Case Study: Opiates use for Anesthesia & analgesia
|
|
- Caroline Phillips
- 5 years ago
- Views:
Transcription
1 rganic Lecture Series Receptor Sites and Drug Design Case Study: piates use for Anesthesia & analgesia 52 rganic Lecture Series PAI 53
2 Drug interactions at the cellular level rganic Lecture Series The lock and key model. A substrate is a substance whose reactions are catalyzed by an enzyme. Herea drug occupying the receptor site of the natural substrate. 54 Drug interactions at the cellular level Medicinal rganic Chemistry Lecture Series Induced fit theory: the receptor site (proteins) can adapt their conformations to fit the compound. The site is not rigid, but rather elastic or flexible. Example with enzyme-substrate: 55
3 rganic Lecture Series The functional groups and their placement in three-dimensional space determines to a large degree a molecule s biological activity. The portion of a molecule that determines the biological effects of a drug is called the pharmacophore. 56 Medicinal Uses for Morphine: rganic Lecture Series as an adjunct to general anesthesia in epidural anesthesia or intrathecal analgesia for palliative care (i.e. to alleviate pain without curing the underlying reason for it, usually because the latter is found impossible) as an antitussive for severe cough; (Codeine is better) Codeine 57
4 rganic Lecture Series An analgesic (also known as a painkiller) is any member of the group of drugs used to relieve pain (achieve analgesia). The word analgesic derives from Greek an- ("without") and algos ("pain"). A general anesthetic is a drug that brings about a reversible loss or alteration of consciousness. Local anesthesia is any technique to render part of the body insensitive to pain without affecting consciousness. 58 H Medicinal rganic Chemistry Lecture Series H 3 C CH 3 H Morphine H 3 C CH 3 Diacetyl-morphine (Heroin) Why do humans have receptor sites for such a complex structure? 59
5 rganic Lecture Series Endorphins ("endogenous morphine") are endogenous opioid peptides (discovered in 1974) An enkephalin is a pentapeptide involved in regulating perception of pain in the body 60 piate antagonist-reversal agent rganic Lecture Series H H aloxone CH 3 piate reversal agent (competitive antagonist) -high affinity for µ-receptor site H CH 3 xycodone 61
6 rganic Lecture Series H piate antagonist-reversal agent H altrexone piate reversal agent (blocks pleasure centers) -used for treatment of alcohol dependence (alcoholism) & opiate addiction 62 H H Medicinal rganic Lecture Chemistry Series R CH 3 Morphine CH 3 H H H R CH 3 H 63
7 rganic Lecture Series "" R 4 1 CH 3 64 rganic Lecture Series 1960-a new opiate, which was based on the piperidine structure was introduced: Fentanyl is about 100 X the potency of morphine 65
8 H rganic Lecture Series How does fentanyl and morphine compare? CH 3 H 66 Commercial Synthesis of Fentanyl Medicinal rganic Lecture Chemistry Series Cl H 2 Br H 2 K 2 C 3 abh 4 H H H Fentanyl 67
9 Anaquest Approach to 4,4-Disubstituted Piperdines: rganic Lecture Series H 2 C HCl reflux KC H H CH EtH H 3 + C 2 Et H Et 3 Cl C 2 Et C 2 Et H 2 Pd(H) 2 /C H 2 68 C 2 Et Medicinal rganic Lecture Chemistry Series H 2 S K 2 C 3 Br Br K 2 C 3 C 2 Et S Fast acting-less potent than fentanyl C 2 Et Br 5-10X more potent than fentanyl 10,000 X more potent K 2 C 3 than morphine C 2 Et Modify ester- ew class of drugs? 69
10 rganic Lecture Series rganic compounds are transformed to molecules of increasing polarity, then excreted by the kidneys: B A B inactivation C ase I: xidation-reduction Hydrolysis Demethylation ase II: Synthesis (acylation, methylation etc.) Conjugation-covalent bonding with carbohydrates, AA or sulfates 70 Metabolism of Piperidine Analgetics Medicinal rganic Lecture Chemistry Series 71
11 rganic Lecture Series C 2 H H Known to be inactive metabolite LAH Cl H Et 3 R Et 3 Cl R 72 rganic Lecture Series R armacological Profile: MHP: ED 50 =0.06 potent analgetic MHP: >15 min long acting analgetic K i = 3-9 (strength of µ receptor binding) Anesthesia 2-3 Minutes-short acting 73
12 Medicinal rganic Lecture Chemistry Series R(R) Esters& Carbonates Already covered by Anaquest Patent 74 rganic Lecture Series Ultra short acting analgesic Remifentanil is a specific µ-receptor agonist. It is potent & short acting- (1/2 life~4 min) a reduction in sympathetic nervous system tone, respiratory depression and analgesia. dose-dependent decrease in heart rate arterial pressure respiratory rate and tidal volume near normal 75
Receptor Sites and Drug Design
Receptor Sites and Drug Design Case Study: piates use for Anesthesia & analgesia 1 PAI 2 The functional groups and their placement in three-dimensional space determines to a large degree a molecule s biological
More informationWR Fentanyl Symposium. Opioids, Overdose, and Fentanyls
Opioids, Overdose, and Fentanyls Outline: What are opioids? Why are we experiencing and opioid crisis? Potency, purity, and product How do opioids cause overdose and overdose deaths? What is naloxone and
More informationAnalgesia is a labeled indication for all of the approved drugs I will be discussing.
Comparative Opioid Pharmacology Disclosure Analgesia is a labeled indication for all of the approved drugs I will be discussing. I ve consulted with Glaxo (remifentanil), Abbott (remifentanil), Janssen
More informationTHE OPIUM POPPY OPIOID PHARMACOLOGY 2/18/16. PCTH 300/305 Andrew Horne, PhD MEDC 309. Papaver somniferum. Poppy Seeds Opiates
OPIOID PHARMACOLOGY PCTH 300/305 Andrew Horne, PhD andrew.horne@ubc.ca MEDC 309 THE OPIUM POPPY Papaver somniferum Sleep-bringing poppy Poppy Seeds Opiates Opium Poppy Straw 1 OPIATES VS. OPIOIDS Opiates:
More informationAgonists: morphine, fentanyl Agonists-Antagonists: nalbuphine Antagonists: naloxone
Opioid Definition All drugs, natural or synthetic, that bind to opiate receptors Agonists: morphine, fentanyl Agonists-Antagonists: nalbuphine Antagonists: naloxone Opioid agonists increase pain threshold
More informationMEDICINAL CHEMISTRY II EXAM #3
MEDICIAL CEMISTRY II EXAM #3 May 2, 2008 ame Med. Chem umber SECTI A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 60
More informationNarcotic analgetics (opiates, opioids) Morphine
Analgesic agents, analgesic drugs, painkillers arcotic analgetics (opiates, opioids) Opium alkaloids Analgesic: a drug bringing about insensibility to pain without loss of consciousness. Pain: physiological
More informationAnalgesic Drugs PHL-358-PHARMACOLOGY AND THERAPEUTICS-I. Mr.D.Raju,M.pharm, Lecturer
Analgesic Drugs PHL-358-PHARMACOLOGY AND THERAPEUTICS-I Mr.D.Raju,M.pharm, Lecturer Mechanisms of Pain and Nociception Nociception is the mechanism whereby noxious peripheral stimuli are transmitted to
More informationOP01 [Mar96] With regards to pethidine s physical properties: A. It has an octanol coefficient of 10 B. It has a pka of 8.4
Opioid MCQ OP01 [Mar96] With regards to pethidine s physical properties: A. It has an octanol coefficient of 10 B. It has a pka of 8.4 OP02 [Mar96] Which factor does NOT predispose to bradycardia with
More informationKaram Darwish. Dr. Munir. Munir Gharaibeh
7 Karam Darwish Dr. Munir Munir Gharaibeh Opioid Analgesics Pain is an important symptom as it is usually the symptom that brings the patient to the hospital, and an Analgesic is a drug used to relieve
More informationMEDICINAL CHEMISTRY II EXAM #2 April 1, 2005
MEDIIAL EMITRY II EXAM #2 April 1, 2005 ame Med. hem umber ETI A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 50 points
More informationDrugs Used In Management Of Pain. Dr. Aliah Alshanwani
Drugs Used In Management Of Pain Dr. Aliah Alshanwani 1 Drugs Used In Management Of Pain A CASE OF OVERDOSE Sigmund Freud, the father of psychoanalysis His cancer of the jaw was causing him increasingly
More informationOpioid Pharmacology. Dr Ian Paterson, MA (Pharmacology), MB BS, FRCA, MAcadMEd. Consultant Anaesthetist Sheffield Teaching Hospitals
Opioid Pharmacology Dr Ian Paterson, MA (Pharmacology), MB BS, FRCA, MAcadMEd Consultant Anaesthetist Sheffield Teaching Hospitals Introduction The available opioids and routes of administration - oral
More informationOverview of Pharmacodynamics. Psyc 472 Pharmacology of Psychoactive Drugs. Pharmacodynamics. Effects on Target Binding Site.
Pharmacodynamics Overview of Pharmacodynamics Psychology 472: Pharmacology of Psychoactive Drugs Generally is defined as effects of drugs on a systems Can be associated with any system Neural, Heart, Liver,
More informationPharmacogenetics of Codeine. Lily Mulugeta, Pharm.D Office of Clinical Pharmacology Pediatric Group FDA
Pharmacogenetics of Codeine Lily Mulugeta, Pharm.D Office of Clinical Pharmacology Pediatric Group FDA 1 Codeine Overview Naturally occurring opium alkaloid Demethylated to morphine for analgesic effect
More informationJanuary 25, Introduction to Pharmacology
January 25, 2015 Introduction to Pharmacology Edward Fisher, Ph.D., R.Ph. Professor and Associate Dean for Academic Affairs Director MS Clinical Psychopharmacology University of Hawaii at Hilo College
More informationWhat is an opioid? What do opioids do? Why is there an opioid overdose crisis? What is fentanyl? What about illicit or bootleg fentanyls?
What is an opioid? What do opioids do? Why is there an opioid overdose crisis? What is fentanyl? What about illicit or bootleg fentanyls? What is an opioid? What do opioids do?: The term opioid can be
More informationb. Explain the structure-activity relationships of the opioid agonists and antagonists. HO
B. 2 Opioid agonists and antagonists a. Provide a brief overview of the history of morphine. 300 BC juice extracted from papavertum somniferum described by Theophratus contains phenanthrines and isoquinolones
More informationPAIN & ANALGESIA. often accompanied by clinical depression. fibromyalgia, chronic fatigue, etc. COX 1, COX 2, and COX 3 (a variant of COX 1)
Pain - subjective experience associated with detection of tissue damage ( nociception ) acute - serves as a warning chronic - nociception gone bad often accompanied by clinical depression fibromyalgia,
More informationDr M H Mosaddegh Pharm D, PhD
Dr M H Mosaddegh Pharm D, PhD opioid All compounds related to opium Opium derived from opos, Greek word of juice, juice of opium poppy, Papaver somniferum Opiates Drugs derived from opium. Included the
More informationFentanyls and Naloxone. Opioids, Overdose, and Naloxone
Opioids, Overdose, and Naloxone Presenter Disclosure Presenter s Name: Michael Beazely I have no current or past relationships with commercial entities Speaking Fees for current program: I have received
More informationPatrick, An Introduction to Medicinal Chemistry 5e Chapter 11 Pharmacokinetics and related topics
Patrick, An Introduction to dicinal Chemistry 5e Answers to end-of-chapter questions 1) In contrast to benzene, toluene has an accessible methyl group which can be manipulated easily by metabolic enzymes.
More informationLife History of A Drug
DRUG ACTION & PHARMACODYNAMIC M. Imad Damaj, Ph.D. Associate Professor Pharmacology and Toxicology Smith 652B, 828-1676, mdamaj@hsc.vcu.edu Life History of A Drug Non-Specific Mechanims Drug-Receptor Interaction
More information3/15/2018. Pain. Pain. Opioid Analgesics Addiction. Pain
Pain Pain Well, I guess that explains the abdominal pains. Well, I guess that explains the abdominal pains. Pain is a component of virtually all clinical strategies, and management of pain is a primary
More informationNervous System Communication. Nervous System Communication. The First Nerve Cells 1/2/11
Nervous System Communication Nervous System Communication Process information Transfer information to other neurons Generate behavior and experience The First Nerve Cells Developed in primitive animals
More informationClinical pharmacological aspects of heroin and fentanyl overdoses
Clinical pharmacological aspects of heroin and fentanyl overdoses Ola Dale Professor Norwegian University of Technology of Science St. Olav s University Hospital, Trondheim, Norway 1 Opioids Sydenham 1680:
More informationGeneral anesthetics. Dr. Shamil AL-Noaimy Lecturer of Pharmacology Dept. of Pharmacology College of Medicine
General anesthetics Dr. Shamil AL-Noaimy Lecturer of Pharmacology Dept. of Pharmacology College of Medicine Rationale General anesthesia is essential to surgical practice, because it renders patients analgesic,
More informationMetabolism. Objectives. Metabolism. 26 July Chapter 28 1
Metabolism bjectives Describe various processes by which drugs are metabolized Describe induction and inhibition of metabolism Use the venous equilibration model to describe hepatic clearance and the effect
More informationOpioid use in older adults Is it a good idea? Regional Geriatric Rounds April 26, 2013
Opioid use in older adults Is it a good idea? Regional Geriatric Rounds April 26, 2013 Allen R. Huang, MDCM, FRCPC, FACP, AGSF Division of Geriatric Medicine allenhuang@toh.on.ca I have no conflict of
More informationAre codeine and dihydrocodeine the same
Home Search Are codeine and dihydrocodeine the same Dihydrocodeine is prescribed for moderate-to-severe types of pain. Learn more about the medication, including dosage and side effects, at Patient. 27-5-2010
More informationChapter31. Opioid Analgesics & Antagonists
Chapter31 Opioid Analgesics & Antagonists Pain Acute pain: Identified event, resolves days weeks Usually nociceptive Chronic pain: Cause often not easily identified, multifactorial Indeterminate duration
More informationOpiates: Use, Abuse, and Detection
piates: Use, Abuse, and Detection Dr. Leo Kadehjian Palo Alto, California Abused Prescription Drugs pioids CS Depressants Morphine, codeine, etc. xycodone (xycontin) Buprenorphine Methadone entanyl Meperidine
More informationPharmacology of Opioid Analgesics
Pharmacology of Opioid Analgesics Harvey Berman, PhD, MPH Department of Pharmacology and Toxicology hberman@buffalo.edu (716) 829-2658 1 01-OPIOID_ANALGESIA_2018 - November 17, 2018 NO SIGNIFICANT FINANCIAL,
More informationAnalgesics OPIOID ANALGESICS
Analgesics Opioid (Narcotic analgesics) Non-opioid (Nonsteroidal antiinflammatory drugs) OPIOID ANALGESICS Morphine is the most important alkaloid of opium the dried juice obtained from the capsules of
More informationIs it Heroin or Prescription Drugs?
Is it Heroin or Prescription Drugs? Dr. Leo Kadehjian Palo Alto, California piates are outranked only by alcohol as humanity s oldest, most widespread, and most persistent drug problem Harvard Mental Health
More informationMerja Kokki MD, PhD Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, School of Medicine, University of Eastern Finland
Long-acting opioids in obstetric analgesia and the newborn Merja Kokki MD, PhD Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, School of Medicine, University of Eastern Finland
More informationDr. Hiwa K. Saaed. PhD Pharmacology & Toxicology College of Pharmacy, University of Sulaimani Analgesic
12/17/18 Analgesics Opioids" Pharmacology Dr. Hiwa K. Saaed PhD Pharmacology & Toxicology College of Pharmacy, University of Sulaimani 2018-2019 1 Analgesic Analgesic an agent that selectively relieves
More informationOptimal sedation and management of anxiety in patients undergoing endobronchial ultrasound (EBUS)
Optimal sedation and management of anxiety in patients undergoing endobronchial ultrasound (EBUS) Georgios Dadoudis Anesthesiologist ICU DIRECTOR INTERBALKAN MEDICAL CENTER Optimal performance requires:
More informationOption D: Medicinal chemistry
Option D: Medicinal chemistry 15 /25 hours 156 Essential idea: Medicines and drugs have a variety of different effects on the functioning of the body. D.1 Pharmaceutical products and drug action Risks
More informationA. Correct! Nociceptors are pain receptors stimulated by harmful stimuli, resulting in the sensation of pain.
Pharmacology - Problem Drill 19: Anti-Inflammatory and Analgesic Drugs No. 1 of 10 1. are pain receptors stimulated by harmful stimuli, resulting in the sensation of pain. #01 (A) Nociceptors (B) Histamines
More informationPolypeptides. Dr. Mamoun Ahram Summer, 2017
Polypeptides Dr. Mamoun Ahram Summer, 2017 Resources This lecture Campbell and Farrell s Biochemistry, Chapters 3 (pp.72-78) and 4 Definitions and concepts A residue: each amino acid in a (poly)peptide
More informationLecture 1 and 2 ONE. Definitions. Pharmacology: the study of the interaction of drugs within living systems
Lecture 1 and 2 ONE 1. Explain what pharmacology encompasses and how it relates to other disciplines 2. Discuss the types of drug target and the factors that influence the binding of drugs to these targets
More informationPrescription Pain Management. University of Hawai i Hilo Pre- Nursing Program NURS 203 General Pharmacology Danita 1 Narciso Pharm D
Prescription Pain Management University of Hawai i Hilo Pre- Nursing Program NURS 203 General Pharmacology Danita 1 Narciso Pharm D 2 Objectives Understand how to preform a pain assessment Know which medications
More informationChapter 23 Enzymes 1
Chapter 23 Enzymes 1 Enzymes Ribbon diagram of cytochrome c oxidase, the enzyme that directly uses oxygen during respiration. 2 Enzyme Catalysis Enzyme: A biological catalyst. With the exception of some
More informationAt a Glance. Background Information. Lesson 3 Drugs Change the Way Neurons Communicate
Lesson 3 Drugs Change the Way Neurons Communicate Overview Students build upon their understanding of neurotransmission by learning how different drugs of abuse disrupt communication between neurons. Students
More informationThe Nervous System. Chapter 4. Neuron 3/9/ Components of the Nervous System
Chapter 4 The Nervous System 1. Components of the Nervous System a. Nerve cells (neurons) Analyze and transmit information Over 100 billion neurons in system Four defined regions Cell body Dendrites Axon
More informationAn overview of Medication Assisted Treatment (MAT) and acute pain management on MAT
An overview of Medication Assisted Treatment (MAT) and acute pain management on MAT Goals of Discussion Recognize opioid use disorder (OUD) Discuss the pharmacology of medication assisted treatments (MAT)
More informationNERVOUS SYSTEM NERVOUS SYSTEM. Somatic nervous system. Brain Spinal Cord Autonomic nervous system. Sympathetic nervous system
SYNAPTIC NERVOUS SYSTEM NERVOUS SYSTEM CENTRAL NERVOUS SYSTEM PERIPHERAL NERVOUS SYSTEM Brain Spinal Cord Autonomic nervous system Somatic nervous system Sympathetic nervous system Parasympathetic nervous
More informationMethadone Maintenance
Methadone Maintenance A Practical Guide to Pharmacotherapy Methadone/Buprenorphine 101 Workshop, April 1, 2017 Ron Joe, MD, DABAM Objectives I. Pharmacology Of Methadone II. Practical Application of Pharmacology
More informationIdeal Sedative Agent. Pharmacokinetics. Benzodiazepines. Pharmacodynamics 11/11/2013
Ideal Sedative Agent Pharmacology of Benzodiazepines Used for Conscious Sedation in Dentistry Peter Walker Anxiolysis Analgesic No effect on CVS No effect on respiratory system Not metabolised Easy and
More informationIdeal Sedative Agent. Benzodiazepines 11/12/2013. Pharmacology of Benzodiazepines Used for Conscious Sedation in Dentistry.
Pharmacology of Benzodiazepines Used for Conscious Sedation in Dentistry Peter Walker Ideal Sedative Agent Anxiolysis Analgesic No effect on CVS No effect on respiratory system Not metabolised Easy and
More informationOPIATES AND ADDICTION MEDICATIONS. Dr. Carroll W. Thornburg, D.O Chief Medical Officer in Primary Care and Addiction Services
OPIATES AND ADDICTION MEDICATIONS Dr. Carroll W. Thornburg, D.O Chief Medical Officer in Primary Care and Addiction Services Dr. Carroll W. Thornburg, D.O Chief Medical Officer in Primary Care and Addiction
More informationGeneral Anesthesia. Mohamed A. Yaseen
General Anesthesia Mohamed A. Yaseen M.S,c Surgery Before Anesthesia General Anesthesia ( GA ) Drug induced absence of perception of all sensation allowing surgery or other painful procedure to be carried
More informationManagement of Pain. Agenda: Definitions Pathophysiology Analgesics
C. Brian Warriner, MD, FRCPC Professor and Past Chair UBC Department of Anesthesiology, Pharmacology and Therapeutics brian.warriner@vch.ca Agenda: Definitions Pathophysiology Analgesics Gases(N 2 O) Opiates
More informationniap Terms and Definitions
Our topic today is about analgesics. niap General concept: pain brings patients to the Doctors at the same time. Fear from the pain can keep the patient from going to the Doctors at appropriate time. We
More informationMarket Share & Competition
Psych 181: Lecture 3 Overview of Pharmaceutical Industry Drug nomenclature and classification Pharmacokinetics Pharmacodynamics Professor Anagnostaras Market Share & Competition Pharmaceutical Automobile
More informationPharmacology for CHEMISTS
Pharmacology for CHEMISTS JOSEPH G. CANNON ACS Professional Reference Book AMERICAN CHEMICAL SOCIETY OXFORD UNIVERSITY PRESS Washington D.C. New York Oxford 1999 CONTENTS I Chemical and Biological Bases
More informationInteraction between Sedation and Weaning: How to Balance Them? Guillermo Castorena MD Fundacion Clinica Medica Sur Mexico
Interaction between Sedation and Weaning: How to Balance Them? Guillermo Castorena MD Fundacion Clinica Medica Sur Mexico Balance is not that easy! Weaning Weaning is the liberation of a patient from
More informationReview of Biochemistry
Review of Biochemistry Chemical bond Functional Groups Amino Acid Protein Structure and Function Proteins are polymers of amino acids. Each amino acids in a protein contains a amino group, - NH 2,
More informationOST. Pharmacology & Therapeutics. Leo O. Lanoie, MD, MPH, FCFP, CCSAM, ABAM, MRO
OST Pharmacology & Therapeutics Leo O. Lanoie, MD, MPH, FCFP, CCSAM, ABAM, MRO Disclaimer In the past two years I have received no payment for services from any agency other than government or academic.
More information3/26/14. Opiates PSY B396 ALCOHOL, ALCOHOLISM, & DRUG ABUSE. Early History Cont d. Early History. Opiate Use in the 19th century. Technology Advances
Opiates PSY B396 ALCOHOL, ALCOHOLISM, & DRUG ABUSE Chapter 10 Opiates The most dramatic example of the doubleedged sword character of drugs Most potent painkillers Prototype addictive drug: Heroin Early
More informationFrom opium to analgesic tests: An introduction to the functioning and studying of the opioid system
Practice-oriented, student-friendly modernization of the biomedical education for strengthening the international competitiveness of the rural Hungarian universities TÁMOP-4.1.1.C-13/1/KONV-2014-0001 From
More informationPHRM20001: Pharmacology - How Drugs Work!
PHRM20001: Pharmacology - How Drugs Work Drug: a chemical that affects physiological function in a specific way. Endogenous substances: hormones, neurotransmitters, antibodies, genes. Exogenous substances:
More informationFrom opium to analgesic tests: An introduction to the functioning and studying of the opioid system
Practice-oriented, student-friendly modernization of the biomedical education for strengthening the international competitiveness of the rural Hungarian universities TÁMOP-4.1.1.C-13/1/KONV-2014-0001 From
More informationOPIOIDS. Dr S Walton Eastbourne DGH 2012
OPIOIDS Dr S Walton Eastbourne DGH 2012 Learning objectives Terminology Receptors Pharmacology of Opioids Partial Agonist/ antagonist Side effects Bits about some individual drugs Terminology Terminology
More information44th Annual CME Conference for Physician Assistants. Alexander Bautista, MD Assistant Professor Anesthesiology and Pain Medicine
44th Annual CME Conference for Physician Assistants Alexander Bautista, MD Assistant Professor Anesthesiology and Pain Medicine Fifth Vital Sign: 15 years later Opioid Epidemic Relevant Disclosure and
More informationChemistry 506: Allied Health Chemistry 2. Chapter 22: Biosynthetic Pathways. Making Complex Biomolecules
Chemistry 506: Allied Health Chemistry 2 1 Chapter 22: Biosynthetic Pathways Making Complex Biomolecules Introduction to General, rganic & Biochemistry, 5 th Edition by Bettelheim and March: Chapter 22,
More information9. The phenomenon that occurs upon taking additional doses of acetaminophen for pain when a 100 percent response has been attained is called A.
1 Student: 1. The main source of new drugs derived today is: A. Synthetic sources B. Animal sources C. Plant sources D. Mineral sources 2. The nonproprietary name of a medication is also known as the:
More informationAbuse Potential of Morphine/ Dextromethorphan Combinations
S26 Journal of Pain and Symptom Management Vol. 19 No. 1(Suppl.) January 2000 Proceedings Supplement NMDA-Receptor Antagonists: Evolving Role in Analgesia Abuse Potential of Morphine/ Dextromethorphan
More informationChapter 4. Drug Biotransformation
Chapter 4 Drug Biotransformation Drug Biotransformation 1 Why is drug biotransformation necessary 2 The role of biotransformation in drug disposition 3 Where do drug biotransformation occur 4 The enzymes
More informationSlide 1. Slide 2. Slide 3. Opioid (Narcotic) Analgesics and Antagonists. Lesson 6.1. Lesson 6.1. Opioid (Narcotic) Analgesics and Antagonists
Slide 1 Opioid (Narcotic) Analgesics and Antagonists Chapter 6 1 Slide 2 Lesson 6.1 Opioid (Narcotic) Analgesics and Antagonists 1. Explain the classification, mechanism of action, and pharmacokinetics
More informationHydrocodone compound cough syrup. Pinni Meedha Mojutho Ammanu Dengina Koduku Part 1 Kama Kathalu
Search for: Search Search Hydrocodone compound cough syrup Pinni Meedha Mojutho Ammanu Dengina Koduku Part 1 Kama Kathalu Free online pharmacy compare service for consumers with many brand and generic
More informationOpiates after subutex
Opiates after subutex The Borg System is 100 % Opiates after subutex 20-5-2010 How long after taking suboxone. If this is your first visit,. Two opiates to wd from all at once, it was so horrible I had
More information6/6/2018. Nalbuphine: Analgesic with a Niche. Mellar P Davis MD FCCP FAAHPM. Summary of Advantages. Summary of Advantages
Nalbuphine: Analgesic with a Niche Mellar P Davis MD FCCP FAAHPM 1 Summary of Advantages Safe in renal failure- fecal excretion Analgesia equal to morphine with fewer side effects Reduced constipation
More informationOPIOIDS. Testing and Interpretation
OPIOIDS Testing and Interpretation TOPICS OF DISCUSSION Effects of Opioids Opiates vs. Opioids Drug Testing Recent Trends OPIOIDS: Testing and Interpretation 2018 2 EFFECTS OF OPIOIDS 3 Opioid Receptors
More informationOpiates. Justine Biragane, McKaylee Copher, Lynsey Crumbie, Claire Jones
Opiates Justine Biragane, McKaylee Copher, Lynsey Crumbie, Claire Jones History & Evolution Opiates are natural pain relievers that are derived from opium, found in poppy plants. The use of opiates dates
More informationPHA2022. Pharmacology considers: - Pharmacotherapy: o Drug-response relationship o Selectivity of action o Structure-action relationship.
PHA2022 Pharmacology considers: - Pharmacotherapy: o Drug-response relationship o Selectivity of action o Structure-action relationship Lecture 1 ONE 1. Define the terms pharmacodynamics and pharmacokinetics
More informationCl or C here H 2 N. 4. Consider the following local anesthetic agents and find the pharmacophore. Double bonds. have been omitted for clarity.
Lecture 15 omework Key Medicinal Chemistry 1. Associate each one of the following terms with one of the three phases: pharmaceutical (PC), pharmacokinetic (PK), pharmacodynamics (PD) PC refers to getting
More information3. AMINO ACID AND PEPTIDES
3. AMINO ACID AND PEPTIDES 3.1 Amino Acids and Peptides General structure - Only 20 amino-acids are found in proteins - Amino group and carboxyl group - α-carbon and side chain group 3.1 Amino Acids and
More informationMedicinal Chemistry I Examination Name December 15, 2009 Med. Chem. #
Medicinal Chemistry Examination ame December 15, 2009 Med. Chem. # Part. 80 Points (40 Questions; 2 Points Each) Select the BEST answer for each of the following. f none of the answers are correct, do
More informationPharmacology of Selected Opioid Analgesics
Pharmacology of Selected Opioid Analgesics Harvey Berman, PhD, MPH Department of Pharmacology and Toxicology hberman@buffalo.edu 829-2658 1 02-OPIOID_ANALGESIA_2018 - November 17, 2018 As a consequence
More informationNarcotic Analgesics. Jacqueline Morgan March 22, 2017
Narcotic Analgesics Jacqueline Morgan March 22, 2017 Pain Unpleasant sensory and emotional experience with actual or potential tissue damage Universal, complex, subjective experience Number one reason
More informationMetabolic Changes of Drugs and Related Organic Compounds. Oxidative Reactions. Shokhan J. Hamid. 3 rd stage/ 1 st course Lecture 6
Metabolic Changes of Drugs and Related Organic Compounds Oxidative Reactions 3 rd stage/ 1 st course Lecture 6 Shokhan J. Hamid B. OXIDATION INVOLVING CARBON OXYGEN SYSTEMS: Oxidative O-dealkylation of
More informationRecap: A little chemistry helps to understand a lot of biology
Recap: A little chemistry helps to understand a lot of biology Covalent Bonds Polar and Non-Polar Electronegativity is key! Non-covalent bonds: Intra and inter molecular interactions Hydrogen Bonds Ionic
More informationDr. Nafith Abu Tarboush
11 Dr. Nafith Abu Tarboush July 3 rd 2013 Marah Dannoun Continuation of amino acids applications in life other than tryptophan and tyrosine: 1. Glutamate (glutamic acid): it s modified to give monosodium
More informationPostoperative Pain Management. Nimmaanrat S, MD, FRCAT, MMed (Pain Mgt)
Postoperative Pain Management Nimmaanrat S, MD, FRCAT, MMed (Pain Mgt) Topics to be Covered Definition Neurobiology Classification Multimodal analgesia Preventive analgesia Step down approach Measurement
More informationChapter 25. General Anesthetics
Chapter 25 1. Introduction General anesthetics: 1. Analgesia 2. Amnesia 3. Loss of consciousness 4. Inhibition of sensory and autonomic reflexes 5. Skeletal muscle relaxation An ideal anesthetic: 1. A
More informationAnalgesia for Patients with Substance Abuse Disorders. Lisa Jennings CN November 2015
Analgesia for Patients with Substance Abuse Disorders Lisa Jennings CN November 2015 Definitions n Addiction: A pattern of drug use characterised by aberrant drug-taking behaviours & the compulsive use
More informationNaloxone. Medical Uses. Opiate overdose. From Wikipedia, the free encyclopedia. Naloxone
Naloxone From Wikipedia, the free encyclopedia Naloxone Naloxone, sold under the brandname Narcan among others, is a medication used to reverse the effects of opioids, especially in overdose. [2] Naloxone
More informationCONCERNED ABOUT TAKING OPIOIDS AFTER SURGERY?
CONCERNED ABOUT TAKING OPIOIDS AFTER SURGERY? ASK YOUR DOCTOR ABOUT EXPAREL FOR LONG-LASTING, NON-OPIOID PAIN RELIEF. VISIT EXPAREL.com/patient FOR MORE INFORMATION. YOU HAVE A SAY IN HOW YOUR PAIN IS
More informationBuprenorphine pharmacology
Buprenorphine pharmacology Victorian Opioid Management ECHO Department of Addiction Medicine St Vincent s Hospital Melbourne 2018 Page 1 Opioids full, partial, antagonist Full Agonists - bind completely
More information12/14/2018. Disclosures. Buprenorphine. Drug-Receptor Interactions. Affinity
ECHO Ontario Chronic Pain Bootcamp OPIOID CHALLENGE Buprenorphine/Naloxone: What and How? Friday, December 7, 2018 Disclosures Presenters: John Flannery & Andrew Smith Conflicts of Interest: None John
More informationUnit II Problem 7 Pharmacology: Substance Abuse, Dependence and Addiction
Unit II Problem 7 Pharmacology: Substance Abuse, Dependence and Addiction Drugs are classified as being Used (medically approved) abused (medically NOT approved) - What is the difference between dependence
More informationADRENERGIC RECEPTOR ANTAGONISTS: ALPHA RECEPTOR BLOCKERS
Jack Deuiter, Principles of Drug Action 2, Fall 2000 ADEEGIC ECEPT ATAGISTS: ALPA ECEPT BLCKES General PC/MC: Understand the term "antagonist" and how an antagonist is similar to an agonist, and how an
More informationOpioid Overdose Best Practices Guideline. Table of Contents. A. General description: B: Typical signs and symptoms:
Opioid Overdose Best Practices Guideline Table of Contents A. General description B. Typical signs and symptoms C. Expected course D. Making the diagnosis E. Recommended treatment F. Criteria for hospital
More informationdisease or in clients who consume alcohol on a regular basis. bilirubin
NON-OPIOID Acetaminophen(Tylenol) Therapeutic class: Analgesic, antipyretic Aspirin (ASA, Acetylsalicylic Acid) Analgesic, NSAID, antipyretic Non-Opioid Analgesics COMMON USES WHAT I NEED TO KNOW AS A
More informationToxicant Disposition and Metabolism. Jan Chambers Center for Environmental Health Sciences College of Veterinary Medicine
Toxicant Disposition and Metabolism Jan Chambers Center for Environmental Health Sciences College of Veterinary Medicine chambers@cvm.msstate.edu Definitions Disposition Absorption passage across membrane.
More informationPSY 302 Lecture 6: The Neurotransmitters (continued) September 12, 2017 Notes by: Desiree Acetylcholine (ACh) CoA + Acetate Acetyl-CoA (mitochondria) (food, vinegar) + Choline ChAT CoA + ACh (lipids, foods)
More informationChapter 10 Manipulating Molecules and Designing Drugs
Chapter 10 Manipulating Molecules and Designing Drugs Is our society becoming dependent on prescription drugs? How harmful are illicit drugs? How are effective drugs designed? Herbal remedies: Is natural
More information2018 Learning Outcomes
I. Pain Physiology and Anatomy (20%) A. Describe the basic anatomy of the nervous system. B. Describe the physiological mechanisms of neuronal function (eg- action potentials). C. Review the nociceptive
More information