AVAILABLE BIOMARKER ASSAYS

Transcription

1 AAILABLE BIOMARKER ASSAYS

2 alidation Alpha-2-microglobulin ELISA Anti-CD71/anti-platelet/propidium iodide Anti-KLH IgG ELISA,, Dog, Minipig, Apoptotic, necrotic and dead cells (bone marrow) B (activated and mature) (whole blood) Dog B cells (lymph nodes) B cells, monocytes + MHC II (whole blood and spleen) B cells, monocytes + MHC II (whole blood) B lymphocyte subsets: naïve mature, mature class-switched and immature B cells (whole blood) B, T + activation marker (whole blood) Dog BrdU labeling, Minipig Calbindin Cardiac Troponin I (ctni) SPARCL, Caspase Minipig CD11b CD11c CD163, Dog, Minipig, CD172a, Dog, Minipig, CD19 CD20 CD206 CD25 CD3,, Dog, Minipig, CD45R CD68, : qualified : validated

3 alidation CD7 CD79α Dog CD8, CDH16 (Cadherin-16) CGRP (Calcitonin Gene-Related Peptide) Chondroitin sulfate Human Citrulline LC-MS/MS Minipig, Complement factor Bb ELISA Complement factor C3a ELISA Minipig, Complement factor C5a ELISA Minipig Complement factor CH50 ELISA Complement factor sc5b-9 ELISA Cortisol LC-MS/MS, Dog, Minipig, C-reactive protein (CRP) ELISA Rabbit, Dog, Minipig C-reactive protein (CRP) SPARCL Creatine kinase MB (CKMB) ELISA CRP ELISA Human CYP1A1 CYP2B1 CYP3A1 CYP4A1 Cytokeratin 10 Human Dermatane sulfate Human EGF ELISA enos (endothelial nitric oxide synthase) = NOS 3 Erythroid cells (S phase and proliferation markers) (bone marrow) Estradiol LC-MS/MS : qualified : validated

4 : qualified : validated Parameter Technique Species alidation F4/80 Facteur III (on Willebrands factor), Human Fibrilline Human Fibrinogen,, Rabbit, Dog, Coagulation analyser Minipig, FSH (follicle-stimulating hormone) GFAP (anti-glial fibrillary acid protein),, Minipig,, Human GH (growth hormone) GM-CSF, IFN-γ, IL-2, IL-6, IL-7, IL-8, IL-10, IL-15, Dog IL-18, IP-10, KC, MCP-1, TNFα Haptoglobin ELISA, Dog, Minipig, h-clat on THP-1 cell line Human Histamine ELISA Minipig HMB45 Human HO-1 (heme oxygenase 1) Human IFNg ELISA IFNγ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, MCP1, MIP1α, MIP1β, TNFα IgG/IgM/IgA IL-17A CBA Flow IL-18 ELISA IL-1b ELISA Human IL-1b ELISA IL-1α ELISA Human IL-1β, IL-2, IL-4, IL-6, IFNg, TNFa, MCP-1, MIP- 1a IL-1β, IL-6, TNF-α CBA Flow IL-2, IL-4, IL-5, IL-6, TNF-α, IFN-δ CBA Flow IL-6 ELISA IL-6, IL-10, MCP-1, IFN-δ, TNF-α, IL-12p70 CBA Flow IL-6, MCP-1 Insulin ELISA Involucrine Human

5 alidation IP-10 ELISA Ki-67, Hamster,, Minipig,, Human KU-80 Human Laminin Hamster LH Loricrine Human Ly6C Ly6G Lymphocyte subset: Th cells Dog Lymphocyte subsets: T, B (lymph nodes) Lymphocyte subsets: T, B and NK cells Lymphocyte subsets: T, B, NK Lymphocyte subsets: T, Tc, Th cells, B, NK, CD8+ NK Lymphocyte subsets: T, Tc and Th cells Lymphocyte subsets: T, Tc and Th cells, B, NK Lymphocyte subsets: T, Tc, Th Lymphocyte subsets: T, Tc, Th, B, NK Lymphocyte subsets: T, Th, Tc, B (with or without CD45) Dog Lymphocyte subsets: Th and Tc, B, NK, NKT (whole blood) Melan-A Human MHC II (major histocompatibility complex),, Dog, Minipig, Micronucleus Micronucleus assay on reticulocytes (whole blood) : qualified : validated

6 alidation MMP23 (matrix metalloproteinase 23) MUSST on U937 cell line Human Naïve, central memory and effector memory Tc and Th cells Neopterin ELISA Nephrotoxicity biomarkers : β-2 microglobulin, cystatin C, lipocalin / NGAL Nephrotoxicity biomarkers: calbindin, clusterin, GSTa, KIM-1, osteopontin, EGF, TIMP-1 NGF (nerve growth factor) Human P53 Human PCNA (proliferating cell nuclear antigen) Perlecan Human Phagocytosis (E.coli FITC+: cells phagocytosing E.coli) (whole blood) Phospho Tie 2 PN III Human Progesterone LC-MS/MS Minipig Prolactin ELISA, PSMA (prostate specific membrane antigen) Human PTH (parathormone), Dog Renin ELISA Dog S100 Human SOD (superoxide dismutase) Human T, monocytes ± MHC II, B ± MHC II (whole blood and spleen) T cell panel: T,Th and Tc, Tregs, NK, activated Tc and NK (whole blood, spleen, thymus) : qualified : validated

7 alidation T cell panel: T, Th and Tc, Tregs, NK, activated Tc cells and NK cells (whole blood, spleen, thymus) T cell subsets : Th and Tc, incl cell cycle markers (thymus) T cell subsets + activation marker T cell subsets: Th and Tc (whole blood) Dog T cell subsets: Th and Tc (whole blood, spleen, lymph nodes) T cells, TCRgd T cells, Th, Tc, NK cells (lymph nodes) T, Tc, Th, B Minipig T3 LC-MS/MS T4 LC-MS/MS Testosterone LC-MS/MS TGFb1 CBA Flow Th cells ± phospho STAT5 (whole blood) Thyrosinase Human Thyrp1 Human TNFa ELISA, Human Total IgE ELISA Total IgG ELISA, Rabbit, Total IgM ELISA, Rabbit, TSH ELISA TUNEL (terminal deoxynucleotidyl transferase), Rabbit, Minipig Tyrosine hydroxylase 1 UIBC Chemistry analyser, Dog AChT (vesicular acethylcholine transporter) on Willebrand factor,,, Human : qualified : validated