4D Mesh Flat et 4D Mesh Anatomique
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1 4D Mesh Flat et 4D Mesh Anatomique T DUGUE A DABROWSKI Clinique de St Omer MESH 16 Juin 2017
2 4DMESH STUDY Introduction.
3 Caractéristiques Polypropylène (25%) Monofilament Léger PLLA (75%) Taux de résorption = 75%
4 Evolution de la résistance de l implant Très haute résistance de l implant : limite les récidives, sécurité Résistance supérieure aux 16N/ cm requis. La fibrose prend le relais. Implant adapté à la paroi abdominale : confort du patient
5 Avantages Allégé (30g/m²) Macroporeux Résistance (>16N/cm) PLLA Elasticité Monofilament SR Shrinkage réaction inflammatoire risque de seromes Renfort adéquat Fibres de collagène // et non cross-linked Flexible et confortable risques d infection Concept évolutif récidives (rétraction des bords)
6 FILM TD
7
8 By laparoscopy (TAPP/TEP) -> 3D anatomy
9 Hydrophilic material (PLLA) with gentle gripping effect Large flat surface for wide cover of direct and indirect Hernia sites Landmark for Pubis Sufficient material to cover Cooper s ligament Wave designed to hover the elements of the spermatic cord
10 Treatment of the inguinal hernia with a 4DLap Blue landmark for the pubis 4DLap is in place. Closure of the peritoneum Fixation, maybe
11 Designed to solve laparoscopic challenges 4DLap is a cut-able 3D mesh: adaptable to surgeon s shape needs 4DLap is easily rolled in a tube shape from top to bottom and passed through a 10mm trocar. The rolled-up mesh is then simply unrolled over the inguinal anatomy The material of the mesh is hydrophilic (75% PLLA) which is ideal during placement as the mesh holds by itself to the abdominal wall - gentle gripping effect The 3D wave design which conforms to the inguinal anatomy and the medial landmark allow quick and precise positioning 4DLap is macroporous and transparent: it is easy to see the anatomy through the mesh: avoids any risks of fixation incident Gripping effect, easy orientation, adaptable: key elements to help the surgeon and save their time
12 4DMESH STUDY
13 STUDY DESIGN Observational, national, multicentre, non-comparative with descriptive purpose Main objective: Assess the incidence and the severity of chronic postoperative pain at 1 year in patients who have a 4DMESH implant, in current conditions of use. Primary endpoint: Early and late postoperative chronic pain at 1 month and 1 year: Visual Analogical Scale (VAS) Secondary objectives: Assess the effectiveness and the safety of the device estimating the per and postoperative complication rate. Secondary endpoints: Recurrences and postoperative complications at 1 month and 1 year, The operative time, Prosthesis handling, Recovery of physical, sports and professional activities.
14 STUDY POPULATION o 200 patients included and followed between 12 and 24 months o Men 95%, women 5% o Average age: 57.6 years (min. 20, max. 91) o BMI between km/m² and kg/m² o Never smoked, stopped or occasional smoker 85.9%, daily smoker 14.1% Professional activities (%) Sports activities (%) 40,00 35,00 30,00 25,00 20,00 15,00 10,00 5,00 0,00 37,50 29,00 16,00 13,00 4,50 Without job Administrative job Moderate physic al job Physical job Unknown 45,00 40,00 35,00 30,00 25,00 20,00 15,00 10,00 5,00 0,00 42,50 21,50 16,50 19,50 No activity Sporadic Moderate Intense
15 SURGERY 27% 9% 0% 63% Anesthesia 1% Unknown GA with intubation GA with laryngeal mask LRA Others (TAP bloc, LA) TAPP 39% TEP 4% surgical technique Lichtenstein 57% Conversion to another surgery Associated surgical step (Lichtenstein) % Resected hernia sac 45,69 Non resected hernia sac 54,31 Transversalis Fascia approxima<on 8,66 Lichtenstein 3,52% TAPP 0,50% No 95,98%
16 POSTOPERATIVE FOLLOW-UP Evolution of pain 120,00 100,00 80,00 60,00 40,00 J0 J1 J8 M1 M12 20,00 0,00 Mild pain Moderate pain Important pain
17 STUDY POPULATION 604 patients opérés avec la 4 DMesh entre 12 juin 13 et 14 mars 17 (45 mois d inclusion) Suivi à 1 mois : consultation de routine Suivi à 3 mois : consultation si douleurs persistantes Suivi à 24 mois : consultation téléphonique Suivi à 60 mois : consultation téléphonique 90% des patients à 1 mois de suivi (464 patients) 70% des patients à 2 ans de suivi (408 patients) 0% des patients à 5 ans de suivi
18 POSTOPERATIVE FOLLOW-UP 4Dmesh Evolution of pain from surgery to 1 month follow-up VAS scores D0 D1 D8 1 month
19 POSTOPERATIVE FOLLOW-UP 4DMesh Evolution of pain at pre and post operative (2 years) Moderate pain Intense pain pre-operative 2 years follow-up Moderate pain: >3 et 6 Intense pain >6
20 POSTOPERATIVE FOLLOW-UP One reoperation ( for constant pain) No recurrence.
21 POSTOPERATIVE FOLLOW-UP Patient s feeling Excellent result Good result Moderate result Bad result 4% 2% 27% 67%
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