Transcranial Magnetic Stimulation as a Treatment of Depression and Other Psychiatric/Neurologic Disorders Corporate Medical Policy
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1 Transcranial Magnetic Stimulation as a Treatment of Depression and Other Psychiatric/Neurologic Disorders Corporate Medical Policy File Name: Transcranial Magnetic Stimulation as a Treatment of Depression and Other Psychiatric/Neurologic Disorders File Code: UM.SPSVC.10 Origination Date: 07/2015 Last Review: 11/2018 Next Review: 11/2019 Effective Date: 04/01/2019 Description/Summary Transcranial magnetic stimulation (TMS) is a noninvasive method of delivering electrical stimulation to the brain. A magnetic field is delivered through the skull where it induces electric currents that affect neuronal function. Repetitive TMS (rtms) is being evaluated as a treatment of depression and other psychiatric/neurologic brain disorders. TMS involves placement of a small coil over the scalp; passing a rapidly alternating current through the coil wire, which produces a magnetic field that passes unimpeded through the scalp and bone, resulting in electrical stimulation of the cortex. The literature on rtms for treatment-resistant depression (TRD) includes numerous double-blind, randomized shamcontrolled short-term trials. Results of these trials show mean improvements of uncertain clinical significance across groups as a whole. The percentage of subjects who show a clinically significant response is reported at approximately 2 to 3 times that of sham controls, with approximately 15% to 25% of patients meeting the definition of clinical response. Based on the short-term benefit observed in randomized controlled trials (RCTs), clinical input, and the lack of alternative treatments aside from electroconvulsive therapy (ECT) in patients with TRD, rtms may be considered medically necessary in patients with TRD who meet specific criteria. For other psychiatric/neurologic conditions, the evidence is insufficient to determine whether rtms leads to improved outcomes. The available clinical trials are small and report mixed results for a variety of conditions other than depression. There are no large, highquality trials for any of these other conditions. Therefore, rtms is considered investigational for other psychiatric/neurologic conditions. Page 1 of 10
2 Policy Coding Information Click the links below for attachments, coding tables & instructions. Attachment I- CPT Code List & Instructions When a service may be considered medically necessary Repetitive transcranial magnetic stimulation (rtms) of the brain may be considered medically necessary as a treatment of major depressive disorder when all of the following conditions (1-3) have been met: 1. Confirmed diagnosis of severe major depressive disorder (single or recurrent) documented by standardized rating scales that reliably measure depressive symptoms; AND 2. Any one of the following (a, b, c, or d): a. Failure of 4 trials of psychopharmacologic agents including 2 different agent classes and 2 augmentation trials; OR b. Inability to tolerate a therapeutic dose of medications as evidenced by 4 trials of psychopharmacologic agents with distinct side effects; OR c. History of response to rtms in a previous depressive episode (at least 3 months since the prior episode); OR d. Is a candidate for electroconvulsive therapy (ECT) and ECT would not be clinically superior to rtms (eg, in cases with psychosis, acute suicidal risk, catatonia or life-threatening situation rtms should NOT be utilized); AND 3. Failure of a trial of a psychotherapy known to be effective in the treatment of major depressive disorder of an adequate frequency and duration, without significant improvement in depressive symptoms, as documented by standardized rating scales that reliably measure depressive symptoms. When a service is considered investigational rtms for major depressive disorder that does not meet the criteria listed above is considered investigational. Continued treatment with rtms of the brain as maintenance therapy is considered investigational. Transcranial magnetic stimulation of the brain is considered investigational as a treatment of all other psychiatric/neurologic disorders, including but not limited to bipolar disorder, schizophrenia, obsessive- compulsive disorder, or migraine headaches. Policy Guidelines Repetitive transcranial magnetic stimulation should be performed using a U.S. Food and Drug Administration (FDA) cleared device in appropriately selected patients, by physicians who are adequately trained and experienced in the specific techniques used. A treatment course should not exceed 5 days per week for 6 weeks (total of 30 sessions), followed by a Page 2 of 10
3 3-week taper of 3 TMS treatments in week 1, 2 TMS treatments in week 2, and 1 TMS treatment in week 3. rtms provided in the presence of one of the contraindications below may be considered not medically necessary: a. Seizure disorder or any history of seizure with increased risk of future seizure; OR b. Acute or chronic psychotic symptoms or disorders (such as schizophrenia, schizophreniform or schizoaffective disorder) presenting within the current depressive episode; OR c. Neurologic conditions that include epilepsy, cerebrovascular disease, dementia, increased intracranial pressure, a history of repetitive or severe head trauma, or with primary or secondary tumors in the central nervous system (CNS); OR d. Presence of an implanted magnetic-sensitive medical device located 30 centimeters or less from the TMS magnetic coil or other implanted metal items, including but not limited to a cochlear implant, implanted cardioverter defibrillator (ICD), pacemaker, vagus nerve stimulator, or metal aneurysm clips or coils, staples, or stents. The following should be present for the administration of rtms: a. An attendant trained in basic cardiac life support and the management of complications such as seizures, as well as the use of the equipment must be present at all times; AND b. Adequate resuscitation equipment including, for example, suction and oxygen; AND c. The facility must maintain awareness of response times of emergency services (either fire/ambulance or code team ), which should be available within five minutes. These relationships are reviewed at least annually and include mock drills. Reference Resources 1. Blue Cross and Blue Shield Association Technology Evaluation Center (TEC). Transcranial magnetic stimulation for depression. TEC Assessments 2009; Volume 24, Tab Blue Cross and Blue Shield Association Technology Evaluation Center (TEC). Transcranial magnetic stimulation for depression. TEC Assessments 2011; Volume 26, Tab Blue Cross and Blue Shield Association Technology Evaluation Center (TEC). Transcranial magnetic stimulation for depression. TEC Assessments 2013; Volume 28, Tab Gaynes B, Lux L, Lloyd S et al. Nonpharmacologic Interventions for Treatment - Resistant Depression in Adults. Comparative Effectiveness Review No. 33. (Prepared by RTI International-University of North Carolina (RTI-UNC) Evidence based Practice Center under Contract No I.) AHRQ Publication No. 11-EHC056- EF. Rockville, MD: Agency for Healthcare Research and Quality Available online at: 0.pdf. Last accessed April, Page 3 of 10
4 5. Schutter DJ. Antidepressant efficacy of high-frequency transcranial magnetic stimulation over the left dorsolateral prefrontal cortex in double-blind shamcontrolled designs: a meta-analysis. Psychol Med 2009; 39(1): Gross M, Nakamura L, Pascual-Leone A et al. Has repetitive transcranial magnetic stimulation (rtms) treatment for depression improved? A systematic review and metaanalysis comparing the recent vs. the earlier rtms studies. Acta Psychiatr Scand 2007; 116(3): Lam RW, Chan P, Wilkins-Ho M et al. Repetitive transcranial magnetic stimulation for treatment- resistant depression: a systematic review and metaanalysis. Can J Psychiatry 2008; 53(9): O'Reardon JP, Solvason HB, Janicak PG et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007; 62(11): George MS, Lisanby SH, Avery D et al. Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial. Arch Gen Psychiatry 2010; 67(5): Avery DH, Holtzheimer PE, 3rd, Fawaz W et al. A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression. Biol Psychiatry 2006; 59(2): Rossini D, Lucca A, Zanardi R et al. Transcranial magnetic stimulation in treatmentresistant depressed patients: a double-blind, placebo-controlled trial. Psychiatry Res 2005; 137(1-2): Mogg A, Pluck G, Eranti SV et al. A randomized controlled trial with 4-month followup of adjunctive repetitive transcranial magnetic stimulation of the left prefrontal cortex for depression. Psychol Med 2008; 38(3): Fitzgerald PB, Hoy K, McQueen S et al. A randomized trial of rtms targeted with MRI based neuro- navigation in treatment-resistant depression. Neuropsychopharmacology 2009; 34(5): Grunhaus L, Schreiber S, Dolberg OT et al. A randomized controlled comparison of electroconvulsive therapy and repetitive transcranial magnetic stimulation in severe and resistant nonpsychotic major depression. Biol Psychiatry 2003; 53(4): McLoughlin DM, Mogg A, Eranti S et al. The clinical effectiveness and cost of repetitive transcranial magnetic stimulation versus electroconvulsive therapy in severe depression: a multicentre pragmatic randomised controlled trial and economic analysis. Health Technol Assess 2007; 11(24): Rosa MA, Gattaz WF, Pascual-Leone A et al. Comparison of repetitive transcranial magnetic stimulation and electroconvulsive therapy in unipolar non-psychotic refractory depression: a randomized, single-blind study. Int J Neuropsychopharmacol 2006; 9(6): U.S. Food and Drug Administration. 510(k) Summary: Brainsway deep TMS System Available online at: Last accessed February, Fitzgerald PB, Brown TL, Marston NA et al. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Arch Gen Psychiatry 2003; 60(10): Page 4 of 10
5 19. Fitzgerald PB, Benitez J, de Castella A et al. A randomized, controlled trial of sequential bilateral repetitive transcranial magnetic stimulation for treatmentresistant depression. Am J Psychiatry 2006; 163(1): Fitzgerald PB, Huntsman S, Gunewardene R et al. A randomized trial of low -frequency right- prefrontal-cortex transcranial magnetic stimulation as augmentation in treatment-resistant major depression. Int J Neuropsychopharmacol 2006; 9(6): Triggs WJ, Ricciuti N, Ward HE et al. Right and left dorsolateral pre-frontal rtms treatment of refractory depression: a randomized, sham-controlled trial. Psychiatry Res 2010; 178(3): Koerselman F, Laman DM, van Duijn H et al. A 3-month, follow-up, randomized, placebo-controlled study of repetitive transcranial magnetic stimulation in depression. J Clin Psychiatry 2004; 65(10): Rumi DO, Gattaz WF, Rigonatti SP et al. Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study. Biol Psychiatry 2005; 57(2): Herwig U, Fallgatter AJ, Hoppner J et al. Antidepressant effects of augmentative transcranial magnetic stimulation: randomised multicentre trial. Br J Psychiatry 2007; 191: Jorge RE, Moser DJ, Acion L et al. Treatment of vascular depression using repetitive transcranial magnetic stimulation. Arch Gen Psychiatry 2008; 65(3): Ullrich H, Kranaster L, Sigges E et al. Ultra-high-frequency left prefrontal transcranial magnetic stimulation as augmentation in severely ill patients with depression: a naturalistic sham- controlled, double-blind, randomized trial. Neuropsychobiology 2012; 66(3): Demirtas-Tatlidede A, Mechanic-Hamilton D, Press DZ et al. An open-label, prospective study of repetitive transcranial magnetic stimulation (rtms) in the longterm treatment of refractory depression: reproducibility and duration of the antidepressant effect in medication-free patients. J Clin Psychiatry 2008; 69(6): Richieri R, Guedj E, Michel P et al. Maintenance transcranial magnetic stimulation reduces depression relapse: a propensity-adjusted analysis. J Affect Disord 2013; 151(1): Connolly KR, Helmer A, Cristancho MA et al. Effectiveness of transcranial magnetic stimulation in clinical practice post-fda approval in the United States: results observed with the first 100 consecutive cases of depression at an academic medical center. J Clin Psychiatry 2012; 73(4):e Janicak PG, Nahas Z, Lisanby SH et al. Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study. Brain Stimul 2010; 3(4): Fitzgerald PB, Grace N, Hoy KE et al. An open label trial of clustered maintenance rtms for patients with refractory depression. Brain Stimul Ahmed MA, Darwish ES, Khedr EM et al. Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer's dementia. J Neurol Rabey JM, Dobronevsky E, Aichenbaum S et al. Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality fo r the treatment of Alzheimer's disease: a randomized, double-blind study. J Neural Transm Page 5 of 10
6 34. Weaver L, Rostain AL, Mace W et al. Transcranial magnetic stimulation (TMS) in the treatment of attention-deficit/hyperactivity disorder in adolescents and young adults: a pilot study. J ECT 2012; 28(2): Walpoth M, Hoertnagl C, Mangweth-Matzek B et al. Repetitive transcranial magnetic stimulation in bulimia nervosa: preliminary results of a single-centre, randomised, double-blind, sham-controlled trial in female outpatients. Psychother Psychosom 2008; 77(1): Khedr EM, Abo-Elfetoh N, Rothwell JC. Treatment of post-stroke dysphagia with repetitive transcranial magnetic stimulation. Acta Neurol Scand 2009; 119(3): Kim L, Chun MH, Kim BR et al. Effect of repetitive transcranial magnetic stimulation on patients with brain injury and Dysphagia. Ann Rehabil Med 2011; 35(6): Sun W, Mao W, Meng X et al. Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy: a controlled clinical study. Epilepsia 2012; 53(10): Marlow NM, Bonilha HS, Short EB. Efficacy of Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation for Treating Fibromyalgia Syndrome: A Systematic Review. Pain Pract Short EB, Borckardt JJ, Anderson BS et al. Ten sessions of adjunctive left prefrontal rtms significantly reduces fibromyalgia pain: A randomized, controlled pilot study. Pain 2011; 152(11): Maestu C, Blanco M, Nevado A et al. Reduction of pain thresholds in fibromyalgia after very low- intensity magnetic stimulation: A double-blinded, randomized placebocontrolled clinical trial. Pain Res Manag 2013; 18(6):e U.S. Food and Drug Administration. De Novo classification request for cerena transcranial magnetic stimulator (TMS) device Available online at: Last accessed April, Berlim MT, Neufeld NH, Van den Eynde F. Repetitive transcranial magnetic stimulation (rtms) for obsessive-compulsive disorder (OCD): an exploratory metaanalysis of randomized and sham- controlled trials. J Psychiatr Res 2013; 47(8): Mantovani A, Aly M, Dagan Y et al. Randomized sham controlled trial of repetitive transcranial magnetic stimulation to the dorsolateral prefrontal cortex for the treatment of panic disorder with comorbid major depression. J Affect Disord 2013; 144(1-2): Elahi B, Elahi B, Chen R. Effect of transcranial magnetic stimulation on Parkinson motor function-- systematic review of controlled clinical trials. Mov Disord 2009; 24(3): Benninger DH, Iseki K, Kranick S et al. Controlled study of 50-Hz repetitive transcranial magnetic stimulation for the treatment of Parkinson disease. Neurorehabil Neural Repair 2012; 26(9): Yang YR, Tseng CY, Chiou SY et al. Combination of rtms and Treadmill Training Modulates Corticomotor Inhibition and Improves Walking in Parkinson Disease: A Randomized Trial. Neurorehabil Neural Repair Shirota Y, Ohtsu H, Hamada M et al. Supplementary motor area stimulation for Parkinson disease: a randomized controlled study. Neurology 2013; 80(15): Page 6 of 10
7 49. Myczkowski ML, Dias AM, Luvisotto T et al. Effects of repetitive transcranial magnetic stimulation on clinical, social, and cognitive performance in postpartum depression. Neuropsychiatr Dis Treat 2012; 8: Cohen H, Kaplan Z, Kotler M et al. Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder: a double-blind, placebo-controlled study. Am J Psychiatry 2004; 161(3): Watts BV, Landon B, Groft A et al. A sham controlled study of repetitive transcranial magnetic stimulation for posttraumatic stress disorder. Brain Stimul 2012; 5(1): Isserles M, Shalev AY, Roth Y et al. Effectiveness of deep transcranial magnetic stimulation combined with a brief exposure procedure in post-traumatic stress disorder - A pilot study. Brain Stimul Blue Cross and Blue Shield Association Technology Evaluation Center (TEC). Transcranial magnetic stimulation for the treatment of schizophrenia. TEC Assessments 2011; Volume 26, Tab Slotema CW, Aleman A, Daskalakis ZJ et al. Meta-analysis of repetitive transcranial magnetic stimulation in the treatment of auditory verbal hallucinations: Update and effects after one month. Schizophr Res 2012; 142(1-3): Blumberger DM, Christensen BK, Zipursky RB et al. MRI-targeted repetitive transcranial magnetic stimulation of Heschl's gyrus for refractory auditory hallucinations. Brain Stimul 2012; 5(4): Rosenberg O, Gersner R, Klein LD et al. Deep transcranial magnetic stimulation addon for the treatment of auditory hallucinations: a double-blind study. Ann Gen Psychiatry 2012; 11: Hao Z, Wang D, Zeng Y et al. Repetitive transcranial magnetic stimulation for improving function after stroke. Cochrane Database Syst Rev 2013; 5:CD Hsu WY, Cheng CH, Liao KK et al. Effects of repetitive transcranial magnetic stimulation on motor functions in patients with stroke: a meta-analysis. Stroke 2012; 43(7): Seniow J, Bilik M, Lesniak M et al. Transcranial magnetic stimulation combined with physiotherapy in rehabilitation of poststroke hemiparesis: a randomized, double -blind, placebo-controlled study. Neurorehabil Neural Repair 2012; 26(9): American Psychiatric Association. Practice Guidelines for the treatment of patients with major depressive disorder Available online at: Last accessed February, National Institute for Health and Care Excellence. Interventional Procedure Guideline (IPG) 214 Transcranial magnetic stimulation for severe depression Available online at: Last accessed February, National Institute for Health and Care Excellence. Clinical Practice Guideline (CG) 90 Depression in adults: The treatment and management of depression in adults Available online at: Last accessed February, National Institute for Health and Care Excellence. Bipolar disorder: The management of bipolar disorder in adults, children and adolescents, in primary and secondary care Available online at: Last accessed April, Page 7 of 10
8 64. Miyasaki JM, Shannon K, Voon V et al. Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 66(7): [Practice Guideline]. 2006; 2006/04/12. Available online at: Last accessed April, Kennedy SH, Milev R, Giacobbe P et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. IV. Neurostimulation therapies. J Affect Disord 2009; 117 Suppl 1:S Blue Cross and Blue Shield Association Medical Policy Manual, Policy Number: Last Reviewed December 2015 Document Precedence Blue Cross and Blue Shield of Vermont (BCBSVT) Medical Policies are developed to provide clinical guidance and are based on research of current medical literature and review of common medical practices in the treatment and diagnosis of disease. The applicable group/individual contract and member certificate language, or employer s benefit plan if an ASO group, determines benefits that are in effect at the time of service. Since medical practices and knowledge are constantly evolving, BCBSVT reserves the right to review and revise its medical policies periodically. To the extent that there may be any conflict between medical policy and contract/employer benefit plan language, the member s contract/employer benefit plan language takes precedence. Audit Information BCBSVT reserves the right to conduct audits on any provider and/or facility to ensure compliance with the guidelines stated in the medical policy. If an audit identifies instances of non-compliance with this medical policy, BCBSVT reserves the right to recoup all noncompliant payments. Benefit Determination Guidance Administrative and Contractual Guidance Prior approval is required and benefits are subject to all terms, limitations and conditions of the subscriber contract. NEHP/ABNE members may have different benefits for services listed in this policy. To confirm benefits, please contact the customer service department at the member s health plan. Federal Employee Program (FEP): Members may have different benefits that apply. For further information please contact FEP customer service or refer to the FEP Service Benefit Plan Brochure. It is important to verify the member s benefits prior to providing the service to determine if benefits are available or if there is a specific exclusion in the member s benefit. Page 8 of 10
9 Coverage varies according to the member s group or individual contract. Not all groups are required to follow the Vermont legislative mandates. Member Contract language takes precedence over medical policy when there is a conflict. If the member receives benefits through an Administrative Services Only (ASO) group, benefits may vary or not apply. To verify benefit information, please refer to the member s employer benefit plan documents or contact the customer service department. Language in the employer benefit plan documents takes precedence over medical policy when there is a conflict. Policy Implementation/Update information 07/2015 New policy. Adopted BCBSA policy# Approved by medical policy committee on 3/30/15. Effective 1/1/16. Next review /2017 Removed ICD 9 codes, Updated ICD Codes added F32.89 deleted F32.8, Updated references, Updated formatting to align to BCBSA MPRM # /2018 No changes to policy. Removed ICD-10-CM table. Eligible providers Qualified healthcare professionals practicing within the scope of their license(s). Approved by BCBSVT Medical Directors Date Approved Joshua Plavin, MD, MPH Chief Medical Officer Kate McIntosh, MD, FAAP Senior Medical Director Attachment I CPT Code List & Instructions Code Type Number Description Policy Instructions The following codes will be considered as medically necessary when applicable criteria have been met. CPT Therapeutic repetitive transcranial magnetic stimulation (TMS) treatment; initial, including cortical mapping, motor threshold determination, delivery and management Prior Approval Required Page 9 of 10
10 Code Type Number Description Policy Instructions CPT Therapeutic repetitive transcranial magnetic stimulation (TMS) treatment; subsequent delivery and management, per session Prior Approval Required CPT Therapeutic repetitive transcranial magnetic stimulation (TMS) treatment; subsequent motor threshold re-determination with delivery and management Prior Approval Required Page 10 of 10
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