pros and cons
|
|
- Hugo O’Brien’
- 5 years ago
- Views:
Transcription
1 A Gynecologic Oncology Group Study Randomized Phase III Trial of Whole-Abdominal Irradiation Versus Doxorubicin and Cisplatin Chemotherapy in Advanced Endometrial Carcinoma: v.s. III GOG Marcus E. Randall, Virginia L. Filiaci, Hyman Muss, Nick M. Spirtos, Robert S. Mannel, Jeffrey Fowler, J. Tate Thigpen, and Jo Ann Benda J Clin Oncol 24, 36-44, pros and cons Purpose To compare whole-abdominal irradiation (WAI) and doxorubicin-cisplatin (AP) chemotherapy in women with stage III or IV endometrial carcinoma having a maximum of 2 cm of postoperative residual disease. 2cmIII IV (WAI) (AP) Conclusion Chemotherapy with AP significantly improved progression-free and overall survival compared with WAI. AP WAI progression-free overall survival ( ( ) 5. 6.
2 To compare whole-abdominal irradiation (WAI) and doxorubicin-cisplatin (AP) chemotherapy in women with stage III or IV endometrial carcinoma having a maximum of 2 cm of postoperative residual disease. 2cmIII IV (WAI) (AP) III IV Abdominal radiotherapy for cancer of the uterine cervix and endometrium. Potish RA, Int J Radiat Oncol Biol Phys. Jun;16(6):1453-8, (FIGO)III IV 49 open-field 2. surgical stagingwhole abdominal radiotherapy 3. 2cm The 5-year relapse-free rate was 63% in women with stage + CT III/IV endometrial carcinoma. 4. WBC3,000/l granulocyte1,500/l, platelets100,000/l creatinine2mg%, bilirubin1.5x, AST3X (EF) GOG PS:
3 Adjuvant whole abdomino-pelvic irradiation (WAPI) for high risk endometrial carcinoma Gibbons S, et.al. Int J Radiat Oncol Biol Phys. Sep;21(4): , 1991 III IV 56 WAPI The 7-year actuarial survival was 57.8% for Stage III, and 25.0% for Stage IV. Treatment of high-risk uterine cancer with whole abdomino-pelvic radiation therapy Ron S. et.al.int J Radiat Oncol Biol Phys48: , 2000 WAPI is a safe, effective treatment for patients with optimally debulked advanced-stage uterine endometrial carcinoma. DFS of 79% of 89% III IV 22 2cmIII IV ( ) control arm : 30Gy/20 (PALN): 15Gy/8 Phase II trial of adriamycin in the treatment of advanced Phase II trial of cisplatin as first-line chemotherapy in or recurrent endometrial carcinoma: patients with advanced or recurrent endometrial carcinoma: a GOG study. a GOG Study. Thigpen JT, et.al. Cancer Treat Rep. Jan;63(1):21-7, 1979 Thigpen JT, et.al. Gynecol Oncol. 33(1):68-70, mg/m23 43 CR CR (4%) 8 PR (16%) 2 SD (45%) (37.2%) 50% 2 Adriamycin is an active agent in the treatment of advanced or recurrent endometrial carcinoma. Cisplatin has definite activity when given at the dose and schedule tested to patients with endometrial carcinoma who have not received prior chemotherapy. CR PR SD PD 2/49 (4%) 8/49 (8%) 22/49 (45%) 17/49 (35%)
4 Phase III Trial of Doxorubicin With or Without Cisplatin in Advanced Endometrial Carcinoma: A GOG Study Thigpen, J. T. et al. J Clin Oncol; 22: Response (N = 281) Doxorubicin (n = 150) No. of Patients Complete response 12 Partial response 26 No response 112 HR: (95% CI, to 0.939; P =.014) % Doxorubicin + Cisplatin (n = 131) No. of Patients % (AP) (AP) 60mg/m2 50mg/m mg/m granulocyte1,500/l 100,000/l 2. 60mg/m2 15mg/m2 15mg/m G-CSF 5. 20% 2.0mg 6. Primary endpoint: Progression free survival (): Secondary endpoint: Overall survival (): % Hazard ratio33 ( =0.05) Follow-up ( ) ( 222 ) follow-up 74 Intent-to-treat
5 HR:0.71(95%CI,0.55 to 0.91; p=0.007) HR:0.68(95%CI,0.52 to 0.89; p=0.004)
6 Conclusion Chemotherapy with AP significantly improved progression-free and overall survival compared with WAI. Nevertheless, further advances in efficacy and reduction in toxicity are clearly needed. AP WAI
Present status and future direction of clinical trials in advanced endometrial carcinoma
J Gynecol Oncol Vol. 9, No. 3:57-6, September 8 DOI:.38/jgo.8.9.3.57 Review Article Present status and future direction of clinical trials in advanced endometrial carcinoma Division of Gynecologic Oncology,
More informationProf. Dr. Aydın ÖZSARAN
Prof. Dr. Aydın ÖZSARAN Adenocarcinomas of the endometrium Most common gynecologic malignancy in developed countries Second most common in developing countries. Adenocarcinomas, grade 1 and 2 endometrioid
More informationreceive adjuvant chemotherapy
Women with high h risk early stage endometrial cancer should receive adjuvant chemotherapy Michael Friedlander The Prince of Wales Cancer Centre and Royal Hospital for Women The Prince of Wales Cancer
More informationBackground Management of high risk, early stage endometrial cancer is controversial. Historically, adjuvant pelvic radiation therapy is standard for
A Phase III Trial of Pelvic Radiation Therapy versus Vaginal Cuff Brachytherapy Followed by Paclitaxel/Carboplatin Chemotherapy in Patients with High-risk, Early-stage Endometrial Cancer: A Gynecology
More informationOriginal Date: June 2013 ENDOMETRIAL CANCER
National Imaging Associates, Inc. Clinical guidelines Original Date: June 2013 ENDOMETRIAL CANCER Page 1 of 6 Radiation Oncology Last Review Date: July 2018 Guideline Number: NIA_CG_129 Last Revised Date:
More informationFoROMe Lausanne 6 février Anita Wolfer MD-PhD Cheffe de clinique Département d Oncologie, CHUV
FoROMe Lausanne 6 février 2014 Anita Wolfer MD-PhD Cheffe de clinique Département d Oncologie, CHUV Epithelial Ovarian Cancer (EOC) Epidemiology Fifth most common cancer in women and forth most common
More informationPelvic palliative radiotherapy for gynecological cancers present state of knowledge and pending research questions to answer
Pelvic palliative radiotherapy for gynecological cancers present state of knowledge and pending research questions to answer Esten S. Nakken MD PhD Division of Cancer Medicine Oslo University Hospital
More informationENDOMETRIAL CANCER Updated Apr 2017 by: Dr. Jenny Ko (Medical Oncologist, Abbotsford Cancer Centre)
ENDOMETRIAL CANCER Updated Apr 2017 by: Dr. Jenny Ko (Medical Oncologist, Abbotsford Cancer Centre) Source: UpToDate 2017, ASCO/CCO/Alberta provincial guidelines, NCCN Reviewed by: Dr. Sarah Glaze (Gynecologic
More informationChemotherapy for Advanced Endometrial Cancer with Carboplatin and Epirubicin
Chemotherapy for Advanced Endometrial Cancer with Carboplatin and Epirubicin SYED HAMMAD TIRMAZY, URMILA BARTHAKUR, AHMED EL-MODIR, SUHAIL ANWAR and INDRAJIT FERNANDO The Cancer Center, University Hospitals
More informationARROCase: Locally Advanced Endometrial Cancer
ARROCase: Locally Advanced Endometrial Cancer Charles Vu, MD (PGY-3) Faculty Advisor: Peter Y. Chen, MD, FACR Beaumont Health (Royal Oak, MI) November 2016 Case 62yo female with a 3yr history of vaginal
More informationAdjuvant Therapies in Endometrial Cancer. Emma Hudson
Adjuvant Therapies in Endometrial Cancer Emma Hudson Endometrial Cancer Most common gynaecological cancer Incidence increasing in Western world 1-2% cancer deaths 75% patients postmenopausal 97% epithelial
More informationBEATcc Trial: ENGOT-Cx10 / GEICO 68-C / JGOG1084. GCIG Meeting
BEATcc Trial: ENGOT-Cx10 / GEICO 68-C / JGOG1084 GCIG Meeting Ana Oaknin, MD PhD Head of Gynecologic Cancer Program. Vall d Hebron Institute of Oncology(VHIO). Vall d Hebron University Hospital. GEICO
More informationBackground. TAP, Paclitaxel + Doxorubicin + Cisplatin
A randomized phase II study of paclitaxel/carboplatin/bevacizumab, paclitaxel/carboplatin/temsirolimus and ixabepilone/carboplatin/bevacizumab as initial therapy for measurable stage III or IVA; stage
More informationManagement of high risk early cervical cancer - a view of surgeon Dan DY Kim, M.D., Ph.D.
Management of high risk early cervical cancer - a view of surgeon Dan DY Kim, M.D., Ph.D. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
More informationShould the Optimal Adjuvant Treatment for Patients With Early-Stage Endometrial Cancer With High-Intermediate Risk Factors Depend on Tumor Grade?
ORIGINAL STUDY Should the Optimal Adjuvant Treatment for Patients With Early-Stage Endometrial Cancer With High-Intermediate Risk Factors Depend on Tumor Grade? Chunyan Lan, MD,* Xin Huang, MD,* Qidan
More informationUPDATE IN THE MANAGEMENT OF INVASIVE CERVICAL CANCER
UPDATE IN THE MANAGEMENT OF INVASIVE CERVICAL CANCER Susan Davidson, MD Professor Department of Obstetrics and Gynecology Division of Gynecologic Oncology University of Colorado- Denver Anatomy Review
More information17 th ESO-ESMO Masterclass in clinical Oncology
17 th ESO-ESMO Masterclass in clinical Oncology Cervical and endometrial Cancer Cristiana Sessa IOSI Bellinzona, Switzerland Berlin, March 28 th, 2018 Presenter Disclosures None Cervical Cancer Estimated
More informationCountry Presentations of FNCA FY2007 Workshop on Radiation Oncology
Country Presentations of FNCA FY2007 Workshop on Radiation Oncology Annex 3 Country presentations on CERVIX-III -China: Total Patients: 18, 8 alive: 1 with metastasis lung, another one metastasis to liver;
More informationClinical Trials. Ovarian Cancer
1.0 0.8 0.6 0.4 0.2 0.0 < 65 years old 65 years old Events Censored Total 128 56 184 73 35 108 0 12 24 36 48 60 72 84 27-10-2012 Ovarian Cancer Stuart M. Lichtman, MD Attending Physician 65+ Clinical Geriatric
More informationHypofractionated RT in Cervix Cancer. Anuja Jhingran, MD
Hypofractionated RT in Cervix Cancer Anuja Jhingran, MD Hypofractionated RT in Cervix Cancer: Clinicaltrials.gov 919 cervix trials 134 hypofractionated RT trials Prostate, breast, NSCLC, GBM 0 cervix trials
More informationCUrative Radiotherapy to the primary tumor vs. best supportive care in patients with initially metastatic Cervical carcinoma (CURE-C trial)
CUrative Radiotherapy to the primary tumor vs. best supportive care in patients with initially metastatic Cervical carcinoma (CURE-C trial) EORTC ROG-GCG-QLG Study coordinator Igor Sirák, M.D., Ph.D Department
More informationNeodjuvant chemotherapy
Neodjuvant chemotherapy Dr Robert Huddart Senior Lecturer and Honorary Consultant in Clinical Oncology Royal Marsden Hospital and Institute of Cancer Research Why consider neo-adjuvant chemotherapy? Loco-regional
More informationRole and Timing of Radiotherapy in High-Risk Endometrial Cancer
TURKISH JOURNAL of ONCOLOGY Turk J Oncol 2017;32(3):123 132 INVITED REWIEW Role and Timing of Radiotherapy in High-Risk Endometrial Cancer Güler YAVAŞ Department of Radiation Oncology, Selçuk University,
More informationLocally advanced disease & challenges in management
Gynecologic Cancer InterGroup Cervix Cancer Research Network Cervix Cancer Education Symposium, February 2018 Locally advanced disease & challenges in management Carien Creutzberg Radiation Oncology, Leiden
More informationRandomized Phase III Trials of Intravenous vs. Intraperitoneal Therapy in Optimal Ovarian Cancer
Randomized Phase III Trials of Intravenous vs. Intraperitoneal Therapy in Optimal Ovarian Cancer Deborah K. Armstrong, M.D. Associate Professor of Oncology, Gynecology and Obstetrics Development of Intraperitoneal
More informationJemal A, Siegel R, Ward E, et al: Cancer statistics, CA: Cancer J Clin 59(4):225-49, 2009
Ovarian cancer 2010-22,500 cases diagnosed per year in the United States and 16,500 deaths per year1. - Most patients are diagnosed in late stages; no screening test exists. - Pathology: 4 different types
More informationNordic Society for Gynecological Oncology Advisory Board of Radiotherapy
Nordic Society for Gynecological Oncology Advisory Board of Radiotherapy Guidelines for postoperative irradiation of cervical cancer Contents: 1. Treatment planning for EBRT. 2 2. Target definition for
More informationJ Clin Oncol 25: by American Society of Clinical Oncology INTRODUCTION
VOLUME 25 NUMBER 5 FEBRUARY 10 2007 JOURNAL OF CLINICAL ONCOLOGY O R I G I N A L R E P O R T Phase III Trial of With or Without Paclitaxel in Advanced Uterine Carcinosarcoma: A Gynecologic Oncology Group
More informationImmune Therapy in Clear Cell Ovarian Cancer (ITICC) Hal Hirte Canadian Cancer Clinical Trials Group
Immune Therapy in Clear Cell Ovarian Cancer (ITICC) Hal Hirte Canadian Cancer Clinical Trials Group Results of Phase II Study of Durvalumab and Tremelimumab in recurrent clear cell ovarian cancer Trial
More informationRadiotherapy & Cervical Cancer Dr Mary McCormack Consultant Clinical Oncologist University College Hospital, London,UK
Lead Group Log Radiotherapy & Cervical Cancer Dr Mary McCormack Consultant Clinical Oncologist University College Hospital, London,UK Cervical Cancer treatment Treatment planning should be made on a multidisciplinary
More informationPrognostic factors and treatment outcome after radiotherapy in cervical cancer patients with isolated para-aortic lymph node metastases
Original Article J Gynecol Oncol Vol. 24, No. 3:229-235 pissn 2005-0380 eissn 2005-0399 Prognostic factors and treatment outcome after radiotherapy in cervical cancer patients with isolated para-aortic
More informationSpecial Article. Received 2 December 2013; accepted 15 January Practical Radiation Oncology (2014) 4,
Practical Radiation Oncology (2014) 4, 137 144 www.practicalradonc.org Special Article The role of postoperative radiation therapy for endometrial cancer: Executive Summary of an American Society for Radiation
More informationPET/CT in Gynaecological Cancers. Stroobants Sigrid, MD, PhD Departement of Nuclear Medicine University Hospital,Antwerp
PET/CT in Gynaecological Cancers Stroobants Sigrid, MD, PhD Departement of Nuclear Medicine University Hospital,Antwerp Cervix cancer Outline of this talk Initial staging Treatment monitoring/guidance
More informationControversies in the Management of Advanced Ovarian Cancer
안녕하세요 Controversies in the Management of Advanced Ovarian Cancer Mansoor R. Mirza Nordic Society of Gynaecological Oncology (NSGO) & Rigshospitalet Copenhagen University Hospital, Denmark Primary Debulking
More informationWinship Cancer Institute of Emory University Optimizing First Line Treatment of Advanced Ovarian Cancer
Winship Cancer Institute of Emory University Optimizing First Line Treatment of Advanced Ovarian Cancer Ira R. Horowitz, MD, SM, FACOG, FACS John D. Thompson Professor and Chairman Department of Gynecology
More informationInternational Journal of Women s Health Care
Research Article International Journal of Women s Health Care Uterine Carcinosarcoma: A Single Centre Retrospective Clinical Cohort Analysis C Perna 1 *, G Eminowicz 2, U Asghar 3, G Imseeh 4, AA Kirkwood
More informationACRIN Gynecologic Committee
ACRIN Gynecologic Committee Fall Meeting 2010 ACRIN Abdominal Committee Biomarkers & Endpoints in Ovarian Cancer Trials Robert L. Coleman, MD Professor and Vice Chair, Clinical Research Department of Gynecologic
More informationStage IVB endometrial cancer confined to the abdomen: is chemotherapy superior to radiotherapy?
European Journal of EJGO Gynaecological Oncology Stage IVB endometrial cancer confined to the abdomen: is chemotherapy superior to radiotherapy? D. Akdag Cirik, A. Karalok, I. Ureyen, T. Tasci, S. Koc,
More informationTable Selected Clinical Trials of Anti-Angiogenesis Therapy in Gynecologic Malignancies
Table Selected Clinical Trials of Anti-Angiogenesis Therapy in Gynecologic Malignancies Uterus Study N Eligibility Regimen RR (No. of Responses) Median OS Grade 3/4 Toxicities Nimeiri et al[42] Total:
More informationCombining chemotherapy and radiotherapy of the chest
How to combine chemotherapy, targeted agents and radiotherapy in locally advanced NSCLC? Dirk De Ruysscher, MD, PhD Radiation Oncologist Professor of Radiation Oncology Leuven Cancer Institute Department
More informationCarcinosarcoma Trial rial in s a in rare malign rare mali ancy
Carcinosarcoma Trials in a rare malignancy BACKGROUND Rare and highly aggressive epithelial malignancies Biphasic tumors with epithelial and mesenchymal components Uterine carcinomas (UCS) uncommon with
More informationCOX-2 inhibitor and irradiation. Saitama Cancer Center Kunihiko Kobayashi MD, PhD
COX-2 inhibitor and irradiation Saitama Cancer Center Kunihiko Kobayashi MD, PhD Synthesis of prostaglandins from arachidonic acid by cyclooxygenase (COX) enzymes JNCI 95:1440, 2003 Difference between
More informationLung Cancer Non-small Cell Local, Regional, Small Cell, Other Thoracic Cancers: The Question Isn t Can We, but Should We
Lung Cancer Non-small Cell Local, Regional, Small Cell, Other Thoracic Cancers: The Question Isn t Can We, but Should We Edward Garon, MD, MS Associate Professor Director- Thoracic Oncology Program David
More informationAHFS Final. IV and intraperitoneal regimen for. Criteria Used in. Strength. Strength. Use: Based on. taxane (either IV. following
AHFS Final Determination of Medical Acceptance: Off-label Use of Sequential IV Paclitaxel, Intraperitoneal Cisplatin, and Intraperitoneal Paclitaxel for Initial Adjuvan nt Treatment of Optimally Debulked
More informationThe Role of Radiotherapy in Endometrial Cancer: Current Evidence and Trends
Curr Oncol Rep (2011) 13:472 478 DOI 10.1007/s11912-011-0191-y GYNECOLOGIC CANCERS (JONATHAN A. LEDERMANN, SECTION EDITOR) The Role of Radiotherapy in Endometrial Cancer: Current Evidence and Trends Carien
More informationAdjuvant Radiotherapy in Endometrial Carcinoma David T. Shaeffer and Marcus E. Randall. doi: /theoncologist
Adjuvant Radiotherapy in Endometrial Carcinoma David T. Shaeffer and Marcus E. Randall The Oncologist 2005, 10:623-631. doi: 10.1634/theoncologist.10-8-623 The online version of this article, along with
More informationCombining Lurbinectedin and Doxorubicin The UCLH Experience in Small Cell Lung Cancer
Combining Lurbinectedin and Doxorubicin The UCLH Experience in Small Cell Lung Cancer Dr Martin Forster MD PhD Clinical Senior Lecturer in Experimental Cancer Medicine Consultant in Medical Oncology UCL
More informationResidual Tumor Following Surgery: The Strongest Prognostic Factor or a Myth? Philipp Harter, MD Kliniken Essen Mitte Essen, Germany
Residual Tumor Following Surgery: The Strongest Prognostic Factor or a Myth? Philipp Harter, MD Kliniken Essen Mitte Essen, Germany What Are Our Questions Q1: Prognostic factor residual disease? Q2: Differences
More informationTratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón
Tratamiento Multidisciplinar de Estadios Localmente Avanzados en Cáncer de Pulmón Santiago Ponce Aix Servicio Oncología Médica Hospital Universitario 12 de Octubre Madrid Stage III: heterogenous disease
More informationConcurrent chemoradiotherapy with low-dose daily cisplatin for high risk uterine cervical cancer: a long-term follow-up study
Original Article J Gynecol Oncol Vol. 24, No. 2:108-113 http://dx.doi.org/10.3802/jgo.2013.24.2.108 pissn 2005-0380 eissn 2005-0399 Concurrent chemoradiotherapy with low-dose daily cisplatin for high risk
More informationeastern cooperative oncology group Michael Williams, Fangxin Hong, Brad Kahl, Randy Gascoyne, Lynne Wagner, John Krauss, Sandra Horning
Results of E4402 (RESORT): A Randomized Phase III Study Comparing Two Different Rituximab Dosing Strategies for Low Tumor Burden Indolent B-Cell Lymphoma Michael Williams, Fangxin Hong, Brad Kahl, Randy
More informationA PILOT STUDY OF FIRST-LINE CHEMOTHERAPY WITH 5-FU AND PLATINUM IN ADVANCED AND RECURRENT CANCER OF THE CERVIX
A PILOT STUDY OF FIRST-LINE CHEMOTHERAPY WITH 5-FU AND PLATINUM IN ADVANCED AND RECURRENT CANCER OF THE CERVIX F. Ghaemmaghami 1, N. Behtash 1, F. Yarandi 1, A. Moosavi 1, Gh.R. Toogeh 2 and N. Khanafshar
More informationCombined Modality Therapy State of the Art. Everett E. Vokes The University of Chicago
Combined Modality Therapy State of the Art Everett E. Vokes The University of Chicago What we Know Some patients are cured (20%) Induction and concurrent chemoradiotherapy are each superior to radiotherapy
More informationThe Harvard community has made this article openly available. Please share how this access benefits you. Your story matters.
Consolidation whole abdomen irradiation following adjuvant carboplatin-paclitaxel based chemotherapy for advanced uterine epithelial cancer: feasibility, toxicity and outcomes The Harvard community has
More informationAdjuvant therapy in high-risk early endometrial carcinoma: a retrospective analysis of 46 cases
J Gynecol Oncol Vol. 9, No. :6-0, December 008 DOI:0.80/jgo.008.9..6 Original Article Adjuvant therapy in high-risk early endometrial carcinoma: a retrospective analysis of 6 cases Jin Hwi Kim, Sung Jong
More informationTumor Characteristics in Blacks and Whites
Tumor Characteristics in Blacks and Whites with Endometrial Cancer Larry Maxwell, M.D. Chairman, Dept of OB-GYN at Inova Fairfax Hospital Co-Director, GYN Cancer Center of Excellence Professor, Virginia
More informationGCIG Rare Tumour Brainstorming Day
GCIG Rare Tumour Brainstorming Day Relatively (Not So) Rare Tumours Adenocarcinoma of Cervix Keiichi Fujiwara, Ros Glasspool Benedicte Votan, Jim Paul Aim of the Day To develop at least one clinical trial
More informationWorkshop LA RADIOTERAPIA DEI TUMORI RARI I TIMOMI : INDICAZIONI
XXI CONGRESSO NAZIONALE AIRO Genova, 19-22 novembre 2011 Workshop LA RADIOTERAPIA DEI TUMORI RARI I TIMOMI : INDICAZIONI PIERA NAVARRIA Unità Operativa di Radioterapia e Radiochirurgia Humanitas Cancer
More informationSurvival impact of cytoreductive surgery ın advanced stage EOC
Survival impact of cytoreductive surgery ın advanced stage EOC Ayhan Ali, MD Baskent University School of Medicine Department of Obstetrics and Gynecology, Division of Gynecologic Oncology 1 OVARIAN CANCER
More informationAnshuma Bansal 1 Bhavana Rai
DOI 10.1007/s13224-016-0926-7 ORIGINAL ARTICLE Fractionated Palliative Pelvic Radiotherapy as an Effective Modality in the Management of Recurrent/Refractory Epithelial Ovarian Cancers: An Institutional
More informationChapter 3 Postoperative Adjuvant Therapy
Page 56 Overview Chapter 3 Postoperative Adjuvant Therapy A. Postoperative Recurrence Risk Surgery is the treatment of first choice for uterine body cancer. Procedures include total hysterectomy, bilateral
More informationUROTHELIAL CELL CANCER
UROTHELIAL CELL CANCER Indications and regimens for neoadjuvant systemic treatment Astrid A. M. van der Veldt, MD, PhD, medical oncologist Department of Medical Oncology Erasmus Medical Center Cancer Institute
More informationPostoperative Radiotherapy for Patients with Invasive Cervical Cancer Following Treatment with Simple Hysterectomy
Jpn J Clin Oncol 2003;33(9)477 481 Postoperative Radiotherapy for Patients with Invasive Cervical Cancer Following Treatment with Simple Hysterectomy Shang-Wen Chen 1,2, Ji-An Liang 1,2, Shih-Neng Yang
More informationCorrespondence: Dr AB Olawaiye, 300 Halket Street, Office 2130, Pittsburgh, PA, USA.
DOI: 10.1111/1471-0528.13726 www.bjog.org Gynaecological oncology Survival advantage associated with multimodal therapy in women with node-positive (stage-iiic) uterine papillary serous carcinoma: a National
More informationAdjuvant vaginal cuff brachytherapy for high-risk, early stage endometrial cancer
Original paper Clinical Investigations Adjuvant vaginal cuff brachytherapy for high-risk, early stage endometrial cancer Harriet Belding Eldredge-Hindy, MD 1, Gary Eastwick, BS 1, Pramila Rani Anne, MD
More informationACR Appropriateness Criteria Management of Recurrent Endometrial Cancer EVIDENCE TABLE
1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 015. CA Cancer J Clin. 015;65(1):5-9.. Creutzberg CL, van Putten WL, Koper PC, et al. Surgery and postoperative radiotherapy versus surgery alone for
More informationPrognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases
J Gynecol Oncol Vol. 20, No. 3:158-163, September 2009 DOI:10.3802/jgo.2009.20.3.158 Original Article Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases
More informationReference No: Author(s) 12/05/16. Approval date: committee. June Operational Date: Review:
Reference No: Title: Author(s) Systemic Anti-Cancer Therapy (SACT) Guidelines for Pancreatic Adenocarcinoma Dr Colin Purcell, Consultant Medical Oncologist & on behalf of the GI Oncologists Group, Cancer
More informationNew Paradigms for Treatment of. Erminia Massarelli, MD, PHD, MS Clinical Associate Professor
New Paradigms for Treatment of Head and Neck cancers Erminia Massarelli, MD, PHD, MS Clinical Associate Professor City of Hope Disclosure Statement Grant/Research Support frommerck Bristol Grant/Research
More informationNeoadjuvant Treatment of. of Radiotherapy
Neoadjuvant Treatment of Breast Cancer: Role of Radiotherapy Neoadjuvant Chemotherapy Many new questions for radiation oncology? lack of path stage to guide indications should treatment response affect
More informationPost operative Radiotherapy in Carcinoma Endometrium - KMIO Experience (A Retrospective Study)
Post operative Radiotherapy in Carcinoma Endometrium - KMIO Experience (A Retrospective Study) Sridhar.P, M.D. 1, Sruthi.K, M.D. 2, Naveen.T, M.D. 3, Siddanna.R.P, M.D. 4 Department of Radiation Oncology,
More information3/8/2014. Case Presentation. Primary Treatment of Anal Cancer. Anatomy. Overview. March 6, 2014
Case Presentation Primary Treatment of Anal Cancer 65 year old female presents with perianal pain, lower GI bleeding, and anemia with Hb of 7. On exam 6 cm mass protruding through the anus with bulky R
More informationAHSCT in Hodgkin lymphoma - indication and challenges. Bastian von Tresckow German Hodgkin Study Group Cologne University Hospital
AHSCT in Hodgkin lymphoma - indication and challenges Bastian von Tresckow German Hodgkin Study Group Cologne University Hospital AHSCT in Hodgkin Lymphoma The role of AHSCT in HL Mobilisation failure
More informationDefining clinical and statistical improvement in consolidation or maintenance single-arm trials in Oncology
Defining clinical and statistical improvement in consolidation or maintenance single-arm trials in Oncology Alexia Iasonos, PhD Department of Epidemiology and Biostatistics Joint work with Sabbatini Paul,
More informationChemotherapy for Cervical Cancer. Matsue City Hospital Junzo Kigawa
Chemotherapy for Cervical Cancer Matsue City Hospital Junzo Kigawa Introduction Worldwide, cervical cancer is the second most common cancer in women and affects 530,000 new patients and 275,000 deaths.
More informationU T C H. No disclosure
D U GOG T C H Randomized phase 3 trial comparing primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for stage III epithelial ovarian cancer: OVHIPEC-2 Willemien van
More informationCorresponding author: X.G. Sheng / Z.H. Zhang /
Clinical observational study of conformal radiotherapy combined with topotecan chemotherapy in patients with platinumresistant recurrent ovarian cancer P. Wei 1, Z.H. Zhang 2, L. Li 3, X.L. Du 1, C.P.
More informationVirtual Journal Club: Front-Line Therapy and Beyond Recent Perspectives on ALK-Positive Non-Small Cell Lung Cancer.
Virtual Journal Club: Front-Line Therapy and Beyond Recent Perspectives on ALK-Positive Non-Small Cell Lung Cancer Reference Slides ALK Rearrangement in NSCLC ALK (anaplastic lymphoma kinase) is a receptor
More informationConcomitant (without adjuvant) temozolomide and radiation to treat glioblastoma: A retrospective study
Concomitant (without adjuvant) temozolomide and radiation to treat glioblastoma: A retrospective study T Sridhar 1, A Gore 1, I Boiangiu 1, D Machin 2, R P Symonds 3 1. Department of Oncology, Leicester
More informationAdjuvant Therapy in Locally Advanced Head and Neck Cancer. Ezra EW Cohen University of Chicago. Financial Support
Adjuvant Therapy in Locally Advanced Head and Neck Cancer Ezra EW Cohen University of Chicago Financial Support This program is made possible by an educational grant from Eli Lilly Oncology, who had no
More informationtrial update clinical
trial update clinical by John W. Mucenski, BS, PharmD, Director of Pharmacy Operations, UPMC Cancer Centers The treatment outcome for patients with relapsed or refractory cervical carcinoma remains dismal.
More informationUterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers Clinical Studies
British Journal of Cancer (26) 94, 642 646 All rights reserved 7 92/6 $3. www.bjcancer.com Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid
More informationJonathan Dickinson, LCL Xeloda
Xeloda A blockbuster in the making Jonathan Dickinson, LCL Xeloda Xeloda unique tumor-activated mechanism Delivering more cancer-killing agent straight into cancer Highly effective comparable efficacy
More informationATAC Trial. 10 year median follow-up data. Approval Code: AZT-ARIM-10005
ATAC Trial 10 year median follow-up data Approval Code: AZT-ARIM-10005 Background FDA post-approval commitment analysis to update DFS, TTR, OS and Safety Prof. Jack Cuzick on behalf of ATAC/LATTE Trialists
More informationDoppler ultrasound of the abdomen and pelvis, and color Doppler
- - - - - - - - - - - - - Testicular tumors are rare in children. They account for only 1% of all pediatric solid tumors and 3% of all testicular tumors [1,2]. The annual incidence of testicular tumors
More informationSeptember 10, Dear Dr. Clark,
September 10, 2015 Peter E. Clark, MD Chair, NCCN Bladder Cancer Guidelines (Version 2.2015) Associate Professor of Urologic Surgery Vanderbilt Ingram Cancer Center Nashville, TN 37232 Dear Dr. Clark,
More informationCurrent state of upfront treatment for newly diagnosed advanced ovarian cancer
Current state of upfront treatment for newly diagnosed advanced ovarian cancer Ursula Matulonis, M.D. Associate Professor of Medicine, HMS Program Leader, Medical Gyn Oncology Dana-Farber Cancer Institute
More informationRadiotherapy for rectal cancer. Karin Haustermans Department of Radiation Oncology
Radiotherapy for rectal cancer Karin Haustermans Department of Radiation Oncology O U T L I N E RT with TME surgery? Neoadjuvant or adjuvant RT? 5 x 5 Gy or long-course CRT? RT with new drugs? Selection
More informationPROGNOSTIC FACTORS AND FIRST LINE CHEMOTHERAPY IN AOC
PROGNOSTIC FACTORS AND FIRST LINE CHEMOTHERAPY IN AOC Giorgia Mangili RUF ginecologia oncologica medica IRCCS San Raffaele Milano mangili.giorgia@hsr.it STANDARD CHEMOTHERAPY The standard chemotherapy
More informationHYPERTHERMIA in CERVIX and VAGINA CANCER. J. van der Zee
HYPERTHERMIA in CERVIX and VAGINA CANCER J. van der Zee ESTRO 2006 Deep hyperthermia in Rotterdam HYPERTHERMIA in CERVIX and VAGINA CANCER ESTRO 2006 Hyperthermia and radiotherapy in primary advanced cervix
More informationTreatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy
Korean J Hepatobiliary Pancreat Surg 2011;15:152-156 Original Article Treatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy Suzy Kim 1,#, Kyubo
More informationAdvanced/Recurrent Endometrial Cancer: First-line Treatment should be Chemotherapy PRO. Gini Fleming GCIG June 1, 2017
Advanced/Recurrent Endometrial Cancer: First-line Treatment should be Chemotherapy PRO Gini Fleming GCIG June 1, 2017 EC First-Line Chemotherapy Currently carboplatin/paclitaxel Provides tumor shrinkage
More informationThe role of esophageal brachytherapy
Esophageal cancer is combination with surgery (stents) or EBRT a better solution? Razvan Galalae, MD, PhD Associate Professor, Medical Faculty, Christian Albrecht University Kiel, Germany, and Head of
More informationOvarian Cancer Survival. Ovarian Cancer Follow-up. Ovarian Cancer Treatment. Management of Recurrent Ovarian Carcinoma. 15,520 cancer deaths
Management of Recurrent Ovarian Carcinoma Lee-may Chen, M.D. Department of Obstetrics, Gynecology, & Reproductive Sciences UCSF Comprehensive Cancer Center Ovarian Cancer Survival United States, 28: 1
More informationA stratified clinical approach to uterine sarcoma
A stratified clinical approach to uterine sarcoma Martee L. Hensley, MD Memorial Sloan-Kettering Cancer Center Gynecologic Medical Oncology Weill Cornell Medical College New York, NY USA Disclosure slide
More informationWeekly Versus Triweekly Cisplatin-Based Chemotherapy Concurrent With Radiotherapy in the Treatment of Cervical Cancer
REVIEW ARTICLE Weekly Versus Triweekly Cisplatin-Based Chemotherapy Concurrent With Radiotherapy in the Treatment of Cervical Cancer A Meta-Analysis Xingxing Chen, MD,* Haizhou Zou, MD,Þ Huifang Li, MD,*
More informationChapter 8 Adenocarcinoma
Page 80 Chapter 8 Adenocarcinoma Overview In Japan, the proportion of squamous cell carcinoma among all cervical cancers has been declining every year. In a recent survey, non-squamous cell carcinoma accounted
More informationGynecologic Cancer InterGroup Cervix Cancer Research Network. Management of Cervical Cancer in Resource Limited Settings.
Management of Cervical Cancer in Resource Limited Settings Linus Chuang MD Conflict of Interests None Cervical cancer is the fourth most common malignancy in women worldwide 530,000 new cases per year
More informationChemo-radiotherapy in muscle invasive bladder cancer. Dr Paula Wells St Bartholomew s Hospital London
Chemo-radiotherapy in muscle invasive bladder cancer Dr Paula Wells St Bartholomew s Hospital London Overview Evidence base for cystectomy vs bladder preservation Chemo-radiotherapy vs radiotherapy alone
More information