The Change of Mu Rhythm during Action Observation in People with Stroke. Tae-won Yun, PT, MSc, Moon-Kyu Lee, PT, PhD

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1 1) 동작관찰시뇌졸중환자의뮤리듬변화 The Change of Mu Rhythm during Action Observation in People with Stroke Tae-won Yun PT MSc Moon-Kyu Lee PT PhD Department of Rehab Center Gwangju City Rehabilitation Hospital <Abstract> Purpose The aims of this study was to identify the activation of the mirror neuron system during action observation in people with stroke and the difference between left hemisphere and right hemisphere and to provide possibility of the use of action observation as a clinical method for improving motor function after stroke Methods Seventeen participants were asked to observe 3 different stimulation conditions for 80 seconds A 30 second rest period was given between stimulations Electroencephalogram(EEG) signals from electrodes on the participant s scalp were recorded during action observation The activation of the mirror neuron system() between the picture observation condition and action observation condition was compared with a paired t-test An independent t-test was used to compare difference between C3 and C4 on the activation of the mirror neuron system in the action observation condition Results Result of paired t-test showed a significantly decreased log ratio in the activation of the mirror neuron system in the action observation condition compared to the picture observation condition Result of the independent t-test indicated no significant differences in the activation of the mirror neuron system in the right and left hemisphere Conclusion The mirror neuron system showed greater activation in the action observation condition than in the picture observation condition and activation in the both hemisphere during action observation We conclude that these findings suggest that this may possibly be an efficient clinical intervention method for improving motor function moonkyukorea@gmailcom / /

2 Key Words Action observation Mirror neuron system Mu rhythm Stroke Ⅰ (Blandin 1999) ( 2005) (Rizzolatti Craighero 2004) (Grafton 1996; Muthukumaraswamy 2004) (Rizzolatti 2009) (Iacoboni 2005) (Tettamanti 2005) MN (Buccino 2001) MN (object-directed action) (Zentgraf 2011) (mirror neuron system; ) (Petrosini 2003) F5 (Gallese 1996) (electroencephalogram; EEG) (Bernier 2007) (Mu rhythm) (Bernier 2007; Perry Bentin 2009) (Rizzolatti 1996) (Bernier 2007) 8-13Hz (mirror neuron; MN) (Buccino 2006) EEG (Muthukumaraswamy 2004) fmri(buccino 2004b) MEG(Cheng 2006) PET(Grafton 1996) TMS(Maeda 2002) (Fabbri-Destro Rizzolatti 2008; Schulte-Ruther 2007) (rostal part of the inferior parietal lobule) (lower part of the precentral gyrus) (Rizzolatti Craighero 2004) (Muthukumaraswamy 2004) (Mu suppression) (Nishitani Hari 2000) Buccino (2004a) Maeda (2002)

3 (Buccino 2006) (Franceschini 2010) Ⅱ 2) QEEG-8(LXE3208 LAXTHA Inc ) Hz 05~50 Hz 12-bit AD (International method of electrode placement) (Fig 1) Ag/AgCl F3 F4 C3 C4 P3 P4 O1 O2 1 C 6 MMSE-K(Mini- Mental Status Examination-Korean) ) Figure 1 International method of electrode placement for acquiring the EEG data TeleScan

4 (absolute mu power ratio) (normal) (log transform) (log ratio) ) 3 3 EEG C3 C4 (Oberman 2007) 1 Ⅲ 17 ( 10 7 ) Table 1 Table 1 The general characteristics of subjects (N=17) gender lesion area characteristics precalence period(months) a :mean±sd age(years) subject male 10 female 7 right 7 left 10 a 1529±1727 a 6241±883-00±11-08±11 C3 C4 EEG Kolmogorov- Smirnov t C3 C4 t SPSS for Window 170 α=01 ** P<01 Figure 2 The difference of mu rhythm between the picture observation condition and the action observation condition

5 (p<01)(fig 2) 3 C3 C4 C3-08±12 C4-08±12 (p>01)(fig 3) (Oberman 2007) 20 Figure 3 The difference of mu rhythm between C3 and C4 during the action observation condition Ⅳ Kilner (2009) Holmes(2011) Buccino (2001)

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