Paediatric HIV Drug Resistance 26th-International-Workshop-on-HIV-Drug-Resistance-programme [2].tiff
|
|
- Bernard Eaton
- 5 years ago
- Views:
Transcription
1 Paediatric HIV Drug Resistance 26th-International-Workshop-on-HIV-Drug-Resistance-programme [2].tiff Mo Archary King Edward VIII Hospital / UKZN Paediatric Infectious Diseases Unit
2 Overview State of Pediatric HIV Epidemic Pre-treatment HIV Drug resistance (HIVDR) Drivers of Paediatric HIVDR Acquired HIVDR First-line treatment responses First-line treatment HIVDR Second-line treatment HIVDR
3 Global PaediatricEpidemic Vast majority of HIVinfected children reside in the African region. Majority of children on cart reside in the African region
4 Rapid expansion of global access to Antiretroviral treatment including children/adolescents. Estimated 21.7 million people receiving ART globally, however only 50% of children access ART globally UNAIDS Estimate, 21 countries, 2015
5 Global PaediatricEpidemic -Successes 700, ,000 Number of new HIV infections among children in low- and middle-income countries, and 2015 target New HIV infections 500, , , , ,000-52% % ,000-90% UNAIDS report on the global AIDS epidemic Available at:
6 Projected impact on new child HIV infections by programmes to prevent mother-to-child transmission, 21 Global Plan priority countries in sub-saharan Africa, New HIV infections 350, , , , , ,000 50, coverage maintained ARV coverage scaled up to 90% Eliminate unmet need for family planning Reduce incidence by 50% Target UNAIDS 2015: ( ) UNAIDS report on the global AIDS epidemic Available at:
7 Some countries are doing better than others
8 What is EMTCT
9 Is this goal achievable? countries have attained the criteria
10 How far away in SA from achieving EMTCT
11
12 How is this relevant to a resistance talk?
13 Pre-treatment Resistance in children 30.8% had drug associated mutation T74S, L10V, T69N, E138G 6.8% - clinically relevant drug associated mutations Drug Resistance and Coreceptor Usage in HIV Type 1 Subtype C-Infected Children Initiating or Failing Highly Active Antiretroviral Therapy in South Africa Taryn N. Green et al AIDS RESEARCH AND HUMAN RETROVIRUSES Volume 28, Number 4,
14 Pre-treatment Resistance in children Jordan MR. HIV Drug resistance in African Infants and Young children newly diagnosed with HIV: A multi-country analysis; CID, 2017:65
15 What has changed? Few mothers on cart (short course single or dual maternal ART PMTCT regimen Infant prophylaxis single dose NVP at birth with erratic implementation Majority of mothers on cart either pre-conception or during delivery. Many mothers have had prior exposure to ART for PMTCT single or multiple ART regimens Infant prophylaxis given either NVP or NVP/AZT
16 National PaediatricPre-treatment surveillance HIV Drug Resistance report Geneva: WHO;2017 South African survey: Prevalence of HIVDR = 63.7% (95% CI %) NNRTI resistance = 62.7% (95% CI %) NRTI resistance = 13.9% (95% CI %)
17 Drivers of PaediatricPre-treatment resistance Frequency of adults with unsuppressed HIV VL (U=U) HIVDR in adults of child-bearing potential Infant prophylaxis regimens Implications for NNRTI Firstline Regimen in children
18 Post ART initiation -Early Cohort from Malawi: Virological failure occurred in 66% of children by 12 months HIV DR was detected in 44% - all had NNRTI mutations/ 12% NNRTI and NRTI mutations 41% - had a GSS <3 to their current first line regimen High level resistance to NVP (26%) High Failure rates on first line NNRTI regimens Huibers MHW, 2018; Journal of Antimicrobial Chemotherapy
19 Post ART initiation -Late Cohort from Benin, West Africa Median age 10 yrs (IQR 6-13)/ duration on therapy 5 years (IQR 3-7) Regimens: 76% NNRTI based regimen / 24% PI based regimen Resistance: 71% (NRTI mutation), 84% (NNRTI mutation), 65% (dual-class resistance) 4% PI resistance 25% had undetectable ARV concentrations Drivers of Acquired HIVDR Fofana, 2018; Journal of Antimicrobial Chemotherapy
20 Drivers of Acquired PaediatricHIVDR Interrupted drug supply Drug-drug interactions Failure to change dose with increasing weight Inadequate drug dosing Suboptimal Formulations Characteristics of an Ideal Paediatric Formulation Palatable Infrequent dosing Ease of administration (dispersible table) Fixed dose combination Limited side-effects Limited drug-drug interactions
21 Acquired HIV Drug Resistance Surveillance HIV Drug Resistance report Geneva: WHO;2017
22 Acquired HIVDR Protease Inhibitors Cohort from Western Cape, South Africa Median age 8.8 yrs (IQR )/ duration on therapy 6.9 years (IQR 5-9.9) Regimens: Failing a PI based regimen Resistance Outcomes at 2 years: 96.7% had a KIV VL < 400c/mL Nuttal J, 2018;SAMJ, 2018
23 Acquired HIVDR Protease Inhibitors Cohort from Western Cape, South Africa Median age 8.8 yrs (IQR )/ duration on therapy 6.9 years (IQR 5-9.9) Regimens: Failing a PI based regimen Resistance 3 rd line regimens following PI failure is associated with good outcomes Outcomes at 2 years: 96.7% had a HIV VL < 400c/mL Nuttal J, 2018;SAMJ, 2018
24 Conclusions The goal of the Paediatric ART program is the elimination of vertical transmission. These efforts maybe jeopardized by poor suppression rates and HIVDR in adults. Limited value of a NNRTI based-regimen in paediatrics. Efforts to attain the last 90 hampered by poor paediatric formulations? Impact of the Introduction of Dolutegravir
Scaling up priority HIV/AIDS interventions in the health sector
TOWARDS UNIVERSAL ACCESS? Scaling up priority HIV/AIDS interventions in the health sector Yves Souteyrand, WHO October 2011 Towards universal access targets UN General Assembly High level Meeting June
More informationWHO HIV Drug Resistance Strategy
WHO HIV Drug Resistance Strategy Boston, 27 February 2011 Background Global ART scale-up has been a remarkable achievement benefiting over 5.2 million individuals in resource limited settings Maintaining
More informationCurrent challenges of paediatric HIV care Experiences in Sub-Saharan Africa. Dr. Elizabeth Obimbo University of Nairobi Nairobi, Kenya
Current challenges of paediatric HIV care Experiences in Sub-Saharan Africa Dr. Elizabeth Obimbo University of Nairobi Nairobi, Kenya Current Challenges of Paediatric HIV Care What is Happening in the
More informationVirologic Outcomes of HIV-Infected Children Undergoing a Single-Class Drug Substitution from LPV/r- to EFV-Based cart: A retrospective cohort study.
Virologic Outcomes of HIV-Infected Children Undergoing a Single-Class Drug Substitution from LPV/r- to EFV-Based cart: A retrospective cohort study. K. Reichmuth 1, J. Nuttall, H. Rabie, B. Eley, H. Moultrie,
More information1. Africa Centre for Health and Population Studies 2. London School of Hygiene and Tropical Medicine 3. University College London
A systematic review of the effects of interrupted antiretroviral interventions for prevention of mother-to-child transmission of HIV on maternal disease progression and survival Naidu KK 1, Mori R 2, Newell
More informationImpact of ART resistance in sub Saharan Africa
Impact of ART resistance in sub Saharan Africa Elliot Raizes, MD Division of Global HIV/TB US Centers for Disease Control and Prevention ITREMA Resistance Training Workshop 24 October, 2018 Center for
More informationElimination of mother to child transmission of HIV: is the end really in sight? Lisa L. Abuogi, MD University of Colorado, Denver Dec 3, 2014
Elimination of mother to child transmission of HIV: is the end really in sight? Lisa L. Abuogi, MD University of Colorado, Denver Dec 3, 2014 Outline Background History of prevention of mother to child
More informationPRIORITIES FOR HIV/AIDS PROCUREMENT AND PRODUCT DEVELOPMENT
PRIORITIES FOR HIV/AIDS PROCUREMENT AND PRODUCT DEVELOPMENT Dr Chewe Luo MMed (Paeds), Mtrop Paed, PhD Senior Adviser and Team Leader Country Programme Scale up HIV Section Programme Division UNICEF, NY
More informationAchieving the 3 rd 90 in PEPFAR-supported countries:
Center for Global Health Achieving the 3 rd 90 in PEPFAR-supported countries: What will it take? Is it enough? Elliot Raizes, MD Division of Global HIV and TB Centers for Disease Control and Prevention
More informationHIV Drug Resistance South Africa, How to address the increasing need? 14 Apr. 2016
HIV Drug Resistance South Africa, How to address the increasing need? 14 Apr. 2016 1 Thus the HIV DR needs to focus on prevention and then diagnostic capacity to 1 st provide VL monitoring for early &
More informationhiv/aids Programme Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants
hiv/aids Programme Programmatic update Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants EXECUTIVE SUMMARY April 2012 EXECUTIVE SUMMARY Recent developments
More informationRajesh T. Gandhi, M.D.
HIV Treatment Guidelines: 2010 Rajesh T. Gandhi, M.D. Case 29 yo M with 8 weeks of cough and fever. Diagnosed with smear-positive pulmonary TB. HIV-1 antibody positive. CD4 count 361. HIV-1 RNA 23,000
More informationThe Global Fund s role as a strategic and responsible investor in HIV/AIDS: Paediatrics and PMTCT
The Global Fund s role as a strategic and responsible investor in HIV/AIDS: Paediatrics and PMTCT Peter McDermott Managing Director, CIFF 19 th Board meeting, Geneva 6 th May 2009 Investment Criteria Measurable...change
More informationUpdate on global guidelines. and emerging issues on perinatal HIV prevention. WHO 2013 Consolidated ARV Guidelines
WHO 2013 Consolidated ARV Guidelines Update on global guidelines H I V / A I D S DEPARTMENT and emerging issues on perinatal HIV prevention Children & HIV, St. Petersburg, Russia Sept 25-26, 2014 Dr. Nathan
More informationTowards universal access
Key messages Towards universal access Scaling up priority HIV/AIDS interventions in the health sector September 2009 Progress report Towards universal access provides a comprehensive global update on progress
More informationElimination of New HIV Infections among Children by 2015 and Keeping their Mothers Alive:
Elimination of New HIV Infections among Children by 2015 and Keeping their Mothers Alive: Rationale for the call to action, progress to date and dealing with realities Rene Ekpini, MD, MPH Senior Adviser,
More informationHIV DRUG RESISTANCE IN AFRICA
HIV DRUG RESISTANCE IN AFRICA Francis Ssali Joint Clinical Research Centre, Kampala Interest Meeting Mombasa May 10 th 2012 Scope 1. HIV-DR testing in Africa 2. The Epidemiology of HIV-DR in Africa 3.
More informationAll HIV+ Women on Antiretroviral Therapy Should Breastfeed in Both Low and High Resource Settings VOTE NO!!
All HIV+ Women on Antiretroviral Therapy Should Breastfeed in Both Low and High Resource Settings VOTE NO!! Lynne Mofenson MD Elizabeth Glaser Pediatric AIDS Foundation My Esteemed Opponent Will Likely
More informationThe new epidemic of drug resistant HIV-1
The new epidemic of drug resistant HIV-1 Gillian Hunt Centre for HIV and STI National Institute for Communicable Diseases ICREID March 2018 Status of the global HIV epidemic (2016) WHO Global Summary on
More informationGlobal Plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive
Global Plan towards the elimination of new HIV infections among children by 2015 and keeping their mothers alive DR. Nicholas Muraguri OGW, MD,MPH, MBA, PhD (c) Director, Global Plan Secretariat www.zero-hiv.org
More informationWorld Health Organization Strategy for HIV Drug Resistance Surveillance in Low- and Middle- Income Countries
World Health Organization Strategy for HIV Drug Resistance Surveillance in Low- and Middle- Income Countries Silvia Bertagnolio, MD World Health Organization, Geneva Lusaka, 6 May 2014 Key characteristics
More informationDEPARTMENT. Treatment Recommendations for. Pregnant and Breastfeeding Women: Critical Issues Consolidated ARV Guidelines. Dr.
2013 Consolidated ARV Guidelines H I V / A I D S Treatment Recommendations for DEPARTMENT Pregnant and Breastfeeding Women: Critical Issues Dr. Nathan Shaffer Objectives of Presentation obackground ooverview
More informationIntira Jeannie Collins, Ruth Goodall, Colette Smith and Kara Wools-Kaloustian for the CIPHER Duration of First-Line Project Team.
Switch to second-line ART in HIV-infected children: a Collaborative Initiative for Paediatric HIV Education & Research (CIPHER) Global Cohort Collaboration analysis Intira Jeannie Collins, Ruth Goodall,
More informationAnna Maria Geretti on behalf of co-authors Professor of Virology & Infectious Diseases, University of Liverpool Expert Scientist, Roche Pharma
Anna Maria Geretti on behalf of co-authors Professor of Virology & Infectious Diseases, University of Liverpool Expert Scientist, Roche Pharma Research & Early Discovery Funding: Wellcome Trust, National
More informationPAEDIATRIC HIV INFECTION. Dr Ashendri Pillay Paediatric Infectious Diseases Specialist
PAEDIATRIC HIV INFECTION Dr Ashendri Pillay Paediatric Infectious Diseases Specialist Paediatric HIV Infection Epidemiology Immuno-pathogenesis Antiretroviral therapy Transmission Diagnostics Clinical
More informationModelling the impact of HIVDR : the cost of inaction
WHO Considering programmatic implications of rising levels of HIV drug resistance: finalizing the Global Action Plan Webinars 12 13 Dec 2016 Modelling the impact of HIVDR : the cost of inaction Andrew
More informationThe elimination equation: understanding the path to an AIDS-free generation
The elimination equation: understanding the path to an AIDS-free generation James McIntyre Anova Health Institute & School of Public Health & Family Medicine, University of Cape Town Elimination of perinatal
More informationSouth African goals and national policy
Connecting the dots for EMTCT A Decade of PMTCT South Africa has been one of the counties in sub-saharan Africa to be hard hit by the HIV virus. Despite this, the country did not implement its PMTCT programme
More informationObstetrics and HIV An Update. Jennifer Van Horn MD University of Utah
Obstetrics and HIV An Update Jennifer Van Horn MD University of Utah Obstetrics and HIV Perinatal transmission Testing Antiretroviral therapy Antepartum management Intrapartum management Postpartum management
More informationRationalization of the Pediatric Antiretroviral Formulary to Optimize Pediatric Antiretroviral Treatment in Malawi
Rationalization of the Pediatric Antiretroviral Formulary to Optimize Pediatric Antiretroviral Treatment in Malawi Presented by: Nandita Sugandhi M.D. 6 th International Workshop on HIV Pediatrics July
More informationProgram to control HIV/AIDS
90-90-90 Program to control HIV/AIDS Hamid Sharifi Associate Professor in Epidemiology [sharifihami@gmail.com] 1 Targets for ending the AIDS epidemic 2 New HIV infections in low- and middle-income countries,
More informationPediatric Antiretroviral Therapy
Update on Pediatric Antiretroviral Therapy Lynne M. Mofenson, M.D. Pediatric, Adolescent and Maternal AIDS Branch National Institute of Child Health and Human Development National Institutes of Health
More informationYoung Mothers: From pregnancy to early motherhood in adolescents with HIV
Young Mothers: From pregnancy to early motherhood in adolescents with HIV Lisa L. Abuogi, MD, MSc Assistant Professor University of Colorado, Denver 8 th HIV and Women Workshop March 2, 2018 Boston, MA
More informationHIV DRUG RESISTANCE AND STEWARDSHIP 3 RD LINE PROGRAMME
HIV DRUG RESISTANCE AND STEWARDSHIP 3 RD LINE PROGRAMME SOUTHERN AFRICAN HIV CLINICIANS SOCIETY CONFERENCE - 2014 26 SEPTEMBER 2014 Khadija Jamaloodien Affordable Medicines ANTIMICROBIAL STEWARDSHIP The
More information2nd line failure, provincial evaluation process for 3rd line therapy, 3rd line treatment options James Nuttall
2nd line failure, provincial evaluation process for 3rd line therapy, 3rd line treatment options James Nuttall Paediatric Infectious Diseases Unit, Red Cross War Memorial Children s Hospital & University
More informationPEPFAR Priorities & HIV Drug Resistance: Where are we heading and what has us worried
PEPFAR Priorities & HIV Drug Resistance: Where are we heading and what has us worried Elliot Raizes, MD Division of Global HIV & TB CDC Center for Global Health May 3, 2016 Center for Global Health Division
More informationART for prevention the task ahead
ART for prevention the task ahead Dr Teguest Guerma WHO/HQS WHO's role and vision Status of the epidemic Overview Progress and challenges in treatment and prevention scale up ART for prevention Questions
More informationWHO recommendations for HIVDR surveillance and their application in Latin America and the Caribbean
WHO recommendations for HIVDR surveillance and their application in Latin America and the Caribbean Giovanni Ravasi Pan-American Health Organization, Brazil ravasigi@paho.org Regional Consultation on HIV
More informationNew Directions on WHO ARV Guidelines 2018
New Directions on WHO ARV Guidelines 2018 Elaine Abrams Co-chair WHO Guidelines Development Group ICAP at Columbia University, New York Martina Penazzato Paediatric lead for the HIV Department World Health
More informationHIV and Paediatrics in Central Europe
2nd Central and Eastern European Meeting on Viral Hepatitis and Co-Infection with HIV HIV and Paediatrics in Central Europe Mariana Mărdărescu MD PhD Consultant in Infectious Diseases Senior Doctor in
More informationTOWARDS ELIMINATION OF MOTHER TO CHILD TRANSMISSION OF HIV
TOWARDS ELIMINATION OF MOTHER TO CHILD TRANSMISSION OF HIV Gladwel Muthoni KPA Conference 24 th April, 2018 OUTLINE Burden of HIV in PMTCT Mechanism and timing of Mother to Child Transmission (MTCT) Four
More informationPaediatric Infectious Diseases Unit, Red Cross War Memorial Children s Hospital & University of Cape Town
A Public Sector Antiretroviral Treatment Programme for Treatment-Experienced Children and Adolescents in the Western Cape Province of South Africa Using Darunavir/Ritonavir-, Raltegravir- and Etravirine-Containing
More informationInfertility Treatment and HIV
Infertility Treatment and HIV Infertility Treatment by IVF Or Intra-cytoplasmic Sperm Injections (ICSC) In Chronic HIV-1 Sero- discordant Couples (Poster 670) Retrospective study of outcome of IVF or ICSC
More informationDECLINE IN POSITIVITY RATES AMONG HIV-EXPOSED INFANTS WITH CHANGES IN PMTCT ARV REGIMENS IN NIGERIA: EVIDENCE FROM 7 YEARS OF FIELD IMPLEMENTATION
Abst#_O_01 DECLINE IN POSITIVITY RATES AMONG HIV-EXPOSED INFANTS WITH CHANGES IN PMTCT ARV REGIMENS IN NIGERIA: EVIDENCE FROM 7 YEARS OF FIELD IMPLEMENTATION Hadiza Khamofu, 1 Edward Oladele, 1 Uche Ralph-Opara,
More informationMother to Child HIV Transmission
Koff WC. NEJM 2010;363:e7 Mother to Child HIV Transmission Why We Still Need New Prevention Modalities Lynne M. Mofenson, M.D. Maternal and Pediatric Infectious Disease Branch Eunice Kennedy Shriver National
More informationLinkages between Sexual and Reproductive Health and HIV
Linkages between Sexual and Reproductive Health and HIV Manjula Lusti-Narasimhan Department of Reproductive Health and Research World Health Organization The HIV pandemic 25 years 1981 2006 Rationale for
More informationART TREATMENT PROGRAMME 2004
Presentation title ART TREATMENT PROGRAMME 2004 Cabinet decision in 29 th November 2003 Initial sites were hospital based, required central review National Costing Model of HIV/AIDS Treatment 2010 Cost
More informationUganda. HIV Country Pro le: Maternal mortality per live births (2015) Health expenditure, total (% of GDP) (2015)
WHO/CDS/HIV/18.50 Demographic and socioeconomic data Uganda HIV Country Pro le: 2017 42.9 million Total population (2017) 1 820 US$ GNI per capita, PPP (2017) 343 Maternal mortality per 100 000 live births
More informationEvolving Realities of HIV Treatment in Resource-limited Settings
Evolving Realities of HIV Treatment in Resource-limited Settings Papa Salif Sow MD, MSc Department of Infectious Diseases University of Dakar, Senegal Introduction: ARV access in RLS Scale-up of ART has
More informationCote D'Ivoire. HIV Country Pro le: Maternal mortality per live births (2015) Health expenditure, total (% of GDP) (2015)
WHO/CDS/HIV/18.50 Demographic and socioeconomic data Cote D'Ivoire HIV Country Pro le: 2017 24.3 million Total population (2017) 3 820 US$ GNI per capita, PPP (2017) 645 Maternal mortality per 100 000
More informationTunisian recommendations on ART : process and results
Second Arab Congress of Clinical Microbiology and Infectious Diseases May 24-26, 2012. Tunisian recommendations on ART : process and results M. BEN MAMOU UNAIDS Email: BenmamouM@unaids.org M. CHAKROUN
More informationA smart and doable investment
90-90-90 A smart and doable investment As of December 2013 Adults and children living with HIV Adults and children newly infected Adult & child deaths due to AIDS 35.0 million [33.2 million 37.2 million]
More informationInfant feeding in the ARV era. Department of Obstetrics and Gynaecology Faculty of Health Sciences and Tygerberg Hospital
Infant feeding in the ARV era Gerhard Theron Gerhard Theron Department of Obstetrics and Gynaecology Faculty of Health Sciences and Tygerberg Hospital Global HIV infections: 2007 12 countries account for
More informationPediatric HIV Update NORTHWEST AIDS EDUCATION AND TRAINING CENTER
NORTHWEST AIDS EDUCATION AND TRAINING CENTER Pediatric HIV Update Christian B. Ramers, MD, MPH Assistant Medical Director, Family Health Centers of San Diego HIV/HCV Distance Education Specialist - NWAETC,
More informationHIV and AIDS Estimates
and AIDS Estimates Adults and children living with Adults aged 15 and over living with Women aged 15 and over living with Men aged 15 and over living with 1 300 000 [1 200 000-1 500 000] 1 200 000 [1 100
More informationFactors associated with unsuppressed viral load in HIV-1 infected patients on 1 st line antiretroviral therapy in South Africa
Factors associated with unsuppressed viral load in HIV-1 infected patients on 1 st line antiretroviral therapy in South Africa Dvora Joseph Davey 1, 2, PhD, Zulfa Abrahams 2, PhD 1 BroadReach, South Africa
More informationOverview of Paediatric HIV Treatment and Prevention: From Then to Now. Peter Mugyenyi, Joint Clinical Research Centre Kampala, Uganda
Overview of Paediatric HIV Treatment and Prevention: From Then to Now Peter Mugyenyi, Joint Clinical Research Centre Kampala, Uganda Outline The plight of HIV infected children (1980s and 1990s) Trends
More informationCare of HIV Infected People
Care of HIV Infected People Patrick Ndase, MD, MPH MTN Annual Meeting Marriott Key Bridge, Arlington, VA April 21-23, 2008 Why Care for HIV infected in such a meeting? Site Core Community Why Care for
More informationEarly Antiretroviral Therapy in Newborns: Opportunities and Challenges. Ellen Gould Chadwick MD Northwestern University Feinberg School of Medicine
Early Antiretroviral Therapy in Newborns: Opportunities and Challenges Ellen Gould Chadwick MD Northwestern University Feinberg School of Medicine Conflict of Interest Disclosures for Ellen Chadwick MD
More informationMonitoring of HIV positive mothers and HIV exposed infants in context of Option B+ implementation
Monitoring of HIV positive mothers and HIV exposed infants in context of Option B+ implementation Kenya Outline of the presentation Background: Kenya in Context PMTCT Program progress 2012-2015 Option
More informationCopyright 2011 Joint United Nations Programme on HIV/AIDS (UNAIDS) All rights reserved ISBN
UNAIDS DATA TABLES 2011 Copyright 2011 Joint United Nations Programme on HIV/AIDS (UNAIDS) All rights reserved ISBN 978-92-9173-945-5 UNAIDS / JC2225E The designations employed and the presentation of
More informationPaediatric HIV Resistance. Mohern Archary Paediatric Infectious Diseases Unit King Edward VIII Hospital / University of KwaZulu Natal
Paediatric HIV Resistance Mohern Archary Paediatric Infectious Diseases Unit King Edward VIII Hospital / University of KwaZulu Natal Preliminary evaluation of referrals for Antiretroviral Therapy (ART)
More informationClinical skills building - HIV drug resistance
Clinical skills building - HIV drug resistance Richard Lessells Clinical case 44-year old HIV-positive male HIV diagnosis 2010 Pre-treatment CD4+ count not known Initiated first-line ART (TDF/FTC/EFV)
More informationAssessment of G8 Commitments on Maternal, Newborn and Child Health
Assessment of G8 Commitments on Maternal, Newborn and Child Health Robin Lennox Researcher, G8 Research Group June 13, 2010 In January 2010, Canadian prime minister Stephen Harper announced that maternal,
More informationHIV and Malaria Interactions
HIV and Malaria Interactions Dr. Moses R. Kamya Chair and Professor of Medicine Makerere University College of Health Sciences Kampala, Uganda INTEREST, Mombasa, Kenya 8 th -11 th May 2012 1 Outline Brief
More informationHIV Drug Resistance Regional Update Eastern & Southern African Region
HIV Drug Resistance Regional Update Eastern & Southern African Region Dr R Banda, IST/ESA Dr F Cham, IST/ESA Dr RG Vaz, WHO AFRO HIVDR Steering Committee Meeting, Geneva 11-12 November 2009 1 Presentation
More informationHIV replication and selection of resistance: basic principles
HIV replication and selection of resistance: basic principles 26th International HIV Drug Resistance and Treatment Strategies Workshop Douglas Richman 6 November 2017 CLINICAL DATA DURING SIXTEEN WEEKS
More informationHIV Drug Resistance among Adolescents and Young Adults Failing HIV Therapy in Zimbabwe
HIV Drug Resistance among Adolescents and Young Adults Failing HIV Therapy in Zimbabwe V Kouamou 1, J Manasa 1, D Katzenstein 1, A McGregor 1, CE Ndhlovu 1 & AT Makadzange 1. 1 University of Zimbabwe Introduction
More informationMATERNAL AND CHILD SURVIVAL MEMORANDUM OF CONCERN
MATERNAL AND CHILD SURVIVAL MEMORANDUM OF CONCERN We, the undersigned would like to raise our urgent concerns about the quality and coverage of prevention of mother-to-child transmission of HIV (PMTCT)
More informationHIV Vaccine Clinical Trials at CIDRZ
HIV Vaccine Clinical Trials at CIDRZ Developing a Safe and Effective Vaccine for Prevention of HIV Infections Globally Christine Namakobo Senior Research Nurse Matero Clinical Research Site State of Global
More informationTreat All : From Policy to Action - What will it take?
Strategy Finance Integration Cascade of services People centred Political Will Treat All : From Policy to Action - What will it take? Thursday, 9 June, 13.00 14.30 Conference Room 11, United Nations Questions
More informationSafe Generations Harnessing Implementation Science to Assess the Impact of Option B+ in Swaziland
Safe Generations Harnessing Implementation Science to Assess the Impact of Option B+ in Swaziland Background and Rationale In 2015, the World Health Organization (WHO) endorsed universal treatment for
More informationTRANSITION TO NEW ANTIRETROVIRALS IN HIV PROGRAMMES
POLICY BRIEF HIV TREATMENT TRANSITION TO NEW ANTIRETROVIRALS IN HIV PROGRAMMES JULY 2017 WHO This policy brief provides advice on a phased approach to transitioning to new WHO-recommended HIV treatment
More informationHIV Clinical Management: Antiretroviral Therapy and Drug Resistance
HIV Clinical Management: Antiretroviral Therapy and Drug Resistance Judith S. Currier, MD, MSc Professor of Medicine University of California, Los Angeles Disclosures: Research Grant from Theratechnologies
More informationTransmitted and Acquired HIV Drug Resistance in Latin America. Dr. Luis Enrique Soto Ramírez MEXICO
Transmitted and Acquired HIV Drug Resistance in Latin America Dr. Luis Enrique Soto Ramírez MEXICO Disclosure Advisory boards and speaker for: Abbvie GSK/ViiV MSD Roche Diagnostics OVERVIEW The development
More informationChildren and AIDS Fourth Stocktaking Report 2009
Children and AIDS Fourth Stocktaking Report 2009 The The Fourth Fourth Stocktaking Stocktaking Report, Report, produced produced by by UNICEF, UNICEF, in in partnership partnership with with UNAIDS, UNAIDS,
More informationHIV and AIDS Estimates
and AIDS Estimates Adults and children living with Adults aged 15 and over living with Women aged 15 and over living with Men aged 15 and over living with 200 000 [180 000-210 000] 190 000 [170 000-200
More informationMedical Challenges of HIV/AIDS pandemic: The WHO perspective. SOLTHIS HIV Forum
Medical Challenges of HIV/AIDS pandemic: The WHO perspective SOLTHIS HIV Forum Marco Vitoria HIV/AIDS Department World Health Organization September 2013 Topic 2002 2003 2006 2010 2013 When to start 1
More informationOverview of 2013 WHO consolidated ARV guidelines and update plans. Marco Vitoria HIV/AIDS Department WHO Geneva September 2014
AMDS ANNUAL STAKEHOLDERS AND PARTNERS MEETING Overview of 2013 WHO consolidated ARV guidelines and update plans Marco Vitoria HIV/AIDS Department WHO Geneva September 2014 AMDS ANNUAL STAKEHOLDERS AND
More informationHIV in Zambia MINISTRY OF HEALTH. Dr Albert Mwango, BScHB, MBChB, MPH National Antiretroviral Program Coordinator,
HIV in Zambia Dr Albert Mwango, BScHB, MBChB, MPH National Antiretroviral Program Coordinator, MINISTRY OF HEALTH 8th INTEREST WORKSHOP Intercontinental Hotel, Lusaka May 5 th -9 th, 2013 Background Clinical
More informationSexual and Reproductive Health and HIV. Dr. Rita Kabra Training course in Sexual and Reproductive Health Research Geneva 2012
Sexual and Reproductive Health and HIV Dr. Rita Kabra Training course in Sexual and Reproductive Health Research Geneva 2012 Global estimates of HIV-(2009) People living with HIV 33.3 million [31.4 35.3
More informationExisting and most needed paediatric ARV formulations
Existing and most needed paediatric ARV formulations Martina Penazzato Paediatric HIV advisor WHO HIV Department, Geneva Mach 7th 2016 Paediatric coverage still lags behind 45 40 35 30 25 20 15 10 5 0
More informationPeter Elyanu 1, Addy Kekitiinwa 2,Rousha Li 1, Mary Paul 3, LY Hwang 1
OUTCOMES OF HIV EXPOSED INFANTS BEFORE AND AFTER IMPLEMENTING OPTION B+ PMTCT GUIDELINE IN KAMPALA,UGANDA: A RETROSPECTIVE COHORT STUDY. Peter Elyanu 1, Addy Kekitiinwa 2,Rousha Li 1, Mary Paul 3, LY Hwang
More informationPediatric Antiretroviral Resistance Challenges
Pediatric Antiretroviral Resistance Challenges Thanyawee Puthanakit, MD The HIVNAT, Thai Red Cross AIDS research Center The Research Institute for Health Science, Chiang Mai University Outline The burden
More informationChallenges of HIV drug resistance in resource-limited settings
Challenges of HIV drug resistance in resource-limited settings Marie-Louise Newell Professor of Global Health Faculty of Medicine and Faculty of Social and Human Sciences, University of Southampton, UK
More informationAdvancing Treatment 2.0: Progress on the 2013 Consolidated Guidelines What s new
Advancing Treatment 2.0: Progress on the 2013 Consolidated Guidelines What s new H I V / A I D S D e p a r t m e n t WHO HQ Meg Doherty, MD, MPH, PhD Coordinator Treatment and Care November 5, 2012 1 Overview
More informationImpact of South Africa s PMTCT Programs on Perinatal HIV Transmission: Results of the 1st Year Implementing 2010 WHO Recommended Guidelines
Impact of South Africa s PMTCT Programs on Perinatal HIV Transmission: Results of the 1st Year Implementing 2010 WHO Recommended Guidelines Thu-Ha Dinh, MD., MS., US CDC/GAP Ameena Goga, MD., MS., MRC/HSRU,
More informationPaediatrics and adolescents
Paediatrics and adolescents SAMU SUMMARIES January 2018 samumsf.org Objectives of this Presentation To describe epidemiology the global response to HIV in both populations: children and adolescents To
More informationCare and Treatment of Children and Adolescents with HIV - The Barbados Experience.
Care and Treatment of Children and Adolescents with HIV - The Barbados Experience. M. Anne St John Consultant, Department of Paediatrics Queen Elizabeth Hospital, Barbados Hon Professor, Child Health,
More informationBotswana. HIV Country Profile: Health expenditure, total (% of GDP) (2016) Total fertility rate (births per woman) ( )
WHO/CDS/HIV/18.5 Demographic and socioeconomic data Botswana HIV Country Profile: 217 2.3 million Total population (217) 16 99 US$ GNI per capita, PPP (217) World Bank 129 Maternal mortality per 1 live
More informationThe Contribution of Family Planning towards the Prevention of HIV Mother-to-Child Transmission (PMTCT) in Uganda
The Contribution of Family Planning towards the Prevention of HIV Mother-to-Child Transmission (PMTCT) in Uganda Wolfgang Hladik CDC Uganda The findings and conclusions in this presentation are those of
More informationModule 2: Integration of HIV Rapid Testing in HIV Prevention and Treatment Programs
Module 2: Integration of HIV Rapid Testing in HIV Prevention and Treatment Programs Purpose Pre-requisite Modules Module Time Learning Objectives To provide the participants with the basic concepts of
More informationConcept note. 1. Background and rationale
Concept note Inter-Country Workshops for Strengthening Regional and National Human Capacity to Accelerate Scaling up of National PMTCT and Paediatric Care, Support and Treatment Programmes TOWARDS UNIVERSAL
More informationReverse transcriptase and protease inhibitor resistant mutations in art treatment naïve and treated hiv-1 infected children in India A Short Review
pissn 2349-2910 eissn 2395-0684 REVIEW Reverse transcriptase and protease inhibitor resistant mutations in art treatment naïve and treated hiv-1 infected children in India A Short Review Dinesh Bure, Department
More informationSocio-Demographic Factors associated with Success of Antiretroviral Treatment among HIV Patients in Tanzania
Socio-Demographic Factors associated with Success of Antiretroviral Treatment among HIV Patients in Tanzania Dr. Fausta Franklin Mosha (MD, MSc, MSc, PHD) Ministry of Health and Social Welfare 22 nd October
More informationJames Nuttall Paediatric Infectious Diseases Unit Red Cross Children s Hospital
James Nuttall Paediatric Infectious Diseases Unit Red Cross Children s Hospital Paediatric HIV Infection Symposium, August 21, 2010, Red Cross Children s Hospital Overview of talk The 2010 paediatric guidelines
More informationPreliminary Outcomes of the PMTCT Option B+ programme in Thyolo District, Malawi
Preliminary Outcomes of the PMTCT Option B+ programme in Thyolo District, Malawi Spencer Nundwe 1, Oren Jalon 2, Reinaldo Ortuno 2, Carol Metcalf 3, Sarah Daho 1, Helen Bygrave 3, Michael Murowa 4, Kingsley
More informationWhat's new in the WHO ART guidelines How did markets react?
WHO 2013 ARV Guidelines What's new in the WHO ART guidelines How did markets react? Dr. J. Perriëns Coordinator, HIV Technology and Commodities HIV department, WHO, Geneva When to start in adults Starting
More informationImproving accessibility to antiretroviral drugs: A south-south collaboration
Improving accessibility to antiretroviral drugs: A south-south collaboration Jaideep A Gogtay MD Cipla Ltd Mumbai jgogtay@cipla.com Adults and children estimated to be living with HIV at the end of 2000
More information