Secondary prevention of allergic disease. Dr Adam Fox United Kingdom
|
|
- Corey Atkins
- 6 years ago
- Views:
Transcription
1 Secondary prevention of allergic disease Dr Adam Fox United Kingdom
2 Disclosures Lecture fees: Danone, Mead Johnson, ALK-Abello, Stallergenes, Allergy Therapeutics Industry-sponsored grant: Danone, ALK-Abello Consultancy: NICE, Danone, Mead Johnson, Arla, Thermofisher Scientific
3 St Thomas Hospital, London, UK
4 Contents of Today s Presentation How do we define prevention? Evidence for secondary prevention of allergic disease Grazax Asthma Prevention trial (GAP) Implications of a positive outcome
5 Patient s side Illness Prevention definitions: general Prevention levels absent Doctor s side Disease present absent Primary prevention (illness absent, disease absent) Secondary prevention (illness absent, disease present) present Tertiary prevention (illness present, disease present)
6 Prevention and the allergic march According to ARIA Level Definition with respect to allergy Primary prevention Primary prevention is employed where there is no evidence of allergic sensitisation, focused on populations at high risk of becoming sensitised Secondary prevention Secondary prevention is employed in individuals who show evidence of sensitisation but not evidence of allergic symptoms Tertiary prevention Tertiary prevention are preventive strategies for the management of established allergic rhinitis or asthma Bousquet et al. Allergy 2008;63 (Suppl 86):8-160
7
8 Secondary Prevention
9 Preventive effect Randomised, controlled prospective trials Subcutaneous Immunotherapy Authors/study Population Study design/type Endpoint: preventive effects of SIT Polosa et al Adults, yrs (n=30) AR (Parietaria) Randomised, double-blind, placebo-controlled, 3-year trial Alutard SQ, ALK-Abelló At 3 years: Asthma developed in 14% vs 47% of controls (p=0.056) No asthma PAT Trial (Preventive Allergy Treatment) Möller et al Niggeman et al Children, 6-14 yrs (n=205) AR (grass/birch) Randomised, open, controlled, 10-year follow-up trial Alutard SQ, ALK-Abelló At 3, 5, 10 years: Significant reduction in development of asthma Jacobsen et al No asthma
10 Preventive Allergy Treatment (PAT) Alutard SQ Open, randomised, controlled trial, (Den, Swe, Fin, Nor, Ger) 205 children (6 to 14 years), with clinical history of rhinoconjunctivitis to grass pollen (60%), birch pollen (21%), or both (19%) Despite negative histories of asthma at screening, 42 children (20%) were identified as having mild asthma in the baseline season Subjects randomized to receive either: Alutard SQ (Phl p and/or Bet v) 100,000 SQ Open control group usual therapy Subjects received 3 years treatment and were followed for total of 10 years! Möller et al. JACI 2002;109:251-6 Jacobsen et al. Allergy 2007:62:943-8
11 Subjects developing asthma (%) SCIT preventive effect Reduced risk of developing asthma Subject developing asthma at 3, 5, and 10 years (percent of subjects; n=151) * * * OR=2.5 OR=3.1 OR=2.5 Control Alutard SQ 45% 20 0 ** p< years Treatment Follow-up Möller et al. JACI 2002;109:251-6 Jacobsen et al. Allergy 2007:62:943-8
12 Preventive effect Randomised, controlled prospective trials Sublingual Immunotherapy Authors/study Population Study design/type Preventive effects of SIT Novembre et al Children, 5-14 yrs (n=113) AR (grass) No asthma Randomised, open, controlled, 3-year trial SLIT drops, ALK-Abelló At 3 year: Asthma development: 18% vs 41% of controls (p=0.04, OR 3.8) Marogna et al Children, 5-17 yrs (n=216) AR (multiple species) ± intermittent asthma Randomised, open, controlled, 3-year trial SLIT drops, Anallergo At 3 year: Development of mild persistent asthma: 1.5% vs 28.8% of control (p<0.001)
13 Novembre et al ALK-SLIT drops Open, randomised, controlled trial Italy 113 children (5 to 14 years), with clinical history of rhinoconjunctivitis to grass pollen, no asthma Subjects randomised to receive either: ALK-SLIT drops (biologically standardised 5-grass mixture), pre-seasonally and co-seasonally regimen Open control group usual therapy Subjects received 3 years treatment Novembre E et al. JACI 2004;114:851-7
14 Percent of subjects (%) SLIT drop asthma preventive effect Percentages of children with and without asthma* after 3 years (age and centre adj. odds-ratio = 3.8) 82% Asthma No asthma % ALK-SLIT drops 41% 59% Control group * 3 episodes of wheezing-breathing difficulty and/or cough, separated by 1 week, and requiring bronchodilator Novembre E et al. JACI 2004;114:851-7
15 GRAZAX Asthma Prevention Trial GT-21 (GAP) 16
16 GRAZAX Summary Grazax demonstrated to be both efficacious and well tolerated in children with grass pollen induced rhinoconjunctivitis Grazax proven to result in a disease-modifying effect in adults Grazax induces similar immunological response in children as in adults; supporting hypothesis that disease-modifying effect will also occur in children Extrapolation from adult studies is not acceptable and paediatric studies are required* Hence there is a rationale that Grazax can stop the allergic march and prevent the development of asthma in children with allergic rhinoconjunctivitis The GAP trial we hope will provide a conclusive answer to this question! *Calderon et al. EAACI Position statement, 2012
17 GAP study principles Randomised, parallel group, double-blind, placebo-controlled, multicentre trial Recruit children with proven grass pollen related rhinoconjunctivitis who do not have asthma or overlapping symptomatic allergies Randomised to 3 years of Grazax or Placebo Regularly screen for asthma through treatment and 2 year follow-up period Primary outcome is time to onset of asthma
18 Key entry criteria Children 5-12 years of age at time of randomisation A clinical relevant history of grass pollen induced allergic rhinoconjunctivitis having received symptomatic treatment during GPS 2009 and GPS 2010 Positive SPT response and positive specific IgE against Phleum pratense Without medical history of asthma and/or wheezing within last 2 years or since 5th birthday
19 Screening 1 GAP Trial Design Screening 2 Randomisation Status Grazax n= SQ-T AIT daily Placebo AIT n=310 Year monthly visits Screening (1st season) Treatment period (3 years) Post-treatment period (2 years)
20 Trial Recruitment Enrolment of 620 subjects was planned Total of 812 children randomised, distributed 100 centres 37% girls, 96% Caucasian, mean age at randomisation was 9.4 years 71% of subjects had at least one first degree relative with a history of allergy and 35% had at least one first degree relative with a history of asthma 26
21 27 Sensitisation pattern at screening
22 Clinical Implications of Preventive Trials if Positive?
23 Clinical Implications Significant change in health economics of SIT if disease prevention proven Long-term view required by health providers Enhanced importance of early recognition of allergic disease Requirement for capacity to desensitise significantly larger numbers of children
24 Summary SIT offers potential to halt the allergic march Current studies underway should provide robust answers about disease prevention Disease preventative effects may significantly alter the place of SIT in clinical practice
25 Acknowledgements GAP team St Thomas Hospital Prof Gideon Lack (joint site PI) Dr George DuToit Dr Kate Swan Roisin Fitzsimons Victoria Timms Graham Roberts (CI) Sue Driver (ALK)
Pollen immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis (The PAT-Study)
Pollen immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis (The PAT-Study) Christian Möller 1, Sten Dreborg 2, Hosne A. Ferdousi 3, Susanne Halken 4, Arne Høst
More informationPreventive effect of AIT over the atopic march
Preventive effect of AIT over the atopic march Susanne Halken, Professor, Pediatric Allergist Hans Christian Andersen Children s Hospital Odense University Hospital, DK Type Disclosure In relation to this
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 21 July 2010
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 21 July 2010 GRAZAX 75 000 SQ-T, oral lyophilisate B/30 (CIP: 378 011-6) B/100 (CIP code: 378 012-2) B/90 (CIP code:
More informationALK-Abelló Research & Development. Henrik Jacobi MD, EVP Research & Development
ALK-Abelló Research & Development Henrik Jacobi MD, EVP Research & Development Agenda Latest news on GRAZAX 3rd year data from long-term study (GT-08) Effect on asthma symptoms in children (GT-12) Status:
More informationIntroduction. Methods. Results 12/7/2012. Immunotherapy in the Pediatric Population
12/7/212 Introduction Immunotherapy in the Pediatric Population Michael S. Blaiss, MD Clinical Professor of Pediatrics and Medicine University of Tennessee Health Science Center Memphis, Tennessee Allergen
More informationScottish Medicines Consortium
Scottish Medicines Consortium Standardised allergen extract of grass pollen from Timothy (Phleum pratense) 75,000 SQ-T per oral lyophilisate (Grazax ) No. (367/07) ALK-Abellό Ltd 6 April 2007 The Scottish
More informationImmunotherapy. Chris Doyle Consultant Nurse Respiratory & Allergy Alder Hey Childrens NHS FT. October 18 th 2014
Immunotherapy Chris Doyle Consultant Nurse Respiratory & Allergy Alder Hey Childrens NHS FT Chris.doyle@alderhey.nhs.uk October 18 th 2014 What exactly is Immunotherapy? Medical procedure that uses controlled
More informationPresentation of ALK London, 24 May 2011 UBS GLOBAL SPECIALTY PHARMACEUTICALS CONFERENCE : LONDON : 24 MAY 2011
Presentation of ALK London, 24 May 2011 1 ALK pharma specialist - treatment, prevention and diagnosis of allergies World leader in allergy immunotherapy ~ 33% global market share Expanding Base Business
More informationSLIT: Review and Update
SLIT: Review and Update Disclosure Speaker: ISTA Pharmaceuticals Speaker: GlaxoSmithKline Allergen IT - Evidence Based Evaluation: Rescue Medications Meta-analysis Disease IT # of Patients Rescue Medication
More informationRECOMMENDATIONS FOR APPROPRIATE SLIT TRIALS
RECOMMENDATIONS FOR APPROPRIATE SLIT TRIALS Giovanni Passalacqua Allergy & Respiratory Diseases Dept.Internal MedicineIRCCS S.Martino IST University of Genoa ITALY CHICAGO-WAO-2013 ISHIZAKA NOON UK CSM
More informationA world leader in allergy immunotherapy
A world leader in allergy immunotherapy Company presentation Per Plotnikof, VP Corporate Communications and IR 1 I ALK at a glance Commercial leader and foremost innovator within respiratory allergies
More informationChoosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose
DOI 10.1186/s13601-015-0088-1 Clinical and Translational Allergy REVIEW Open Access Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose Pascal Demoly 1*,
More informationExpert Roundtable on Sublingual Immunotherapy
Expert Roundtable on Sublingual Immunotherapy FACULTY Linda Cox, MD Clinical Associate Professor, Nova Southeastern University Thomas Casale, MD Professor of Medicine, University of South Florida Peter
More informationClinical Study Report SLO-AD-1 Final Version DATE: 09 December 2013
1. Clinical Study Report RANDOMIZED, OPEN, PARALLEL GROUP, PHASE IIIB STUDY ON THE EVALUATION OF EFFICACY OF SPECIFIC SUBLINGUAL IMMUNOTHERAPY IN PAEDIATRIC PATIENTS WITH ATOPIC DERMATITIS, WITH OR WITHOUT
More informationPublic Assessment Report. Scientific discussion. Grazax / Grazura SE/H/612/MR / SE/H/613/MR
Public Assessment Report Scientific discussion Grazax / Grazura allergen extract from Phleum pratense SE/H/612/MR / SE/H/613/MR This module reflects the scientific discussion for the approval of Grazax
More informationAssociate Professor Rohan Ameratunga Immunologist & Allergist, Auckland
Associate Professor Rohan Ameratunga Immunologist & Allergist, Auckland Update on desensitisation Associate Professor Rohan Ameratunga GLORIA Module 4: Allergen Specific Immunotherapy A New Zealand perspective
More informationGrass pollen immunotherapy induces Foxp3 expressing CD4 + CD25 + cells. in the nasal mucosa. Suzana Radulovic MD, Mikila R Jacobson PhD,
Radulovic 1 1 2 3 Grass pollen immunotherapy induces Foxp3 expressing CD4 + CD25 + cells in the nasal mucosa 4 5 6 7 Suzana Radulovic MD, Mikila R Jacobson PhD, Stephen R Durham MD, Kayhan T Nouri-Aria
More informationA world leader in allergy immunotherapy. Jefferies Global Healthcare Conference, London : 19 November 2014 : Flemming Pedersen, CFO & EVP
A world leader in allergy immunotherapy ALK at a glance Leading allergy immunotherapy (AIT) specialist AIT: Treats the root cause of allergy Products in all areas of AIT ALK has 33% of the global AIT market
More informationCuring Allergy. Characteristics of products for specific allergy management. Jorgen Nedergaard Larsen, PhD. Senior scientist. dk.alk-abello.
Characteristics of products for specific allergy management Jorgen Nedergaard Larsen, PhD Senior scientist jnl @ dk.alk-abello.com 11 May 2012 Introduction to ALK-Abelló Pharmaceutical company devoted
More informationCenters. Austria (2), Germany (5), Belgium (1), Netherlands (1), Denmark (1), Slovenia (1)
Study CS-BM32-003 Sponsor Biomay Protocol title Phase IIb study on the safety and efficacy of BM32, a recombinant hypoallergenic vaccine for immunotherapy of grass pollen allergy Clinical trial phase Phase
More informationAllergen Immunotherapy: An Update
Allergen Immunotherapy: An Update Susan Waserman MSc MDCM FRCPC Professor of Medicine Division of Clinical Allergy and Immunology CTS Calgary April 26, 2014 Presenter Disclosure Presenter: Dr Susan Waserman
More informationALK-Abelló A/S. Click View,Header and Footer to change this text to filename and department name
ALK-Abelló A/S June 25, 2008 Click View,Header and Footer to change this text to filename and department name 1 Changing the way we treat allergy Piper Jaffray 19th Annual Health Care Conference, New York
More informationEconomic evaluation of SQ-standardized grass allergy immunotherapy tablet (Grazax ) in children
ClinicoEconomics and Outcomes Research open access to scientific and medical research Open Access Full Text Article Economic evaluation of SQ-standardized grass allergy immunotherapy tablet (Grazax ) in
More informationAllergic Rhinitis and Its Impact on Ast. Rhinitis: A Risk Factor for Asthma? Ronald Dahl, Aarhus University Hospital, Denmark
Allergic Rhinitis and Its Impact on Ast Rhinitis: A Risk Factor for Asthma? Ronald Dahl, Aarhus University Hospital, Denmark Rhinitis and asthma SIT-SLIT Evidence A SIT-SLIT Evidence A? SIT Evidence? Rhinitis
More informationNew Medicine Report (Adopted by the CCG until review and further
New Medicine Report (Adopted by the CCG until review and further GRASS ALLERGEN TREATMENT notice) Document Status Decision following Suffolk D&TC meeting Traffic Light Decision Red for 2007 with review
More informationWe improve quality of life by preventing and curing allergy
We improve quality of life by preventing and curing allergy SEB Enskilda Nordic Small & Mid Cap Seminar 2008 Jens Bager, President & CEO ALK-Abelló a fast growing pharmaceutical company Global pharmaceutical
More informationAllergen Immunotherapy and Asthma. Linda Cox, MD, FAAAI ASCIA 2013 Meeting
Allergen Immunotherapy and Asthma Linda Cox, MD, FAAAI ASCIA 2013 Meeting Allergen Immunotherapy and Asthma Overview: burden/prevalence of asthma and allergic disease Allergen immunotherapy and asthma:
More informationA world leader in allergy immunotherapy
A world leader in allergy immunotherapy R&D and Business Briefing New York, May 2014 ALK s equity story An emerging speciality pharma with a global growth strategy Jens Bager President and CEO Today s
More informationSublingual immunotherapy (SLIT) vs. Subcutaneous immunotherapy (SCIT) Canonica G.W. Personalized Medicine Clinic Asthma & Allergy.
Sublingual immunotherapy (SLIT) vs. Subcutaneous immunotherapy (SCIT) Canonica G.W. Personalized Medicine Clinic Asthma & Allergy Milano Italy President President G.Walter CANONICA DISCLOSURE OF INTERESTS
More informationAUSTRALIAN PRODUCT INFORMATION GRAZAX (75, 000 SQ-T) ORAL LYOPHILISATE TABLETS AUST R NAME OF THE MEDICINE 75,000 SQ-T
AUSTRALIAN PRODUCT INFORMATION GRAZAX (75, 000 SQ-T) ORAL LYOPHILISATE TABLETS AUST R 267955 1. NAME OF THE MEDICINE 75,000 SQ-T 2. QUALITATIVE AND QUANTITATIVE COMPOSITION GRAZAX oral lyophilisate tablets
More informationIncrease in revenues in line with full-year targets (+1.2%) Very strong growth of Oralair exc. USA (+26%) H revenues and results - 24 July 2014
Increase in revenues in line with full-year targets (+1.2%) Very strong growth of Oralair exc. USA (+26%) ( ) H1 2014 revenues and results - 24 July 2014 Forward-looking statement This presentation contains
More informationGLORIA Module 4: Allergen Specific Immunotherapy Its safe use: A New Zealand perspective
Update on desensitisation Associate Professor Rohan Ameratunga GLORIA Module 4: Allergen Specific Immunotherapy Its safe use: A New Zealand perspective Procedure Allergen immunotherapy is the administration
More information(26000)=I
Table E1. Literature search Search Cochrane Databases of Systematic Reviews, Database of Abstracts of Reviews of Effectiveness, and Central; Literature search 2015, April 25 th 1. "asthmazoekacties jan
More informationThree-year Short-term Specific Immunotherapy (SIT): A Multi-centre, Double-blind Placebo-controlled Study with L-tyrosine adsorbed Pollen Allergoids
Three-year Short-term Specific Immunotherapy (SIT): A Multi-centre, Double-blind Placebo-controlled Study with L-tyrosine adsorbed Pollen Allergoids Introduction KJ Drachenberg, U Feeser, and P Pfeiffer
More informationThe Current Status of Sublingual Immunotherapy
The Current Status of Sublingual Immunotherapy Harold S. Nelson, MD Professor of Medicine National Jewish Health and University of Colorado Denver School of Medicine Denver, Colorado Disclosure: Harold
More informationSession: 4819 Q & A Workshop Respiratory Allergies
Section Of Allergy/Immunology American Academy of Pediatrics Session: 4819 Q & A Workshop Respiratory Allergies Chitra Dinakar, M.D., F.A.A.P. Professor of Pediatrics University of Missouri-Kansas City
More informationThe Future of Allergy Treatment Ultra-Fast Allergy Immunotherapy
The Future of Allergy Treatment Ultra-Fast Allergy Immunotherapy 1 Anergis Focus on Allergy Immunotherapy (AIT) High Medical Need and Patient Demand 500 M allergic patients - fastest growing chronic condition
More informationWORDS S UMMARY. R. Mösges, B. Ritter, G. Kayoko, D. Passali, S. Allekotte
Review Carbamylated monomeric allergoids... Carbamylated monomeric allergoids as a therapeutic option for sublingual immunotherapy of dust mite and grass pollen induced allergic rhinoconjunctivitis: a
More informationThe Future of Allergy Treatment Ultra-Fast Allergy Immunotherapy
The Future of Allergy Treatment Ultra-Fast Allergy Immunotherapy 1 Anergis Focus on Allergy Immunotherapy (AIT) High Medical Need and Patient Demand 500 M allergic patients - fastest growing chronic condition
More informationINVESTIGATIONS & PROCEDURES IN PULMONOLOGY. Immunotherapy in Asthma Dr. Zia Hashim
INVESTIGATIONS & PROCEDURES IN PULMONOLOGY Immunotherapy in Asthma Dr. Zia Hashim Definition Involves Administration of gradually increasing quantities of specific allergens to patients with IgE-mediated
More informationMinireview. Claus Bachert. Jakob Noergaard Andreasen b
Minireview Published online: January 30, 2016 Cost-Effectiveness of Immunotherapy in the Treatment of Seasonal Allergic Rhinitis: Identifying Product-Specific Parameters of Relevance for Health Care Decision-Makers
More informationSUMMARY OF PRODUCT CHARACTERISTICS. Standardised allergen extract of grass pollen from Timothy (Phleum pratense) 75,000 SQ-T* per oral lyophilisate.
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE MEDICINAL PRODUCT GRAZAX 75,000 SQ-T oral lyophilisate. 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Standardised allergen extract of grass pollen from
More informationOVERVIEW OF COMMENTS RECEIVED ON DRAFT GUIDELINE ON THE DEVELOPMENT OF PRODUCTS FOR SPECIFC IMMUNOTHERAY FOR THE TREATMENT OF ALLERGIC DISEASE
European Medicines Agency Pre-Authorisation Evaluation of Medicines for Human Use London, 23 June 2008 Doc. Ref. EMEA/CHMP/EWP/330620/2008 OVERVIEW OF COMMENTS RECEIVED ON DRAFT GUIDELINE ON THE DEVELOPMENT
More informationClinical and Experimental Allergy
EC doi: 10.1111/j.1365-2222.2008.03152.x Clinical and Experimental Allergy, 39, 387 393 ORIGINAL PAPER Clinical Allergy Journal compilation c 2008 Blackwell Publishing Ltd Efficacy and safety of 5-grass
More informationHEALTH ECONOMIC ANALYSIS OF ALLERGEN IMMUNOTHERAPY (AIT) FOR THE MANAGEMENT OF ALLERGIC RHINITIS, ASTHMA, FOOD ALLERGY AND VENOM ALLERGY
7 HEALTH ECONOMIC ANALYSIS OF ALLERGEN IMMUNOTHERAPY (AIT) FOR THE MANAGEMENT OF ALLERGIC RHINITIS, ASTHMA, FOOD ALLERGY AND VENOM ALLERGY A SYSTEMATIC OVERVIEW Supplementary materials Miqdad Asaria 1,
More informationClinical and patient based evaluation of immunotherapy for grass pollen and mite allergy
Clinical and patient based evaluation of immunotherapy for grass pollen and mite allergy K. Dam Petersen a, D. Gyrd-Hansen a, S. Kjærgaard b and R. Dahl c a Health Economics, Institute of Public Health,
More informationSpeaking the Same Language: Grading System for Subcutaneous Immunotherapy Systemic Reaction World Allergy Organization Symposium Immunotherapy &
Speaking the Same Language: Grading System for Subcutaneous Immunotherapy Systemic Reaction World Allergy Organization Symposium Immunotherapy & Biologics 2012 Chicago Linda Cox, MD, FAAAAI Linda Cox,
More informationUse of SLIT in allergy practice: Is it ready for prime time? Stanley Fineman, MD, MBA Atlanta Allergy & Asthma Clinic AAIFNC, Feb 7, 2015
Use of SLIT in allergy practice: Is it ready for prime time? Stanley Fineman, MD, MBA Atlanta Allergy & Asthma Clinic AAIFNC, Feb 7, 2015 Disclosures Speakers bureau/consultant: AZ, Genentech/Novartis,
More informationMultiple daily administrations of low-dose sublingual immunotherapy in allergic rhinoconjunctivitis Vasco Bordignon, MD,* and Samuele E.
Multiple daily administrations of low-dose sublingual immunotherapy in allergic rhinoconjunctivitis Vasco Bordignon, MD,* and Samuele E. Burastero, MD Background: Sublingual immunotherapy (SLIT) is an
More informationFace to Face on LAIS Mechanism of action and clinical experiences
Kazan, 14-17 May 2014 Face to Face on LAIS Mechanism of action and clinical experiences Mario di Gioacchino Dept. of Medicine and Ageing Science University of Chieti. Italy Enrico Compalati Allergy & Respiratory
More informationPrescribing Framework for Sublingual Immunotherapy (Grazax)
Hull & East Riding Prescribing Committee Prescribing Framework for Sublingual Immunotherapy (Grazax) Patient s Name:.. NHS Number: Patient s Address:... (Use addressograph sticker) GP s Name:... Communication
More informationA world leader in allergy immunotherapy
A world leader in allergy immunotherapy Investor Relations presentation June 2017 1 I Investor Relations presentation I June 2017 ALK: Towards redefining treatment of severe allergies The commercial leader
More informationThe RHINASTHMA GAV scores without SLIT, at the beginning and at the end of seasonal SLIT
Original article The RHINASTHMA GAV scores without SLIT, at the beginning and at the end of seasonal SLIT Jochen Sieber, 1 Anna Gross, 2 Kija Shah-Hosseini 2 and Ralph Mösges 2 Summary Background: The
More informationNutricia Paediatric Allergy Symposium 24 th May 2016
Nutricia Paediatric Allergy Symposium 24 th May 2016 The speaker had sole editorial control over the content in this slide deck. Any views, opinions or recommendations expressed in the slides are solely
More informationFormat. Allergic Rhinitis Optimising Mananagement. Degree of Quality of life Restriction in the Allergic Patient. The allergy epidemic:
Format Allergic Rhinitis Optimising Mananagement Dr Dominic Mallon FRACP FRCPA Clinical Immunologist and Allergist Fiona Stanley Hospital Impact of allergic rhinitis Diagnosis and management of allergic
More informationABSTRACT. . Jörg Schnitker. Eike Wüstenberg
Pulm Ther (2017) 3:149 161 DOI 10.1007/s41030-017-0030-x ORIGINAL RESEARCH Treatment Satisfaction During Routine Treatment with the SQ Ò -Standardised Grass Allergy Immunotherapy Tablet: A Non-interventional
More informationNew Horizons Session on Specific Immunotherapy (SIT) Session 4: Practical considerations for SIT. When should SIT be started and why?
New Horizons Session on Specific Immunotherapy (SIT) Session 4: Practical considerations for SIT When should SIT be started and why? Lars Jacobsen: Research Centre for Prevention and Health Glostrup University
More informationNew Approaches to Immunotherapy
New Approaches to Immunotherapy Harold S. Nelson, MD Professor of Medicine National Jewish Health and University of Colorado School of Medicine, Denver, Colorado, USA Faculty Disclosure Harold S. Nelson,
More informationLeading R&D pipeline with proven technology. Partners. Injection and drop-based allergy immunotherapy products
ALK at a glance The leading allergy immunotherapy specialist 33% of global allergy immunotherapy market Leading R&D pipeline with proven technology Strategic partnerships to globalise SLIT- tablet portfolio
More informationAndreas Horn 1 Herbert Zeuner. Eike Wüstenberg 2,4 GRAZAX LQ-study group
Clin Drug Investig DOI 10.1007/s40261-016-0388-9 ORIGINAL RESEARCH ARTICLE Health-Related Quality of Life During Routine Treatment with the SQ-Standardised Grass Allergy Immunotherapy Tablet: A Non-Interventional
More informationAdherence During Early Allergen Immunotherapy and Strategies to Motivate and Support Patients
Adherence During Early Allergen Immunotherapy and Strategies to Motivate and Support Patients Authors: Natalija Novak, 1 Timo Buhl, 2,3 *Oliver Pfaar 4,5 1. Department of Dermatology and Allergy, University
More informationSublingual Immunotherapy in Pediatric Patients: Beyond Clinical Efficacy
www.medscape.com To Print: Click your browser's PRINT button. NOTE: To view the article with Web enhancements, go to: http://www.medscape.com/viewarticle/501817 Sublingual Immunotherapy in Pediatric Patients:
More informationScientific Contribution 2017
HAL Allergy Roadmap to Innovative and Registered Allergen Immunotherapy Registered Immunotherapy Phase III Phase II Pivotal Pre Clinical Phase I Dose Tolerability Dose Finding Scientific Contribution 27
More informationR ecently specific immunotherapy (SIT) by the sublingual
620 ORIGINAL ARTICLE Sublingual immunotherapy in asthma and rhinoconjunctivitis; systematic review of paediatric literature S Miceli Sopo, M Macchiaiolo, G Zorzi, S Tripodi... See end of article for authors
More informationClinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study
Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: A 3-year randomized controlled study Maurizio Marogna, MD, a Igino Spadolini, MD, b Alessandro Massolo, BS,
More informationPediatric sublingual immunotherapy efficacy: evidence analysis,
Ann Allergy Asthma Immunol 110 (2013) 402e415 Contents lists available at SciVerse ScienceDirect Review Pediatric sublingual immunotherapy efficacy: evidence analysis, 2009-2012 Désirée Larenas-Linnemann,
More informationReview on immunotherapy in airway allergen sensitised patients
REVIEW Review on immunotherapy in airway allergen sensitised patients J.P.M van der Valk*, N.W. de Jong, R. Gerth van Wijk Department of Internal Medicine, section of Allergology, Erasmus MC, Rotterdam,
More informationScientific Contribution 2018
Allergy in a changing world Scientific Contribution 218 37 th Congress of the European Academy of Allergy and Clinical Immunology EAACI, 26-3 - May 218, Munich, Germany Dear Congress delegate, On behalf
More informationSublingual or subcutaneous immunotherapy for seasonal allergic rhinitis: an indirect analysis of efficacy, safety and cost
bs_bs_banner Journal of Evaluation in Clinical Practice ISSN 1365-2753 Sublingual or subcutaneous immunotherapy for seasonal allergic rhinitis: an indirect analysis of efficacy, safety and cost George
More informationMoving closer to people with allergy
Moving closer to people with allergy Investor Relations Presentation January 2017 1 I Investor Relations Presentation January 2017 ALK: Towards redefining treatment of severe allergies The commercial leader
More informationDefinition of Allergens 2013 Is there a need for Seasonal & Perennial?
MANIFESTO Definition of Allergens 2013 Is there a need for Seasonal & Perennial? Canonica G.W. Baena Cagnani C.E. Bousquet J. Pawankar R. Zuberbier T. Reasons for NOT using the classification of SEASONAL
More informationAllergen immunotherapy: from EBM to doctors and patients need
Allergen immunotherapy: from EBM to doctors and patients need Moscow, Marriott Hotel February 28th, 2019 Dr. Franco Frati Medical Department Milan, Italy From the recognition of the pollen to in vivo tests
More informationA world leader in allergy immunotherapy
A world leader in allergy immunotherapy Investor Relations Presentation April 2017 1 I Investor Relations presentation April 2017 ALK: Towards redefining treatment of severe allergies The commercial leader
More informationAuthors should appear in this order for PubMed:
1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Sublingual Immunotherapy: A focused allergen immunotherapy practice parameter update Authors should appear
More information1 Introduction. Rainer Reiber 1 Hendrik Wolf. Jörg Schnitker
Drugs - Real World Outcomes (2017) 4:65 74 DOI 10.1007/s40801-016-0103-4 ORIGINAL RESEARCH ARTICLE Tolerability of an Immunologically Enhanced Subcutaneous Immunotherapy Preparation in Patients Treated
More informationAllergen immunotherapy in polysensitized patient
R E V I E W Eur Ann Allergy Clin Immunol Vol 48, N 3, 69-76, 2016 M. Hrubiško 1, V. Špičák 2 Allergen immunotherapy in polysensitized patient 1 Dept. Allergy & Clinical Immunology, Oncology Institute St.
More informationComparative analysis of cluster versus conventional immunotherapy in patients with allergic rhinitis
EXPERIMENTAL AND THERAPEUTIC MEDICINE 13: 717-722, 2017 Comparative analysis of cluster versus conventional immunotherapy in patients with allergic rhinitis QIJUN FAN 1, XUEJUN LIU 2, JINJIAN GAO 2, SAIYU
More informationSublingual Immunotherapy as a Technique of Allergen Specific Therapy
Sublingual Immunotherapy as a Technique of Allergen Specific Therapy Policy Number: 2.01.17 Last Review: 7/2018 Origination: 7/2006 Next Review: 7/2019 Policy Blue Cross and Blue Shield of Kansas City
More informationAbstract. Specific Immunotherapy (L Cox, Section Editor)
Curr Treat Options Allergy (2018) 5:275 290 DOI 10.1007/s40521-018-0176-2 Specific Immunotherapy (L Cox, Section Editor) Duration of Allergen Immunotherapy for Long-Term Efficacy in Allergic Rhinoconjunctivitis
More informationALK at a glance The leading allergy specialist
ALK at a glance The leading allergy specialist 33% of global allergy immunotherapy market Leading R&D pipeline with proven technology Strategic partnerships to globalise tablet portfolio Modern allergy
More informationSupplementary Online Content
Supplementary Online Content Scadding GW, Calderon MA, Shamji MH, et al. Effect of 2 Years of treatment with sublingual grass pollen immunotherapy on nasal response to allergen challenge at 3 years among
More informationimmunotherapy to parietaria. A controlled field study
O R I G I N A L A R T I C L E Eur Ann Allergy Clin Immunol VOL 42, N 3, 115-119, 2010 A. Musarra 1, D. Bignardi 2, C. Troise 2, G. Passalacqua 3 Long-lasting effect of a monophosphoryl lipidadjuvanted
More informationEfficacy of sublingual specific immunotherapy on allergic asthma and rhinitis in children s real life
European Review for Medical and Pharmacological Sciences Efficacy of sublingual specific immunotherapy on allergic asthma and rhinitis in children s real life G. DE CASTRO, A.M. ZICARI, L. INDINNIMEO,
More informationBy the end of this lecture physicians will:
No disclosure By the end of this lecture physicians will: 1. Be able to identify patients who need immune work-up. 2. Be able to recognize the manifestation of food allergies. 3. Be knowledgeable about
More informationACCURATE DIAGNOSIS OF ALLERGIC AIRWAY DISEASES
DEPARTMENT OF OTORHINOLARYNGOLOGY UPPER AIRWAYS RESEARCH LABORATORY ACCURATE DIAGNOSIS OF ALLERGIC AIRWAY DISEASES Prof Dr Philippe GEVAERT DISCLOSURES Phillipe Gevaert, MD, PhD, has disclosed the following
More informationAssessing the Relative Risks of Subcutaneous and Sublingual Allergen Immunotherapy
Assessing the Relative Risks of Subcutaneous and Sublingual Allergen Immunotherapy Tolly Epstein, MD, MS Assistant Professor of Clinical Medicine Division of Immunology, Allergy & Rheumatology University
More informationThe evolution of allergen immunotherapy from empirical desensitization to immunological treatment
Eur Ann Allergy Clin Immunol VOL 45, SUPPL. 2, 5-10, 2013 C. Incorvaia 1, I. Dell Albani 2, G. Di Cara 3, P. Piras 4, F. Frati 2 The evolution of allergen immunotherapy from empirical desensitization to
More informationUNDERSTANDING ALLERGY IMMUNOTHERAPY
UNDERSTANDING ALLERGY IMMUNOTHERAPY Provide Allergy Patients Another Option for Relief How many of your patients suffer from allergies? ALLERGIES ARE A BURDENSOME CONDITION FOR MANY PEOPLE IN THE US. In
More informationAllergic Rhinitis Update Prof. Ralph Mösges Otorhinolaryngologist and Allergologist University Hospital of Cologne
Allergic Rhinitis Update 2008 Prof. Ralph Mösges Otorhinolaryngologist and Allergologist University Hospital of Cologne Augustus Claudius Britanicus An atopic family Allergic Rhinitis Update 2008 Epidemiology
More informationOmalizumab (Xolair ) ( Genentech, Inc., Novartis Pharmaceuticals Corp.) September Indication
( Genentech, Inc., Novartis Pharmaceuticals Corp.) September 2003 Indication The FDA recently approved Omalizumab on June 20, 2003 for adults and adolescents (12 years of age and above) with moderate to
More informationTREATING ALLERGIC RHINITIS
TREATING ALLERGIC RHINITIS Prof. Dr. Jean-Baptiste Watelet, MD Department of Otorhinolaryngology Ghent University Hospital Ghent, Belgium Allergic rhinitis (AR) is a nasal disease with the presence of
More informationDerriford Hospital. Peninsula Medical School
Asthma and Allergic Rhinitis iti What is the Connection? Hisham Khalil Consultant ENT Surgeon Clinical Senior Lecturer, PMS Clinical Sub-Dean GP Evening 25 June 2008 Plymouth Derriford Hospital Peninsula
More informationOpinion 8 January 2014
The legally binding text is the original French version TRANSPARENCY COMMITTEE Opinion 8 January 2014 WYSTAMM 1 mg/ml, oral solution 120 ml vial with syringe for oral administration (CIP: 34009 222 560
More informationCorporate presentation January A new generation of allergy immunotherapies
Corporate presentation January 2015 A new generation of allergy immunotherapies Disclaimer Neither this presentation nor any verbal communication shall constitute, or form part of, any offer, invitation
More informationThe Role of Allergy Testing to Achieve Personalized Treatment Goals for Allergic Rhinitis and Asthma
The Role of Allergy Testing to Achieve Personalized Treatment Goals for Allergic Rhinitis and Asthma FACULTY Henry A. Wojtczak, MD Pediatric Pulmonologist Naval Medical Center San Diego, CA Dr. Wojtczak
More informationCan dog allergen immunotherapy reduce concomitant allergic sensitization to other furry animals? A preliminary experience
L E T T ER T O T H E E D I T O R Eur Ann Allergy Clin Immunol Vol 49, N 2, 92-96, 2017 G. Liccardi 1,2, L. Calzetta 2,3, A. Salzillo 1, L. Billeri 4, G. Lucà 3, P. Rogliani 2,3 Can dog allergen immunotherapy
More informationClinical and Translational Allergy. Open Access RESEARCH
DOI 10.1186/s13601-016-0097-8 Clinical and Translational Allergy RESEARCH Tolerability of the SQ standardised grass sublingual immunotherapy tablet in patients treated with concomitant allergy immunotherapy:
More informationSublingual Immunotherapy as a Technique of Allergen Specific Therapy
Sublingual Immunotherapy as a Technique of Allergen Specific Therapy Policy Number: 2.01.17 Last Review: 7/2014 Origination: 7/2006 Next Review: 7/2015 Policy Blue Cross and Blue Shield of Kansas City
More informationA world leader in allergy immunotherapy
A world leader in allergy immunotherapy R&D and Business Briefing New York, May 2014 ALK R&D and Business Briefing Agenda 13.00: ALK An emerging speciality pharma company with a global growth strategy
More informationMohamed Shamji, PhD. CS. FAAAAI
Short Course treatment of Subcutaneous Peptide Hydrolysate from Lolium Perenne - gp-asit+ TM - suppresses Basophil Responses and induces IgGassociated Blocking Antibodies: A RDPCT Mohamed Shamji, PhD.
More information