Center for Brain Biology & Behavior

Transcription

1 University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln DBER Speaker Series Discipline-Based Education Research Group Center for Brain Biology & Behavior Dennis L. Molfese University of Nebraska-Lincoln, dmolfese2@unl.edu Victoria J. Molfese University of Nebraska - Lincoln, vmolfese2@unl.edu Follow this and additional works at: Molfese, Dennis L. and Molfese, Victoria J., "Center for Brain Biology & Behavior" (2014). DBER Speaker Series This Presentation is brought to you for free and open access by the Discipline-Based Education Research Group at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in DBER Speaker Series by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln.

2 Center for Brain Biology & Behavior Dennis L. Molfese, Ph.D.! Mildred Francis Thompson Professor! Director: Center for Brain, Biology & Behavior (CB3)! Director: Big Ten/Ivy League/CIC Traumatic Brain Injury Research! Editor-In-Chief: Developmental Neuropsychology Victoria J. Molfese, Ph.D.! Chancellor Professor! Director: Early Development & Learning Laboratory! Department of Child Youth & Family Studies

3 UNL Athletics Complex Holland Computing Center Center for Brain Biology & Behavior Nebraska Athletic Performance Laboratory

4 Center for Brain Biology & Behavior CB3 Research Areas Human & Animal Models of TBI Neural Modeling Cognitive & Social Neuroscience Endocrine System Attention, Perception & Memory Vestibular/Balance, Biomechanics Genetics Cognition, Language & Performance Lifespan Development Therapeutic Interventions

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9 CB3 Unique Tools & Training fmri/dti/mri + ERP + Eye Tracking 12 High-Density EEG/ERP Labs 21 Behavior Science Labs Endocrine Lab Genetics Lab 3 Vestibular/Balance Labs 3 Eye Tracking Labs 2 Super Computing Labs 100 gbps Link - Big10/NIH/FITBIR Informatics System MEG (UNMC) Big10-Ivy League Concussion Questionnaire

10 Magnetic Resonance Imaging (MRI, fmri, DTI, SPECT) high density electrodes + eye tracker + Photogrammetry Siemens 3 Tesla 70 cm bore Structure Function HD ERP DTI

11 Child Testing

12 Endocrine Laboratory Douglas Granger, ASU Judy Burnfield, NAPL Dennis Molfese, CB3

13 Genetics Laboratory Identifying Genetic Risks & Factors that Mitigate Traumatic Brain Injury Few studies use pre vs post TBI testing to investigate genetic risk for impairment (Weaver, et al., 2012) Candidate genes: APOE Tau Neurotransmitter system genes Glutamate GABA Dopamine Serotonin

14 Feasibility of Using HD ERPs On/In the Field Resting State After Strenuous Exercise

15 Vestibular/Balance Lab Videonystagmography (VNG) Subjec)ve Visual Ver)cal Gait Tes)ng Rota)onal Chair Dr. Julie Honaker Ves)bulo- Ocular Reflex (VOR)

16 X2 Patch Accelerometer Investigation G-force Number Location (6 vectors) Frequency (e.g., days, months, seasons, teams) Time-link to game film Correlate with ERPs

17 Two-Back Memory Task Numbers Match No history of persistent headache (n=16) History of persistent headache (n=19) Match 2.5 na Same Mismatch.01 na Molfese et al., under review ms

18 Intervention For TBI 20-40% With TBI Experience Vision-Disorders Normal Visual World World Distorted by TBI Post-Trauma Vision Syndrome (PTVS) Visual Midline Shift Syndrome (VMSS)

19 Intervention For TBI Stimulus Without Prisms: Large areas of cortex recruited but fail to resolve discrepant AUDITORY & VISUAL input With Prisms: Eliminates disagreement between Visual & Auditory inputs, restricting processing to visual cortex Hudac, Kota & Molfese, 2011

20 Prisms: Eliminate conflict between Visual & Auditory inputs Reduce number of cortical regions needed to resolve discrepant AUDITORY & VISUAL input, returning visual processing to visual cortex

21 Current Major Initiatives: CTE: All former UNL Athletes Normative data, Longitudinal/Cross-sectional, Biomarkers for Risk & Recovery, Longterm outcomes, Intervention success.! NCAA-DoD: All Athletes across all sports Establish universal baseline measures to detect concussion and monitor recovery.! Longitudinal Concussion Study: Football, Soccer First year college players across years of play. Neuropsychology, symptoms, brain imaging.! TBI: Behavior, neurocognition, endocrine, genetics & brain imaging.!!

22 Model for Head Injury

23 Normal MODEL TBI First Presentation of Stimuli Second Presentation of stimuli Repeated presentation of stimuli

24 QUESTIONS?!! Dennis L. Molfese, Ph.D! 2014 The Board of Regents of the University of Nebraska. All rights reserved.