Material Safety Data Sheet

Transcription

1 Material Safety Data Sheet NFPA HMIS Personal Protective Equipment Health Hazard Fire Hazard 0 See Section 5. Section. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Chymotrypsin SPECTRUM LABORATORY PRODUCTS INC. 44 S. SAN PEDRO STREET GARDENA, CA 9048 Alfapsin, Quimotrase, Zolyse; Alpha Chymotrypsin Chymotrypsin Catalog Number(s). CAS# RTECS TSCA CI# XX756, C GC IN CASE OF EMERGENCY CHEMTREC (4hr) Page Number: TSCA 8(b) inventory: Chymotrypsin Chemical Family Chemical Formula Supplier Proteolytic Enzyme SPECTRUM LABORATORY PRODUCTS INC. 44 S. SAN PEDRO STREET GARDENA, CA 9048 CALL (30) Section.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Chymotrypsin Toxicological Data on Ingredients Chymotrypsin: ORAL (LD50): Acute: >4000 mg/kg [Rat]. >6000 mg/kg [Mouse]. Section 3. Hazards Identification Potential Acute Health Effects Potential Chronic Health Effects Hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Slightly hazardous in case of ingestion. CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: The substance may be toxic to blood, gastrointestinal tract, skin, feet, finger. Repeated or prolonged exposure to the substance can produce target organs damage.

2 Chymotrypsin Page Number: Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Inhalation Serious Inhalation Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 5 minutes. Cold water may be used. Get medical attention. In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used.wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances May be combustible at high temperature. Slightly flammable to flammable in presence of open flames and sparks, of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances Risks of explosion of the product in presence of mechanical impact: Risks of explosion of the product in presence of static discharge: Fire Fighting Media and Instructions Fire Hazards Explosion Hazards SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

3 Chymotrypsin Page Number: 3 Section 7. Handling and Storage Precautions Storage Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as moisture. Light Sensitive. Heat Sensitive. Moisture Sensitive. Store in light-resistant containers. Avoid moist storage conditions and keep dry. Keep container tightly closed. Keep container in a cool, well-ventilated area. Store at or below 4 C (39. F). It will be stable for years at 4 C Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Personal Protection in Case of a Large Spill Exposure Limits Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Lyophilized powdered solid.) Odor Odorless. Molecular Weight ph (% soln/water) Taste Color White. Off-white. Boiling Point Melting Point Critical Temperature Specific Gravity Vapor Pressure Not applicable. Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties See solubility in water. Solubility Partially soluble in cold water, hot water.

4 Chymotrypsin Page Number: 4 Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Moisture, heat Reactive with moisture. Corrosivity Polymerization Moisture, and heat. May produce ammonia when dissolved in alkaline solution Will not occur. Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Absorbed through skin. Eye contact. Inhalation. Acute oral toxicity (LD50): >4000 mg/kg [Rat]. May cause damage to the following organs: blood, gastrointestinal tract, skin, feet, finger. Hazardous in case of skin contact (irritant), of inhalation. Slightly hazardous in case of ingestion. Potential Health Effects: Skin: Highly irritant. Extended exposure will result in digestion of the skin. Eyes: Will digest proteins of the eye. Inhalation: Inhalation of fine chymotrypsin dust can result in degradation of lung tissue. Ingestion: May cause gastrointestinal tract irritation. However, it is not considered to an ingestion hazard because Chymotrypsin is inactivated and destroyed by stomach acids. If absorbed into the blood, it may affect the blood, and cardiovascular system. Section. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Toxicity of the Products of Biodegradation the Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

5 Chymotrypsin Page Number: 5 Section 3. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 4. Transport Information DOT Classification Identification Not a DOT controlled material (United States). Not applicable. Special Provisions for Transport Not applicable. DOT Section 5. Other Regulatory Information and Pictograms Federal and State Regulations TSCA 8(b) inventory: Chymotrypsin California Proposition 65 Warnings Other Regulations EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications WHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC) R36/38- Irritating to eyes and skin. S- Keep out of the reach of children. S46- If swallowed, seek medical advice immediately and show this container or label. HMIS (U.S.A.) Health Hazard Fire Hazard Personal Protection 0 E National Fire Protection Association (U.S.A.) Health Flammability Specific hazard WHMIS (Canada) DSCL (Europe) TDG (Canada)

6 Chymotrypsin Page Number: 6 ADR (Europe) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles. Section 6. Other Information MSDS Code References Other Special Considerations C435 Validated by Sonia Owen on 8//006. Verified by Sonia Owen. Printed 9//006. CALL (30) Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.