HIV-1 AccuVert Seroconversion Panel (PRB966) / Batch #

Transcription

1 s/co c/ml DATA SHEET OVERVIEW (PRB966) is a 10-member panel of undiluted, naturally occurring plasma samples. Panel members represent serial bleeds collected from a single patient over the course of 51 days during the development of an HIV infection and subsequent response. Each sample represents a single collection event. No preservatives were added. Test results from commercially-available, antigen, and antibody assays are included for characterization of each panel member. This panel of human plasma samples demonstrates a change in expression from negative to positive for HIV-1 analytes during the development and progression of an HIV infection. All results were generated using commercially available tests performed at SeraCare or recognized reference laboratories (RL) by individuals who routinely use these procedures. For Research Use Only. Not for use in diagnostic procedures. Data are provided for informational purposes. SeraCare Life Sciences does not claim that others can duplicate test results exactly. CAUTION: Potentially infectious materials. Follow Universal Precautions. Panel members were found positive for markers of HIV infection; all were found negative for HBsAg, HBV DNA, anti-hcv and HCV RNA. Evolution of HIV Markers in Early Infection HIV-1/2 & Group O Positive cut-off 3.00E E E E E E Days since first bleed 0.00E+00 This graph demonstrates the evolution of early HIV infection, illustrated with test results over time for different analytes or analyte combinations. Assays displayed are Standard, Beckman Coulter, ARCHITECT combo and the PRISM HIV-1/2 & group O. Page 1 of 5

2 Information SeraCare Batch # SeraCare Donor ID Bleed Date Days Since 1 st Bleed 01 BM BD Oct BM BD Oct BM BD Oct BM BD Oct BM BD Nov BM BD Nov BM BD Nov BM BD Nov BM BD Nov BM BD Nov Ultra Sensitive (copies/ml) 1 Standard (copies/ml) 1 01 <50 NT 02 <50 NT 03 <50 NT 04 <50 NT 05 <50 NT x 10 2 NT 07 NT 1.9 x NT 2.8 x NT 4.8 x NT 8.2 x 10 4 Test Date 16-Aug Aug-2007 Test Site SeraCare SeraCare Kit Part Code Kit Lot No. J00667 J00667 Kit Exp. Date Mar-2008 Mar Results in bold red are considered reactive. NT = not tested Page 2 of 5

3 HIV-1 Antigen & Confirmatory Beckman Coulter Perkin Elmer Zeptometrix Elecsys OraSure Rapid HIV-1 (Result) Maxim Western Blot HIV-1 2 Band Pattern Result NEG No Bands NEG NEG No Bands NEG NEG No Bands NEG NEG No Bands NEG NEG No Bands NEG NEG No Bands NEG NEG No Bands NEG NEG No Bands NEG NEG No Bands NEG NEG No Bands NEG Test Date 04-Apr Aug Aug May Aug Aug-2007 Test Site SeraCare SeraCare SeraCare RL SeraCare SeraCare Kit Part Code NEK 050A NA Kit Lot No. 2066F A Kit Exp. Date 18-Apr Mar Jan-2008 Aug Sep Oct Formerly Calypte - Cambridge Biotech Western Blot Page 3 of 5

4 /Ab ARCHITECT AxSym PRISM Dade Behring Enzygnost Integral II Elecsys Combination Murex Combination Test Date 10-May May May Jun May May-2007 Test Site RL RL RL RL RL RL Kit Part Code NA NA NA NA NA NA Kit Lot No HN LU HN L Kit Exp. Date 02-Jan Oct Oct Jun-2008 Nov Nov-2007 Page 4 of 5

5 HIV-1/2 Antibody & Group O 1 EIA HIV-1/2 PRISM HIV O Plus AxSym Siemens ADVIA Centaur enhanced Murex HIV 1.2.O > > Test Date 31-Jul May May May May-2007 Test Site SeraCare RL RL RL RL Kit Part Code 3A77 NA NA NA NA Kit Lot No M HN LU L Kit Exp. Date 27-Sep Jan Oct Mar Feb-2008 The package insert for this panel can be found at A printed copy of the package insert or data sheet may be requested by at info@seracare.com, or by phone at ASK ABOUT RELATED SERACARE PRODUCTS AccuSet Performance Panels HIV Disease State Materials ACCURUN Independent Quality Controls SeraCon and Basematrix Processed Plasma Page 5 of 5