BRO-ZEDEX RANGE Knowledge Express
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1 BRO-ZEDEX RANGE Knowledge Express Composition: Bro Zedex Terbutaline Sulphate 1.25mg + Bromhexine HCL 4 mg + Guaiphenesin 50 mg + Menthol 2.5mg/5ml Bro Zedex SF - Terbutaline Sulphate 1.25mg + Bromhexine HCL 4 mg + Guaiphenesin 50 mg + Menthol 2.5mg/5ml (Sugar Free Base of Sucralose) Bro Zedex LS Kid: Sulphate 1 mg + Ambroxol HCL 30 mg + Guaiphenesin 50 mg + mentholated base /5ml Bro Zedex LS Plus: Sulphate 1 mg + Ambroxol HCL 30 mg + Guaiphenesin 50 mg + Mentholated sugar free base /5ml (Sugar Free Base of Sucralose) Brozedex LS drops: Sulphate 0.25 mg + Ambroxol HCL7.5mg + Guaiphenesin 12.5mg /ml Indication: Composition Bro Zedex Bro Zedex SF Bro Zedex LS Kid Bro Zedex LS+ Brozedex LS drops Indication Productive Cough Productive Cough in Diabetic Patients Bronchospastic Cough in Children associated with acute bronchitis and bronchial asthma Chronic Respiratory Conditions in elderly like COPD, Asthma, Bronchitis with comorbidity Wheezing and chest congestion in kids associated with bronchitis, bronchial asthma
2 Dose: SR.NO BRAND 1 Bro Zedex COMPOSITION / 5ml Terbutaline Sulphate 1.25mg + Bromhexine HCL 4 mg + Guaiphenesin 50 mg + Menthol 2.5mg/5ml INDICATION/POSITIONING Moderate-Severe Productive/Bronchospastic cough AGE GROUP & DOSING Adults -10ml 2-3 times/day 6-12 years 5 ml TID 3 6 years 2.5 ml TID 2 to 6 years 2.5 ml BID 2 Brozedex LS kid Sulphate 1 mg + Ambroxol HCL 30 mg + Guaiphenesin 50 mg + Menthol 0.8 mg Expectorant/5ml Moderate-Severe Bronchospastic/Productive cough in kids 6 12 years: start with 2.5 ml thrice daily and increase to 5 ml of syrup 2-3 times daily. Adults (>12 years) : 5ml three times daily. This may be increased to 10 ml syrup twice daily. Adults (>12 3 Brozedex LS Plus Sulphate 1 mg + Ambroxol HCL 30 mg + Guaiphenesin 50 mg + Menthol 0.1 mg Expectorant/5ml (Sugar Free Base) Chronic Respiratory Conditions in elderly like COPD, Asthma, Bronchitis with co-morbidity years) : 5ml three times daily. This may be increased to 10 ml syrup twice daily. 4 Brozedex LS drops Sulphate 0.25 mg + Ambroxol Wheezing and chest congestion in kids associated with bronchitis, bronchial asthma 2ml three times daily.
3 HCL7.5mg + Guaiphenesin 12.5mg /ml Key Message: Bro-Zedex Nair Hospital Mumbai confirms that Brozedex is most viscous compared to other leading brands. Bro Zedex is 100% more viscous compared to leading brands like Ascoril. Brozedex offers faster symptomatic relief in 30 mins Terbutaline in Brozedex relaxes airway muscles, improves pulmonary function & breathing Bromhexine in Brozedex is a mucolytic agent with antioxidant properties Guaiphenesin in Brozedex improves expectoration Menthol in Brozedex offers cooling soothing effect. Brozedex is celebrating 26 years of freedom to express in productive cough associated LRTI and AECB Hence in productive cough Brozedex offers freedom from cough for last 26 years Brozedex SF Studies have shown that cough syrups contain substantial amount of sugar. Department of Clinical Pharmacology, Nair Hospital confirms, most commonly preferred brands like Asco, Gri_Lt, Or Bro-Zit, contains on an average 3 tsp sugar per 30 ml of syrup (per day dose) ie 48 gram sugar / 100 ml of conventional cough syrup. Also conventional cough syrup contains 4 times more sugar then a cold drink ( 12 gm / 100 ml of sugar in cold drink versus 48 gm/ 100 ml of cough syrup ). Therefore in diabetic and hypertensive patients, when every spoon of sugar counts, Brozedex SF is an ideal choice as it is available in sugar free form. Bro Zedex LS Kid Brozedex LS Kid in Bronchospatic cough, is the 1 st syrup with calibrated patented spoon ie Brozedex LS Kid is exclusively designed to offer dosing convenience; accuracy and contamination free dosing tool to help mothers which is alo published in the form of CAPCON study in Indian Journal of Clinical Practise July Brozedex LS kid has 1 mg of levosalbutmol with better bronchodilation & safety profile compared to salbutamol Brozedex LS kid reduces need of nebulization& concomitant medication and has 95% more treatment satisfaction rates compared to salbutamol
4 Brozedex LS kid formulation is DCGI approved with patented calibrated spoon that provides hygienic and accurate dosing to your patients Bro Zedex LS+ In chronic respiratory condition like Asthma, Bronchitis, COPD recommend Brozedex L S Plus which is the only sugar free form of combination available in India Brozedex LS Plus offers superior tolerability and safety compared to Salbutamol Brozedex LS Plus is an effective bronchodilator compared to Salbutamol Brozedex LS Plus formulation is DCGI approved with sugar free form, yet sweet to taste. RX Brozedex LS Plus that offers sugar free safety, superior tolerability and efficacy of levosalbutamol combination in chronic respiratory condition like Asthma, Bronchitis, COPD Brozedex LS drops Wheezing & chest congestion limits the expression of childhood, Brozedex LS drops offers cough relief for lasting smiles Brozedex LS drops has 0.25 mg of levosalbutmol with better bronchodilation & safety profile compared to salbutamol 7.5mg of Ambroxol in Brozedex LS drops reduces sputum volume & viscosity 12.5 mg Guaiphenesin in Brozedex LS drops improves expectoration Brozedex LS drops comes along with a scientifically calibrated dropper for dosage accuracy. Calibration in dropper of Brozedex LS drops starts from 0.1 ml to 1 ml. Rx Brozedex LS drops for cough relief with lasting smiles
5 Ingredient Pedia dose Adult dose Reference Guaiphenesin 2-6 years: 50 to 100 mg orally every 4 hours; maximum 600 mg/day 6-12 years: 100 to 200 mg orally every 4 hours; maximum 1200 mg/day 12 years & above: 200 to 400 mg orally every 4 hours; maximum 2400 mg/day Micromedex. Along with terbutaline / levosalbutamol the Guaiphenesin requirement can correspondingly be reduced. Terbutaline 2.5 to 5 mg ORALLY every 6 hr 3 times daily, MAX 15 mg/day 50% of Salbutamol dosage 50% of Salbutamol dosage given 2 to 3 times daily mg to 0.2mg/kg/dose every 8 hour oral As per text book Drug Dosages in Children, 8 th ED ;Meharban Singh and Asok Deorari Bromhexine 2-4 mg three times daily below 5 years of age 8 to 16 milligrams orally three times daily. Micromedex 4 mg twice daily for children under 5 years of age 30 milligrams twice daily alternatively 4 mg four times daily for children 5 to 10 years of age Ambroxol Up to 2 years - 15 milligrams (mg) daily; 2 to 5 years - 15 to 30 mg daily; 5 to 12 years - 30 to 45 mg daily 12 years and older - 60 to 90 mg daily Oral adult doses of 60 to 180 milligrams/day in 2 or 3 divided doses. Average 120 mg/day. Micromedex Many doctors feel that the dosing of Ambroxol in this combination is on the higher side but as children are poor at expectorating sputum, additional
6 mucolytic support and dosing strength is now being widely accepted instead of a higher dosing strength of expectorant. Competitor Knock out points : Sr no Brand Company Knock out point 1 Ascoril Glenmark - Sub therapeutic dose of Bromhexine of 2 mg / 5ml leads to compromised results. - Micromedex recommends 8 to 16 mg TID of Bromhexine in adults and - 4 mg twice daily for children under 5 years of age - Menthol is only 0.5 mg / 5ml this may not lead to cooling soothing effect - Viscosity of Ascoril is only 50.55centipoise compared to 144 centipoise of Brozedex 2 Ascoril LS Glenmark - Very poor taste leads to non-compliance in Little ones - Conventional method of dosage administration with caps leads to unhygienic and inaccurate dosing in little patients and is proven in CAPCON study publishes in IJCP ( Indian Journal of Clinical Practice )July Brozeet LS Alembic mg of is not approved by DCGI - Pineapple flavor has lot of after taste which leads to poor patient compliance
7 4 Brozeet LS Plus Alembic - Very poor taste leads to non-compliance in patients - Does not have sugar free formulae as 48 gm of sugar is there / 100 ml which may add complication in patients with co-morbidities associated with Asthma, COPD & Bronchitis 5 Kufril LS drops Med manor - Does not have accurately calibrated dropper ; calibration starts with 0.25 mg which may lead to inaccuracy of dosage administration 6 Kofarest PD drops Centaur - Does not have accurately calibrated dropper ; calibration is not visible clearly which may mislead the patients / care takers Pack/ MRP / NSV and Competition Sr. No Name of the SKU MRP in Rs. NSV in Rs. 1 Brozedex Brozedex SF Brozedex LS kid Brozedex LS Plus Brozedex LS drops Pack Competitor brand Company 100 ml bottle Ascoril Glenmark Brozeet Alembic Macberry XT Macleods Soventus Emcure Tus Q X Blue cross 100 ml bottle Ascoril SF Glenmark Brozeet SF Alembic 60 ml bottle Ascoril LS Glenmark Brozeet LS Alembic Macberry Junior Macleods Chericof LS Sun Kufril LS Med manor 100 ml bottle Ascoril LS Glenmark Brozeet LS Plus Alembic Macberry LS Macleods Chericof LS Sun Kufril LS Med manor 15 ml bottle Ascoril LS drops Glenmark Kufril LS drops Med manor Kofarest PD drops Centaur
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