Institute for Health and Consumer Protection European Centre for the Validation of Alternative Methods (ECVAM)

Transcription

1 EUROPEAN COMMISSION Curriculum Vitae 1. Name, Gender, Nationality Family Name Name Gender Nationality Basketter David Arthur Male British If you wish you can place a photograph of you here. 2. Overall Scientific Expertise Please specify in keywords (see section 3 of your application form). If you wish you may indicate how you acquired each specific expertise (e.g. through education, in your function as, through participation in ). CV Members of the ECVAM Scientific Advisory Committee (ESAC) Page 1 of 8

2 3. Professional Experience Professional Experience 1 (most recent) Occupation or Consultant Toxicologist position held Date (starting) Date (finishing) Current job Main activities Provision of a wide ranging toxicology consultancy service to companies around the world (chemical, pharmaceutical, household, cosmetic, both large and small). Specialised skills in allergy and irritancy as well as risk assessment. Main responsibilities Provision of toxicology review services; drafting of publications; negotiation with regulators, dermatologists; oral presentation; chairing of committees; participation in validation acitivities. Name of employing Address of employing (City, Country sufficient) Type of sector Professional Experience 2 DABMEB Consultancy Ltd 2 Normans Road, Sharnbrook, UK Specify (e.g. Academia, Industry, Governmental Body, Public institution, Civil Society Organisation etc.) Occupation or Senior Scientist position held Date (starting) Date (finishing) Main activities Safety evalution toxicologist with a wide range of responsibilities, particularly focused on allergy and irritancy, from in vitro method development, through in vivo testing to clinical studies. Some years spent being the toxicologist responsible for the safety of Unilever hair products globally. Main responsibilities Development of novel approaches to hazard identification and risk assessment. Safety assessment of the Unilever product portfolio (cosmetics, household products, chemicals). Liaison/influencing on safe levels of ingredients, acceptance of new test methods. For the latter part of my career, the key activity was to exercise global influence and to lead changes in regulatory toxicology. Name of employing Unilever Address of employing Colworth House, Sharnbrook, UK (City, Country sufficient) Type of sector Industry CV Members of the ECVAM Scientific Advisory Committee (ESAC) Page 2 of 8

3 Professional Experience 3 Occupation or Laboratory Scientist position held Date (starting) Date (finishing) Main activities Laboratory biochemistry Main responsibilities Fractionation of biological extracts Name of employing Weddel Pharmaceuticals Address of employing Old London Road, St Albans, UK (City, Country sufficient) Type of sector Industry 4. Educational Background Educational qualification 1 (most recent) Description of qualification achieved (e.g. Bachelor of science in tissue engineering) Principal subject (e.g. Animal Physiology) Fellowship of the Royal College of Pathology Toxicology (awarded by examination of publication record) Other subjects Date (starting) Date (finishing) Name of (incl. The Royal College of Pathologists city and country) awarding degree Title of degree awarded FRCPath Educational qualification 2 Description of qualification Doctor of Science achieved (e.g. Bachelor of science in tissue engineering) Principal subject (e.g. Animal The Toxicology of Contact Dermatitis Physiology) Other subjects Date (starting) Date (finishing) Name of (incl. University of London city and country) awarding degree Title of degree awarded DSc CV Members of the ECVAM Scientific Advisory Committee (ESAC) Page 3 of 8

4 Educational qualification 3 Description of qualification Bachelor of Science achieved (e.g. Bachelor of science in tissue engineering) Principal subject (e.g. Animal Physiology Physiology) Other subjects Biochemistry Date (starting) Date (finishing) Name of (incl. University of London city and country) awarding degree Title of degree awarded BSc 5. Fellowships, Awards, Membership in Learned Societies, Editorial Boards and Advisory Bodies 5.1 Fellowships Fellowship I Title of fellowship Fellowship of the Institute of Biology Description of fellowship Lifetime (type, maximal duration, prestige) Date (starting) Date (finishing) Funding/awarding Institute of Biology Address (city + country London, UK sufficient) Fellowship II Title of fellowship Fellowship of the British Toxicology Society Description of fellowship Lifetime (type, maximal duration, prestige) Date (starting) Date (finishing) Funding/awarding British Toxicology Society Address (city + country London, UK sufficient) CV Members of the ECVAM Scientific Advisory Committee (ESAC) Page 4 of 8

5 Fellowship III Title of fellowship Fellowship Academy of Toxicological Sciences Description of fellowship Lifetime (type, maximal duration, prestige) Date (starting) Date (finishing) Funding/awarding Academy of Toxicological Sciences Address (city + country USA sufficient) 5.2 Awards Award I Title of award Description of award (type, prestige etc.) Smith Kline Beecham Award for Animal Welfare The award is given to an individual judged to have made a significant contribution to animal welfare in toxicology. Date November 2000 Awarding Smith Kline Beecham Address (city + country sufficient) UK 5.3 Membership in learned societies & professional associations & editorial boards Society / Association / Editorial Board I Society / Association Description of society's / association's / board's activities 1. Contact Dermatitis 2. Cutaneous and Ocular Toxicology 1. Section Editor Toxicology for the journal Contact Dermatitis 2. Editorial board member CV Members of the ECVAM Scientific Advisory Committee (ESAC) Page 5 of 8

6 Membership from 2005 to (if currently member, please state 'current') present 5.4 Membership in advisory bodies / committees Advisory body / committee I Name of advisory body Description of the roles and responsibilities of the advisory body Sens-it-iv Scientific Advisory Board Chairman of the above board, advising on this Framework 6 EU research project. Membership from May 2008 to (if currently member, please state 'current') Current CV Members of the ECVAM Scientific Advisory Committee (ESAC) Page 6 of 8

7 6. Publications Nr. Citation 1 Basketter DA, Broekhuizen C, Fieldsend M, Kirkwood, Mascarenhas R, Maurer K, Pedersen C, Rodriguez C and Schiff H-E (2010) Defining occupational and consumer exposure limits for enzyme protein respiratory allergens under REACH. Toxicology, 268, Jirova D, Basketter D, Liebsch M, Bendova H, Keilova K, Marriott M and Kandarova H. (2010) Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data. Contact Dermatitis, 62, Coulter E M, Jenkinson C, Farrell J, Lavergne SN, Pease C K, White A, Aleksic A, Basketter DA, Williams D P, King C, Pirmohamded M, Park K, Naisbitt D J. (2010) Measurement of CD4+ and CD8+ cytokine secretion and gene expression changes in p-phenylenediamine allergic and tolerant individuals. J Invest Dermatol, 130, Kimber I, Basketter DA and Hartung T. (2010) The evolution of validation. Cutaneous and Ocular Toxicology, 29, Kern PS, Gerberick GF, Ryan CA, Kimber I, Aptula A and Basketter DA (2010) Historical local lymph node data for the evaluation of skin sensitization alternatives: a second compilation. Dermatitis, 21, Basketter DA (2010) Methyldibromo glutaronitrile, skin sensitisation and quantitative risk assessment. Cut. Ocul. Toxicol, 29, Basketter DA, Dearman RJ, Kimber I, Gerberick GF and Kimber I. (2009) The impact of LLNA group size on the identification and potency classification of skin sensitizers: a review of published data. Cutaneous and Ocular Toxicology, 28, Casati S, Aeby P, Kimber I, Maxwell G, Ovigne JM, Roggen E, Rovida C, Tosti L and Basketter DA (2009) Selection of chemicals for the development and evaluation of in vitro methods for skin sensitisation testing. Alternatives to Laboratory Animals, 37, McFadden JP, White JML, Basketter DA and Kimber I. (2009) Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis. Trends in Immunology, 30, Roberts DW and Basketter DA (2009). Reactivity assays, substances, samples and in vitro alternatives: why should we care? Contact Dermatitis. 61: Basketter DA (2009) The human repeated insult patch test in the 21st century: a commentary on ethics and validity. Cutaneous and Ocular Toxicology, 28, Basketter DA, McFadden JF, Gerberick GF, Cockshott A and Kimber I. (2009) Nothing is perfect, not even the local lymph node assay. A commentary and the implications for REACH. Contact Dermatitis, 60, White JML, White IR, Kimber I, Basketter DA, Buckley DA and McFadden JP (2009) Atopic dermatitis and allergic reactions to individual fragrance chemicals. Allergy, 64, Basketter DA and Kimber I (2009) Updating the skin sensitisation in vitro data assessment paradigm in Journal of Applied Toxicology,29, Kimber I and Basketter DA (2008) Thresholds, dose response relationships and dose metrics in allergic contact dermatitis. Letter. British Journal of Dermatology, 159, CV Members of the ECVAM Scientific Advisory Committee (ESAC) Page 7 of 8

8 16 Dearman RJ, Basketter DA, Maxwell G and Kimber I. (2008) Synergistic Effects of Chemical Insult and Toll-Like Receptor Ligands on Dendritic Cell Activation. Toxicology in Vitro, 22, McNamee PM, Basketter DA, Gerberick GF, Gilpin DA, Hall BM, Jowsey I and Robinson MK (2008) A review of critical factors in the conduct and interpretation of the human repeat insult patch test. Regulatory Toxicol and Pharmacol, 52, Kimber I, Dearman R J, Basketter D A, Ryan C A, Gerberick G F, Lalko J and Api A M. (2008) Dose metrics in the acquisition of skin sensitization: thresholds and importance of dose per unit area. Regulatory Toxicology and Pharmacology, 52, Api A M, Basketter D A, Cadby PA, Cano M-F, Ellis G, Gerberick G F, Griem P, McNamee P M, Ryan C A, Safford B. (2008) Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. Regulatory Toxicology and Pharmacology, 52, Jirova D, Liebsch M, Basketter D, Kandarova H, Keilova K, Bendova H, Marriott M, Spiller E. (2008) comparison of human skin irritation and photo-irritation patch test data with cellular in vitro assays and animal in vivo data. AATEX 14, Basketter DA. (2008) Skin immunology and sensitisation. In Principles and Practice of Skin Toxicology. Eds Chilcott RP and Price S, Wiley, Chichester, pp Buckley DA, Basketter DA, Kan-King-Yu D, White IR, White JML and McFadden JP. (2008) Atopy and contact allergy to fragrance 1: Allergic reactions to the fragrance mix 1 (the Larssen mix). Contact Dermatitis, 59, Robinson S, Basketter D, Bussi R, Coenen J, Connolly P, Elvig-Jørgensen SG, Hermans H, Hoffmeister A, Lacerda A, Linge JP, Spielmann H, Török M, van der Valk J, Watson T. (2008) Dissemination strategies: how do they influence the uptake of the new Three Rs methods across laboratories and other boundaries? A report of a Workshop held by the European Partnership for Alternative Approaches to Animal Testing (EPAA) Working Group 3. Altern Lab Anim. 36: Basketter DA. (2008) Skin sensitisation: strategies for risk assessment and risk management. Brit J Dermatol, 159, Holden NJ, Bedford PA, McCarthy NE, Marks NE, Ind PW, Jowsey I, Basketter DA and Knight SC (2008) Dendritic cells from control but not atopic donors respond to contact and respiratory sensitiser treatment in vitro with differential cytokine production and altered stimulatory capacity. Clinical and Experimental Allergy, 38, Basketter D A. (2008) Information derived from sensitisation test methods: test sensitivity, false positives and false negatives. Regulatory Toxicology and Pharmacology, 50, Basketter DA, Cockshott A, Corsini E, Gerberick GF, Idehara K, Kimber I, van Loveren H, Takeyoshi M, Matheson J, Mehling A, Omori T, Rovida C, Sozy T, Stokes W and Casati S. (2008) An evaluation of performance standards and nonradioactive endpoints for the local lymph node assay. ATLA, 36, CV Members of the ECVAM Scientific Advisory Committee (ESAC) Page 8 of 8