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1 EPIGENETICS Enzymes Kits Cell Lines Screening Services INNOVATIVE PRODUCTS TO FUEL YOUR EXPERIMENTS Unique, expert portfolio

2 HISTONE METHYLTRANSFERASES HISTONE DEMETHYLASES ACETYLTRANSFERASES BROMODOMAINS DEACETYLASES RECOMBINANT, ASSAY READY PROTEINS > 200 INCLUDING COMPLEXES INHIBITOR SCREENING ASSAYS > 200 AVAILABLE INHIBITORS & ANTIBODIES METHYLATION, CHROMATIN, CANCER, TRANSCRIPTION SUBSTRATES HISTONES, OCTAMERS, NUCLEOSOMES, BIOTINYLATED VERSIONS CUSTOM & BULK PRODUCTION CLONING, SCALE-UP, PURIFICATION, EXPRESSION SCREENING SERVICES MULTIPLE DETECTION METHODS TABLE OF CONTENTS BPS ADVANTAGES 3 ACETLYTRANSFERASES 4 BROMODOMAINS 5 DEACETYLASES/SIRTUINS 8 DEMETHYLASES 11 METHYLTRANSFERASES 13

3 BPS ADVANTAGES MADE IN HOUSE GET ANSWERS STRAIGHT FROM THE SOURCE OPTIMAL TECH AND CUSTOMER SUPPORT > 12 YEARS EXPERIENCE CITED IN HUNDREDS OF PUBLICATIONS MATURE PROTEIN PORTFOLIO FULL HDAC AND SIRTUIN SUITE MOST EXTENSIVE DNMT OFFERING ON MARKET HUMAN, MURINE, AND MONKEY VERSIONS OF RECOMBINANT PROTEINS MULTIPLE TAGGED VERSIONS INCLUDING GST, FLAG, HIS, STREPTAVIDIN (AVI-TAG ) PROTEIN COMPLEXES PROTEIN MUTANTS FULL LENGTH AND CATALYTIC DOMAINS HIP PROTEINS = HIGH PURITY & LOW AGGREGATION (VIA FPLC) MULTIPLE READ OUT METHODS FOR ASSAYS ALPHA SCREEN CHEMILUMINESCENCE FLUORESCENCE INTENSITY FLUORESCENCE POLARIZATION (FP) TIME-RESOLVED FLUOROMETRIC TR-FRET/FRET (HTRF) EXPRESSION & SCREENING SERVICES

4 ACETYLTRANSFERASE(S) GCN5 Chemiluminescent Assay Kit 50079L 96 reactions GCN5 Fluorogenic Assay Kit reactions P300 (KAT3B) Fluorogenic Assay Kit reactions P300 Homogeneous Assay Kit reactions 10x HAT Assay Buffer ml AICAR mg ATAT1, GST-tag µg C mg C mg GCN5 (KAT2A), FLAG-tag µg HAT Stop Solution ml KAT5 (TIP60), GST-Tag µg p300 (KAT3B), His-GST-tags µg P300 Chemiluminescent Assay Kit 50077L 96 reactions 4

5 BROMODOMAIN(S) ATAD2A Inhibitor Screening Assay Kit reactions ATAD2A TR-FRET Assay Kit reactions ATAD2B Inhibitor Screening Assay Kit reactions ATAD2B TR-FRET Assay Kit reactions BAZ2B Inhibitor Screening Assay Kit reactions BPTF/FALZ TR-FRET Assay Kit reactions BRD1 Inhibitor Screening Assay Kit reactions BRD1 TR-FRET Assay Kit reactions BRD2 (BD1+BD2) TR-FRET Assay Kit reactions BRD2 (BD2) Inhibitor Screening Assay Kit reactions BRD3 (BD1) Inhibitor Screening Assay Kit reactions BRD3 (BD1+BD2) TR-FRET Assay Kit reactions BRD3 (BD2) Inhibitor Screening Assay Kit reactions BRD4 (BD1) Inhibitor Screening Assay Kit reactions BRD4 (BD1) TR-FRET Assay Kit reactions BRD4 (BD1+BD2) TR-FRET Assay Kit reactions BRD4 (BD2) Inhibitor Screening Assay Kit reactions BRD4 (BD2) TR-FRET Assay Kit reactions BRD9 (BD1) Inhibitor Screening Assay Kit reactions BRD9 TR-FRET Assay Kit reactions BRDT (BD1+BD2) TR-FRET Assay Kit reactions BRPF3 Inhibitor Screening Assay Kit reactions BRPF3 TR-FRET Assay Kit reactions CECR2 Inhibitor Screening Assay Kit reactions CECR2 TR-FRET Assay Kit reactions CREBBP Inhibitor Screening Assay Kit reactions SMARCA2 Inhibitor Screening Assay Kit reactions SMARCA4/BRG1 Inhibitor Screening Assay Kit reactions TAF1 (BD1+BD2) TR-FRET Assay Kit reactions TAF1 (BD1/BD2) Inhibitor Screening Assay Kit reactions TAF1 (BD2) Inhibitor Screening Assay Kit reactions TAF1 (BD2) TR-FRET Assay Kit reactions TAF1L (BD1+BD2) TR-FRET Assay Kit reactions TAF1L (BD1/BD2) Inhibitor Screening Assay Kit reactions TAF1L (BD2) Inhibitor Screening Assay Kit reactions 5

6 BROMODOMAIN(S) (CONT'D) TRIM24 Inhibitor Screening Assay Kit reactions TRIM24 TR-FRET Assay Kit reactions WDR9/BRWD1 TR-FRET Assay Kit reactions (+)-JQ mg (+)-JQ mg (+)-JQ mg (-)-JQ mg (-)-JQ mg 3x BRD Homogeneous Assay Buffer ml 3x BRD Homogeneous Assay Buffer ml 3x BRD Homogeneous Assay Buffer ml 3x BRD Homogeneous Detection Buffer ml 3x BRD Homogeneous Detection Buffer ml 3x BRD TR-FRET Assay Buffer ml 3x BRD TR-FRET Assay Buffer ml 3x Homogeneous BRD Detection Buffer ml ASH1L, His-tag µg ATAD2A, GST-tag µg ATAD2A, His-tag µg ATAD2B (KIAA1240), GST-tag µg ATAD2B (KIAA1240), His-tag µg BACE1 FRET Assay Kit reactions BAZ1A, GST-tag µg BAZ1B, GST-tag µg BAZ1B, His-tag µg BAZ2B, His-tag µg BET Bromodomain Ligand µm BRD1, GST-tag µg BRD1, His-tag µg BRD2 (BD1), GST-tag µg BRD2 (BD1), His-tag µg BRD2 (BD1+BD2), GST-tag µg BRD2 (BD1+BD2), His-tag µg BRD2 (BD2), GST-tag µg BRD2 (BD2), His-tag µg BRD3 (BD1), GST-tag µg BRD3 (BD1), His-tag µg BRD3 (BD1+BD2), GST-tag µg BRD3 (BD1+BD2), His-tag µg BRD3 (BD2), GST-tag µg BRD3 (BD2), His-tag µg BRD4 (BD1), GST-tag µg BRD4 (BD1), His-tag µg BRD4 (BD1+BD2) µg BRD4 (BD1+BD2), GST-tag µg BRD4 (BD1+BD2), His-tag µg BRD4 (BD2), GST-tag µg BRD4 (BD2), His-tag µg BRD9, GST-tag µg BRD9, His-tag µg BRDT (BD1), GST-tag µg BRDT (BD1), His-tag µg BRDT (BD1+BD2), GST-tag µg BRDT (BD2), GST-tag µg BRDT (BD2), His-tag µg Bromodomain Ligand µm Bromodomain Ligand µm Bromodomain Ligand µm Bromodomain Non-Acetylated Ligand µm Bromodomain Non-Acetylated Ligand µm Bromodomain Non-Acetylated Ligand µm Bromodomain Non-Acetylated Ligand µm Bromosporine mg BRPF1, His-tag µg BRPF3, GST-tag µg CECR2, GST-tag µg CECR2, His-tag µg CHS mg CREBBP (KAT3A), GST-tag µg CREBBP (KAT3A), His-tag µg CREBBP TR-FRET Assay Kit Reactions FALZ (BPTF), GST-tag µg FALZ (BPTF), His-tag µg GCN5 ( ), His-tag µg I-BET mg I-BET mg I-BET151 (GSK A) mg I-BET151 (GSK A) mg I-BET151 (GSK A) mg I-CBP112 (Hydrochloride) mg OTX mg OTX mg OTX mg P300 ( ), His-tag µg 6

7 BROMODOMAIN(S) (CONT'D) PB1 (BD4), His-tag µg PB1 (BD6), His-tag µg PCAF (KAT2B), His-tag µg PFI mg PHIP (BD1), GST-tag µg PHIP (BD1), His-tag µg RediSolution (+)-JQ mg RVX mg SGC-CBP mg SGC-CBP mg SMARCA2 TR-FRET Assay Kit reactions SMARCA2, GST-tag µg SMARCA2, His-tag µg SMARCA2, His-Tag, Biotin-Labeled μg SMARCA4 (BRG1), GST-tag µg SMARCA4 (BRG1), His-tag µg SMARCA4/BRG1 TR-FRET Assay Kit reactions TAF1 (BD1), His-tag µg TAF1 (BD1+BD2), GST-tag µg TAF1 (BD2), GST-tag µg TAF1 (BD2), His-tag µg TAF1L (BD1), GST-tag µg TAF1L (BD1), His-tag µg TAF1L (BD1+BD2), GST-tag µg TAF1L (BD2), GST-tag µg TAF1L (BD2), His-tag µg TRIM24 (TIF1), GST-tag µg TRIM24 (TIF1), His-tag µg TRIM28, GST-tag µg TRIM28, His-tag µg WDR9/BRWD1 (BD2), GST-tag µg WDR9/BRWD1 (BD2), His-tag µg ZMYND11, GST-tag µg ZMYND8, GST-tag µg 7

8 DEACETYLASE(S)/SIRTUINS HDAC class 2a Fluorogenic Assay Kit reactions HDAC Fluorogenic Assay Kit reactions HDAC Fluorogenic Assay Kit (Green) reactions HDAC1 Fluorogenic Assay Kit reactions HDAC1 Kinetic Assay Kit reactions HDAC2 Fluorogenic Assay Kit reactions HDAC2 Kinetic Assay Kit reactions HDAC3 Fluorogenic Assay Kit reactions HDAC3 Kinetic Assay Kit reactions HDAC4 Fluorogenic Assay Kit reactions HDAC5 Fluorogenic Assay Kit reactions HDAC7 Fluorogenic Assay Kit reactions HDAC8 Fluorogenic Assay Kit reactions HDAC9 Fluorogenic Assay Kit reactions SIRT1 (Sirtuin1) Fluorogenic Assay Kit reactions SIRT2 (Sirtuin2) Fluorogenic Assay Kit reactions SIRT3 (Sirtuin3) Fluorogenic Assay Kit reactions SIRT5 (Sirtuin5) Fluorogenic Assay Kit reactions (S)-HDAC mg 4-iodo-SAHA mg AGK mg Apicidin mg AR-42 (OSU-HDAC42) mg AR-42 (OSU-HDAC42) mg AR-42 (OSU-HDAC42) mg Belinostat (PXD101) mg Belinostat (PXD101) mg Belinostat (PXD101) mg CBHA mg Chidamide mg CI mg CUDC mg 8

9 DEACETYLASE(S)/SIRTUINS (CONT'D) Droxinostat mg Droxinostat mg EX mg Fluorogenic HDAC class 2a substrate nmole Fluorogenic HDAC class 2a substrate 2 (green) nmole Fluorogenic HDAC substrate nmole Fluorogenic HDAC Substrate 2 (Green fluorescence) nmole Fluorogenic HDAC substrate nmole Fluorogenic SIRT substrate nmole Fluorogenic Sirtuin 5 Substrate nmole Fluorogenic Sirtuin 6 Substrate µl HC Toxin µg HDAC Assay Buffer ml HDAC developer (2X) ml HDAC1, FLAG-tag, His-tag µg HDAC1, His-Tag, FLAG-Tag (Mouse) µg HDAC10, GST-tag, His-tag µg HDAC10, N-FLAG-tag µg HDAC µg HDAC11 Fluorogenic Assay Kit reactions HDAC11, GST-tag µg HDAC2, FLAG-tag µg HDAC2, His-tag µg HDAC3/NcoR2 Complex, His-tag µg HDAC4, GST-tag, His-tag µg HDAC5 (full length), GST-tag µg HDAC5, Catalytic Domain, His-tag µg HDAC6 (H216A), GST-tag µg HDAC6 (H611A), GST-tag µg HDAC6 Fluorogenic Assay Kit reactions HDAC6, FLAG-tag µg HDAC6, GST-tag µg HDAC6, GST-Tag (Mouse) µg HDAC7, GST-tag µg HDAC8, His-tag µg HDAC9, His-tag µg HNHA mg ITF mg JNJ mg JNJ mg JNJ mg Kaempferol mg Kinetic HDAC Assay Developer ml LAQ824 (NVP-LAQ824,Dacinostat) mg LAQ824 (NVP-LAQ824,Dacinostat) mg M mg MC mg MC mg Mocetinostat mg MS-275 (Entinostat) mg NcoR2 (SMRT), GST-tag µg Oxamflatin mg Oxamflatin mg Panobinostat mg Parthenolide mg Parthenolide mg PCI mg PCI (CRA ) mg PCI (CRA ) mg PCI (CRA ) mg pf-hdac1, Malaria, His-tag, FLAG-tag µg Pracinostat (SB939) mg Pracinostat (SB939) mg Pracinostat (SB939) mg Pyroxamide mg Resminostat (RAS2410) mg Resminostat (RAS2410) mg Resveratrol mg Resveratrol mg Resveratrol mg RGFP mg RGFP mg RGFP mg Rocilinostat (ACY-1215) mg Rocilinostat (ACY-1215) mg Rocilinostat (ACY-1215) mg Romidepsin (FK228, depsipeptide) mg Romidepsin (FK228, depsipeptide) mg SAHA (Vorinostat) mg Salermide mg SB mg Scriptaid mg SIRT1/2 Inhibitor IV mg Sirtinol mg 9

10 DEACETYLASE(S)/SIRTUINS (CONT'D) Droxinostat mg Droxinostat mg EX mg Fluorogenic HDAC class 2a substrate nmole Fluorogenic HDAC class 2a substrate 2 (green) nmole Fluorogenic HDAC substrate nmole Fluorogenic HDAC Substrate 2 (Green fluorescence) nmole Fluorogenic HDAC substrate nmole Fluorogenic SIRT substrate nmole Fluorogenic Sirtuin 5 Substrate nmole Fluorogenic Sirtuin 6 Substrate µl HC Toxin µg HDAC Assay Buffer ml HDAC developer (2X) ml HDAC1, FLAG-tag, His-tag µg HDAC1, His-Tag, FLAG-Tag (Mouse) µg HDAC10, GST-tag, His-tag µg HDAC10, N-FLAG-tag µg HDAC µg HDAC11 Fluorogenic Assay Kit reactions HDAC11, GST-tag µg HDAC2, FLAG-tag µg HDAC2, His-tag µg HDAC3/NcoR2 Complex, His-tag µg HDAC4, GST-tag, His-tag µg HDAC5 (full length), GST-tag µg HDAC5, Catalytic Domain, His-tag µg HDAC6 (H216A), GST-tag µg HDAC6 (H611A), GST-tag µg HDAC6 Fluorogenic Assay Kit reactions HDAC6, FLAG-tag µg HDAC6, GST-tag µg HDAC6, GST-Tag (Mouse) µg HDAC7, GST-tag µg HDAC8, His-tag µg HDAC9, His-tag µg HNHA mg ITF mg JNJ mg JNJ mg JNJ mg Kaempferol mg 10

11 DEMETHYLASE(S) FBXL10 (KDM2B) Homogeneous Assay Kit reactions FBXL11 (KDM2A) Homogeneous Assay Kit reactions JARID1A (KDM5A) Homogeneous Assay Kit reactions JARID1B (KDM5B) Homogeneous Assay Kit reactions JARID1C (KDM5C) Homogeneous Assay Kit reactions JHDM1D (KDM7A) Homogeneous Assay Kit reactions JMJD1A (KDM3A) Homogeneous Assay Kit reactions LSD1 (KDM1A) Chemiluminescent Assay Kit reactions LSD1 (KDM1A) Fluorescent Assay Kit reactions LSD1 (KDM1A) Fluorescent Assay Kit reactions LSD1 (KDM1A) Homogeneous Assay Kit reactions 2x LSD1 Buffer ml 3x LSD1 Buffer ml 4x DMT Detection Buffer ml 4x HDM Assay Buffer ml 4x HDM Assay Buffer ml 4x HDM Assay Buffer ml 4x HDM Assay Buffer ml 4x HDM Incomplete Assay Buffer ml Anti-Dimethyl Histone H3 (Lys27) Monoclonal, Primary Antibody F 25 µl Anti-JMJD1A, Primary Antibody Q 25 µl Anti-JMJD2, Primary Antibody E 40 μl Blocking Buffer ml FBXL10 (KDM2B) Chemiluminescent Assay Kit reactions FBXL10 (KDM2B, JHDM1B), FLAG-tag µg FBXL11 (KDM2A, JHDM1A), FLAG-Avi-tags µg FTO Chemiluminescent Assay Kit reactions FTO, His-Tag µg GSK J4 HCl mg GSK J4 HCl mg H3K4me2 Substrate μl Histone H3 K27cMe1, Full Length, His-tag µg Histone H3 K27cMe2, Full Length, His-tag µg Histone H3 K27cMe3, Full Length, His-tag µg Histone H3 peptide (1-21), Dimethyl K9, Biotin-labeled µl 11

12 DEMETHYLASE(S) (CONT'D) Histone H3 peptide (1-21), Monomethyl K9, Biotin-labeled µl Histone H3 peptide (1-21), Trimethyl K9, Biotin-labeled µl Histone H3-H4 Tetramer H3K27cMe2, His-tag µg Histone H3-H4 Tetramer H3k27cMe3, His-tag µg Histone Octamer H3K27cMe2, His-tag µg Histone Octamer H3K27cMe3, His-tag µg JARID1A (KDM5A) Chemiluminescent Assay Kit reactions JARID1A (KDM5A), FLAG-tag µg JARID1A (KDM5A), His-Avi-tags, FLAG-tag µg JARID1B (KDM5B) Chemiluminescent Assay Kit reactions JARID1B (KDM5B) TR-FRET Assay Kit reactions JARID1B (KDM5B), Full Length, FLAG-tag µg JARID1B (KDM5B, PLU-1), His-FLAG-tags µg JARID1C(KDM5C), FLAG-tag µg JHDM1D (KDM7A) Chemiluminescent Assay Kit reactions JHDM1D (KDM7A), FLAG-tag µg JMJD1A (KDM3A), FLAG-tag µg JMJD1B (KDM3B), FLAG-tag µg OG-L mg OG-L mg PHF8 (KDM7B) Homogeneous Assay Kit reactions PHF8 (KDM7B), (2-525), FLAG-tag μg PHF8 (KDM7B), Full-length, FLAG-tag μg Posaconazole mg Posaconazole mg Secondary Anti-HRP-labeled Antibody H 10 µl TET1 Chemiluminescent Assay Kit reactions TET1, FLAG-tag µg TET2 Chemiluminescent Assay Kit reactions TET2, FLAG-His-tag ug TET3, FLAG-Tag, His-Tag µg Tranylcypromine (2-PCPA) mg UTX (KDM6A), C-term FLAG-tag µg UTX (KDM6A), N-terminal FLAG-tag μg UTX Chemiluminescent Assay Kit reactions UTX(KDM6A) Homogeneous Assay Kit reactions JMJD2A (KDM4A) Homogeneous Assay Kit reactions JMJD2A(KDM4A) (1-350), His-tag µg JMJD2B (KDM4B) Homogeneous Assay Kit reactions JMJD2B (KDM4B), GST-tag µg JMJD2B(KDM4B), FLAG-tag µg JMJD2C (KDM4C) Chemiluminescent Assay Kit reactions JMJD2C (KDM4C) Homogeneous Assay Kit reactions JMJD2C, GST-Tag µg JMJD2D (KDM4D) Chemiluminescent Assay Kit reactions JMJD2D (KDM4D), GST-tag µg JMJD2E (KDM4DL) Homogeneous Assay Kit reactions JMJD2E (KDM4DL), GST-tag µg JMJD3 (KDM6B) Chemiluminescent Assay Kit reactions JMJD3 (KDM6B) Homogeneous Assay Kit reactions JMJD3 (KDM6B), FLAG-tag µg JMJD6, GST-tag µg LSD1 (KDM1A), Variant µg LSD1 (KDM1A), Variant 2, GST-tag µg LSD1 Substrate µl LSD1 Variant 1, GST-tag µg LSD2 (KDM1B), GST-Tev-Tag µg LSD2(KDM1B) Homogeneous Assay Kit (Dimethyl) reactions LSD2(KDM1B) Homogeneous Assay Kit (Monomethyl) reactions Mouse JARID1B (KDM5B, PLU-1), FLAG-tag µg 12

13 METHYLTRANSFERASE(S) DNMT Universal Chemiluminescent Assay Kit reactions DNMT1 Chemiluminescent Assay Kit 52050L 96 reactions DNMT3A Chemiluminescent Assay Kit reactions DNMT3B Chemiluminescent Assay Kit reactions DOT1L (KMT4) Chemiluminescent Assay Kit reactions EHMT1/GLP Chemiluminescent Assay Kit reactions EZH1 Chemiluminescent Assay Kit reactions EZH1 Chemiluminescent Assay Kit reactions EZH2 (A677G) Chemiluminescent Assay Kit reactions EZH2 (Y641F) Chemiluminescent Assay Kit reactions EZH2 (Y641N) Chemiluminescent Assay Kit reactions EZH2 (Y641N) TR-FRET Assay Kit reactions EZH2 Chemiluminescent Assay Kit 52009L 96 reactions EZH2 Homogeneous Assay Kit reactions G9a Chemiluminescent Assay Kit 52001L 96 reactions G9a Homogeneous Assay Kit reactions Histone H3(K9) Universal Methyltransferase New Assay Kit reactions Histone H4(R3) Methyltransferase Assay Kit reactions MLL1 Complex Chemiluminescent Assay Kit reactions NSD1 Chemiluminescent Assay Kit reactions NSD2 Chemiluminescent Assay Kit reactions PRMT1 Chemiluminescent Assay Kit 52004L 96 reactions PRMT1 Homogeneous Assay Kit reactions PRMT3 Chemiluminescent Assay Kit 52005L 96 reactions PRMT3 Homogeneous Assay Kit reactions PRMT4 Chemiluminescent Assay Kit 52041L 96 reactions PRMT5 Chemiluminescent Assay Kit 52002L 96 reactions PRMT5 Homogeneous Assay Kit reactions PRMT8 Homogeneous Assay Kit reactions SETD2 Chemiluminescent Assay Kit reactions SetDB1 Chemiluminescent Assay Kit reactions SUV39H1 Chemiluminescent Assay Kit 52006L 96 reactions SUV39H2 Chemiluminescent Assay Kit 52008L 96 reactions SUV4-20H1 Chemiluminescent Assay Kit reactions 3-Deazaneplanocin (DZNep) mg 13

14 METHYLTRANSFERASE(S) (CONT'D) 3-Deazaneplanocin (DZNep) mg 3-Deazaneplanocin A (DZNep) hydrochloride mg 3-Deazaneplanocin A (DZNep) hydrochloride mg 400 µm S-Adenosylmethionine µl 4x DNMT Assay Buffer ml 4x DNMT Assay Buffer ml 4x HMT Assay Buffer ml 4x HMT Assay Buffer A 30 ml 4x HMT Assay Buffer ml 4x HMT Assay Buffer 2A A 30 ml 4x HMT Assay Buffer ml 4x HMT Assay Buffer ml 4x HMT Assay Buffer ml 4x HMT Assay Buffer ml 4x HMT Assay Buffer ml AEBP2, His-tag µg AMI-1 (sodium salt) mg Anti- Adenosyl Homocysteine Antibody ml Anti-Dimethyl Histone H3 (Lys27) Monoclonal, Primary 52140F 25 µl Antibody 6 Anti-JMJD1A, Primary Antibody Q 25 µl Anti-JMJD2, Primary Antibody E 40 μl Anti-Trimethyl Histone H3 (Lys27) Monoclonal 52140C µl Anti-Trimethyl Histone H3 (Lys27) Monoclonal 52140C µl Azacytidine (Vidaza) mg BIX01294 (hydrochloride hydrate) mg Blocking Buffer ml Chaetocin mg Core Histone Octamers mg CoREST, His-tag µg CTPB mg DNMT1, GST-tag µg DNMT1, His-FLAG-tags µg DNMT2, GST-tag µg DNMT3a, GST-tag µg DNMT3A/DNMT3L Complex, His-tag, GST-tag µg DNMT3B/DNMT3L Complex, GST-tag, His-tag µg DNMT3B/DNMT3L Complex, His-tag, GST-tag µg DOT1L (KMT4), GST-tag µg EED, FLAG-tag µg EHMT1 (GLP), GST-tag µg Ellagic acid mg Entacapone mg Entacapone mg EPZ mg EPZ mg EPZ mg EPZ mg EPZ mg EPZ mg EPZ mg EPZ mg EPZ mg EPZ mg EZH1/EED/SUZ12, His-tag µg EZH1/EED/SUZ12/RbAp48/AEBP2, His-tag µg EZH2 (A677G) Chemiluminescent Assay Kit reactions EZH2 (A677G)/EED/SUZ12/RbAp48/AEBP2, His-tag µg EZH2 (A677T)/EED/SUZ12/RbAp48/AEBP2, His-tag µg EZH2 (A687V)/EED/SUZ12/RbAp48/AEBP2, His-tag µg EZH2 (A738T) /EED/SUZ12/RbAp48/AEBP2, FLAG-Tag, µg His-Tag EZH2 (A738T) Chemiluminescent Assay Kit reactions EZH2 (A738T) Chemiluminescent Assay Kit reactions EZH2 (del153y)/eed/suz12/rbap48/aebp2, FLAG, His-tag µg EZH2 (E740K)/EED/SUZH12/RbAp48/AEBP2, FLAG-tag, His-tag µg EZH2 (F667I)/EED/SUZH12/RbAp48/AEBP2, FLAG-tag, His-tag µg EZH2 (H689Y)/EED/SUZ12/RbAp48/AEBP2, FLAG-tag, His-tag µg EZH2 (non-complexed), His-GST-tags µg EZH2 (P132S)/EED/SUZ12/RbAp48/AEBP2, FLAG-tag, His-tag µg EZH2 (R679C)/EED/SUZH12/RbAp48/AEBP2, FLAG-tag, µg His-tag EZH2 (Y641C) /EED/SUZ12/RbAp48/AEBP2, His-tag µg EZH2 (Y641F) /EED/SUZ12/RbAp48/AEBP2, His-tag µg EZH2 (Y641F) Chemiluminescent Assay Kit reactions EZH2 (Y641H) /EED/SUZ12/RbAp48/AEBP2, His-tag µg EZH2 (Y641N) /EED/SUZ12/RbAp48/AEBP2, His-tag, FLAG-tag µg EZH2 (Y641N) Chemiluminescent Assay Kit reactions EZH2 (Y641S) /EED/SUZ12/RbAp48/AEBP2, His-tag µg EZH2 / EED / SUZ12, His-tag, FLAG-tag µg EZH2 Chemiluminescent Assay Kit reactions EZH2(Y641F) TR-FRET Assay Kit reactions EZH2-EED Binding Assay Kit reactions EZH2/EED, His-tag, FLAG-tag µg EZH2/EED/SUZ12/RbAp48, His-tag, FLAG-tag µg EZH2/EED/SUZ12/RbAp48/AEBP2, FLAG-tag, His-tag µg EZH2/SUZ12/RbAp48, His-GST-tags, His-tag µg 14

15 METHYLTRANSFERASE(S) (CONT'D) G9a (EHMT2), GST-tag (E. coli-derived) µg G9a (EHMT2), GST-tag (Sf9-derived) µg Histone H1, Full Length, His-tag µg Histone H1, Full Length, His-tag mg Histone H2a, Full Length, Biotin-labeled, His-tag µg Histone H2a, Full Length, Biotin-labeled, His-tag mg Histone H2a, Full Length, His-tag mg Histone H2a, Full Length, His-tag µg Histone H2b, Full Length, His-tag µg Histone H2b, Full Length, His-tag mg Histone H mg Histone H μg Histone H3 (2-58), GST-tag µg Histone H3 (K27M), His-tag µg Histone H3 Dimethyl-K27 ELISA Detection Kit reactions Histone H3 K27C, Full Length, His-tag µg Histone H3 K27cMe1, Full Length, His-tag µg Histone H3 K27cMe2, Full Length, His-tag µg Histone H3 peptide (1-21) nmole Histone H3 peptide (1-21), Biotin-labeled nmole Histone H3 peptide (21-44) nmole Histone H3 peptide (21-44), Biotin-labeled nmole Histone H3 Peptide (21-44), Monomethyl K27, Biotin-labeled nmole Histone H3, Full Length, Biotin-labeled, His-tag µg Histone H3, Full Length, Biotin-labeled, His-tag mg Histone H3, Full Length, His-tag µg Histone H3, Full Length, His-tag mg Histone H3-H4 Tetramer H3K27C Unmodified, His-tag µg Histone H3-H4 Tetramer H3K27cMe2, His-tag µg Histone H3/H4 Tetramer (full length), His-tag µg Histone H3/H4 Tetramer (full length), His-tag µg Histone H4 (2-58), GST-tag µg Histone H4 peptide (1-21) nmole Histone H4 peptide (1-21), Biotin-labeled nmole Histone H4 peptide (1-21), Dimethyl R3, Biotin-labeled µl Histone H4, Full Length, His-tag mg Histone H4, Full Length, His-tag µg Histone Octamer (Full length) μg Histone Octamer (full length), His-tag μg Histone Octamer H3K27C Unmodified, His-tag µg Histone Octamer H3K27cMe2, His-tag µg Histone Octamer, Biotin-labeled, His-tag µg Histone-H2A-( )-Ac-OH mg Histone-H2A-( )-Ac-OH mg MECP2, GST-tag µg Metnase (SETMAR), FLAG-tag µg METTL3/METTL14 Complex, GST-Tag µg MLL1/WDR5/Ash2L/RbBP5 (MLL1/WAR Complex), His-tag µg MLL1/WDR5/Ash2L/RbBP5/DPY30 (MLL1/WARD Complex), µg FLAG, His-tag Mouse DNMT3B, His-tag, FLAG-tag µg Native nucleosome (HEK293-derived) mg Native Nucleosome (HeLa-derived) mg NSD1, GST-tag μg NSD2 (catalytic domain), GST-tag µg NSD2 Chemiluminescent Assay Kit reactions NSD3 ( ) (WHSC1L1), GST-tag µg NSD3 Chemiluminescent Assay Kit reactions NSD3 Chemiluminescent Assay Kit reactions PRDM12, GST-tag µg PRDM14, GST-tag µg PRMT1, GST-tag (E. coli-derived) µg PRMT1, GST-tag (Sf9-derived) µg PRMT3, GST-tag µg PRMT4 (CARM1), FLAG-tag (HEK293-derived) µg PRMT4 Homogeneous Assay Kit reactions PRMT4 peptide substrate, Biotin-labeled nmole PRMT5 Chemiluminescent Assay Kit reactions PRMT5 TR-FRET Assay Kit reactions PRMT5/MEP50, Biotin-Labeled µg PRMT5/MEP50, FLAG-tag, His-tag (HEK293-derived) µg PRMT5/MEP50, FLAG-tag, His-tag (Sf9-derived) µg PRMT6 (HRMT1L6) Chemiluminescent Assay Kit reactions PRMT6 (HRMT1L6) Homogeneous Assay Kit reactions PRMT6 (HRMT1L6), His-tag µg PRMT7, His-FLAG-tag µg PRMT8 Chemiluminescent Assay Kit reactions PRMT8, His-FLAG-tags µg PRMT9 Homogeneous Assay Kit reactions PRMT9, FLAG-Tag, His-Tag μg PRMT9, FLAG-Tag, Strep-Tag μg Recombinant Nucleosome (E. coli-derived) mg Recombinant Nucleosome (E. coli-derived) µg Recombinant Nucleosome (E. coli-derived), Biotin-labeled, Histag µg S-adenosyl homocysteine µl 15

16 METHYLTRANSFERASE(S) (CONT'D) S-adenosyl homocysteine, Fluorescein-labeled µl SAP145, GST-Tag μg Secondary Anti-HRP-labeled Antibody H 10 µl Set7/9 (Sf9), His-GST-tags µg Set7/Set9, GST-tag (E. coli-derived) µg Set8, Active, GST-tag µg SETD2, GST-tag µg SetDB1, His-GST-tags µg SGC mg SGC mg SMYD2 (KMT3C) Chemiluminescent Assay Kit reactions SMYD2 (KMT3C), FLAG-tag µg SMYD3 (35-end), GST-tag µg SMYD3 (full length), FLAG-tag µg SMYD3 Homogeneous Assay Kit reactions SMYD4 Chemiluminescent Assay Kit reactions SMYD4, FLAG-tag µg SUV39H1, Full Length, GST-tag µg SUV39H1, GST-tag µg SUV39H2, GST-tag µg SUV4-20H1, GST-tag µg SUV4-20H2, GST-tag µg SUZ12, His-FLAG-tags µg UNC mg UNC0321 (TFA salt) mg UNC mg WDR5, FLAG-tag μg WDR5, His-tag µg WDR5, His-Tag, Biotin-Labeled μg 16

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