Key words: Chlamydia pneumoniae, acute upper resiratory infections, culture, micro-if method

Transcription

1 Key words: Chlamydia pneumoniae, acute upper resiratory infections, culture, micro-if method

2 Table 1 Prevalence of antibodies to C. pneumoniae in patients and control group There was no statistically significant difference in seroprevalence between patients and controls at the p=0.05 level by the chi-square test

3 Table 2 Results of selological test and tonsilar crypt culture in 10 patients with C. pneumoniae infection a/b: acute/convalesent serum titer Table 3 Results of isolation of microbial organisms from tonsilar crypts in patients with or without C. pneumoniae infection Two bacterial species were isolated from tonsilar crypt in 2 patients

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5 1) Grayston, J. T., Kuo, C. C., Wang, S. P. & Altman, J.: A new Chlamydia psittaci strain, TWAR, isolated in acute respiratory tract infections. N. Eng. J. Med., 315: , ) Marrie, T. J., Grayston, J. T., Wang, S. P. & Kuo, C. C.: Pneumonia associated with the TWAR strain of Chlamydia. Ann. Int. Med., 106: 507 3) Kleemola, M., Saikku, P., Visakorpi, R., Wang, S. P. & Grayston, J. T.: Epidemics of pneumonia caused by TWAR, a new Chlamydia organ- ism, in military trainees in Finland. J. Infect. Dis., 157 : , ) Saikku, P., Wang, S. P., Kleemola, M., Brander, E., Rusanen, E. & Grayston, J. T.: An epidemic of mild pneumonia due to an unnsual strain of Chlamydia psittaci. J. Infect. Dis., 151: , ) Grayston, J. T., Campbell, L. A., Kuo, C. C., Mordhorst, C. H., Saikku, P., Thom, D. H. & Wang, S. P.: A new respiratory pathogen: Chlamydia pneumoniae strain TWAR. J. Inf. Dis., 161: , ) Wang, S. P. & Grayston, J. T.: Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. Am. J. Ophthal., 70 : , ) Grayston, J. T., Wang, S. P., Kuo, C. C. & Campbell, L. A.: Current knowledge on Chlamydia pneumoniae, strain TWAR, an important cause of pneumonia and other acute respiratory diseases. Eur. J. Microbiol. Infect. Dis., 8: 191

6 10) Grayston, J. T., Kuo, C. C., Campbell, L. A. & Wang, S. P.: Chlamydia pneumoniae sp. nov. for Chlamydia sp. Strain TWAR. Int. J. Syst. Bacteriol., 39: 88-90, ) Pether, J. V. S., Wang, S. P. & Grayston, J. T.: 14) Kobayashi, S., Morishita, T., Miyake, T., Fukushi, H., Hirai, K., Ishihara, Y. & Isomura, S.: Prevalence of Chlamydia pneumoniae in Japan. J. Infect. Dis., 163 : , Chlamydia pneumoniae, strain TWAR, as the 15) Thom, D. H., Grayston, J. T., Wang, S. P., Kuo, cause of an outbreak in a boys' school previously C. C. & Altman, J.: Chlamydia pneumoniae called psittacosis. Epidem. Inf., 103: 395 strain TWAR, Mycoplasma pneumoniae, and viral infections in acute respiratory disease in a university student health clinic population. Am. J. Epidemiol., 132: , ) Grayston, J. T.: Chlamydia pneumoniae, strain TWAR. Chest, 95: , ) Monto, A. S. & Ullman, B. M.: Acute respiratory illness in an American community. J. A. M. A., 227: , Acute Upper Resiratory Tract Infections Associated with Chlamydia pneumoniae Kazuhiro HASHIGUCHI & Hiroshi OGAWA Ear Nose Throat Clinic, The Kitasato Institute Hospital Yukumasa KAZUYAMA Research and Development Center of Hygienic Science, Kitasato University From March 1990 to January 1991, a total of 46 outpatients with acute upper respiratory infections (URTI) were studied to determine the etiological role of Chlamydia pneumoniae. Sera from 40 patients were tested by micro-if method for evidence of recent or past infections of this organism, and swab specimens from tonsilar crypt from 26 were cultured. Sera from 20 patients without any evidence of acute infectious disease were selected as controls. The seroprevalence of antibodies to C. pneumoniae was 52.5% in patients group and 30.0% in the control group. No statistical difference was found in seroprevalence between patients and controls. Serological evidence of acute infections with C. pneumoniae was found in 7 (17.5%) patients with acute URTI, but was not found in any of the control group. Of 26 patients, three (11.5%) had C. pneumoniae isolated from a tonsilar crypt swab specimen. Therefore ten of the 46 patients with acute URTI were associated with C. pneumoniae. It is suggested that C. pneumoniae is a common pathogen in acute upper respiratory infections without any evidence of lower respiratory tract symptoms.