LONG R 3 IGF-I ELISA Kit, Revision 2 Material Safety Data Sheet
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- Emory Barrett
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1 Section 1 Product Identification Supplier: Repligen Corporation 41 Seyon Street, Building #1, Suite 100 Waltham, MA Phone: (781) ; Fax: (781) Product Name: LONG R 3 IGF-I ELISA Kit Synonyms: LR3 ELISA kit Catalog No(s): Section 2 Composition / Information on Ingredients Component CAS Weight % (PBS) Not Applicable 100% (Ovalbumin) % (Sodium Azide) % Reagent B (LONG R 3 IGF-I) Not Applicable 85-95% Reagent C (Biotinylated mouse antibody) Not Applicable <1% (Streptavidin HRP Conjugate) <1% (3,3',5,5'-Tetramethylbenzidine) % Section 3 Hazards Identification Emergency Overview: Reagent B Reagent C Irritating to eyes and skin WARNING. HARMFUL IF SWALLOWED OR IN CONTACT WITH SKIN WARNING. HARMFUL IF SWALLOWED OR IN CONTACT WITH SKIN May be irritating to eyes and skin May be irritating to eyes and skin Not investigated HMIS: Health Hazard: 2 Temporary or minor injury may occur Flammability: 0 Will not ignite at room temperature Reactivity: 0 Stable NFPA: Health Hazard: 2 Intense or continued but not chronic exposure could cause temporary I incapacitation or possible residual injury Fire: 0 Flash point between 38 C/100 F and 93 C/200 F Instability: 0 Normally stable. Not reactive with water EU Risk/Safety Phrases: R22: Harmful if swallowed R36: Irritating to eyes R37: Irritating to respiratory system R38: Irritating to skin S36/37/39: Wear suitable protective clothing, gloves, face/eye protection 1
2 Section 4 First Aid Measures IF SWALLOWED: Wash out mouth and consult a physician. EYES: Immediately flush eyes with plenty of water for at least 15 minutes remove contact lenses if possible, seek medical attention. SKIN: Immediately flush skin with plenty of water, remove contaminated clothing. Seek medical advice IF SWALLOWED: Seed medical advice. Do not induce vomiting. Reagent B/C/D IF SWALLOWED: Seek medical attention IF SWALLOWED: Induce vomiting and seek medical advice. Section 5 Fire Fighting Measures Wear self contained breathing apparatus and protective suit. FIRE EXTINGUISHING MEDIA: Water, water spray, foam, dry powder, CO 2. Section 6 Steps to be Taken in the event of a Spill or Discharge: Applies to all kit components: (, Reagents A, B, C, D, E) Personal Protection: Disposal procedure: Wear lab coat, gloves and eye protection. Avoid contact with spilled material. Avoid breathing vapor or mist/dust. Provide adequate ventilation. Do not allow spilled material to enter soil, waterways or drains. Do not allow spilled material to accumulate in confined areas. Control spillage with non-flammable absorbent materials such as sand, earth or vermiculite. Contact licensed waste disposal contractor for proper disposal. Do not dispose of in drains. Follow all applicable federal, state, and local environmental regulations. 2
3 Section 7 Handling and Storage Applies to all kit components: (, Reagents A, B, C, D, E) General Precautions: Ventilation: Respiratory Protection: Eye/skin Protection: Storage: Use appropriate personal protective equipment, and observe good laboratory hygiene (see section 8). Keep and use only in a well ventilated area Not required if ventilation is adequate. Standard safe laboratory practices recommended. Wear lab coat, gloves and eye protection at all times while handling. Keep containers closed. Keep away from flames, sparks or ignition sources. Store at 2-8 C/36-46 F for maximum shelf life (does not impact safety) Section 8 Exposure Controls/Personal Protection Applies to all kit components: (, Reagents A, B, C, D, E) General: Avoid exposure. Do not breathe vapor or mist. Avoid contact with eyes, skin and clothing. Use only with adequate ventilation. Wash thoroughly after handling Personal protective equipment: Standard laboratory practices recommended. Personal protective equipment should be selected to provide adequate protection based upon the procedures being performed. Wear laboratory coat, gloves and safety glasses when handling. Respiratory protection not required if ventilation is adequate. Clean any exposed skin after handling, before leaving the working area, and before eating, smoking or using the lavatory. Clean any contaminated clothing before re-use. Section 9 Physical and Chemical Properties Reagents B, C Dry powder. Soluble in water. Neutral ph when prepared Clear liquid colorless to light yellow, Neutral ph. Soluble in water Lyophilized solid. Soluble in water Colorless liquid. Neutral ph. Will not burn or ignite. Soluble in water. Clear to light yellow liquid. Soluble in water. Section 10 Stability and Reactivity (PBS) Reagents A-E Stable. Hygroscopic. Incompatible with strong oxidizing agents and acids. Stable under normal operating conditions 3
4 Section 11 Toxicological Information (PBS) (Ovalbumin) (Sodium Azide) Reagent B (LONG R3 IGF-I) May be harmful by inhalation, ingestion, or skin absorption. Causes eye and skin irritation. Irritating to mucous membranes and upper respiratory tract. Ingestion of large quantities can cause weakness, GI irritation and circulatory disturbance. LD 50 oral (mouse) >24,000 mg/kg ATE oral 5 mg/kg LC 50 Inhalation (rat) >37mg/m 3 LD 50 dermal (rabbit) 20mg/kg Not determined. May be skin, eye and/or respiratory irritant. Reagent C (Biotinylated murinehybridoma mab) May be harmful is inhaled, swallowed or absorbed through skin. May cause irritation of eyes, skin and respiratory tract. (Streptavidin HRP Conjugate) (3,3',5,5'-Tetramethylbenzidine) Section 12 Ecological Information May cause skin and eye irritation and skin sensitization in susceptible persons. Toxicological properties have not been investigated (PBS) Reagent B Reagent C Hazardous to aquatic life. Harmful to aquatic organisms No known hazards Section 13 Disposal Considerations Dispose of in accordance with all applicable federal, state, and local environmental regulations. Do not allow spilled material to enter soil, waterways or drains. See also sections 6, 7 and 8. Section 14 Transport Information Not regulated. Section 15 Regulatory Information EU Risk Phrases: R36/37/38: Irritating to eyes, respiratory system and skin R22: Harmful if swallowed S36/37/39: Wear suitable protective clothing, gloves and face/eye protection 4
5 Section 16 Other Information The material published in this has been compiled from our experience and data presented in various publicly available publications. It is the user's responsibility to determine the suitability of this information for the adoption of necessary safety precautions. Repligen makes no warranty or representation about the accuracy or completeness nor fitness for purpose of the information contained herein. 5
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