Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements van de Hoef, T.P.

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1 UvA-DARE (Digital Academic Repository) Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements van de Hoef, T.P. Link to publication Citation for published version (APA): van de Hoef, T. P. (2015). Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 16 Aug 2018

2 Tim P. van de Hoef Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements Tim P. van de Hoef

3 Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements Tim Pieter van de Hoef

4 Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements Dissertation, University of Amsterdam, The Netherlands ISBN: Author: Tim Pieter van de Hoef Cover: Jazzberry Blue Lay-out & printing: Optima Grafische Communicatie Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged. The research described in this thesis was supported by a grant of the Dutch Heart Foundation (DHF- 2006B186) Additional financial support for publication of this thesis was provided by: Volcano Corporation, InfraRedx Inc., Miracor Medical Systems GmbH, Stichting Gilles Hondius Foundation, Academic Medical Center University of Amsterdam, Abbott Vascular, Daichi Sankyo Nederland BV, Medis Medical Imaging Systems BV, Stentys S.A., Wellinq Medical BV, ABN Amro Bank BV, Cardialysis BV, Chipsoft BV, Servier Nederland Farma BV, St Jude Medical, Acist Europe BV, and Pie Medical Imaging BV. Copyright 2015 Tim van de Hoef, Amsterdam, The Netherlands All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, without the prior permission in writing of the author

5 Novel insights into the complexity of ischaemic heart disease derived from combined coronary pressure and flow velocity measurements ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. D.C. van den Boom ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op donderdag 2 juli 2015, te 12:00 uur door Tim Pieter van de Hoef geboren te Soest

6 Promotiecommissie Promotores Prof. dr. J.J. Piek Universiteit van Amsterdam Prof. dr. ir. J.A.E. Spaan Universiteit van Amsterdam Co-promotores Prof. dr. J.G.P. Tijssen Universiteit van Amsterdam Dr. M. Meuwissen Amphia Ziekenhuis Breda Dr. ir. M. Siebes Universiteit van Amsterdam Overige leden Dr. J. Escaned Universidad Complutense de Madrid Prof. dr. S. Redwood King s College London Prof. dr. E.T. van Bavel Universiteit van Amsterdam Prof. dr. M.J.A.P. Daemen Universiteit van Amsterdam Prof. dr. D.J. Duncker Erasmus Universiteit Rotterdam Prof. dr. R.J.G. Peters Universiteit van Amsterdam Faculteit der Geneeskunde

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9 Table of contents Chapter 1 General introduction and outline of the thesis 11 Part A Diagnostic complexity of ischaemic heart disease 19 Chapter 2 Coronary pressure-flow relations as basis for the understanding of coronary physiology. J Mol Cell Cardiol Apr;52(4): Chapter 3 Fractional flow reserve as a surrogate for inducible myocardial ischaemia. Nat Rev Cardiol 2013 Aug;10(8): Chapter 4 Chapter 5 Chapter 6 Chapter 7 Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity. Circ Cardiovasc Intv 2014 Jun;7(3): Impact of hyperaemic microvascular resistance on fractional flow reserve measurements in patients with stable coronary artery disease: insights from combined stenosis and microvascular resistance assessment. Heart Jun;100(12): Impact of age on intracoronary physiological indices of stenosis severity and microcirculatory function Submitted. Coronary flow capacity: a cross-modality concept to enhance the diagnosis and risk-stratification of ischaemic heart disease. J Am Coll Cardiol Intv [Accepted for publication] Part B Hyperaemia-free assessment of physiological stenosis severity 155 Chapter 8 Diagnostic accuracy of combined intracoronary pressure and flow velocity information during baseline conditions: adenosine-free assessment of functional coronary lesion severity. Circ Cardiovasc Interv Aug 1;5(4): Chapter 9 Head-to-head comparison of basal stenosis resistance index, instantaneous wave-free ratio, and fractional flow reserve: diagnostic accuracy for stenosis-specific myocardial ischemia. EuroIntervention 2014 [Epub ahead of print]. 173

10 Chapter 10 Basal stenosis resistance derived from simultaneous pressure and flow velocity measurements. Submitted. 195 Part C Prognostic implications of and therapeutic strategies directed towards the microcirculation Chapter 11 Impaired coronary autoregulation is associated with long-term fatal events in patients with stable coronary artery disease. Circ Cardiovasc Intv 2013 Aug;6(4): Chapter 12 Impact of coronary microvascular function on long-term cardiac mortality in patients with acute ST-segment elevation myocardial infarction. Circ Cardiovasc Interv 2013 Jun 1;6(3): Chapter 13 Intracoronary hemodynamic effects of pressure-controlled intermittent coronary sinus occlusion (PICSO): results from the first-in-man Prepare PICSO study. J Interv Cardiol Dec;25(6): Chapter 14 Pressure-controlled intermittent coronary sinus occlusion (PICSO) in acute ST-segment elevation myocardial infarction: Results of the Prepare RAMSES study. EuroIntervention 2015 [Epub ahead of print] Part D Discussion: Facing the complexity of ischaemic heart disease 291 Chapter 15 Fundamentals in clinical coronary physiology: why coronary flow is 293 more important than coronary pressure. Eur Heart J [Accepted for publication] Chapter 16 Summary of the thesis and future perspectives 313 Samenvatting van het proefschrift 326 Part E Appendices 333 List of publications 335 Authors and affiliations 341 Curriculum vitae 345 Portfolio 349 Acknowledgements/ Woord van dank/ Agradecimientos 353