BULLETIN # 73. Manitoba Drug Benefits and Interchangeability Formulary Amendments. The following amendments will take effect on July 17, 2013

Transcription

1 BULLETIN # 73 Manitoba Drug Benefits and Interchangeability Formulary Amendments The following amendments will take effect on July 17, 2013 The amended Manitoba Specified Drug Regulation and Drug Interchangeability Formulary Regulation will be available on the Manitoba Health website on the effective date of July 17, 2013 Bulletin 73 is currently available for download: Inside This Issue Part 1 Additions Page 1-2 Part 2 Additions Page 3 Part 3 Additions Page 3-6 New Interchangeable Categories Page 6-7 New Interchangeable Products Page 7-11 Product Deletions Page 11 Category Deletions Page Interchangeable Product Price Changes Page Discontinued Products Page Manufacturer Updates Page 17-18

2 DIN TRADE NAME GENERIC STRENGTH FORM MFR* Allerject Apo-Allopurinol epinephrine allopurinol 0.15 mg/0.15 ml 0.3 mg/0.3 ml 100 mg 200 mg 300 mg Injection Apo-Anastrozole anastrozole 1 mg APX Apo-Mometasone mometasone 50 mcg Nasal Spray APX Aviane 21 Aviane 28 Part 1 Additions levonorgestrel/ ethinyl estradiol SAA APX 0.10 mg/0.02 mg TEV BD Insulin Syringe with BD Ultrafine - 0.3cc/6 mm/31 G Syringe/Needle BTD Clickfine Insulin Pen Needle - 31 G 32 G Pen Needles INS CO Anastrozole anastrozole 1 mg COB CO Rosuvastatin Freya 21 Freya 28 Jamp-Alprazolam rosuvastatin 10 mg 20 mg 40 mg COB desogestrel/ethinyl estradiol 0.15 mg/0.03 mg MYL alprazolam 0.25 mg 0.5 mg 1 mg 2 mg Jamp-Anastrozole anastrozole 1 mg JPC Jamp-Colchicine colchicine 0.6 mg JPC Jamp-Indapamide indapamide 1.25 mg 2.5 mg Jamp-K8 potassium chloride 600 mg JPC Jamp-Metoprolol-L Jamp-Potassium Chloride metoprolol 25 mg 50 mg 100 mg JPC JPC JPC potassium chloride 1500 mg Oral Solution JPC Jamp-Quetiapine quetiapine 25 mg 100 mg 200 mg 300 mg JPC 1 of 18

3 Jamp-Rosuvastatin rosuvastatin Bulletin #73 10 mg 20 mg 40 mg Jamp-Zopiclone zopiclone 7.5 mg JPC Methotrexate (with preservative) JPC methotrexate 25 mg/ml Injection SDZ MyGlucoHealth - - Blood Glucose Test Strips EHS Mylan-Gabapentin gabapentin 600 mg MYL Novo-Letrozole letrozole 2.5 mg TEV Ovima 21 Ovima 28 levonorgestrel/ethinyl estradiol 0.15 mg/0.03 mg APX pms-tetrabenazine tetrabenazine 25 mg PMS Ran-Anastrozole anastrozole 1 mg RAN Ran-Atenolol atenolol 25 mg RAN Ran-Bicalutamide bicalutamide 50 mg RAN Ran-Candesartan candesartan 4 mg 8 mg 16 mg 32 mg Ran-Clopidogrel clopidogrel 75 mg RAN Ran-Letrozole letrozole 2.5 mg RAN RAN Ran-Sertraline sertraline 25 mg 50 mg 100 mg RAN Sandoz Candesartan candesartan 32 mg SDZ Sandoz Fluvastatin fluvastatin 20 mg 40 mg Capsules SDZ Sandoz Latanoprost/Timolol latanoprost/timolol maleate 50 mcg/5 mg/5 ml Ophthalmic Solution SDZ Sandoz Rosuvastatin Teva Quetiapine XR rosuvastatin quetiapine 10 mg 20 mg 40 mg 50 mg 150 mg 200 mg 300 mg 400 mg Viramune XR nevirapine 400 mg BOE *Abbreviation of Manufacturers' Names SDZ TEV 2 of 18

4 Part 2 Additions 4 mg Apo-Montelukast montelukast 5 mg (a) Indicated as adjunctive therapy for asthma in cases where: (i) maximum doses inhaled corticosteroids have not effectively controlled symptoms, or (ii) evidence of serious adverse effects associated with corticosteroids exists, eg. adrenal suppression, increased lung infections; (b) Indicated as first line therapy for exercise induced asthma. APX mg Apo-Naratriptan naratriptan 2.5 mg For the treatment of ACUTE migraine attacks in patients where standard therapy has failed. APX Ran-Finasteride finasteride 5 mg RAN For the treatment of symptomatic benign prostatic hyperplasia. Part 3 Additions The following products will be considered for Pharmacare reimbursement upon an individual prescriber/patient request basis Aclasta zoledronic acid 5 mg/100 ml Injection NVT For female patients with post-menopausal osteoporosis (PMO) at high risk for fracture and satisfy at least two of the following three criteria: (i) Age > 75 years; (ii) A prior fragility fracture; (iii) A bone mineral density (BMD) T-score -2.5; OR Female patients with PMO with a serious intolerance to oral bisphosphonates or for whom oral bisphosphonates are contraindicated. 3 of 18

5 Actemra (New Indication) tocilizumab 80 mg/4 ml 200 mg/10 ml 400 mg/20 ml Injection For the treatment of active systemic juvenile idiopathic arthritis (sjia) in patients 2 years of age and older who: (i) have responded inadequately to previous therapy with one or more non steroidal anti-inflammatory drugs; and (ii) who have responded inadequately to previous therapy with one or more systemic corticosteroids. HLR Apo-Riluzole riluzole 50 mg APX For the treatment of Amyotrophic Lateral Sclerosis (ALS) Edurant rilpivirine 25 mg JAN For the treatment of HIV-1 infected treatment-naïve patients Gilenya fingolimod 0.5 mg Capsule NVT For the treatment of patients with Relapsing Remitting Multiple Sclerosis (RRMS) who meet all the following criteria: (i) Failure to respond to full and adequate courses of at least one interferon OR glatiramer acetate; OR documented intolerance to both therapies; (ii) One or more clinically disabling relapses in the previous year; (iii) Significant increase in T2 lesion load compared with that from a previous MRI scan or at least one gadolinium-enhancing lesion; (iv) Requested and followed by a neurologist experienced in the management of RRMS; and (v) Recent Expanded Disability Status Scale (EDSS) score. Exclusion Criteria: (i) In combination neither with other disease modifying therapies (e.g. Avonex, Betaseron, Copaxone, Rebif, Extavia, Tysabri) nor in combination with Fampyra. (ii) In patients with an EDSS > 5.5 (iii) In patients who have had a heart attack or stroke in the last six months, or in patients with a history of sick sinus syndrome, atrioventricular block, significant QT prolongation, bradycardia, ischemic heart disease, or congestive heart failure; (iv) In patient less than 18 years of age; and In patients with a needle phobia or preference for oral therapy over injections in patients without clinical contraindication to interferon or glatiramer therapy Jamp-Lactulose lactulose 667 mg/ml Oral Solution JPC For the treatment of portal systemic encephalopathy. 4 of 18

6 Jamp-Pioglitazone pioglitazone 15 mg JPC As per Actos criteria ( Januvia (New Strengths) sitagliptin 25 mg 50 mg Tablet MFX As per Januvia criteria ( Ran-Alendronate alendronate 5 mg 10 mg 70 mg RAN As per Fosamax criteria ( Ran-Pioglitazone pioglitazone 15 mg 30 mg 45 mg RAN As per Actos criteria ( Sandoz Risedronate risedronate 35 mg SDZ As per Actonel criteria ( Simponi golimumab 50 mcg/0.5 ml 50 mcg/0.5 ml Injection JAN Rheumatoid Arthritis: For treatment of patients over 18 years of age who have moderate to severe active rheumatoid arthritis who have failed treatment with at least 3 DMARD therapies, one of which is methotrexate and/or leflunomide unless intolerance or contraindications to these agents is documented. One combination therapy of DMARDs must also be tried. Initial application information should include information on disease activity such as the number of tender joints, swollen joints, erythrocyte sedimentation rate and C-reactive protein value. Ankylosing Spondylitis: For the treatment of patients with active ankylosing spondylitis who have failed to respond to an adequate trial of at least three different nonsteroidal anti-inflammatory drugs (NSAIDs) and, in patients with peripheral joint involvement, have failed to respond to methotrexate or sulfasalazine. Psoriatic Arthritis: For the treatment of patients over 18 years of age who have active psoriatic arthritis who have failed treatment with at least 3 DMARD therapies, one of which is methotrexate and/or leflunomide unless intolerance or contraindications to these agents is documented. One combination therapy of DMARDs must also have been tried. Initial application information should include information on disease activity such as the number of tender joints, swollen joints, erythrocyte sedimentation rate and C-reactive protein value. Request for coverage must be made by a medical specialist in rheumatology. 5 of 18

7 mg Toviaz fesoterodine Tablet PFI 8 mg For patients with an overactive bladder (OAB) with who cannot tolerate or have insufficient response to oxybutynin Tysabri (Revised Criteria) natalizumab 300 mg/15 ml Injection BIG For the treatment of Relapsing-Remitting Multiple Sclerosis (RRMS) who meet all the following criteria: The patient s physician is a neurologist experienced in the management of Relapsing-Remitting Multiple Sclerosis (RMSS); AND the patient: (i) Has a current EDSS less than or equal to 5.0; AND (ii) Has failed to respond to a full and adequate course (i.e. at least six months) of at least one modifying therapy OR has contraindications/intolerance to at least two disease modifying therapies; AND (iii) Has had one of the following types of relapses in the past year: o The occurrence of one relapse with partial recovery during the past year and has at least one gadolium-enhancing lesion on brain MRI, or significant increase in T2 lesion load compared to a previous MRI; OR o The occurrence of two or more relapses with partial recovery during the past year; or o The occurrence of two or more relapse with complete recovery during the past year, and has at least one gadolium-enhancing lesion on brain MRI, or significant increase in T2 lesion load compared to a previous MRI Votrient pazopanib 200 mg Tablet GSK For patients with advanced or metastatic clear cell renal carcinoma who, based on the mutual assessment of the treating physician and the patient, are unable to tolerate ongoing use of an effective dose of sunitinib. New Interchangeable Categories The following new interchangeable categories and products were added: Generic Name - Strength - Form DIN Trade Name Manufacturer Latanoprost/Timolol - 50 mcg/5 mg/ml - Ophthalmic Solution Xalacom PFI Sandoz Latanoprost/Timolol SDZ Price in Dollars $ per ml Methotrexate - 25 mg/ml - Injection Methotrexate (with preservative) Methotrexate (with preservative) HOI SDZ $ per ml of 18

8 Mometasone - 50 mcg - Nasal Spray $ Nasonex MFX Apo-Mometasone APX Quetiapine - 50 mg - $ Seroquel XR AZC Teva-Quetiapine XR TEV Quetiapine mg - $ Seroquel XR AZC Teva-Quetiapine XR TEV Quetiapine mg - $ Seroquel XR AZC Teva-Quetiapine XR TEV Quetiapine mg - $ Seroquel XR AZC Teva-Quetiapine XR TEV Quetiapine mg - $ Seroquel XR AZC Teva-Quetiapine XR TEV Tetrabenazine - 25 mg - Tablet $ Nitoman VAL pms-tetrabenazine PMS New Interchangeable Products The following products have been added to existing interchangeable drug categories: Alendronate - 5 mg - $ Ran-Alendronate RAN of 18

9 Alendronate - 10 mg - $ Ran-Alendronate RAN Alendronate - 70 mg - $ Ran-Alendronate RAN Allopurinol mg - $ Apo-Allopurinol APX Allopurinol mg - $ Apo-Allopurinol APX Allopurinol mg - $ Apo-Allopurinol APX Alprazolam mg - $ Jamp-Alprazolam JPC Alprazolam mg - $ Jamp-Alprazolam JPC Alprazolam - 1 mg - $ Jamp-Alprazolam JPC Alprazolam - 2 mg - $ Jamp-Alprazolam JPC Anastrozole - 1 mg - $ Apo-Anastrozole APX CO Anastrozole COB Jamp-Anastrozole JPC Ran-Anastrozole RAN Atenolol - 25 mg - $ Ran-Atenolol RAN Bicalutamide - 50 mg - $ Ran-Bicalutamide RAN Candesartan - 4 mg - $ Ran-Candesartan RAN Candesartan - 8 mg - $ Ran-Candesartan RAN Candesartan - 16 mg - $ Ran-Candesartan RAN of 18

10 Candesartan - 32 mg - $ Ran-Candesartan RAN Sandoz Candesartan SDZ Clopidogrel - 75 mg - $ Ran-Clopidogrel RAN Desogestrel/Ethinyl Estradiol mg/0.03 mg $ Freya 21 MYL ** Desogestrel/Ethinyl Estradiol mg/0.03 mg $ Freya 28 MYL ** Finasteride - 5 mg - $ Ran-Finasteride RAN Fluvastatin - 20 mg - Capsules $ Sandoz Fluvastatin SDZ ** Fluvastatin - 40 mg - Capsules $ Sandoz Fluvastatin SDZ ** Gabapentin mg - $ Mylan-Gabapentin MYL ** Indapamide mg - $ Jamp-Indapamide JPC ** Indapamide mg - $ Jamp-Indapamide JPC ** Lactulose mg/ml - Oral Suspension Jamp-Lactulose JPC $ per ml Letrozole mg - $ Novo-Letrozole TEV Ran-Letrozole RAN Levonorgestrel/Ethinyl Estradiol /0.03 mcg - $ Ovima 21 APX Levonorgestrel/Ethinyl Estradiol /0.03 mcg - $ Ovima 28 APX Levonorgestrel/Ethinyl Estradiol /0.02 mcg - $ Aviane 21 TEV Levonorgestrel/Ethinyl Estradiol /0.02 mcg - $ Aviane 28 TEV of 18

11 Metoprolol - 25 mg - $ Jamp-Metoprolol-L JPC ** Metoprolol - 50 mg - $ Jamp-Metoprolol-L JPC ** Metoprolol mg - $ Jamp-Metoprolol-L JPC ** Montelukast - 4 mg - $ Apo-Montelukast APX Montelukast - 5 mg - $ Apo-Montelukast APX Naratriptan - 1 mg - $ Apo-Naratriptan APX ** Naratriptan mg - $ Apo-Naratriptan APX ** Pioglitazone - 15 mg - $ Jamp-Pioglitazone JPC Ran-Pioglitazone RAN Pioglitazone - 30 mg - $ Ran-Pioglitazone RAN Pioglitazone - 45 mg - $ Ran-Pioglitazone JPC Quetiapine - 25 mg - $ Jamp-Quetiapine JPC ** Quetiapine mg - $ Jamp-Quetiapine JPC ** Quetiapine mg - $ Jamp-Quetiapine JPC ** Quetiapine mg - $ Jamp-Quetiapine JPC ** Riluzole - 50 mg - $ Apo-Riluzole APX Risedronate - 35 mg - $ Sandoz Risedronate SDZ of 18

12 Rosuvastatin - 10 mg - $ CO Rosuvastatin COB Jamp-Rosuvastatin JPC Sandoz Rosuvastatin SDZ Rosuvastatin - 20 mg - $ CO Rosuvastatin COB Jamp-Rosuvastatin JPC Sandoz Rosuvastatin SDZ Rosuvastatin - 40 mg - $ CO Rosuvastatin COB Jamp-Rosuvastatin JPC Sandoz Rosuvastatin SDZ Sertraline - 25 mg - Capsules $ Ran-Sertraline RAN ** Sertraline - 50 mg - Capsules $ Ran-Sertraline RAN ** Sertraline mg - Capsules $ Ran-Sertraline RAN ** Zopiclone mg - $ Jamp-Zopiclone JPC ** ** The price has resulted in a change to the lowest price in the category. The following products have been deleted. Product Deletions C.E.S conjugated estrogen mg VAL K-DUR potassium chloride 1500 mg MFX Kenacomb gramicidin/neomycin/ nystatin/triamcinolone 0.1% SQU Novo-Benzydamine benzydamine 1.5 mg/ml TEV - Aurothiomalate - 50 mg/ml - Injection - Haloperidol - 2 mg - - Haloperidol - 5 mg - Levobunolol % - Ophthalmic Solution Category Deletions 11 of 18

13 - Nadolol - 40 mg - - Nadolol - 80 mg - - Penicillin V mg - - Prazosin - 1 mg - - Prazosin - 2 mg - - Prazosin - 5 mg - - Propranolol - 10 mg - - Propranolol - 40 mg - - Propranolol - 80 mg - - Tiaprofenic Acid mg - Interchangeable Product Price Changes The following changes in prices have occurred: ($) Actonel risedronate 5 mg Tablet Actonel risedronate 30 mg Tablet Actonel risedronate 35 mg Tablet Agrylin anagrelide 0.5 mg Tablet Alertec modafinil 100 mg Tablet Asacol mesalazine 400 mg Tablet Betaject betamethasone 6 mg/ml Injection ** Betaderm betamethasone 0.05% Ointment Betaderm betamethasone 0.1% Ointment Betaderm betamethasone 0.05% Cream Betaderm betamethasone 0.1% Cream Didrocal etidronate/ calcium carbonate 400/1250 mg Kit Gluconorm repaglinide 0.5 mg Tablet Gluconorm repaglinide 1 mg Tablet Gluconorm repaglinide 2 mg Tablet Mint-Atenolol atenolol 25 mg Tablet ** Mint-Atenolol atenolol 50 mg Tablet ** Mint-Atenolol atenolol 100 mg Tablet ** Mint-Ciprofloxacin ciprofloxacin 250 mg Tablet ** Mint-Ciprofloxacin ciprofloxacin 500 mg Tablet ** Mint-Ciprofloxacin ciprofloxacin 750 mg Tablet ** Mint-Fluoxetine fluoxetine 10 mg Capsule ** Mint-Fluoxetine fluoxetine 20 mg Capsule ** Mint-Pioglitazone pioglitazone 15 mg Tablet ** Mint-Pioglitazone pioglitazone 30 mg Tablet ** Mint-Pioglitazone pioglitazone 45 mg Tablet ** of 18

14 Mint-Pravastatin pravastatin 10 mg Tablet **' Mint-Pravastatin pravastatin 20 mg Tablet ** Mint-Pravastatin pravastatin 40 mg Tablet ** Mint-Risperidon risperidone 0.25 mg Tablet ** Mint-Risperidon risperidone 0.5 mg Tablet ** Mint-Risperidon risperidone 1 mg Tablet ** Mint-Risperidon risperidone 2 mg Tablet ** Mint-Risperidon risperidone 3 mg Tablet ** Mint-Risperidon risperidone 4 mg Tablet ** Mint-Simvastatin simvastatin 5 mg Tablet ** Mint-Simvastatin simvastatin 10 mg Tablet ** Mint-Simvastatin simvastatin 20 mg Tablet ** Mint-Simvastatin simvastatin 40 mg Tablet ** Mint-Simvastatin simvastatin 80 mg Tablet ** Mylan-Alendronate alendronate 10 mg Tablet Mylan-Alendronate alendronate 70 mg Tablet Mylan-Atenolol atenolol 50 mg Tablet Mylan-Atenolol atenolol 100 mg Tablet Mylan-Carvedilol carvedilol mg Tablet Mylan-Carvedilol carvedilol 6.25 mg Tablet Mylan-Carvedilol carvedilol 12.5 mg Tablet Mylan-Carvedilol carvedilol 25 mg Tablet Mylan-Cyclobenzaprine cyclobenzaprine 10 mg Tablet Mylan-Domperidone domperidone 10 mg Tablet Mylan-Fentanyl Matrix fentanyl 25 mcg Tablet Mylan-Finasteride finasteride 5 mg Tablet Mylan-Fonsinopril fosinopril 10 mg Tablet Mylan-Fonsinopril fosinopril 20 mg Tablet Mylan-Gabapentin gabapentin 100 mg Tablet Mylan-Gabapentin gabapentin 300 mg Tablet Mylan-Gabapentin gabapentin 400 mg Tablet Mylan-Lisinopril lisinopril 5 mg Tablet Mylan-Lisinopril lisinopril 10 mg Tablet Mylan-Lisinopril lisinopril 20 mg Tablet Mylan-Metformin metformin 500 mg Tablet Mylan-Metformin metformin 850 mg Tablet Mylan-Ondansetron ondansetron 4 mg Tablet Mylan-Ondansetron ondansetron 8 mg Tablet Mylan-Paroxetine paroxetine 10 mg Tablet Mylan-Paroxetine paroxetine 20 mg Tablet Mylan-Paroxetine paroxetine 30 mg Tablet Mylan-Pioglitazone pioglitazone 30 mg Tablet of 18

15 Mylan-Pioglitazone pioglitazone 45 mg Tablet Mylan-Pravastatin pravastatin 10 mg Tablet Mylan-Pravastatin pravastatin 20 mg Tablet Mylan-Pravastatin pravastatin 40 mg Tablet Mylan-Risedronate risedronate 35 mg Tablet Mylan-Sertraline sertraline 25 mg Tablet Mylan-Sertraline sertraline 50 mg Tablet Mylan-Sertraline sertraline 100 mg Tablet Mylan-Simvastatin simvastatin 10 mg Tablet Mylan-Simvastatin simvastatin 20 mg Tablet Mylan-Simvastatin simvastatin 40 mg Tablet Mylan-Simvastatin simvastatin 80 mg Tablet Mylan-Sotalol sotalol 80 mg Tablet Mylan-Sotalol sotalol 160 mg Tablet Mylan-Terbinafine terbinafine 250 mg Tablet ratio-aclavulanate amoxicillin/clavulanic acid 125 mg/ml Suspension ratio-amcinonide amcinonide 0.1% Lotion ** ratio-amcinonide amcinonide 0.1% Ointment ** ratio-topisalic Lotion betamethasone/ salicylic acid 0.5/20 mg Lotion ** ratio-lenoltec No.2 acetaminophen/caffeine/ codeine 300/15/15 mg Tablet ** ratio-lenoltec No.3 acetaminophen/caffeine/ codeine 300/15/30 mg Tablet ** ratio-mometasone mometasone 0.1% Ointment ** ratio-nystatin nystatin 100,000 U/mL Suspension ** Sandoz Alendronate alendronate 10 mg Tablet Sandoz Alendronate alendronate 70 mg Tablet Sandoz Candesartan candesartan 8 mg Tablet Sandoz Candesartan candesartan 16 mg Tablet Sandoz Candesartan candesartan 32 mg Tablet ** Sandoz Clopidogrel clopidogrel 75 mg Tablet Sandoz Cyclosporine cyclosporine 25 mg Capsule Sandoz Cyclosporine cyclosporine 50 mg Capsule Sandoz Cyclosporine cyclosporine 100 mg Capsule Sandoz Diltiazem CD diltiazem 120 mg Capsule Sandoz Diltiazem CD diltiazem 180 mg Capsule Sandoz Diltiazem CD diltiazem 240 mg Capsule Sandoz Diltiazem CD diltiazem 300 mg Capsule Sandoz Diltiazem T diltiazem 120 mg Capsule Sandoz Diltiazem T diltiazem 180 mg Capsule Sandoz Diltiazem T diltiazem 240 mg Capsule of 18

16 Sandoz Diltiazem T diltiazem 300 mg Capsule Sandoz Diltiazem T diltiazem 360 mg Capsule Sandoz Entacapone entacapone 200 mg Capsule Sandoz Finasteride finasteride 5 mg Tablet Sandoz Irbesartan HCT irbesartan/hctz 150/12.5 mg Tablet Sandoz Irbesartan HCT irbesartan/hctz 300/12.5 mg Tablet Sandoz Irbesartan HCT irbesartan/hctz 300/25 mg Tablet Sandoz Irbesartan irbesartan 75 mg Tablet Sandoz Irbesartan irbesartan 150 mg Tablet Sandoz Irbesartan irbesartan 300 mg Tablet Sandoz Lisinopril lisinopril 5 mg Tablet Sandoz Lisinopril lisinopril 10 mg Tablet Sandoz Lisinopril lisinopril 20 mg Tablet Sandoz Losartan HCT losartan/hctz 50/12.5 mg Tablet Sandoz Losartan HCT losartan/hctz 100/12.5 mg Tablet Sandoz Losartan HCT losartan/hctz 100/25 mg Tablet Sandoz Losartan losartan 25 mg Tablet Sandoz Losartan losartan 50 mg Tablet Sandoz Losartan losartan 100 mg Tablet Sandoz Metformin FC metformin 500 mg Tablet Sandoz Metformin FC metformin 850 mg Tablet Sandoz Olanzapine ODT olanzapine 5 mg Tablet Sandoz Olanzapine ODT olanzapine 10 mg Tablet Sandoz Olanzapine ODT olanzapine 15 mg Tablet Sandoz Olanzapine olanzapine 2.5 mg Tablet Sandoz Olanzapine olanzapine 5 mg Tablet Sandoz Olanzapine olanzapine 7.5 mg Tablet Sandoz Olanzapine olanzapine 10 mg Tablet Sandoz Olanzapine olanzapine 15 mg Tablet Sandoz Ondansetron ondansetron 4 mg Tablet Sandoz Ondansetron ondansetron 8 mg Tablet Sandoz Paroxetine paroxetine 10 mg Tablet Sandoz Paroxetine paroxetine 20 mg Tablet Sandoz Paroxetine paroxetine 30 mg Tablet Sandoz Pioglitazone pioglitazone 30 mg Tablet Sandoz Pioglitazone pioglitazone 45 mg Tablet Sandoz Pravastatin pravastatin 10 mg Tablet Sandoz Pravastatin pravastatin 20 mg Tablet Sandoz Pravastatin pravastatin 40 mg Tablet Sandoz Risedronate risedronate 35 mg Tablet Sandoz Sertraline sertraline 25 mg Capsule of 18

17 Sandoz Sertraline sertraline 50 mg Capsule Sandoz Sertraline sertraline 100 mg Capsule Sandoz Sotalol sotalol 160 mg Tablet Sandoz Telmisartan telmisartan 40 mg Tablet Sandoz Telmisartan telmisartan 80 mg Tablet Sandoz Terbinafine terbinafine 250 mg Tablet Sandoz Valsartan HCT valsartan/hctz 80/12.5 mg Tablet Sandoz Valsartan HCT valsartan/hctz 160/12.5 mg Tablet Sandoz Valsartan HCT valsartan/hctz 160/25 mg Tablet Sandoz Valsartan HCT valsartan/hctz 320/12.5 mg Tablet Sandoz Valsartan HCT valsartan/hctz 320/25 mg Tablet Sandoz Valsartan valsartan 80 mg Tablet Sandoz Valsartan valsartan 160 mg Tablet Sandoz Valsartan valsartan 320 mg Tablet Testosterone testosterone 100 mg/ml Injection Teva-5-ASA mesalamine 400 mg Tablet ** Teva-Carbamazepine carbamazepine 200 mg Tablet ** Teva-Doxepin doxepine 150 mg Capsule ** Teve-Furosemide furosemide 40 mg Tablet ** Teva-Morphine SR morphine sulfate 100 mg Tablet ** Teva-Morphine SR morphine sulfate 200 mg Tablet ** Teva-Naratriptan naratriptan 1 mg Tablet Teva-Prednisone prednisone 5 mg Tablet ** Teva-Prednisone prednisone 50 mg Tablet ** Teva-Quetiapine quetiapine 150 mg Tablet ** Teva-Ranitidine ranitidine 15 mg/ml Solution ** Teva-Risedronate risedronate 30 mg Tablet ** Teva-Risedronate risedronate 5 mg Tablet ** Teva-Spironolactone spironolactone 100 mg Tablet ** Teva-Spironolactone spironolactone 25 mg Tablet ** Teva-Spironolactone/ HCTZ Teva-Spironolactone/ HCTZ ** The price change has resulted in a change to the lowest price in the category. spironolactone/hctz 25/25 mg Tablet ** spironolactone/hctz 50/50 mg Tablet ** Discontinued Products The following products will be deleted with the next Formulary amendments Apo-Haloperidol haloperidol 2 mg Tablet Apo-Haloperidol haloperidol 5 mg Tablet Apo-Propranolol propranolol 10 mg Tablet 16 of 18

18 Apo-Propranolol propranolol 40 mg Tablet Apo-Propranolol propranolol 80 mg Tablet Apo-Tiaprofenic tiaprofenic acid 200 mg Tablet Apo-Tiaprofenic tiaprofenic acid 300 mg Tablet Dilaudid hydromorphone 250 mg Powder Norflex orphenadrine 100 mg Tablet Novo-Ketorolac ketorolac 10 mg Tablet Novo-Nadolol nadolol 40 mg Tablet Novo-Nadolol nadolol 80 mg Tablet Novo-Pen-VK 500 penicillin 300 mg Tablet ratio-ketorolac ketorolac 0.5% Ophthalmic Solution ratio-ramipril ramipril 15 mg Capsules Tambocor flecainide 50 mg Tablet Tambocor flecainide 100 mg Tablet Manufacturer Updates The following product has had a name change: Teva-Lamotrigine (was: Novo-Lamotrigine) lamotrigine 25 mg 100 mg 150 mg Tablet The following product has had a name and ownership change: Apo-Fentanyl Matrix (was: Novo-Fentanyl Matrix) fentanyl 25 mcg 50 mcg 75 mcg 100 mcg Patch The following product has had a name and ownership change: Teva-Ipratropium Sterinebs (Was: Mylan-Ipratropium Sterinebs) ipratropium bromide 0.25 mg/ml Solution Teva-Combo Sterinebs (Was: Mylan-Combo Sterinebs) ipratropium bromide 0.5 mg/2.5 mg/ 2.5 ml Solution Teva-Salbutamol Sterinebs (Was: Gen-Salbutamol Sterinebs) Teva-Salbutamol Sterinebs (Was: Gen-Salbutamol Sterinebs) salbutamol 2 mg/ml Solution salbutamol 1 mg/ml Solution 17 of 18

19 The following product has had an ownership change: Airomir (now: Valeant) Viroptic (now: Valeant) salbutamol 100 mcg Inhaler trifluridine 1% Liquid The following products have been transferred to Teva Canada Limited: Apri 21 ethinyl estradiol/desogestrel 0.03 mg/0.15 mg Tablet Apri 28 ethinyl estradiol/desogestrel 0.03 mg/0.15 mg Tablet Aviane Aviane 28 ethinyl estradiol/levonorgestrel ethinyl estradiol/levonorgestrel 0.02 mg/0.10 mg Tablet 0.02 mg/0.10 mg Tablet The following product has been transitioned to an NPN: Slow K (was DIN ) potasium chloride 600 mg Tablet 18 of 18