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1 Author: John Williams, M.D., Ph.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Non-commercial Share Alike 3.0 License: We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.
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3 M1 - GI Sequence Pancreas John Williams, M.D., Ph.D. Winter, 2009
4 PANCREAS Gray s Anatomy, wikimedia commons
5 The pancreas is made up of three functional components: Endocrine Islets 2% Exocrine Acinar 80% Digestive Enzymes Exocrine - Ducts 8% Bicarbonate Rich Fluid Innervation Vagal Acini Ach main transmitter Ducts Islets Sympathetic Islets NE main transmitter Blood Vessels
6 John Williams modified from Kent Christensen
7 REGULATION OF PANCREATIC SECRETION Jim Sherman
8 Stimulation of Pancreatic Secretion during the Intestinal Phase Frank Boumphrey, M.D., wikimedia commons
9 Stimulation of Pancreatic Secretion during the Intestinal Phase Paracrine stimulation Within the mucosa Endocrine stimulation John Williams modified from undetermined source
10 Source Undetermined
11 Concentration of Ions in Pancreatic Juice as a Function of Flow Fig. 9-2 Johnson, L. Gastrointestinal Physiology, 7 th ed. Mosby Elsevier, Philadelphia, PA; 2007: 87.
12 Pancreatic Bicarbonate output increases in response to low Duodenal ph Fig. 9-5 Johnson, L. Gastrointestinal Physiology, 6 th ed. Mosby Elsevier, St. Louis, MO; 2001: 102.
13 Mechanism of Pancreatic Bicarbonate Secretion John Williams
14 INTRACELLULAR TRANSPORT OF PANCREATIC SECRETORY PROTEINS Source Undetermined
15 Stimulus-secretion Coupling of Pancreatic Enzyme Secretion John Williams
16 Source Undetermined
17 Activation of Pancreatic Proenzymes in the Intestine involves Enterokinase and activated Trypsin ` Jim Sherman
18 Additional Source Information for more information see: Slide 4: Gray s Anatomy Plate 1100, Wikimedia Commons, Slide 6 John Williams modified from Kent Christensen Slide 7 Jim Sherman Slide 8: Frank Boumphrey, M.D., Wikimedia Commons, CC:BY-SA Slide 9 John Williams modified from undetermined Slide 10 Source Undetermined Slide 11 Fig. 9-2 Johnson, L. Gastrointestinal Physiology, 7 th ed. Mosby Elsevier, Philadelphia, PA; 2007: 87. Slide 12 Fig. 9-5 Johnson, L. Gastrointestinal Physiology, 6 th ed. Mosby Elsevier, St. Louis, MO; 2001: 102. Slide 13 John Williams Slide 14 Source Undetermined Slide 15 John Williams Slide 16 Source Undetermined Slide 17 Jim Sherman
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Attribution: University of Michigan Medical School, Department of Microbiology and Immunology
Attribution: University of Michigan Medical School, Department of Microbiology and Immunology License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution
Attribution: University of Michigan Medical School, Department of Microbiology and Immunology
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Attribution: University of Michigan Medical School, Department of Microbiology and Immunology
Attribution: University of Michigan Medical School, Department of Microbiology and Immunology License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution
Attribution: University of Michigan Medical School, Department of Microbiology and Immunology
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1 What is pancreatic cancer? This fact sheet provides an introduction to the function of the pancreas and pancreatic cancer. If you have any questions about pancreatic cancer, speak to our specialist nurses
M1 - Immunology, Winter 2008
University of Michigan Deep Blue deepblue.lib.umich.edu 2008-09 M1 - Immunology, Winter 2008 Fantone, J.; Pietropaolo, M. T. Fantone, J., Pietropaolo, M. T. (2008, August 13). Immunology. Retrieved from
Author(s): Joe Lex, MD, FACEP, FAAEM, MAAEM (Temple University) 2013
Project: Ghana Emergency Medicine Collaborative! Document Title: Test-Taking Skills! Author(s): Joe Lex, MD, FACEP, FAAEM, MAAEM (Temple University) 2013! License: Unless otherwise noted, this material
Why would fatty foods aggravate the patient s RUQ pain? What effect does cholecystokinin (CCK) have on gastric emptying?
CASE 28 A 43-year-old woman presents to the emergency department with the acute onset of abdominal pain. Her pain is located to the right upper quadrant (RUQ) and radiates to the right shoulder. She reports