CLINICALCASE PROVOST J, SEKFALI R, AMOROSO F, ZAMBROWSKI O, MIERE A
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1 CLINICALCASE PROVOST J, SEKFALI R, AMOROSO F, ZAMBROWSKI O, MIERE A Department of ophthalmology, Souied E. (MD,PhD) Centre Hospitalier Intercommunal de Créteil Université Paris Est
2 HISTORY 13 years old girl Right Eye Left Eye Origin: Morocco Her medical history is unremarkable Symptoms Headaches Blurred vision in the last 2 weeks Right eye Central scotoma Visual acuity 20/100 20/20 Slit lamp No inflammatory signs Intra ocular pressure No inflammatory signs
3 COLOR FUNDUS
4 Autofluorescence
5 Visual Field
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10 Early phase
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14 Multifocal ElectroRetinogram RIGHT EYE LEFT EYE
15 Diagnosis?
16 CASES OF MACULAR STIPPLED PIGMENTED LESIONS Acute posterior multifocal choroiditis Multiple evanescent white dot syndrome Acute posterior multifocal placoid pigment epitheliopathy Acute unilateral idiopathic maculopathy Serpignnous choroiditis Punctuate inner choroidopathy Multifocal choroiditis Laser induced retinopathy Acute retinal pigment epithilitiis
17 WORKUP Immunology AAN : negative Bartonella : negative Angiotensin converting enzyme : N Infectious diseases Tuberculosis (INF G) negative TPHA VDRL Toxoplasmosis Toxocariasis Zika virus HSV VZV = vaccinal status + Lyme = WB + (IgM) / ELISA - MRI Brain Thoracic CT scanner
18 CASES OF MACULAR STIPPLED PIGMENTED LESIONS Acute posterior multifocal choroiditis Multiple evanescent white dot syndrome Acute posterior multifocal placoid pigment epitheliopathy Acute unilateral idiopathic maculopathy Serpignnous choroiditis Punctuate inner choroidopathy Multifocal choroiditis Laser induced retinopathy Acute retinal pigment epithilitiis
19 Solution 1 AUIM : Acute Unilateral Idiopathic Maculopathy
20 Physiopathology Coxsackievirus infection Epidemiology Rare disease Young people A prodromal flu-like illness Symptoms Acute onset of unicentral central visual lost Evolution Spontaneously recovery (few weeks) Srour M, Querques G, Rostaqui O, Souied EH. Early spectral-domain optical coherence tomography findings in unilateral acute idiopathic maculopathy. Retina Nov-Dec;33(10):2182-4
21 Physiopathology Coxsackievirus infection Epidemiology Rare disease Young people A prodromal flu-like illness Symptoms Acute onset of unicentral central visual lost Evolution Spontaneously recovery (few weeks) Srour M, Querques G, Rostaqui O, Souied EH. Early spectral-domain optical coherence tomography findings in unilateral acute idiopathic maculopathy. Retina Nov-Dec;33(10):2182-4
22 Solution 2 PUNCTUATE INNER CHOROIDOPATHY
23 PIC Punched-out chorioretinal lesions Fundus biomicroscopy Acute : gray or yellow lesions Older: yellow-white atrophic No inflammatory cells Physiopathology Precise etipathogenesis remains unclear Epidemiology Young healthy Myopic women No known associated systemic disease Symptoms Photopsia Floaters A temporal blind spot / enlarged blind spot Munk MR, Jung JJ, Biggee K, Tucker WR, Sen HN, Schmidt-Erfurth U, Fawzi AA, Jampol LM. Idiopathic multifocal choroiditis/punctate inner choroidopathy with acute photoreceptor loss or dysfunction out of proportion to clinically visible lesions. Retina Feb;35(2):334-43
24 Solution 2 PONCTUATE INNER CHOROIDOPATHY
25 Solution 3 ACUTE RETINAL PIGMENT EPITHELIITIS
26 Acute retinal pigment epitheliitis (ARPE), also known as Krill s disease, has been described by Krill and Deutman in 1972 Physiopathology Unknown transient dysfunction or inflammation at the interface between the RPE and photoreceptor outer segments Epidemiology Young, healthy adults Males = females Rare disease Unilateral or bilateral Evolution Spontaneously resolved (few months) Incomplete recovery Outer layer nuclear External Layer Membrane Recurrence rare but possible Acute Retinal Pigment Epitheliitis: Spectral-Domain Optical Coherence Tomography Findings in 18 Cases; Han Joo Cho, Sang Youn Han, Sung Won Cho, Dong Won Lee, Tae Gon Lee, Chul Gu Kim,and Jong Woo Kim. Department of Ophthalmology, Kim s Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, South Korea
27 Acute Retinal Pigment Epitheliitis: Spectral-Domain Optical Coherence Tomography Findings in 18 Cases; Han Joo Cho, Sang Youn Han, Sung Won Cho, Dong Won Lee, Tae Gon Lee, Chul Gu Kim,and Jong Woo Kim. Department of Ophthalmology, Kim s Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, South Korea
28 ARPE: DIAGNOSTIC CRITERIA 1. Presented with acute visual blurring or central scotoma 2. Localized areas of pigment stippling associated with yellowish, often halo-like, zones of hypopigmentation in the fovea 3. No sign of any other ocular disease including anterior uveitis or vitritis Acute Retinal Pigment Epitheliitis: Spectral-Domain Optical Coherence Tomography Findings in 18 Cases; Han Joo Cho, Sang Youn Han, Sung Won Cho, Dong Won Lee, Tae Gon Lee, Chul Gu Kim,and Jong Woo Kim. Department of Ophthalmology, Kim s Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, South Korea
29 TAKE HOME MESSAGE - Fundus - Stippled lesions - Yellowish halo - Fluorescein angiography - Unremarkable findings - Or patchy macular hyperfluorescence - ICG angiography - Hyperfluorescence with central hypofluorescence at the macula - OCT - Disruption of the inner layer of the RPE, ISe line, and ELM Acute Retinal Pigment Epitheliitis: Spectral-Domain Optical Coherence Tomography Findings in 18 Cases; Han Joo Cho, Sang Youn Han, Sung Won Cho, Dong Won Lee, Tae Gon Lee, Chul Gu Kim,and Jong Woo Kim. Department of Ophthalmology, Kim s Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine,
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