The Challenges of Analytical Method Validation for Hallucinogens and Designer Stimulants in Biological Samples Using LC-TOF
|
|
|
- Sabrina Matthews
- 5 years ago
- Views:
Transcription
1 The Challenges of Analytical Method Validation for Hallucinogens and Designer Stimulants in Biological Samples Using LC-TOF Barry K Logan, Ph.D., NMS Labs National Director, Forensic Services
2 Goals The Need: Accurate, sensitive, versatile tools. Identification Detection Routine analysis Novel, complex, esoteric and designer drugs and other analytes in a variety of matrices and sample types. The solution: LCMS/MS LCTOF, LCQTOF
3 NMS Labs Center for Innovation Time Professional activities Client Enquiries Crim. Casework Internet purchases Web Intelligence DEA scheduling Customer Feedback Academic collaboration International contacts Vendor activity Crim. Blood Urine JWH-018 JWH-073 ~17 Cpds. ~35 Cpds. ~42 Cpds. JWH-018 JWH-073 JWH-019 JWH-250 CP47,497 HU210 JWH-081 JWH-122 JWH-200 JWH-210 AM-2201 AM-694 RCS-4 RCS-8 JWH-203 JWH-022 AM-2233 AM-1248 XLR-11 UR-144 AKB-48 A720,296 JWH-018 mets JWH-073 mets CP47,497 (C8) CP47,497 (C7) HU-210 JWH-019 met JWH-250 met AM-2201 met JWH-018 mets JWH-073 mets RCS-4 met JWH-122 met JWH-210 met JWH-081 met JWH-200 met JWH-250 met JWH-210 met JWH-081 met JWH-122 met JWH-398 met Synthetic Cannabinoids
4 Time NMS Labs Center for Innovation Professional activities Client Enquiries Crim. Casework Internet purchases Web Intelligence DEA scheduling Customer Feedback Academic collaboration International contacts Vendor activity Crim. MDMA MDA MDEA TFMPP BZP DBZP 5-MeO-DIPT ~10 Cpds. ~30 Cpds. ~70 Cpds. Blood/urine atropine benzylpiperazine dextromethorphan dimethyltryptamine ketamine MDA MDMA mescaline phencyclidine scopolamine 2C-B 2C-B-FLY 2C-T-7 5-MeO-DIPT AMT BDB MBDB Mephedrone LSD bufotenin psilocin salvinorin A salvinorin B TFMPP Blood/urine Expanded MDPV Methylone Amphetamine m-cpp O-desmethyltramadol DMAA 3,4-DMMC 4-MEC Pentylone 2C-C 2C-E 2C-I 2C-P 2C-T-2 Bromo-Dragon Fly 5-MeO-DALT Buphedrone Ethylone Petedrone Phenazepam. Stimulants and Hallucinogens
5 The Scope Bath Salts and Stimulant Designer Drugs Expanded 43 Compounds Classical Stimulants Amphetamine, Methamphetamine, MDMA, MDEA, DOM, DOB, PMA, Cocaine, Benzoylecgonine Cathinones Cathinone, Mephedrone, Buphedrone, Methylone, Ethylone, Butylone, Pentylone, Mmethcathinone, Methedrone, Naphyrone, 3-FMC, 4-FMC, 4-MEC, 3,4-DMMC,
6 The Scope Bath Salts and Stimulant Designer Drugs Expanded 43 Compounds (Continued) 2C Series Stimulants with Hallucinogenic Properties 2C-B, 2C-C, 2C-E, 2C-H, 2C-I, 2C-N, 2C-P, 2C-T-2, 2C-T-7 Benzylpiperazines BZP, TFMPP, DBZP, MBZP, m-cpp Others Phenazepam, Mitragynine, 7-OH Mitragynine, O-desmethyltramadol, DMAA
7 The Technology Performance Checklist: High Sensitivity High Performance High Resolution Mass Accuracy (>5ppm) User Friendly and Adaptable Data Reduction Tools Versatility Stable Performance Robust Design Technical Support Value/ROI
8 The Technology Spectrometry (LCTOF/LCQTOF) Agilent 1290 HPLC system Agilent 6230 with Jet Stream Technology Mass Hunter Software
9 The Technology Spectrometry (LCTOF/LCQTOF) Agilent 1290 HPLC system Agilent 6230 with Jet Stream Technology Agilent 6530 QTOF Mass Hunter Software
10
11 Time of Flight (TOF) 6200/6500 Series Time of Flight Mass Spectrometry (LCTOF/LCQTOF) Ionization Fine droplets Reference nebulizer Continual Mass Accuracy Correction Optics Skimmer Octopole ion guide Optimized lens geometry (QTOF) Hyperbolic Quadrupole Mass Filter Hexapole Collision Cell Pulser Flight Tube Detector
12 Spectrometry (LCTOF/LCQTOF) - Control
13 Establishing Acceptance Criteria A sample is considered positive if the following are true: The area is greater than or equal to 25% of the average area of the responses for the two decision point cut off calibrators (10ng/mL). The retention times are within +/ min of the average retention time of the decision point cut off calibrators. The Mass Accuracy is within +/- 30ppm
14 Spectrometry (LCTOF/LCQTOF) - Control
15 Spectrometry (LCTOF/LCQTOF)
16 Spectrometry (LCTOF/LCQTOF) - Control
17 Spectrometry (LCTOF/LCQTOF) Case 1
18 Spectrometry (LCTOF/LCQTOF) Case 1
19 Spectrometry (LCTOF/LCQTOF) Case 1
20 Spectrometry (LCTOF/LCQTOF) Case 1
21 Spectrometry (LCTOF/LCQTOF) Case 1
22 Spectrometry (LCTOF/LCQTOF) Case 1
23 Spectrometry (LCTOF/LCQTOF) Case 1
24 Spectrometry (LCTOF/LCQTOF) Case 1 Criterion Mass Defect RT Diff Apparent Conc. Value ppm 0.016min 36ng/mL Not Confirmed X
25 Spectrometry (LCTOF/LCQTOF) Case 2
26 Spectrometry (LCTOF/LCQTOF) Case 2
27 Spectrometry (LCTOF/LCQTOF) Case 2
28 Liquid Chromatography-TOF Case 1 Case 2 Criterion Case 1 Case 2 Mass Defect ppm -2.6ppm RT Diff 0.016min 0.002min Apparent Conc. 3.6ng/mL 52.6ng/mL Result Not Confirmed Confirmed
29 Spectrometry (LCTOF/LCQTOF) Case 2 Methedrone C 11 H 15 NO MDMA C 11 H 15 NO
30 Spectrometry (LCTOF/LCQTOF) Case 2 Methedrone C 11 H 15 NO Confirmed by LCMSMS MDMA C 11 H 15 NO
31 Qualitative Validation Assay Validation Cut-off Verification Sensitivity and Specificity Interfering Substances Carryover Matrix Matching Stability
32 Time of Flight 8756B/U Bath Salts and Stimulants Designer Drugs Expanded 8085B/U Drug Impaired Driving/DRE Forensic Toxicology Bath Salts Add-On Test design based on: 43 compounds Regular updates based on trends Compounds found in bath salts casework Federally Scheduled Drugs Covers additional drugs scheduled in many states Drugs emerging in Europe
33 Designer Drugs Trends NMS Labs Designer Drugs Trends Report August
34 Compare and Contrast LCMSMS LCTOF LCQTOF Target Compound Analysis Must set up scanning groups Comprehensive Screening Acquire all data and query database later Target Compound analysis (Range) Acquires more limited data in QTOF mode WYSIWYG Post hoc identification Post hoc identification Compound specific transitions Limited structural confirmation May differentiate isobars Molecular formula information No structural information TOF does not differentiate isobars Molecular formula information for fragments Limited Structural information May differentiate isobars Lower Cost Higher cost Even higher cost
35 Acknowledgements NMS Labs Alex Maggitti Sherri Kacinko Matthew McMullin Fran Diamond Agilent Tom Gluodenis Jay Levine Mary Cuddrye John Hughes
THE EXPANDING REACH OF THE DESIGNER DRUG MOVEMENT IN 2011: CHALLENGES FOR FORENSIC TOXICOLOGY & CHEMISTRY
THE EXPANDING REACH OF THE DESIGNER DRUG MOVEMENT IN 2011: CHALLENGES FOR FORENSIC TOXICOLOGY & CHEMISTRY Barry K Logan PhD, DABFT, National Director Forensic Services, NMS Labs Willow Grove PA History
Flakka : The Truth Behind the Latest Designer Drug Media Storm. Donna Papsun, MS, D-ABFT-FT Forensic Toxicologist, NMS Labs
Flakka : The Truth Behind the Latest Designer Drug Media Storm Donna Papsun, MS, D-ABFT-FT Forensic Toxicologist, NMS Labs Flakka Flakka Headlines What is Flakka? Flakka = Spanish slang for thin, pretty
Quantitative Method for Amphetamines, Phentermine, and Designer Stimulants Using an Agilent 6430 LC/MS/MS
Quantitative Method for Amphetamines, Phentermine, and Designer Stimulants Using an Agilent 6430 LC/MS/MS Application Note Forensic Toxicology Authors Jason Hudson, Ph.D., James Hutchings, Ph.D., and Rebecca
Amphetamines, Phentermine, and Designer Stimulant Quantitation Using an Agilent 6430 LC/MS/MS
Amphetamines, Phentermine, and Designer Stimulant Quantitation Using an Agilent 643 LC/MS/MS Application Note Forensics Authors Jason Hudson, Ph.D., James Hutchings, Ph.D., and Rebecca Wagner, Ph.D. Virginia
LCMS-8050 Drugs of Abuse: 113 Analytes with Polarity Switching
Liquid Chromatography Mass Spectrometry SSI-LCMS-8 LCMS-8 Drugs of Abuse: Analytes with Polarity Switching LCMS-8 Summary Seventy six analytes and their internal standards are described below. Multiple
Shawn P. Vorce Technical Director Chesapeake Toxicology Resources
Shawn P. Vorce Technical Director Chesapeake Toxicology Resources "The opinions or assertions presented hereafter are the private views of Shawn P. Vorce and should not be construed as official or as reflecting
Advancing your Forensic Toxicology Analyses; Adopting the Latest in Mass Spectrometry Innovations
Advancing your Forensic Toxicology Analyses; Adopting the Latest in Mass Spectrometry Innovations For Research Use Only. Not for use in diagnostic procedures. 1 2015 AB Sciex RUO-MKT-11-1018-A For research
Quantitative Analysis of Drugs of Abuse in Urine using UHPLC Coupled to Accurate Mass AxION 2 TOF Mass Spectrometer
application Note Liquid Chromatography/ Mass Spectrometry Authors Sharanya Reddy Blas Cerda PerkinElmer, Inc. Shelton, CT USA Quantitative Analysis of Drugs of Abuse in Urine using UHPLC Coupled to Accurate
Tests recently added to the NMS Labs test menu. New Tests are effective immediately.
Immediate Action In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed
Designer Drugs Is Your Drug Testing Program Keeping Up? 2
The challenges detecting the latest advent of designer drugs has become a moving target. With the increasing number of new compounds entering the United States every year, law enforcement and treatment
Workflow for Screening and Quantification of the SAMHSA (NIDA) Panel in Urine Using UHPLC-TOF
APPLICATIO OTE Liquid Chromatography/ Mass Spectrometry Authors: Avinash Dalmia Joanne Mather PerkinElmer, Inc. Shelton, CT Workflow for Screening and Quantification of the SAMHSA (IDA) Panel in Urine
SWATH Acquisition Enables the Ultra-Fast and Accurate Determination of Novel Synthetic Opioids
SWATH Acquisition Enables the Ultra-Fast and Accurate Determination of Novel Synthetic Opioids Data Independent Acquisition on TripleTOF and X-Series QTOF Systems for Seized Drug Analysis Oscar G. Cabrices
Objectives. Why new drugs? New drugs of abuse: synthetic cannabinoids, stimulants, and 10/14/2015. Describe several new drugs of abuse
New drugs of abuse: synthetic cannabinoids, stimulants, and more Robert G. Hendrickson, MD Professor, Emergency Medicine, OHSU Program Director, Medical Toxicology Fellowship Associate Medical Director,
Determination of Bath Salts (Pyrovalerone Analogs) in Biological Samples
Determination of Bath Salts (Pyrovalerone Analogs) in Biological Samples Application Note Forensic Toxicology Authors Joe Crifasi Saint Louis University Forensic Toxicology Laboratory Saint Louis, Mo.
Drug Threats in the United States: 2019 Update
Drug Threats in the United States: 209 Update J I L L M. H E A D S P E C I A L T E S T I N G A N D R E S E A R C H L A B O R AT O R Y D R U G E N F O R C E M E N T A D M I N I S T R AT I O N Objectives.
Rapid and Sensitive Analysis of a 93-Compound Forensic Panel in Urine using the QTRAP /Triple Quad 4500 LC- MS/MS System
Rapid and Sensitive Analysis of a 93-Compound Forensic Panel in Urine using the QTRAP /Triple Quad 4500 LC- MS/MS System Xiang He, 1 Casey Burrows 1, Matthew Noestheden 2, Michael Jarvis, 2 Adrian Taylor,
National Drug Early Warning System (NDEWS) Texas Sentinel Community Site Appendix Data Tables, 2015 NDEWS Coordinating Center
National Drug Early Warning System (NDEWS) Texas Sentinel Community Site Appendix Data Tables, 2015 NDEWS Coordinating Center Table 1: Demographic and Socio-Economic Characteristics, 2009-2013, ACS Table
Validation of a Benzodiazepine and Z-Drug Method Using an Agilent 6430 LC/MS/MS
Validation of a Benzodiazepine and Z-Drug Method Using an Agilent 6430 LC/MS/MS Application Note Forensics Authors Jason Hudson, Ph.D., James Hutchings, Ph.D., and Rebecca Wagner, Ph.D. Virginia Department
National Drug Early Warning System (NDEWS,
April 18, 217 CENTER FOR SUBSTANCE ABUSE RESEARCH United States Sentencing Commission Synthetic Cannabinoids, Cathinones, and MDMA Written Testimony: Eric D. Wish, PhD, CESAR Director* CESAR 4321 Hartwick
Agilent s LC/MS Portfolio and Applications Examples
Agilent s LC/MS Portfolio and Applications Examples Sean Orlowicz LC/MS Product Specialist Agilent Technologies 31August Agilent s > 40 year heritage in mass spectrometry 1971, 5930A GC/MS 1971-2011 2005,
4-Fluoroethamphetamine
NMS Labs 2300 Stratford Ave Willow Grove, PA 19090 4-Fluoroethamphetamine Sample Type: Seized Material Latest Revision: January 3, 2019 Date Received: July 31, 2018 Date of Report: January 3, 2019 1. GENERAL
Cannabinoid Profiling and Quantitation in Hemp Extracts using the Agilent 1290 Infinity II/6230B LC/TOF system
Cannabinoid Profiling and Quantitation in Hemp Extracts using the Agilent 9 Infinity II/63B LC/TOF system Application Brief Authors Mike Adams, Karen Kaikaris, and A. Roth CWC Labs Joan Stevens, Sue D
INTER AMERICAN DRUG ABUSE CONTROL COMMISSION C I C A D
INTER AMERICAN DRUG ABUSE CONTROL COMMISSION C I C A D Secretariat for Multidimensional Security FIFTY SECOND REGULAR SESSION November 28 30, 2012 San José, Costa Rica OEA/Ser.L/XIV.2.52 CICAD/doc.1980/12
Trend Report: Q Synthetic Cannabinoids in the United States
POSITIVE SAMPLES New Synthetic Cannabinoid Identified in December 2018 in Heart Blood 4F-MDMB-BINACA Synthetic Cannabinoid Positivity Between July and December 2018 (by Date Analyzed) 60 50 40 5F-ADB 5F-ADB
Novel psychoactive substances in postmortem toxicology. Pirkko Kriikku, PhD Forensic Toxicologist
Novel psychoactive substances in postmortem toxicology Pirkko Kriikku, PhD Forensic Toxicologist Postmortem toxicology in Finland Population: 5.5 million Deaths: ~51 000 per year Medico-legal cause-of-death
Ultra High Definition Optimizing all Analytical Dimensions
Ultra High Definition Optimizing all Analytical Dimensions Sensitivity Dynamic Range Signal Response Linearity Separation Speed Peak Capacity Chromatogram Mass Spectrum Mass Accuracy Resolving Power Acquisition
Ultra-Fast Forensic Toxicological Screening and Quantitation under 3 Minutes using SCIEX X500R QTOF System and SCIEX OS 1.
Ultra-Fast Forensic Toxicological Screening and Quantitation under 3 Minutes using SCIEX X500R QTOF System and SCIEX OS 1.0 Software Xiang He 1, Adrian M. Taylor 2, Michael Jarvis 2 and Alexandre Wang
Impurity Identification using a Quadrupole - Time of Flight Mass Spectrometer QTOF
Impurity Identification using a Quadrupole - Time of Flight Mass Spectrometer QTOF PUSHER TOF DETECTOR ZSPRAY TM Ion Source SAMPLING CONE SKIMMER RF HEXAPOLE RF HEXAPOLE QUADRUPOLE IN NARROW BANDPASS MODE
POINT OF CARE TESTING
POINT OF CARE TESTING POINT OF CARE INSTANT TESTING Randox Testing Services offers a wide range of products to enable you to carry out on-site drug and alcohol testing for instant results. Our products
Modernizing the Forensic Lab with LC-MS/MS Technology
Modernizing the Lab with LC-MS/MS Technology Innovative SCIEX Analytical Tools for the Rapid Identification of Drugs of Abuse in Samples Oscar G. Cabrices 1, Holly McCall 1, Xiang He 1, Alexandre Wang
National Drug Early Warning System (NDEWS) Sentinel Community Site (SCS) Drug Use Patterns and Trends: SCS Snapshot
National Drug Early Warning System (NDEWS) Sentinel Community Site (SCS) Drug Use Patterns and Trends: SCS Snapshot The SCS Snapshot is prepared by NDEWS Coordinating Center staff and contains graphics
Agilent 6410 Triple Quadrupole LC/MS. Sensitivity, Reliability, Value
Agilent 64 Triple Quadrupole LC/MS Sensitivity, Reliability, Value Sensitivity, Reliability, Value Whether you quantitate drug metabolites, measure herbicide levels in food, or determine contaminant levels
NPS New Psychoactive Substances
NPS New Psychoactive Substances NPS are drugs that are synthetically designed to replicate the effects of illegal substances. People may refer to these drugs as legal highs, but many of the substances
Ion Exchange and Reversed Phase interactions in selective Bio-SPME extractions of designer drugs
Ion Exchange and Reversed Phase interactions in selective Bio-SPME extractions of designer drugs Frank Michel, Craig R. Aurand, Robert E. Shirey, Yong Chen, Leonard M. Sidisky sigma-aldrich.com/analytical
Development of a Screening Analysis by LC Time-Of-Flight MS for Drugs of Abuse Application
Development of a Screening Analysis by LC Time-Of-Flight MS for Drugs of Abuse Application Forensic Toxicology Authors Courtney Milner and Russell Kinghorn Baseline Separation Technologies Pty Ltd. Abstract
Alcohol. Ethanol Highlands Parkway, Suite 100 Smyrna, GA 30082
Alcohol The alcohol of interest is ethanol. Ethanol has a sedative effect in the brain. Ethanol intoxication symptoms include blurred vision, slurred speech, poor coordination and difficulty thinking depending
National Drug Early Warning System (NDEWS) Sentinel Community Site (SCS) Drug Use Patterns and Trends: SCS Snapshot
National Drug Early Warning System (NDEWS) Sentinel Community Site (SCS) Drug Use Patterns and Trends: SCS Snapshot The SCS Snapshot is prepared by NDEWS Coordinating Center staff and contains graphics
SPICE Prevention Issues Measures in Switzerland in the fight against new drugs such as SPICE and bath salts
SPICE Prevention Issues 2012 Measures in Switzerland in the fight against new drugs such as SPICE and bath salts Werner Bernhard, Lars Ambach, Wolfgang Weinmann Institute of Forensic Medicine, University
INTER-AMERICAN DRUG ABUSE CONTROL COMMISSION C I C A D
INTER-AMERICAN DRUG ABUSE CONTROL COMMISSION C I C A D Secretariat for Multidimensional Security FIFTY-FIFTH REGULAR SESSION April 29 - May 1, 2014 Washington, D.C. OEA/Ser.L/XIV.2.55 CICAD/doc.2106/14
Legal Highs in Spain, by Energy Control July 2011
English translation Legal Highs in Spain, by Energy Control July 2011 In recent years, consumption of a group of substances not subject to drug control regulations and sold in different forms (powder,
A Simple and Accurate Method for the Rapid Quantitation of Drugs of Abuse in Urine Using Liquid Chromatography
Application Note LCMS-109 A Simple and Accurate Method for the Rapid Quantitation of Drugs of Abuse in Urine Using Liquid Chromatography Time of Flight (LC-TOF) Mass Spectrometry Introduction Many clinical
Drugs of Abuse I Serum
Drugs of Abuse I Serum 2017-11 1.10 For quality monitoring of quantitative measurements by chromatographic methods These reference materials are produced on the basis of human matrices. The highly accurate
Drug Testing Basics. by Erowid
Drug Testing Basics by Erowid INDEX 1. What do they Test for? 2. Test Types 3. Test Sensitivity 4. Detection Periods WHAT DO THEY TEST FOR? The first thing to know about drug testing is what the standard
Designer Drugs (Spice/K2, Bath Salts, & Beyond Update) By: Paul L. Cary Toxicology Laboratory University of Missouri
Designer Drugs (Spice/K2, Bath Salts, & Beyond - 2012 Update) By: Paul L. Cary Toxicology Laboratory University of Missouri Synthetic Cananbinoids & Designer Stimulants (Novelty Powders) history designer
Results from the STRIDA project. Matilda Bäckberg PhD, M.Sc.Pharm The Swedish Poisons Information Centre
Results from the STRIDA project Matilda Bäckberg PhD, M.Sc.Pharm The Swedish Poisons Information Centre Email: Matilda.Backberg@gic.se No. of calls Statistics from telephone service 1800 Amfetamin Amphetamine
Minneapolis/St. Paul, Minnesota Drug Abuse Trends: January 2014 Update
Minneapolis/St. Paul, Minnesota Drug Abuse Trends: January 2014 Update Carol Falkowski Drug Abuse Dialogues ABSTRACT Heroin and other opiate addiction continued to escalate in the Twin Cities in 2013.
FACT SHEET. A selection of internet-based information. Methedrone (bk-pmma)
FACT SHEET A selection of internet-based information Methedrone (bk-pmma) Scientific Institute of Public Health Drugs and Illegal Substances Program National Focal Point on Drugs Juliette Wytsmanstreet
10/1/2010. Accredited by ASCLD/LAB International Standard (ISO/IEC 17025) ASCLD/LAB Supplemental. Quality Systems Manual SWGDRUG. Section Methods/SOPs
Drug Chemistry Section Susan Gross Forensic Science Supervisor Minnesota BCA Drug Chemistry Section - Who we are - What we do - Goals of section - Statistics - Trends Who we are MN Bureau of Criminal Apprehension
Synthetic Drug Threats in the United States: 2018 Update
Synthetic Drug Threats in the United States: 2018 Update JILL M. HEAD SPECIAL TESTING AND RESEARCH LABORATORY DRUG ENFORCEMENT ADMINISTRATION Objectives 1. Overview of the DEA Emerging Trends & Reference
A Novel Platform of On-line Sample Pre-treatment and LC/MS/MS Analysis for Screening and Quantitation of Illicit Drugs in Urine
PO-CON737E A Novel Platform of On-line Sample Pre-treatment and LC/MS/MS Analysis for Screening and Quantitation of Illicit Drugs in Urine ASMS 7 WP 353 Shao Hua Chia ; Zhi Wei Edwin Ting ; Daisuke Kawakami
A Comprehensive Screening of Illicit and Pain Management Drugs from Whole Blood Using SPE and LC/MS/MS
A Comprehensive Screening of Illicit and Pain Management Drugs from Whole Blood Using SPE and LC/MS/MS Introduction Drug analysis from whole blood is gaining popularity due to a more complete measurement
Conventional and emerging drugs of abuse: the current situation
Conventional and emerging drugs of abuse: the current situation NEW PSYCHOACTIVE SUBSTANCES -THE HIGHS AND LOWS Maritim Hotel, Munich, 12-13 November 2015 Michael Uhl Director of Chemistry Unit Bavarian
The New 6495 Triple Quadrupole LC/MS
The New 6495 Triple Quadrupole LC/MS Experience A New Level of Confidence Martin Haex Product Specialist MS and Automation 1 Overview of Topics The New 6495 QQQ LC/MS Technology Innovations Quantitation
Workflow for Screening and Quantification of the SAMHSA (NIDA) Panel in Serum Using UHPLC-TOF
APPLICATIO OTE Liquid Chromatography/ Mass Spectrometry Authors: Avinash Dalmia Bonnie Marmor PerkinElmer, Inc. Shelton, CT Workflow for Screening and Quantification of the SAMHSA (IDA) Panel in Serum
[ APPLICATION NOTE ] APPLICATION BENEFITS INTRODUCTION WATERS SOLUTIONS KEYWORDS
![[ APPLICATION NOTE ] APPLICATION BENEFITS INTRODUCTION WATERS SOLUTIONS KEYWORDS](/thumbs/87/95409880.jpg "[ APPLICATION NOTE ] APPLICATION BENEFITS INTRODUCTION WATERS SOLUTIONS KEYWORDS")
A Comprehensive Method for the Analysis of Pain Management Drugs and Drugs of Abuse Incorporating Simplified, Rapid Mixed-Mode SPE with UPLC-MS/MS for Clinical Research Jonathan P. Danaceau, Scott Freeto,
A NOVEL METHOD OF M/Z DRIFT CORRECTION FOR OA-TOF MASS SPECTROMETERS BASED ON CONSTRUCTION OF LIBRARIES OF MATRIX COMPONENTS.
A NOVEL METHOD OF M/Z DRIFT CORRECTION FOR OA-TOF MASS SPECTROMETERS BASED ON CONSTRUCTION OF LIBRARIES OF MATRIX COMPONENTS. Martin R Green*, Keith Richardson, John Chipperfield, Nick Tomczyk, Martin
National Drug Early Warning System (NDEWS) Sentinel Community Site (SCS) Drug Use Patterns and Trends: SCS Snapshot
National Drug Early Warning System (NDEWS) Sentinel Community Site (SCS) Drug Use Patterns and Trends: SCS Snapshot The SCS Snapshot is prepared by NDEWS Coordinating Center staff and contains graphics
High-Throughput, Cost-Efficient LC-MS/MS Forensic Method for Measuring Buprenorphine and Norbuprenorphine in Urine
High-Throughput, Cost-Efficient LC-MS/MS Forensic Method for Measuring and in Urine Xiaolei Xie, Joe DiBussolo, Marta Kozak; Thermo Fisher Scientific, San Jose, CA Application Note 627 Key Words, norbuprenorphine,
New patterns of drug use in Hungary
New patterns of drug use in Hungary Gergely Horváth Hungarian National Focal Point PDU Annual Expert Meeting 2012 Lisbon, 25-26 September 2012 First glance From 2009 on decrease in heroin availability,
METHOD DEVELOPMENT FOR THE DETECTION OF SYNTHETIC CATHINONES AND INVESTIGATION OF THEIR METABOLISM USING HUMAN MICROSOMES TRAVIS BRACHTENBACH
METHOD DEVELOPMENT FOR THE DETECTION OF SYNTHETIC CATHINONES AND INVESTIGATION OF THEIR METABOLISM USING HUMAN MICROSOMES By TRAVIS BRACHTENBACH Bachelor of Science in Biochemistry University of Tulsa
ORAL FLUID AS A CHEMICAL TEST FOR THE DRE PROGRAM : HISTORY, THE FUTURE, AND PRACTICAL CONSIDERATIONS
ORAL FLUID AS A CHEMICAL TEST FOR THE DRE PROGRAM : HISTORY, THE FUTURE, AND PRACTICAL CONSIDERATIONS Barry K Logan PhD, DABFT National Director of Forensic Services, NMS Labs Willow Grove PA Disclaimer
Lisa Booze, PharmD, CSPI
Lisa Booze, PharmD, CSPI Psychoactive drugs created to avoid existing laws Modify existing drugs or new drugs with different chemical structures >200 new drugs and 8 classes of drugs since 2009 80 new
National Drug Early Warning System (NDEWS) Sentinel Community Site (SCS) Drug Use Patterns and Trends: SCS Snapshot
National Drug Early Warning System (NDEWS) Sentinel Community Site (SCS) Drug Use Patterns and Trends: SCS Snapshot The SCS Snapshot is prepared by NDEWS Coordinating Center staff and contains graphics
Pills, Powders, Potions and Paraphernalia
Pills, Powders, Potions and Paraphernalia A P R N 2 0 1 6 C N F E R E N C E W E D N E S D A Y, F E B R U A R Y 1 7, 2 0 1 6 C H A R L E S T N, S C D E M I G A R V I N, B S, P H A R M. D., R. P h., F -ABFT
LC/MS/MS Analysis of Metabolites of Synthetic Cannabinoids JWH-018 and JWH-073 in Urine
Abstract A liquid chromatographic method was developed to resolve a comprehensive set of metabolites of JWH-018 and JWH-073. In addition to the chromatographic analysis method, an extraction method was
April 28, RE: Immediate Action test change notification. Dear Valued Client:
April 28, 2010 RE: Immediate Action test change notification Dear Valued Client: The following pages detail important information regarding a test requiring database modifications. Please be advised that
Future Analytical Considerations
An Analytical Chemist's Approach to Legalized Marijuana: Future Analytical Considerations Jeffery H. Moran Branch Chief, Arkansas Department of Health Arkansas Public Health Laboratory Disclaimer I have
Toxicological Investigation of Drug Impaired Driving Toxicology Laboratory Survey
Toxicological Investigation of Drug Impaired Driving Toxicology Laboratory Survey Kayla J. Lowrie, MS, Jennifer Turri, BS, Jill Yeakel, MSFS, Barry K. Logan, PhD, DABFT, Arcadia University, 450 S. Easton
Forensic Toxicology Scope of Testing and Detection Limits
Forensic Toxicology Scope of Testing and Detection Limits Table of Contents QUALITATIVE ANALYSES... 2 Volatile Screen by GC/FID... 2 Carbon Monoxide by Microdiffusion... 2 Ethylene Glycol by GC/MS... 2
National Drug Early Warning System (NDEWS) Los Angeles County Sentinel Community Site Appendix Data Tables, 2015
National Drug Early Warning System (NDEWS) Los Angeles County Sentinel Community Site Appendix Data Tables, 2015 NDEWS Coordinating Center Table 1: Demographic and Socio-Economic Characteristics, 2009-2013,
Jane Maxwell, UT Addiction Research Institute, Drug Trends: Old Drugs and New Problems - New Drugs and New Problems
Drug Trends: Old Drugs and New Problems - New Drugs and New Problems Jane Maxwell, Ph.D. Center for Social Work Research The University of Texas at Austin The author has no financial disclosure 2 3 4 5
Evaluation of the Impact of Expanding ELISA Screening in DUID Investigations. Aileen Lu*, Karen S. Scott, Aya Chan-Hosokawa, and Barry K.
Evaluation of the Impact of Expanding ELISA Screening in DUID Investigations Aileen Lu*, Karen S. Scott, Aya Chan-Hosokawa, and Barry K. Logan FSF Emerging Forensic Scientist Award Oral Presentation Disclosure
Toxicology Screening of Whole Blood Extracts Using GC/Triple Quadrupole/MS
Toxicology Screening of Whole Blood Extracts Using GC/Triple Quadrupole/MS Application Note Forensic Toxicology Authors Bruce Quimby and Mike Szelewski Agilent Technologies, Inc. 2850 Centerville Road
NEW TRENDS IN USE, CONSEQUENCES / DAMAGES AND MARKETS. 2nd Annual Meeting of National Drug Observatories COPOLAD II Lisbon, November 2017
NEW TRENDS IN USE, CONSEQUENCES / DAMAGES AND MARKETS 2nd Annual Meeting of National Drug Observatories COPOLAD II Lisbon, 13-17 November 217 THE QUESTIONS In the last two years What recent changes and
Tests recently added to the NMS Labs test menu. New Tests are effective immediately.
Immediate Action In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed
The Development of LC/MS Methods for Determination of Polar Drugs of Abuse in Biological Samples
WA20259 The Development of LC/MS Methods for Determination of Polar Drugs of Abuse in Biological Samples Michael S. Young and Kevin M. Jenkins Waters Corporation, 34 Maple Street, Milford, MA 01757 Introduction
Drugs and The Internet
Issue 2, March 2014 Funded by the Australian Government under the Substance Misuse Prevention and Service Improvement Grants Fund Product of: The National Illicit Drug Indicators Project Recommended Van
Key findings for drug use patterns & drug markets
EDRS participants & Recruitment Key findings for drug use patterns & drug markets Risk behaviours Help seeking Implications 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 Number of EDRS participants
MS/MS Library Creation of Q-TOF LC/MS Data for MassHunter PCDL Manager
MS/MS Library Creation of Q-TOF LC/MS Data for MassHunter PCDL Manager Quick Start Guide Step 1. Calibrate the Q-TOF LC/MS for low m/z ratios 2 Step 2. Set up a Flow Injection Analysis (FIA) method for
Drug Checking: l esperienza ed i dati. Alberto SALOMONE
Drug Checking: l esperienza ed i dati Alberto SALOMONE NIGHTLIFE NPS REPLACEMENT EXTASY: Synthetic cathinones LSD: NBOMe series HEROIN: fentanyl and analogs DRUG CHECKING STRATEGY SAMPLE unknown substance
Toxicology 101. Arizona Problem Solving Courts April 25, 2016
Toxicology 101 Arizona Problem Solving Courts April 25, 2016 Aaron Brown, Ph.D. Technical Group Lead Norchem Drug Testing Laboratory Cordant Health Solutions Flagstaff, Arizona Toxicology Toxicology is
Quantitative Analysis of Opiates in Urine Using RRHT LC/MS/MS. Application. Authors. Introduction. Abstract. Forensics
Quantitative Analysis of piates in Urine Using RRHT LC/MS/MS Application Forensics Authors Sheher Mohsin Agilent Technologies, Inc. 10 N. Martingale Rd., Suite 550 Schaumburg, IL 60173 USA Yanan Yang Agilent
The Challenge of New Psychoactive Substances (NPS) A Presentation for CAD by Dr Des Corrigan October 2015
The Challenge of New Psychoactive Substances (NPS) A Presentation for CAD by Dr Des Corrigan October 2015 New Psychoactive Substances Any substance, natural or synthetic which can produce stimulation or
Jonathan Rochon, Pier-Luc Plante, Serge Auger, Réal Paquin, Jacques Corbeil, Pierre Picard
Dried Blood Spots in Tips Targeted Drug Screening in 9 Seconds per Sample Using Laser Diode Thermal Desorption Mass Spectrometry (LDTD-MS/MS) Jonathan Rochon, Pier-Luc Plante, Serge Auger, Réal Paquin,
LC/QTOF Discovery of Previously Unreported Microcystins in Alberta Lake Waters
LC/QTOF Discovery of Previously Unreported Microcystins in Alberta Lake Waters Ralph Hindle Vogon Laboratory Services Ltd. Cochrane, Alberta, Canada Xu Zhang David W. Kinniburgh Alberta Centre for Toxicology
Quantitative Determination of Drugs of Abuse in Human Plasma and Serum by LC/MS/MS Using Agilent Captiva EMR Lipid Cleanup
Application Note Forensic Testing Quantitative Determination of Drugs of Abuse in Human Plasma and Serum by LC/MS/MS Using Agilent Captiva EMR Lipid Cleanup Author Limian Zhao Agilent Technologies, Inc.
Hallucinogens. Hallucinogens. Hallucinogens
Hallucinogens Hallucinogens Hallucinogens are substances that alter sensory processing in the brain, causing perceptual disturbances, changes in thought processing, and depersonalization Hallucinogens
A review of the collision induced dissociation fragmentation and the metabolism of synthetic cathinone derivatives
A review of the collision induced dissociation fragmentation and the metabolism of synthetic cathinone derivatives Nichola Cunningham A thesis submitted in fulfilment of the requirements for the degree
DETERMINATION OF CANNABINOIDS, THC AND THC-COOH, IN ORAL FLUID USING AN AGILENT 6490 TRIPLE QUADRUPOLE LC/MS
FORENSICS AND TOXICOLOGY ANALYSIS DETERMINATION OF CANNABINOIDS, THC AND THC-COOH, IN ORAL FLUID USING AN AGILENT 6490 TRIPLE QUADRUPOLE LC/MS Solutions for Your Analytical Business Markets and Applications
Fiona Coope (BSc) Forensics Director
Fiona Coope (BSc) Forensics Director Who We Are ESG is the UK s leading provider of testing, inspection and compliance services, with comprehensive solutions in Infrastructure, the Built Environment and
Synthetic Drugs What Clinicians Need To Know. Danesh Alam MD, DFAPA, FASAM
Synthetic Drugs What Clinicians Need To Know Danesh Alam MD, DFAPA, FASAM 1 Educational Objectives I At the end of this presentation, participants will be able to: Attendees will be able to describe basic
High resolution mass spectrometry for bioanalysis at Janssen. Current experiences and future perspectives
High resolution mass spectrometry for bioanalysis at Janssen. Current experiences and future perspectives Lieve Dillen Drug Safety Sciences Analytical Sciences, Non-regulated Bioanalysis Presentation outline
Analytic Techniques Utilisedfor Drug Checking
Analytic Techniques Utilisedfor Drug Checking Challenges and Current Developments Anton Luf Head of checkit! Laboratory Clinical Institute for Laboratory Medicine Medical University of Vienna checkit!
ANALYTICAL REPORT 1. bk-2c-b ( C10H12BrNO3) 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethan-1-one
Vodovodna 95 1000 Ljubljana SLOVENIJA T: +386 (0)1 428 44 93 E: nfl@policija.si www.policija.si Remark other NPS detected: none ANALYTICAL REPORT 1 bk-2c-b ( C10H12BrNO3) 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethan-1-one
One Source Toxicology Laboratory, 1213 Genoa Red Bluff, Pasadena, Texas 77504
Validation of Analysis of Amphetamines, Opiates, Phencyclidine, Cocaine, and Benzoylecgonine in Oral Fluids by Liquid Chromatography Tandem Mass Spectrometry Subbarao V. Kala*, Steve E. Harris, Tom D.
Quantitation by High Resolution Mass Spectrometry: Case Study of TOF MS for the Quantitation of Allopurinol from Human Plasma
Quantitation by High Resolution Mass Spectrometry: Case Study of TOF MS for the Quantitation of Allopurinol from Human Plasma Shaokun Pang 1, Weixing Sun 2, Adrien Musuku 2, Xavier J. Misonne 1 1 SCIEX,
Fully Automated Online Sample Preparation and LC-MS/MS Analysis of Drugs of Abuse in Oral Fluids
PO-CON1753E Fully Automated Online Sample Preparation and LC-MS/MS Analysis of Drugs of Abuse in Oral Fluids ASMS 2017 TP-442 Joshua F. Emory 1, Nathan DeFreitas 2, Michael Roberts 1, Manoj Tyagi 2, M.
Sue D Antonio Application Chemist Cedar Creek, TX
Sue D Antonio Application Chemist Cedar Creek, TX What is Hemp Oil? CBD hemp oil is a natural botanical extract of the common hemp plant. CBD hemp oil is derived from the seeds and stem of the Cannabis
INTER-AMERICAN DRUG ABUSE CONTROL COMMISSION C I C A D
INTER-AMERICAN DRUG ABUSE CONTROL COMMISSION C I C A D Secretariat for Multidimensional Security FIFTY-EIGHTH REGULAR SESSION November 11-13, 2015 Trujillo, Perú OEA/Ser.L/XIV.2.58 CICAD/doc.2207/15 6