2016 Rising STAR Award from The University of Texas System Board of Regents, Houston, Texas.

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1 CURRICULUM VITAE Fabricio H.M. Do Monte, DVM, PhD Departments of Psychiatry and Anatomy & Neurobiology University of Puerto Rico School of Medicine Office A231, 2 nd Floor of Main Building, San Juan, Puerto Rico Tel: (787) , Lab/Fax: (787) PERSONAL INFORMATION Full name: Fabricio Hoffmann Martins Do Monte Birth information: 15/01/ Rio de Janeiro Brazil fabriciodomonte@gmail.com EDUCATION & ACADEMIC POSITIONS 2016 present Assistant Professor (Dept. of Neurobiology & Anatomy) McGovern School of Medicine The University of Texas Health Science Center at Houston Postdoctoral Fellow and Research Associated (Laboratory of Dr. Gregory J. Quirk) University of Puerto Rico School of Medicine, San Juan, Puerto Rico, USA Doctorate in Neuropharmacology (Laboratory of Dr. Antonio P. Carobrez) Universidade Federal de Santa Catarina, UFSC, Florianópolis, Brazil Master's in General Pharmacology (Laboratory of Dr. Antonio P Carobrez) Universidade Federal de Santa Catarina, UFSC, Florianópolis, Brazil Bachelor's in Veterinary Medicine. Universidade do Estado de Santa Catarina, UDESC, Lages, Brazil. GRANTS Thalamic circuits in the integration of fear and reward; National Institute of Health (NIH) - Pathway to Independence Award K99/R00. (PI: Do Monte) The noradrenergic system in the mechanisms of extinction and reconsolidation of aversive memories; National Institute for Scientific and Technological Development of Brazil, CNPq. (PI: Do Monte) Participation of beta-adrenergic receptors in the modulation of innate fear responses; National Institute for Scientific and Technological Development of Brazil, CNPq. (PI: Do Monte). HONORS & AWARDS 2016 Rising STAR Award from The University of Texas System Board of Regents, Houston, Texas Travel award from Simons Foundation Autism Research Initiative (SFARI) to attend the Gordon Research Conference on Amygdala in Health & Disease 2015, Stonehill College, Easton, MA K99/R00 Pathway for Independence Award from National Institute of Mental Health Travel award from FENS/IBRO (Federation of European Neuroscience Societies/The International Brain Research Organization) to participate in the FENS Forum, Barcelona, Spain Travel award from the University of Wisconsin to attend Wisconsin Symposium on Emotion 2011, Madison, WI. 1

2 2010 Poster award in the 23rd European College of Neuropsychopharmacology Congress 2010, Amsterdam, The Netherlands Travel award from IBRO to attend the Short-term Course in Neuroscience, Latin American School of Neuroscience 2009, Montevideo, Uruguay Travel award from IBRO to attend the Society for Neuroscience meeting 2009, Chicago, IL Travel award from Brazilian Society of Behavior and Neuroscience to attend the Society for Neuroscience meeting 2007, San Diego, CA. RESEARCH TRAINING EXPERIENCE Plexon Neurophysiology and Behavior Workshop, Dallas, Texas, USA Research Internship in optogenetics & single-unit recording (Laboratory of Dr. Kay Tye) Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA Research Internship in optogenetics (Laboratory of Dr. Barry Connors) Brown University, Providence, RI, USA Research Internship in neuroanatomy (Laboratory of Dr. Newton S. Canteras) Universidade de São Paulo, São Paulo, Brazil Research Internship in psychopharmacology (Laboratory of Dr. Jorge Quillfeldt). Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. TEACHING EXPERIENCE Delivered lectures to Medical Students on Behavioral Sciences and Introduction to Psychiatry. University of Puerto Rico School of Medicine, San Juan, PR Delivered lectures to Master s and Doctorate Students of Neuropharmacology on Mechanisms of Signal Transduction, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil Organizer and teacher in the 2 nd, 3 rd, 4 th, 5 th Winter Course of Pharmacology, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil Delivered lectures to Master s Students of Pharmacology on Psychophysiology of Animal Behavior, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. SCIENTIFIC JOURNAL REFEREE Learning & Memory, Neuropsychopharmacology, Psychopharmacology, Biological Psychiatry, elife, Journal of Neurophysiology, Brain Research, Neural Plasticity, Behavioral Brain Research, NeuroReport, Neuroscience Research, Psychoneuroendocrinology. PAPERS IN PEER-REVIEWED JOURNALS (*First author equal contribution) 24. Do Monte, FH*; Minier-Toribio*, A; Quiñones-Laracuente, K; Medina-Colón, EM; Quirk, GJ. Thalamic regulation of sucrose-seeking during unexpected reward omission. Neuron, 94(2): e4,

3 23. Martínez-Rivera, FJ; Rodríguez-Romaguera, J; Lloret-Torres, ME; Do Monte, FH; Quirk GJ, Barreto-Estrada, JL. Bidirectional modulation of extinction of drug seeking by deep brain stimulation of the ventral striatum. Biological Psychiatry, 80 (9): , Do Monte, FH; Quirk, GJ; Li, B; Penzo, MA. Retrieving fear memories, as time goes by Molecular Psychiatry, 21(8): , Rosas-Vidal, LE; Rodriguez-Romaguera, J; Do Monte, FH; Andero, R. Targeting the reconsolidation of extinction memories: a novel potential strategy to treat anxiety disorders. Molecular Psychiatry, 20(11):1264-5, Do Monte, FH*; Manzano-Nieves*, G; Quiñones-Laracuente, K; Ramos-Medina, L; Quirk, GJ. Revisiting the role of infralimbic cortex in fear extinction with optogenetics. The Journal of Neuroscience, 35(8): , (Top 1% most cited paper in the academic field 12 months following publication, according to Web of Science). 19. Do Monte, FH; Quiñones-Laracuente, K; Quirk GJ. A temporal shift in the circuits mediating retrieval of fear memory. Nature, 519(7544): , (Top 1% most cited paper in the academic field 12 months following publication, according to Web of Science, with a commentary featured in the journal Nature Reviews Neuroscience : Yates, D. (2015). Neural circuits: a nucleus of fear. Nature Reviews Neuroscience 16, 121). 18. Rodriguez-Romaguera, J; Do Monte, FH; Tanimura, Y; Quirk, GJ; Haber, SN. Deep brain stimulation enhancement of fear extinction: evidence for medial orbitofrontal involvement. Neuropsychopharmacology, 40(7): , Bravo-Rivera, C; Diehl, MM; Roman-Ortiz, C; Rodriguez-Romaguera, J; Rosas-Vidal, LE; Bravo-Rivera, H; Quiñones- Laracuente, K and Do Monte, FH*. Long-range GABAergic neurons in the prefrontal cortex modulate behavior. Journal of Neurophysiology, 114: , Rosas-Vidal, LE; Do Monte, FH; Sotres-Bayon, F; Quirk, GJ. Hippocampal-prefrontal BDNF and memory for fear extinction, Neuropsychopharmacology, 39(9): , Do Monte, FH; Rodriguez-Romaguera, J; Rosas-Vidal, LE; Quirk, GJ. Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit. Frontiers in Behavioral Neuroscience. 7:102, Do Monte, FH; Souza, RR; Bitencourt, RM; Kroon, JA; Takahashi, RN. Infusion of cannabidiol into infralimbic cortex facilitates fear extinction via CB1 receptors. Behavioral Brain Research, 250c:23-27, Do Monte, FH; Souza, RR; Wong, TT; Carobrez, AP. Systemic or intra-prelimbic cortex infusion of prazosin impairs fear memory reconsolidation. Behavioral Brain Research, 244: , Rodriguez-Romaguera, J*; Do Monte, FH*; Quirk GJ. Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear. Proceedings of the National Academy of Science - USA, 109(22): , Padilla-Coreano, N*; Do Monte, FH*; Quirk, GJ. A time-dependent role of midline thalamic nuclei in the retrieval of fear memory. Neuropharmacology, 62(1): , Do Monte, FH; Kincheski, G; Pavesi, E; Sordi, R; Assreuy, J; Carobrez, AP. Role of beta-adrenergic receptors in the ventromedial prefrontal cortex during contextual fear extinction in rats. Neurobiology of Learning and Memory, 94(3): , Stern, CA; Do Monte, FH; Gazarini, L; Carobrez, AP; Bertoglio, LJ. Activity in prelimbic cortex is required for adjusting the anxiety response level during the elevated plus-maze retest. Neuroscience, 170: , Do Monte, FH; Allensworth, M; Carobrez, AP. Impairment of contextual conditioned fear extinction after microinjection of alpha-1-adrenergic blocker prazosin into the medial prefrontal cortex. Behavioral Brain Research, 211:85-95, Do Monte, FH; Canteras, NS; Fernandes, D; Assreuy, J; Carobrez, AP. New perspectives in beta-adrenergic mediation of innate and learned fear response to predator odor. The Journal of Neuroscience, 28(49): ,

4 6. Canteras, NS; Kroon, JA; Do Monte, FH; Pavesi, E; Carobrez, AP. Sensing danger through the olfactory system: the role of the hypothalamic dorsal premammillary nucleus. Neuroscience and Biobehavioral Reviews, 32: , Santos Jr, JG; Blanco, MM; Do Monte, FH; Russi, MA; Lanziotti, VM; Leal, LK; Cunha, GM. Sedative and anticonvulsivant effects of hydroalcoholic extract of Equisetum arvense. Fitoterapia, 76: , Santos Jr, JG; Do Monte, FH; Blanco, MM; Lanziotti, VM; Maia, FD; Leal, LK. Cognitive enhancement in aged rats after chronic administration of Equisetum arvense L. with demonstrated antioxidant properties in vitro. Pharmacology Biochemistry and Behavior, 81: , Santos Jr, JG; Tabosa, A; Do Monte, FH; Blanco, MM; Freire, AO; Mello, LE. Electroacupuncture prevents cognitive deficits in pilocarpine-epileptic rats. Neuroscience Letters, 384: , Do Monte, FH; Santos Jr, JG; Russi, MA; Lanziotti, VM; Leal, LK; Cunha, GM. Antinociceptive and anti-inflammatory properties of the hydroalcoholic extract of stems from Equisetum arvense L. in mice. Pharmacological Research, 49: , Santos Jr, JG; Do Monte, FH; Russi, MA, Augustine, P, Lanziotti,VM. Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats. Brazilian Journal of Medical and Biological Research, 35: , ABSTRACTS IN SCIENTIFIC CONFERENCES (last 5 years) (* trainees under my supervision) 18. Quinones-Laracuente, K; Do Monte, FH; Vega-Medina, A. Quirk, GJ. Time dependent shifts in fear signaling recruits distinct layers of prelimbic cortex. 15 th Annual Molecular and Cellular Cognition Society meeting (MCCS), San Diego, Do Monte, FH; Minier-Toribio*, AM; Quirk, GJ. Projections from the paraventricular nucleus of the thalamus to the amygdala modulate cued food-seeking during reward omission. Gordon Research Conference on Amygdala in Health & Disease 2015, Easton, MA. 16. Quinones-Laracuente, K; Do Monte, FH; Quirk, GJ. Neural correlates of conditioned fear retrieval in the paraventricular thalamus. 23 rd Puerto Rico Neuroscience Conference 2014, Bayamon, PR. 15. Quinones-Laracuente, K; Do Monte, FH; Quirk, GJ. Neural correlates of conditioned fear retrieval in the paraventricular thalamus. 44 rd Annual Society for Neuroscience Meeting 2014, Washington, DC. 14. Do Monte, FH; Quirk, GJ. Optogenetic silencing of prelimbic inputs to paraventricular thalamus impairs long-term fear retrieval. 22 rd Puerto Rico Neuroscience Conference 2013, Ponce, PR. 13. Manzano-Nieves, G*; Do Monte, FH; Quirk, GJ. Extinguishing fear: revisiting the infralimbic cortex with an optogenetic approach. 43 rd Annual Society for Neuroscience Meeting, 2013, San Diego, CA. 12. Do Monte, FH; Quirk, GJ. Optogenetic silencing of prelimbic inputs to paraventricular thalamus impairs long-term fear retrieval. 43 rd Annual Society for Neuroscience Meeting, 2013, San Diego, CA. 11. Rosas-Vidal, LE*; Do Monte, FH; Rodriguez-Romaguera, J*; Quirk, GJ. Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit. 43 rd Annual Society for Neuroscience Meeting, 2013, San Diego, CA. 10. Martinez, FJ; Rodriguez-Romaguera, J*; Do Monte, FH; Quirk, GJ. Deep brain stimulation of the ventral striatum impairs extinction of morphine-induced conditioned place preference. 43 rd Annual Society for Neuroscience Meeting, 2013, San Diego, CA. 9. Do Monte, FH; Quirk, GJ. Optogenetic silencing of corticothalamic-amygdalar circuit impairs long-term fear retrieval. Gordon Research Conferences 2013, Amygdala in Health & Disease, Stonehill College, Easton, MA. 4

5 8. Do Monte, FH; Quirk, GJ. Post-training recruitment of the paraventricular thalamus into the circuit for retrieval of conditioned fear. 21 rst Puerto Rico Neuroscience Conference 2012, San Juan, PR. 7. Manzano-Nieves, G*; Do Monte, FH; Quirk, GJ. Extinguishing Fear: Revisiting the Infralimbic Cortex with an Optogenetic Approach. Annual Biomedical Research Conference for Minority Students 2012, San Jose, CA. 6. Do Monte, FH; Padilla-Coreano, N*; Sanchez-Ramos, AS*; Quirk, GJ. Midline thalamic nuclei are required for maintenance of remote fear memory. 8 th Forum of the Federation of European Neuroscience Societies (FENS 2012), Barcelona, Spain. 5. Rodriguez-Romaguera, J*; Do Monte, FH; Tanimura, Y; Quirk, GJ; Haber, SN. Convergence of medial and orbital prefrontal cortical fibersin the ventral striatum mediate DBS-enhancement of fear extinction. 51 st Annual meeting of the American College of Neuropsychopharmacology, ACNP 2012, Hollywood, Florida. 4. Do Monte, FH; Quirk, GJ. Post-training recruitment of the paraventricular thalamus into the circuit for retrieval of conditioned fear. 42 nd Annual Society for Neuroscience Meeting, 2012, New Orleans, LO. 3. Rodriguez-Romaguera, J*; Do Monte, FH; Tanimura, Y; Quirk, GJ; Haber, SN. Origins of striatal fibers mediating DBSenhancement of fear extinction. 42 nd Annual Society for Neuroscience Meeting, 2012, New Orleans, LO. 2. Rosa-Vidal, LE*; Guindín-Orama, MI; Do Monte, FH; Quirk, GJ. Infralimbic, but not prelimbic, BDNF is necessary and sufficient for fear extinction. 42 nd Annual Society for Neuroscience Meeting, 2012, New Orleans, LO. 1. Do Monte, FH; Padilla-Coreano, N*; Quirk, GJ. A time-dependent role of midline thalamic nuclei in the retrieval of fear memory. 20 th Puerto Rico Neuroscience Conference, 2012, San Juan, PR. INVITED SCIENTIFIC TALKS 12. Do Monte, FH. Temporal dynamics of memory retrieval. Division of Biological Sciences, University of California San Diego, San Diego, CA, Do Monte, FH. Temporal dynamics of memory retrieval. Department of Psychology, University of California Los Angeles, Los Angeles, CA, Do Monte, FH. Temporal dynamics of memory retrieval. Monell Chemical Sense Center, Philadelphia, PA, Do Monte, FH. Integrating fear and reward memories: focus on the paraventricular thalamus. 24 th Annual Puerto Rico Neuroscience Conference. San Juan, PR, Do Monte, FH. The paraventricular thalamus in the integration of reward and aversion. Gordon Research Conference. Amygdala in Health & Disease. Easton, MA, Do Monte, FH. Recruitment of corticothalamic-amygdalar circuits for retrieval of fear memory. Thalamus and Corticothalamic Interactions. Janelia Research Campus, Ashburn, VA, Do Monte, FH. Post-training reorganization of the fear retrieval circuit. 13 th Annual Molecular and Cellular Cognition Society meeting (MCCS), Washington, DC, Do Monte, FH. Midline thalamic nuclei in retrieval and maintenance of fear memory. First Federation of Latin-American and Caribbean Neuroscience Society Conference, Cancún, Mexico, Do Monte, FH. Deep brain stimulation (DBS) for obsessive compulsive disorder (OCD), 3 rd Annual Research Symposium, San Juan, PR, Do Monte, FH. The role of noradrenergic system in the modulation of fear memories. Department of Psychiatry, School of Medicine, University of Puerto Rico, San Juan, PR,

6 2. Do Monte, FH. Role of main olfactory system in the recognition of unconditioned vs. conditioned aversive odor cues. Brazilian Society of Experimental Biology Meeting, Águas de Lindóia, SP, Brazil, Do Monte, FH. Participation of beta-adrenergic receptors in the extinction of aversive memories: role of the medial prefrontal cortex. Latinamerican School of Neuroscience, IBRO, Montevideo, Uruguay, ADDITIONAL CONTRIBUTIONS TO THE FIELD 2015 present - Council member of Molecular and Cellular Cognition Society (MCCS) present External Reviewer The Danish Council for Independent Research in Medical Sciences present - Board member of Faculty of LANGUAGES English: Spanish: Portuguese: Understanding Fluent, Speaking Fluent, Writing Fluent, Reading Fluent Understanding Fluent, Speaking Fluent, Writing Fluent, Reading Fluent Understanding Fluent, Speaking Fluent, Writing Fluent, Reading Fluent 6