Innovation in radiotherapy: How to prove its value for money?
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1 Innovation in radiotherapy: How to prove its value for money? Yolande Lievens, MD, PhD Radiation Oncology Ghent University Hospital & Ghent University, Belgium Co-Chair ESTRO-HERO project ESTRO President 2010 Universitair Ziekenhuis Gent
2 ESTRO s vision 2020 Every cancer patient in Europe will have access to state of the art radiation therapy, as part of a multi-disciplinary approach where treatment is individualised for the specific patient s cancer, taking account of the patient s personal circumstances
3 optimize local tumour control minimize normal tissue toxicity improved therapeutic ratio
4 TCP - Tumour Control Probability NTCP - Normal Tissue Complication Probability Nahum AE. Comput Math Methods Med. 2012
5 the value of innovation - breast conventional RT intensity-modulated RT 95% 90% 95% 100% 100% 98% 102% 105% 110% 112% Donovan et al, R&O 2007
6 the value of innovation - breast P< Pain (Gr. 2-3) Breast IMRT p=0.002 Desquamation (Gr. 2-4) p= (global) P<0.001 (breast) p= (global) p= (breast) Quality of Life (EORTC global/breast) Dosimetric inhomogeneity independently predicted for (chronic) pain and should be minimized to the greatest extent possible. Pignol et al, J Clin Oncol 2008 Mak et al, IJROBP 2014
7 the value of innovation - lung conventional RT intensity-modulated RT 95% 90% 95% 100% 100% 98% 102% 105% 110% 112% SBRT 66Gy/22Gy vs 3D-CRT 70Gy/2Gy no statistically significant difference, Phase II, low patient numbers Nyman et al, R&O 2016
8 the value of innovation - lung conventional RT intensity-modulated RT 95% 90% 95% 100% 100% 98% 102% 105% 110% 112% radiotherapy all patients Palma et al, JCO 2010
9 ? Tier 1: health status survival degree of health/recovery Tier 2: process of recovery time to recovery/to return to normal activities disutility of care /treatment process? Tier 3: sustainability of health sustainability of health/recovery; nature of recurrences long-term consequences of therapy? Adapted from Porter ME. NEJM 2010
10 changing radiation technology changing imaging modalities changing patient population changing disease presentation changing surgical techniques changing systemic treatment technology and techniques outcome acute and long-term toxicity randomised data are difficult and insufficient time
11 Financing extent clinical use market introduction investment by HC provider CEA BIA? Cost calculation? Effectiveness? Performance & safety premarket emerging diffusing established obsolete t early development launch demonstrate value / medical practice time Lievens et al, Acta Oncol 2015
12 the development trap Developing evidence for comparative effectiveness with no reimbursement is difficult, but the absence of evidence makes justifying reimbursement difficult. Smith et al, IJROBP 2016
13 Sullivan et al, Lancet Oncol 2011
14 late side effects! Mak et al, Eur Res J 2016
15
16 blended evidence generation Source: Redesigning clinical effectiveness paradigm. Institute of Medicine, 2010.
17 the right treatment for the right patient Widder et al, IJROBP 2016
18 no reimbursement for SBRT! what is the (level 1) evidence? the cost? the value for money? the budgetary impact?
19 Coverage with Evidence Generation in Belgium Collaboration National Institute for Health & Disability Insurance Health Care Knowledge Centre Belgian Radiation Oncology professionals real-life data collection = feasible! 18/24 centres participate Hulstaert et al, Report 198 KCE 2013 Lievens et al, J Thor Oncol 2015
20 Cost ( ) Free breathing - center A Free breathing - center B Free breathing - center C Free breathing - center D Free breathing - center E Free breathing - center F Gating - center G Gating - center H Tracking - center I Tracking or Free breathing - center J N of fractions average cost SBRT: 6,221 Hulstaert et al, Report 198 KCE 2013
21 prospective real-life data collection = feasible 44% oligom % primary ( 3 Mets) 2198 cases in 3 years 1210 Primary lung (peripheral) lesion Primary (para-) spinal lesion Primary lung lesion (central lesion and/or lesion > 5cm) Primary prostate lesion Hepatic metastases (Para-)spinal metastases Lung metastases
22 A pragmatic observational basket study to evaluate radical radiotherapy for oligo-metastatic cancer patients. a collaborative ESTRO-EORTC initiative
23 5 M + s u i t a b l e f o r a b l a t i v e R T a pragmatic observational basket study WP 1 WP 2 WP 3 Common Data Elements collected across diseases + tumor type-specific data collection Follow-up to death or lost to follow-up minimum criteria!
24 all cancer types a pragmatic observational basket study SBRT oligo SBRT oligo follow-up of common + pathology-specific data survival and local control acute and late radiotherapy side effects QoL, PROMs and economic data Mak et al, Eur Res J 2016
25 innovative radiotherapy more accurate, more effective long-term horizon for capturing outcome and costs, immediate investments development trap calls for an innovative view on evidence generation, costing and financing
26 NEEDS optimal radiotherapy utilisation in European countries AVAILABILITY equipment & staffing guidelines reimbursement in Europe ECONOMIC EVALUATION of radiotherapy treatments and techniques in Europe ACTIVITY-BASED COSTING cost and productivity at the national level within European countries HERO-project Lievens & Grau. R&O 2012
27 Thank you for your attention!
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