Selvakumar Subbian. PROFESSIONAL EMPLOYMENT Present Position

Transcription

1 Selvakumar Subbian 251 Branch Brook Drive, Belleville, New Jersey Tel: ; Web: PROFESSIONAL EMPLOYMENT Present Position Assistant Professor 09/2013-Present Public Health Research Institute (PHRI) Center, Department of Medicine, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, New Jersey. Previous Academic Appointment Research Teaching Specialist 11/ /2013 Public Health Research Institute,Department of Medicine at University of Medicine and Dentistry of New Jersey, Newark, New Jersey. Research Assistant 04/ /2003 Department of Immunology, Tuberculosis Research Center (Indian Council for Medical Research), Chennai, India. Lecturer 02/ /2003 Department of Molecular Biology Bioinformatics, Punjab Technical University, Chennai, India EDUCATION Ph.D (Basic medical sciences) 04/2003 The Tamilnadu Dr. MGR Medical University, Chennai, India Dissertation: Regulation of gene expression in mycobacteria: Regulation of a highly inducible acetamidase genes of Mycobacterium smegmatis Advisor: Dr. Sujatha Narayanan, Dept. of Immunology, Tuberculosis Research Center, Chennai, India. Master of Science (MSc-Biomedical Genetics) 05/1995 The University of Madras, Chennai, India Thesis: Chromosomal abnormalities in congenital cataract Bachelor of Science (BSc-Biochemistry) 04/1993 Bharathiar University, Coimbatore, India Postgraduate Training: Rutgers University, Newark, New Jersey 11/ /2013 Public Health Research Institute (PHRI) at Department of Medicine Research Area: Host-pathogen interactions in tuberculosis; Adjunctive immune-modulatory therapy for tuberculosis. Advisor: Dr. Gilla Kaplan Texas A&M System Health Science Center (TAMHSC), College station, Texas. Page 1 of 11

2 Department of Microbial and Molecular Pathogenesis 11/ /2008 Research Area: Identification and characterization of mycobacterial virulence determinants. Advisor: Dr. Jeffrey D. Cirillo University of Nebraska at Lincoln, Lincoln, Nebraska 05/ /2005 Department of Veterinary and Basic Medical Sciences, Research Area: Mycobacterial pathogenesis: Host entry mechanisms of pathogenic mycobacteria. Advisor: Dr. Jeffrey D. Cirillo GRANT SUPPORT A. Ongoing Research Support R01 AI Shi, Lanbo and Subbian, Selvakumar (MPI) 06/06/ /05/2022 Title: The Warburg effect and host immune response in tuberculosis. Description: This project investigates the impact of host cell metabolic changes on their immune functions during active and latent tuberculosis. OPP Subbian, Selvakumar (PI) 09/02/ /01/2021 Bill and Melinda Gates Foundation Title: Impact of host directed therapy on latent Mtb infection and reactivation. Description: This project examines to test the efficacy of host directed therapeutics on sterilizing Mtb during latent infection and preventing reactivation. OPP Siegal, Alex (PI) 04/01/ /30/2018 Bill and Melinda Gates Foundation Title: Quantitative assessment of the tipping point in Mycobacterium tuberculosismacrophage infection. Description: This project examines phenotypically divergent, pathogenic Mtb populations for their ability to cause infection/disease in a rabbit model of pulmonary tuberculosis. R03 AI Rodriguez G Marcela (PI) 06/14/ /31/2018 NIH/NIAID Title: Defining the iron environment of M. tuberculosis granulomas Description: The major goals of this project is to examine iron metabolism related gene expression, cellular, bacteriological and iron content of TB granulomas. B. Completed R21 AI Subbian, Selvakumar (PI) 02/01/ /31/2017 NIH/NIAID Title: Adjunctive immune modulation to improve TB treatment Description: This application explores the potential of host-directed, phosphodiesterase inhibition therapy as adjunct to antibiotics in improving tuberculosis treatment. R03 AI Subbian, Selvakumar (PI) 06/01/ /31/2017 NIH/NIAID Title: Impact of iron supplementation on the latency and reactivation of tuberculosis Description: This application proposes to study the effect of iron-supplementation therapy on the establishment and reactivation of latent tuberculosis. Page 2 of 11

3 PC5316 Subbian, Selvakumar (PI) 04/01/ /31/2017 New Jersey Health Foundation Title: Effect of BCG vaccination on the innate response to Mycobacterium tuberculosis infection in infants Description: This project explores the innate immune response changes in the macrophages of BCG-vaccinated/unvaccinated infants in response to pathogenic Mycobacterium tuberculosis infection. Inspiration grant Subbian, Selvakumar (PI) 07/ /2015 Rutgers Health Foundation Title: Adjunctive PDE4 inhibition therapy for tuberculosis Description: This project to test the proof-of-concept for the usefulness of a PDE4 inhibitor as adjunctive therapy for tuberculosis. BMGF grant Fallows, Dorothy (PI) 06/ /2015 Title: The rabbit model as a platform to evaluate TB vaccines Description: This proposal examine a rabbit model of pulmonary Mtb infection to evaluate the efficacy of TB vaccines. R01HL Bader, Joel (PI) 09/ /2014 NIH/NHLB Title: A multidisciplinary approach to understanding TB latency and reactivation Description: The goal of this project is to determine the immunological correlates of latent and active TB using informatics and animal models. R01AI Russell, David (PI) 04/ /2013 NIH/NIAID Title: Environmental cues and responses in tuberculosis Description: This application investigates the intracellular niches of Mtb persistence in the lung granulomas of animal models and TB patients HONORS and AWARDS 1. Young Investigator Award. Theobald Smith Society, a body of American Society for Microbiology (ASM), USA. June Invited guest speaker at the Keystone Symposium on Novel Therapeutic Approaches to Tuberculosis (C7-2014) at Keystone, Colorado. March 31-April 4 th, Best poster award for Differential Activation of Early Innate Immunity Predicts the Outcome of Mycobacterium tuberculosis infection in Rabbit Lungs at the symposium on Innate Immune Mechanisms Controlling Inflammation and Infection New Jersey Medical School at University of Medicine and Dentistry of New Jersey-School of Medicine, Newark, New Jersey, March Awarded second prize for the poster, EphA2-deficient mice display altered granuloma morphology and lung immune cell composition following tuberculosis infection at Molecular Basis of Infectious Diseases Retreat Texas A&M Health Science Center, Houston, Texas. March Travel award from National Institute for Allergy and Infectious Diseases (NIAID)/NIH to present Illuminating Reactive Oxygen and Nitrogen Species Resistance Mechanisms through Analysis of Bioluminescence-like Genes in Mycobacteria to present at the Keystone symposium on Tuberculosis: From Lab Research to Field Trials. Jan Page 3 of 11

4 6. Junior and Senior Research Fellowship for PhD from the Council for Scientific and Industrial Research, India. Jan Jan Qualified National Level Eligibility Test for Research and Lectureship from the Council for Scientific and Industrial Research, India. Jan University-level second rank (BSc Biochemistry), Bharathiar University, Coimbatore, India. April Silver medal for academic proficiency (BSc Biochemistry), Bharathiar University, Coimbatore, India. April Membership in Professional Societies American Society for Microbiology (ASM) Member and International minority student mentor New York Academy of Sciences (NYAS) 2003-Present 2011-Present Service on Major Committees A. NIH grant review panel member 2013 B. Institutional Animal Care and Use Committee (IACUC), Rutgers University Present C. Institutional Biosafety Committee (IBC), Rutgers University 2016-Present D. Associate member, Graduate Studies in Biomedical Sciences, Rutgers University Present Editorial Boards 1). Nature Scientific Reports, ). PLOS ONE, ). British Journal of Applied Science and Technology (BJAST), ). Journal of Global Infectious Diseases (JGID), AdHoc Reviewer 1). Proceedings of the National Academy of Sciences (PNAS), ). American Journal of Respiratory and Critical Care Medicine (AJRCCM), ). Cell Host Microbe, ). British Journal of Pharmacology, ). Biochemica Biophysica Acta, ). EBioMedicine, ). Nature Scientific Reports, ). PLOS ONE, ). Journal of Interferon and Cytokine Research (JICR), ). Journal of Immunology Research, ). Immunobiology, ). Journal of Global Infectious Diseases (JGID), ). British Journal of Applied Science and Technology (BJAST), PUBLICATIONS: A. Refereed Original Article in Journal (35 articles since 2000): 1. Kurthkoti K, Amin H, Marakalala MJ, Ghanny S, Subbian S, Sakatos A, Livny J, Fortune SM, Berney M, Rodriguez GM. The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Page 4 of 11

5 Granulomas. MBio Aug 15;8(4). pii: e doi: /mBio PMID: Guerrini V, Subbian S, Santucci P, Canaan S, Gennaro ML, Pozzi G. Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage. PLoS One Dec 13;11(12):e doi: /journal.pone PubMed PMID: ; PubMed Central PMCID: PMC Tasker C, Subbian S, Gao P, Couret J, Levine C, Ghanny S, Soteropoulos P, Zhao X, Landau N, Lu W, Chang TL. IFN-ε protects primary macrophages against HIV infection. JCI Insight Dec 8;1(20):e PubMed PMID: ; PubMed Central PMCID: PMC Dehnad A, Ravindran R, Subbian S*, Khan IH. Development of immune-biomarkers of pulmonary tuberculosis in a rabbit model. Tuberculosis (Edinb) Dec;101:1-7.doi: /j.tube PubMed PMID: (*Communication author) 5. Unissa AN, Subbian S, Hanna LE, Selvakumar N. Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis. Infect Genet Evol Nov;45: doi: /j.meegid PMID: Subbian S*, Koo MS, Tsenova L, Khetani V, Zeldis JB, Fallows D, Kaplan G. Pharmacologic Inhibition of Host Phosphodiesterase-4 Improves Isoniazid-Mediated Clearance of Mycobacterium tuberculosis. Front Immunol Jun 17;7:238. doi: /fimmu ecollection PubMed PMID: ; PubMed Central PMCID: PMC (*Communication author) 7. Shi L, Eugenin EA, Subbian S*. Immunometabolism in Tuberculosis. Front Immunol.2016 Apr 21;7:150. doi: /fimmu ecollection Review. PubMed PMID: ; PubMed Central PMCID: PMC (*Communication author) 8. Subbian S*, Tsenova L, Holloway J, Peixoto B, O'Brien P, Dartois V, Khetani V, Zeldis JB, Kaplan G. Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model. EBioMedicine Jan 14;4: doi: /j.ebiom ecollection 2016 Feb. PubMed PMID: ; PubMed Central PMCID: PMC (*Communication author) 9. Subbian S*, Tsenova L, Kim MJ, Wainwright HC, Visser A, Bandyopadhyay N, Bader JS, Karakousis PC, Murrmann GB, Bekker LG, Russell DG, Kaplan G. Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study. PLoS One Jul 2;10(7):e doi: /journal.pone ecollection PMID: (*Communication author) 10. Subbian S*, Pandey R*, Soteropoulos P, Rodriguez GM. Vaccination with an attenuated ferritin mutant protects mice against virulent Mycobacterium tuberculosis. J Immunol Res Article ID: (*Equal first authorship). 11. Liu TB*, Subbian S*, Pan W, Eugenin E, Xie J, Xue C. Cryptococcus inositol utilization modulates the host protective immune response during brain infection. Cell Commun Signal Sept10;12(1):51. PMID: (*Equal first authorship). 12. Subbian S*, Eugenin E, Kaplan G. Detection of Mycobacterium tuberculosis in Latently Infected Lungs by Immunohistochemistry and Confocal Microscopy. J Med Microbiol Aug 26. pii: jmm doi: /jmm PMID: (*Communication author) 13. Tsenova L, O'Brien P, Peixoto B, Soteropoulos P, Fallows D, Kaplan G,.Subbian S. Etanercept exacerbates inflammation and pathology in a rabbit model of active pulmonary Page 5 of 11

6 tuberculosis. J Cytokine and Interferon Res Sep;34(9): PMID: Manca C, Koo MS, Peixoto B, Fallows D, Kaplan G, Subbian S. Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection. PLoS One. 2013; Aug 28; 8(8):e PMID: Subbian S, Bandyopadhyay N, Tsenova L, O'Brien P, Khetani V, Kushner NL, Peixoto B, Soteropoulos P, Bader JS, Karakousis PC, Fallows D, Kaplan G. Early innate immunity determines outcome of Mycobacterium tuberculosis primary infection in rabbits. Cell Commun Signal. 2013; Aug 19; 11(1):60. PMID: Das R, Koo MS, Kim BH, Jacob ST, Subbian S, Yao J, Leng L, Levy R, Murchison C, Burman WJ, Moore CC, Scheld WM, David JR, Kaplan G, MacMicking JD, Bucala R. Macrophage migration inhibition factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci (PNAS). 2013;110 (32):E PMID: Subbian S, O'Brien P, Kushner NL, Yang G, Tsenova L, Peixoto B, Bandyopadhyay N, Bader JS, Karakousis PC, Fallows D, Kaplan G. Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis. Cell Commun Signal Feb 28; 11(1):16. PMID: Subbian S, Tsenova L, O Brien P, Yang G, Kushner NL, Parsons S, Peixoto B, Fallows D, Kaplan G. Spontaneous latency in a rabbit model of pulmonary tuberculosis. Am J Pathol Nov 181 (5): PMID: Subbian S, Tsenova L, Yang G, O'Brien P, Parsons S, Peixoto B, Taylor L, Fallows D, Kaplan G. Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response. Open Biol Dec;1(4): PMID: Koo MS*, Subbian S*, Kaplan G. Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages. Cell Commun Signal Jan 26;10(1):2. PMID: (*Equal first authorship). 21. Subbian S, Tsenova L, O'Brien P, Yang G, Koo MS, Peixoto B, Fallows D, Dartois V, Muller G, Kaplan G. Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog Sep;7(9):e PMID: Subbian S, Tsenova L, O'Brien P, Yang G, Koo MS, Peixoto B, Fallows D, Zeldis JB, Muller G, Kaplan G. Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology. Am J Pathol Jul;179(1): PMID: Koo MS, Manca C, Yang G, O'Brien P, Sung N, Tsenova L, Subbian S, Fallows D, Muller G, Ehrt S, Kaplan G. Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice. PLoS One Feb 25;6(2):e PMID: Kong Y, Yao H*, Ren H*, Subbian S*, Cirillo SL, Sacchettini JC, Rao J, Cirillo JD. Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice. Proc Natl Acad Sci. U S A Jul 6;107(27): PMID: (*Equal second authorship). 25. Kong Y, Subbian S, Cirillo SLG, Cirillo JD. Application of optical imaging to study of extrapulmonary spread by tuberculosis. Tuberculosis.2009; 89 Suppl 1: S15-7. PMID: Cirillo SLG, Subbian S, Chen B, Weisbrod TR, Jacobs Jr. WR, Cirillo JD. Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination. Infect. Immun Jun;77(6): PMID: Page 6 of 11

7 27. Khounlotham M, Subbian D, Smith III R, Cirillo SLG, Cirillo JD. Mycobacterium tuberculosis interferes with the response to infection by inducing the host epha2 receptor. J.Infect. Dis Jun 15;199(12): PMID: Park B, Subbian S, El-Etr SH, Cirillo SLG, Cirillo JD. Use of gene dosage effects for a whole-genome screen to identify Mycobacterium marinum macrophage infection loci. Infect. Immun Jul;76(7): PMID: Dusthackeer A, Kumar V, Subbian S, Sivaramakrishnan G, Zhu G, Subramanyam B, Hassan S, Nagamaiah S, Chan J, Narayanan PR. Construction and evaluation of luciferase reporter phages for the detection of non-replicating tubercle bacilli. J Microbiol Meth Apr; 73(1): PMID: Subbian S, Narayanan S. Identification and characterization of the regulatory elements of the inducible acetamidase operon from Mycobacterium smegmatis. Can J Microbiol May; 53(5): PMID: Subbian S, Mehta PK, Cirillo SLG, Bermudez LE, Cirillo JD. A Mycobacterium marinum mel2 mutant is defective for growth in macrophages producing reactive oxygen and nitrogen species. Infect. Immun Jan; 75(1): PMID: Subbian S, Mehta PK, Cirillo SLG, Bermudez LE, Cirillo JD. The Mycobacterium marinum mel2 locus displays similarity to bacterial bioluminescence systems and plays a role in defense against reactive oxygen and nitrogen species. BMC Microbiol Jan 19; 7:4. PMID: Mehta PK, Pandey AK, Subbian S, El-Etr SH, Cirillo SLG, Samrakandi MM, Cirillo JD. Identification of Mycobacterium marinum macrophage infection mutants. Microbial Pathogenesis. 2006; 40(4): PMID: El-Etr SH, Subbian S, Cirillo SLG, Cirillo JD. Identification of two Mycobacterium marinum loci that affect interactions with macrophages. Infect. Immun Dec; 72(12): PMID: Narayanan S, Subbian S, Ranganathan A, Sambandamurthy VK, Narayanan PR. Transcriptional analysis of inducible acetamidase gene of Mycobacterium smegmatis. FEMS Microbiol Lett. 2000; 192: PMID: B. Book Chapter: 1. Subbian S, Karakousis PC, Kaplan G Rabbit model of tuberculosis. Chapter 24; Section 5: In vivo laboratory models of tuberculosis in Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Mukundan H, Waters RW, Chambers MA, Larsen MH (Eds.). CABI Publications, Wallingford, UK. C. Other Articles (Professional Communications): 1. Subbian S, Park B, Cirillo SLG, Cirillo JD. Illuminating a new path: Bioluminescencerelated pathways and resistance to reactive oxygen and nitrogen species. Proc US-Japan Co-op. Med. Sci. Prog Jul: Cirillo SLG, Mehta PK, Pandey AK, Subbian S, Park B, Khounlotham M, El-Etr SH, Samrakandi MM, Cirillo JD. Identification of mycobacterial genes that affect interactions with macrophages. Proc. US-Japan Co-op. Med. Sci. Prog Jul: D. Abstracts (poster): 1. Mavrianos J, Ranpura A, Ranganathan D, Subbian S, Chauhan N. Oxidative stress resistance and modulation of macrophage proinflammatory response by Candida albicans Page 7 of 11

8 mitochondrial mutants. 13 th ASM Conference on Candida and Candidiasis. (Poster/Abstract#174). Seattle, WA. April 13-17, Subbian S, Tsenova L, Kim MK, Wainwright HC, Visser A, Bandyopadhyay N, Bader JS, Karakousis PC, Murrmann GB, Bekker LG, Russell DG, Kaplan G. Lesion Specific Immune Activation in Granulomas of Patients with Pulmonary Tuberculosis. Keystone Symoposia on Host Response in Tuberculosis (J3). Santa Fe, New Mexico, USA. Jan 22-27, Shepherd T, Janagama H, Sule P, Galbadage T, Cirillo SLG, Zinniel D, Subbian S, Barletta R, Cirillo JD. Mycobacterium tuberculosis luxr1 (Rv3295) Is Important for Pulmonary Tuberculosis in Mice. Molecular Basis of Infectious Diseases Retreat at Texas A&M Health Science Center, Houston, Texas. Mar Subbian S, Koo M-S, Tsenova L, O Brien P, Holloway J, Peixoto B, Fallows D, Khetani V, Zeldis JB, Kaplan G. Changing the course of TB pathogenesis and treatment (Abstract #0403). Keystone symposium on Novel Therapeutic Approaches to Tuberculosis (C7-2014) at Keystone, Colorado, March 31-April 4 th, Tsenova L, Soteropoulos P, Fallows D, Kaplan G, Subbian S. Etanercept exacerbates inflammation and pathology in a rabbit model of active pulmonary tuberculosis. World TB day symposium: countdown to 2015 at New York Academy of Sciences, March 24, Pandey R, Subbian S, Rodriguez GM. Role of iron storage proteins in iron homeostasis and pathogenesis of Mycobacterium tuberculosis. World TB day symposium: countdown to 2015 at New York Academy of Sciences, March 24, Subbian S, Bandyopadhyay N, Tsenova L, O Brien P, Khetani V, Kushner NL, Peixoto B, Bader JS, Karakousis PC, Fallows D, Kaplan G. Differential activation of early innate immunity predicts the outcome of Mycobacterium tuberculosis infection in rabbit lungs (Abstract # 13). Symposium on Innate Immune Mechanisms Controlling Inflammation and Infection at the New Jersey Medical School, UMDNJ, Newark, NJ on March 18-19, Shepherd T, Galbadage T, Janagama H, Subbian S, Cirillo JD. MMAR1239/Rv3295 is a transcriptional regulator important for mycobacterial virulence at Molecular Basis of Infectious Diseases Retreat 2012 at Texas A&M Health Science Center, Houston, Texas. Mar Galbadage T, Patel D, Subbian S, Zinniel DK, Cirillo SLG, Barletta RG and Cirillo JD. Virulence gene regulatory locus MMAR_1239 in Mycobacterium marinum. Molecular Basis of Infectious Diseases Retreat 2012 at Texas A&M Health Science Center, Houston, Texas. Mar Subbian S, Tsenova L, O'Brien P, Yang G, Koo MS, Peixoto B, Fallows D, Zeldis JB, Muller G, Kaplan G. Impact of the modulation of macrophage activation by a Phosphodiesterase-4 (PDE4) inhibitor on the isoniazid response to Mycobacterium tuberculosis. Gorden Research Conference on Phagocytes held at Davidson College, Davidson, NC during June 19-24, Kong Y, Yao H, Ren H, Subbian S, Rao J and Cirillo JD. Application of reporter-enzymefluorescence imaging to the study of Tuberculosis in vivo. (Abstract # 09-GM-A-3325-ASM). American Society for Microbiology General Meeting at Philadelphia during May 17-21, Cirillo SLG, Subbian S, Kong Y, Chang MH, Nawar H, Shi Y, Cirillo JD. Molecular imaging strategies for tuberculosis: visualizing the White Plague. (Abstract# 0046). World Page 8 of 11

9 Molecular Imaging Congress at the Acropolis Convention Center, Nice, France during September 10-13, Khounlotham M, Subbian S, Smith R, Cirillo SLG, Cirillo JD. EphA2-deficient mice display altered granuloma morphology and lung immune cell composition following tuberculosis infection. () at Texas A&M Health Science Center, Houston, Texas. March 28, Mehta PK, Subbian S, Cirillo SLG and Cirillo JD. Association of mycobacterial mel2 locus with enhanced TNF-alpha production and increased intracellular survival in murine macrophages. International Symposium on New Frontiers in Tuberculosis Research. International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India. December 4-6, Subbian S, Cirillo SLG and Cirillo JD. Illuminating reactive oxygen and nitrogen species resistance mechanisms through analysis of bioluminescence-like genes in mycobacteria. (Abstract # 433). Keystone symposia on Tuberculosis: From Lab Research to Field Trials at Vancouver, Canada during March 20-25, Haight J, Campbell M, Williams AM, Subbian S, Cirillo SLG, Willey J, and Cirillo JD. Use of streptomyces to study quorum sensing in mycobacteria. Sixth Annual Nebraska- BRIN/INBRE meeting, Lincoln, NE. Jul Williams AM, Campbell M, Perlinger T, Subbian S, Cirillo SLG, Willey J and Cirillo JD. Isolation of a biologically active quorum sensing molecule from Mycobacterium smegmatis. Sixth Annual Nebraska-BRIN/INBRE meeting, Lincoln, NE. Jul Subbian S, Mehta PK, Cirillo SLG, Cirillo JD. The mycobacterial mel2 locus displays similarity to microbial bioluminescence systems and affects survival in macrophages. 106 th ASM meeting, Orlando, Florida, USA. May Subbian S, Narayanan S, Narayanan PR. Regulators and operators involved in the regulation of the highly inducible acetamidase operon from M. smegmatis. Bioinformatics in Tuberculosis Research. Indian Institute of Technology (IIT), Karaghpur, India. Jan Subbian S, Narayanan S, Narayanan PR. Transcriptional regulation of acetamidase gene expression in M. smegmatis. International Symposium on Mycobacterial Diseases: Pathogenesis, Protection and Control, Kolkatta, India. Jan E. Presentations (Oral): 1. Subbian S. Host metabolic changes in tuberculosis. Panel member. The Many Hosts of Mycobacteria VII. Colorado State University, Ft. Collins, CO. August 9-11, Subbian S. Changing the course of TB pathogenesis and treatment. Oral presentation at Keystone Symposia on Novel Therapeutic Approaches to Tuberculosis (C7-2014) at Keystone, Colorado on 04/03/ Subbian S. Early immune response to Mycobacterium tuberculosis infection in rabbit lungs. NJMS, UMDNJ on 04/01/ Subbian S. Effect of CC11050 in mouse and rabbit models of pulmonary TB.Bill and Melinda Gates Foundation Drug Accelerator Meeting at Washington. November 11-12, Subbian S. Pulmonary cavitary TB in rabbits: a failed host immune response. NJMS, UMDNJ on 01/09/2012. Page 9 of 11

10 6. Subbian S, Karakousis PC and Kaplan G. Active cavitary TB and spontaneous latency in rabbits. The Many Hosts of Mycobacteria V: Advancing Translational Science. NIH, Bethesda, MD during July 16-17, Subbian S and Kaplan G. Characterizing transcriptional responses in rabbits actively and latently infected with Mycobacterium tuberculosis. Johns Hopkins University Center for TB Research Seminar on June 21, Subbian S. Perturbing host-pathogen interactions as s means of improving TB treatment. PHRI, UMDNJ on 02/02/ TEACHING and RESEARCH MENTORSHIP A. Lecturership: Punjab Technical University, Chennai, India Lecturer in Bioinformatics Gene expression and regulation in pro and eukaryotes 02/ /2003 (4 hours per week) B. Research Mentor Training: Postdoctoral Fellows: Afsal Kolloli, Pooja Singh, Rutgers University, Doctoral Committee: Valarie Kimyata, Rutgers University, 2017 Predoctoral Students: 1. Public Health Research Institute, Rutgers University, Newark, New Jersey: i. Viraj Khetani (06/ /2012) ii. Sumaaya Mohamed (06/ /2017) 2. Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center at College Station, Texas: i. Alfredo Echeverria (04/ /2008) ii. Randy Eman (05/ /2007) iii. Megan Files (06/ /2008) iv. Greg Maberry (06/ /2008) 3. Department of Veterinary and Basic Medical Sciences, University of Nebraska at Lincoln, Lincoln, Nebraska: i. Elizabeth Thiemann (08/ /2005) ii. Karen Lee (08/ /2005) iii. Angela Williams (06/ /2005) Page 10 of 11

11 REFERNCES: Dr. Gilla Kaplan Director, Global Health Program-Tuberculosis Bill and Melinda Gates Foundation 500 Fifth Avenue North Seattle, WA Phone: Dr. David McMurray Regents Professor Department of Microbial Pathogenesis and Immunology Reynolds Medical Building Rm. 407A College Station, TX Phone: Fax: Dr. Jeffrey D Cirillo Regents Professor Department of Microbial Pathogenesis and Immunology 8447 Riverside Parkway Medical Research & Education Building (MREB), Rm Bryan, TX Phone: Fax: jdcirillo9@gmail.com Dr. Deepak Kaushal Professor of Microbiology and Immunology Tulane University School of Medicine Tulane National Primate Research Center 1430 Tulane Ave, New Orleans, LA Phone: Fax: dkaushal@tulane.edu Page 11 of 11