided Todd s Paralysis. The following may occur: A. Excitotoxic damage to the dentate gyrus B. Neuronal reorganization leading to hyperexcitable hippocampus C. Increased risk of later seizures D. All of the above
26 Example of Excitotoxicity in Hippocampus after Status Epilepticus
27 Important Factors in Epileptogenesis Alteration/expression/membrane localization in GABAA subunits resulting in changes in phasic/tonic inhibition and response to modulators (BZD/Zn) Up-regulation of NMDA and AMPA is seen in both models of epileptogenesis and from TLE pathology Reorganization of neuronal networks Brooks-Kayal AR, et al. J Neurosci. 1999; Stasheff SF, et al. Science. 1989; Sharfman HE. Prog Brain Res
28 Synaptic Reorganization Resulting in Hyperexcitability and Epilepsy Seizures result in neuronal death of the hilar dentate neurons The hilar dentate neuron is the target of the dentate granule mossy fiber axon These fibers seek new synaptic contacts, at times, reinnervating themselves resulting in a recurrent positive feedback loop Tauck DL, et al. J Neurosci. 1985; Sutula T, et al. Science ;Sharfman Prog Brain Res,2007
29 Hippocampal Reorganization Holmes MM, et al. Behav Neurosci
30 Synaptic Reorganization Resulting in Hyperexcitability and Epilepsy Hyperexcitability is due to the loss of feed forward inhibition due to loss of excitatory input to the inhibitory basket cell Loss of the inhibitory neurons feedback inhibition Probably all three mechanisms are involved Sloviter RS, et al. Science
31 Changes in Synaptic Connectivity in Epilepsy Sloviter RS, et al. Science
32 Hippocampal Epilepsy Dentate Gyrus as Gatekeeper A - Normal circuitry Dentate gyrus Parahippocampal gyrus Hippocampus Hippocampus Dentate gyrus _ + + _ G BC + BC Mossy cell Dentate gyrus Parahippocampal gyrus B -Temporal lobe epilepsy Dentate gyrus _ + + _ G BC + BC Mossy cell Hippocampus Dentate gyrus Parahippocampal gyrus Sloviter RS. Ann Neurol
33 Receptor Activation During Seizure Tonic-Clonic Electrographic Paroxysm EEG Neuron AMPA GABA NMDA 1sec Non-T Ca ++ Primary Epileptogenic Zone Zone of Dissemination Lothman EW. Epilepsy: Models, Mechanisms, and Concepts
34 Inflammation in Experimental Models In many animal models of epilepsy and acute seizures there is up-regulation of inflammation with microglial activation and increased expression of transcription factors and cytokines that help coordinate the inflammatory response Toll-like receptor (TLR) family upregulated in microglia leading to transcriptional activation of cytokines, chemokines in the MHC class I and II This contributes to the seizure-related neuronal death and neuronal reorganization seen in hippocampal epilepsies Zimmer LA, et al. J Comp Neurol. 1997; Turrin NP, et al. Neurobiol Dis
35 Breakdown of BBB In mice, CNS infection with LCMV results in seizures and death CD8+ T cells recognize LCMV infected cells, bind to them and kill them CD8+ T cells secrete chemokines, which trigger influx of myeloid cells and breakdown of BBB Depleting the myeloid cells delays seizures and death, suggesting a causal role of inflammation, breakdown of BBB, and fatal seizures LCMV=lymphocytic choriomeningitis virus Kim JV, et al. Nature
36 Breakdown of BBB Pilocarpine model of experimental seizures and epilepsy Pilocarpine results in transient adherence between WBCs and endothelial cells of BBB resulting in a leaky BBB This permits albumin and other proteins to cross the BBB causing down regulation of astrocytic K+ channels, disrupting K+ homeostasis producing seizures and epilepsy. Seizures induce angiogenesis with porous BBB. Suppressing this interaction between WBC and endothelial cells and porous BBB prevented seizures and progression to epilepsy Fabene PF, et al. Nat Med. 2008; Ivens S, et al. Brain. 2007; Rigau V, et al. Brain
37 Paraneoplastic/Autoimmune Encephalitis Clinical phenotype Myelitis, limbic or brainstem encephalitis Antibodies intracellular proteins ie, anti-hu, anti-ma2, anti CRMPs encephalomyelitis Antibodies to synaptic proteins ie, anti-nmda, anti-ampa, LG1 antibody, anti-gaba A,B, anti-caspar2, anti-lgi1 Treatment: Steroids, IVIG, PLEX, remove tumor. If no response rituximab, cyclophosphamide Graus F, et al. Lancet Neurol
38 Epilepsy and Other Chronic Convulsive Diseases Every fit, slight or severe, is in some degree the effect of those which precede it, the cause of those that follow it. Gowers WR
39 Pathophysiology of Epilepsy ONTOGENY EPILEPTOGENESIS Lothman EW. Epilepsy: Models, Mechanisms, and Concepts
40 Epileptogenesis Genetics Initiating Event Critical modulators Structural/ Functional changes Clinical Seizures CHRONIC EPILEPSY Age Refractory Epilepsy? Neurobehavioral changes, Cognitive impairment? Latent Period
41 Basic Mechanisms of Epilepsy Seizures beget seizures Kindling model of epilepsy Model of partial epilepsy as well as neuronal learning Chronic epilepsy is maladaptive learning Prevent, rather than treat, intractable epilepsy Gowers WR
42 Anticonvulsant Agents Identified by maximal electroshock or metrazol models Stop expression or spread of seizures Na + channel/gaba mechanism of action Little effect on interictal spiking No effect on epileptogenesis (development of seizures) as judged by the kindling model of epilepsy
43 Antiepileptogenic Agent Affects the development with variable effects on the expression of seizures Interferes with the development of kindling Suppresses interictal spiking Action via glutamate mechanisms/ca ++? Protects neuronal circuits from the deleterious effects of epileptic discharges
44 Kindling Model of Epilepsy In 1967, Goddard reported on a new phenomenon he called kindling : Electrical stimulation in the rat amygdala that initially produced no clinical change in the animals behavior but did produce an after discharge (AD) if repeated daily days produced a permanent epileptic condition Goddard GV. Nature
45 EEG: Kindling; Day Prolongation and Spread of the AD Day 1 Day 6 Day 14
46 Kindling Model Widespread effects on neurotransmitters, receptors, neuronal processes, and gene expression Potentiation EPSP in stimulated pathway Long term potentiation (LTP) occurs early in the kindling process This allows better coupling between EPSP and neuronal output Goddard GV. Nature. 1967; Bertram E. Epilepsia
47 This residual disposition to repetition of the same activity is the physical basis of memory, of muscular training, of all cerebral education and it is the basis of the morbid education of the brain which underlies epilepsy. Gowers WR
48 Kindling Model Only model to allow a quantitative analysis of epileptogenesis and its prevention with AEDs Study the effect of AED on AD length and the number of electrical stimulations to reach a certain seizure stage Model for SPS, CPS, and CPS with secondary generalization Bertram E. Epilepsia
49 AEDs Effect on Epileptogenesis Sodium channel blockers treat kindled seizure but do not inhibit the kindling process Sodium channel blockers (DPH,CBZ) offer no prophylaxis in the development of epilepsy Valproate, levetiracetam, and perhaps zonisamide, topiramate, and perampanel blunt the epileptogenic process as judged by the kindling model? Prevents the development of epilepsy
50 Conclusions Understanding the basic mechanisms of seizures allows increased understanding of the MOA of our AEDS and offers additional treatment targets in the treatment of seizures (ie, gap junction blockers). Understanding basic mechanisms of epilepsy offers novel treatment options that may prevent the development of intractable epilepsy and its cognitive and behavioral sequelae.
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